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1.
Omega (Westport) ; 87(3): 921-940, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34275388

RESUMO

A qualitative approach was used to explore how online web forums might facilitate recovery and the process of coping. Ten online web forums written by young people who have personally experienced the death of a parent formed the data of this study. Previous research suggests forum users do not receive the supportive reactions from face-to-face interactions that they desire. Thematic analysis found that forums created an environment where young people can process the bereavement of a parent. Forums allowed young people to use their experience of bereavement to positively support others with similar experiences. The findings imply that the process of using forums can positively impact individuals who have experienced the loss of a parent. This supports recommendations by professionals, to consider online forums as a coping strategy. This study presents one of the few analyses of web forums written by young people who have experienced parental bereavement.


Assuntos
Luto , Humanos , Adolescente , Pesar , Pais , Adaptação Psicológica
2.
Aust N Z J Obstet Gynaecol ; 62(1): 47-54, 2022 02.
Artigo em Inglês | MEDLINE | ID: mdl-34455584

RESUMO

BACKGROUND: Informed consent in obstetrics should involve full disclosure of risks, benefits and alternative interventions. However, we have found no evidence of a formal informed consent process before an attempt at vaginal delivery in published policy or practice. The idea of informed consent in vaginal birth has attracted controversy and has been the subject of some debate. AIM: To explore the perspectives and experiences of informed consent and birth preparedness/complication readiness for birthing women in a high resource setting. MATERIALS AND METHODS: Qualitative study using semi-structured interviews to examine experiences and perspectives of women following birth. RESULTS: Forty telephone interviews were concluded. Eight statement categories were identified: (i) no issues of consent, (ii) absent/inadequate informed consent, (iii) adequate birth preparedness/complication readiness, (iv) inadequate birth preparedness/complication readiness, (v) desire to forfeit decision making to a trusted and accountable health professional, (vi) belief that informed consent is not realistic in birth under some circumstances, (vii) negative feelings related to birth and (viii) poor postnatal follow-up. CONCLUSIONS: When complications arose during birth, 20% of participants felt that informed consent was absent/inadequate, 25% of participants suggested policy change in favour of a formal informed consent process and 55% of participants suggested policy change in favour of increased birth preparedness/complication readiness. Our study suggests that informed consent for vaginal birth and formal birth preparedness/complication readiness should form part of routine antenatal care. Women's preferences for decision-making and informed consent should be established before birth.


Assuntos
Conhecimentos, Atitudes e Prática em Saúde , Gestantes , Estudos Transversais , Feminino , Humanos , Consentimento Livre e Esclarecido , Gravidez , Cuidado Pré-Natal
3.
Clin Psychol Psychother ; 29(5): 1494-1514, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35912665

RESUMO

BACKGROUND: Mindfulness-based Cognitive Therapy (MBCT) is a relapse-prevention intervention for people experiencing major depression. Three qualitative meta-syntheses investigating experiences of taking part in MBCT and/or Mindfulness-based Stress Reduction (MBSR) across different diagnostic populations reported themes including control, choice, group processes, relationships and struggles. As multiple studies have been published since, we aimed to update, systematically review and synthesize the experiences of participants with depression taking part in MBCT. METHODS: Four databases were searched systematically (PsycInfo, Web of Science, Medline and CINAHL) up to and including 12 November 2021. Twenty-one qualitative studies met the review criteria. All papers were rated as fair using a quality appraisal tool. Meta-ethnography was applied. RESULTS: Across 21 studies of participants with current or previous depression who had participated in MBCT, three overarching themes were developed: 'Becoming skilled and taking action', 'Acceptance' and 'Ambivalence and Variability'. Participants became skilled through engagement in mindfulness practices, reporting increased awareness, perspective and agency over their experiences. Participants developed acceptance towards their experiences, self and others. There was variability and ambivalence regarding participants' expectations and difficulties within mindfulness practices. LIMITATIONS: Many studies were conducted in MBCT-research centres that may hold conflicts of interest. Many studies did not address the impact of the participant-researcher relationship thus potentially affecting their interpretations. Studies were skewed towards the experiences of female participants. CONCLUSIONS: Our findings help to enhance participant confidence in MBCT, alongside understanding the processes of change and the potential for difficulties. MBCT is beneficial and provides meaningful change for many but remains challenging for some.


Assuntos
Terapia Cognitivo-Comportamental , Transtorno Depressivo Maior , Atenção Plena , Humanos , Feminino , Transtorno Depressivo Maior/terapia , Depressão/psicologia , Antropologia Cultural , Resultado do Tratamento
4.
Int Urogynecol J ; 31(4): 793-797, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-31529327

RESUMO

INTRODUCTION AND HYPOTHESIS: Cystocele recurrence remains a major challenge. Anterior colporrhaphy (AC) offers variable success rates that are mostly poorer than native-tissue repairs in other compartments. We compared outcomes after the use of Uphold™ transvaginal mesh kit and AC. METHODS: A retrospective external audit including patients after Uphold™ mesh implantation (2010-2016) analysed against previously published data obtained in identical fashion after AC at the same hospital (2002-2005). Patients underwent an interview, clinical examination and 4D-translabial ultrasound. Offline analysis was performed blinded against all other data. RESULTS: Of 264 patients after mesh and 242 patients after AC, we saw 82 (31%) and 83 (34%), after a median interval of 3.9 years (range 0.4-7.3). Mean age was 64 years (34-86), mean body mass index was 27.7 kg/m2 (15-56) and median vaginal parity 3 deliveries (1-9). AC and mesh groups significantly differed with regard to median follow-up interval (4.3 vs 3.2 years), mean age (61.3 ± 12 vs 67.2 ± 7.5 years), vaginal parity (3 vs 2), past instrumental delivery (20 out of 83 vs 36 out of 82) and concurrent hysterectomy, other prolapse repair or midurethral sling (35 out of 83 vs 1 out of 82, 58 out of 83 vs 76 out of 82 and 12 out of 83 vs 29 out of 82 respectively). The mesh group had 9 cases of dyspareunia, 4 of chronic pelvic pain and 4 vaginal mesh exposures. Univariate comparison between groups for satisfaction and sonographic cystocele favoured mesh. However, point Ba, symptoms of prolapse and reoperation for prolapse were not significantly different. Associations were confirmed on multivariate analysis. CONCLUSIONS: This analysis of two audit projects suggests that the transvaginal Uphold™ mesh kit may confer some advantages over AC for cystocele repair.


Assuntos
Cistocele , Prolapso de Órgão Pélvico , Telas Cirúrgicas , Idoso , Cistocele/diagnóstico por imagem , Cistocele/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade , Prolapso de Órgão Pélvico/cirurgia , Gravidez , Estudos Retrospectivos , Telas Cirúrgicas/efeitos adversos , Resultado do Tratamento
5.
Int Urogynecol J ; 31(9): 1771-1776, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32535687

RESUMO

INTRODUCTION AND HYPOTHESIS: An increase in vaginal delivery with forceps may increase rates of pelvic floor trauma. This study was designed to predict trauma rates resulting from policies preferencing forceps. METHODS: This is an observational cohort study utilizing data from 660 primiparae enrolled in an RCT in two tertiary obstetric units in Sydney, Australia. Participants were assessed clinically and with 4D translabial ultrasound in the late third trimester and again at 3-6 months postpartum. Incidence of trauma associated with mode of delivery was adjusted to reflect change associated with a conversion of vacuum to forceps delivery. Primary outcome measures were third-/fourth-degree tear, levator avulsion (LA) and external anal sphincter (EAS) trauma diagnosed sonographically. RESULTS: Five hundred four women were seen at a mean of 5.1 (2.3-24.3) months postpartum. After exclusion of 21 because of missing data, 483 women were analysed: 112 (23%) had a CS, 268 (55%) a normal vaginal delivery (NVD), 69 (14%) a vacuum (VD) and 34 (7%) a forceps (FD). One hundred fifty-two women had EAS trauma and/or LA; 17 sustained both. After VD, 32/69 (46%) women suffered LA and/or EAS trauma; after FD, it was 33/34 (97%). Converting VD to FD was estimated to result in an increase in trauma from 152/483 (31%) to 187/483 (39%). A formula can be generated based on local obstetric and ultrasound data to estimate trauma incidence. CONCLUSIONS: A change in obstetric practice resulting in the conversion of primary VD to primary FD would be expected to substantially increase the likelihood of pelvic floor trauma.


Assuntos
Parto Obstétrico , Instrumentos Cirúrgicos , Austrália , Parto Obstétrico/efeitos adversos , Feminino , Humanos , Forceps Obstétrico/efeitos adversos , Gravidez , Fatores de Risco , Ultrassonografia , Vácuo
6.
Int Urogynecol J ; 30(9): 1581-1585, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-30904935

RESUMO

INTRODUCTION AND HYPOTHESIS: Our primary objective was to describe long-term outcomes after posterior colporrhaphy with and without mesh augmentation. METHODS: This was a retrospective study including 93 patients after posterior colporrhaphy (native tissue in 39 and synthetic mesh augmented in 54). The indication was symptoms of prolapse with clinical posterior vaginal wall prolapse. Mesh augmentation and concomitant prolapse operations were performed at the surgeon's discretion. Patients underwent interview, clinical examination and 4D pelvic floor ultrasound. Imaging analysis was done with the reviewer blinded against all other data. Generalized linear modeling was used to compare groups with logistic regression for binary and linear regression for continuous outcomes. RESULTS: Patients were seen on average 5.3 years after surgery and described persistent symptoms of prolapse in 32% and of obstructed defecation in 33%. Clinical recurrence (Bp ≥ -1) was seen in 20%, while sonographic recurrence (rectal ampulla descent to ≥ 15 mm below the symphysis pubis) was noted in 12%. A true rectocele was diagnosed in 33% of patients. No major differences in outcomes were found between those who underwent native tissue and those who had a mesh-augmented repair. CONCLUSIONS: Mesh augmentation was not superior to native tissue posterior colporrhaphy, and both were only moderately effective in eliminating a true rectocele and symptoms of obstructed defecation 5 years after reconstructive surgery.


Assuntos
Colposcopia/métodos , Prolapso de Órgão Pélvico/cirurgia , Procedimentos de Cirurgia Plástica/métodos , Telas Cirúrgicas , Ultrassonografia/métodos , Adulto , Idoso , Colposcopia/efeitos adversos , Constipação Intestinal/diagnóstico por imagem , Constipação Intestinal/etiologia , Feminino , Humanos , Pessoa de Meia-Idade , Diafragma da Pelve/diagnóstico por imagem , Diafragma da Pelve/cirurgia , Prolapso de Órgão Pélvico/diagnóstico por imagem , Complicações Pós-Operatórias/diagnóstico por imagem , Complicações Pós-Operatórias/etiologia , Procedimentos de Cirurgia Plástica/efeitos adversos , Retocele/diagnóstico por imagem , Retocele/etiologia , Estudos Retrospectivos , Resultado do Tratamento
7.
Am J Obstet Gynecol ; 219(4): 379.e1-379.e8, 2018 10.
Artigo em Inglês | MEDLINE | ID: mdl-30063899

RESUMO

BACKGROUND: Trauma to the perineum, levator ani complex, and anal sphincter is common during vaginal childbirth, but often clinically underdiagnosed, and many women are unaware of the potential for long-term damage. OBJECTIVE: In this study we use transperineal ultrasound to identify how many women will achieve a normal vaginal delivery without substantial damage to the levator ani or anal sphincter muscles, and to create a model to predict patient characteristics associated with successful atraumatic normal vaginal delivery. STUDY DESIGN: This is a retrospective, secondary analysis of data sets gathered in the context of an interventional perinatal imaging study. A total of 660 primiparas, carrying an uncomplicated singleton pregnancy, underwent an antepartum and postpartum interview, vaginal exam (Pelvic Organ Prolapse Quantification), and 4-dimensional translabial ultrasound. Ultrasound data were analyzed for levator trauma and/or overdistention and residual sphincter defects. Postprocessing analysis of ultrasound volumes was performed blinded against clinical data and analyzed against obstetric data retrieved from the local maternity database. Levator avulsion was diagnosed if the muscle insertion at the inferior pubic ramus at the plane of minimal hiatal dimensions and within 5 mm above this plane on tomographic ultrasound imaging was abnormal, ie the muscle was disconnected from the inferior pubic ramus. Hiatal overdistensibility (microtrauma) was diagnosed if there was a peripartum increase in hiatal area on Valsalva by >20% with the resultant area ≥25 cm2. A sphincter defect was diagnosed if a gap of >30 degrees was seen in ≥4 of 6 tomographic ultrasound imaging slices bracketing the external anal sphincter. Two models were tested: a first model that defines severe pelvic floor trauma as either obstetric anal sphincter injury or levator avulsion, and a second, more conservative model, that also included microtrauma. RESULTS: A total of 504/660 women (76%) returned for postpartum follow-up as described previously. In all, 21 patients were excluded due to inadequate data or intercurrent pregnancy, leaving 483 women for analysis. Model 1 defined nontraumatic vaginal delivery as excluding operative delivery, obstetric anal sphincter injuries, and sonographic evidence of levator avulsion or residual sphincter defect. Model 2 also excluded microtrauma. Of 483 women, 112 (23%) had a cesarean delivery, 103 (21%) had an operative vaginal delivery, and 17 (4%) had a third-/fourth-degree tear, leaving 251 women who could be said to have had a normal vaginal delivery. On ultrasound, in model 1, 27 women (6%) had an avulsion and 31 (6%) had a residual defect, leaving 193/483 (40%) who met the criteria for atraumatic normal vaginal delivery. In model 2, an additional 33 women (7%) had microtrauma, leaving only 160/483 (33%) women who met the criteria for atraumatic normal vaginal delivery. On multivariate analysis, younger age and earlier gestation at time of delivery remained highly significant as predictors of atraumatic normal vaginal delivery in both models, with increased hiatal area on Valsalva also significant in model 2 (all P ≤ .035). CONCLUSION: The prevalence of significant pelvic floor trauma after vaginal child birth is much higher than generally assumed. Rates of obstetric anal sphincter injury are often underestimated and levator avulsion is not included as a consequence of vaginal birth in most obstetric text books. In this study less than half (33-40%) of primiparous women achieved an atraumatic normal vaginal delivery.


Assuntos
Canal Anal/lesões , Parto Obstétrico , Complicações do Trabalho de Parto/epidemiologia , Diafragma da Pelve/lesões , Transtornos Puerperais/epidemiologia , Adulto , Fatores Etários , Canal Anal/diagnóstico por imagem , Feminino , Idade Gestacional , Humanos , Modelos Teóricos , New South Wales/epidemiologia , Complicações do Trabalho de Parto/diagnóstico por imagem , Complicações do Trabalho de Parto/etiologia , Diafragma da Pelve/diagnóstico por imagem , Gravidez , Prevalência , Transtornos Puerperais/diagnóstico por imagem , Transtornos Puerperais/etiologia , Estudos Retrospectivos , Fatores de Risco , Adulto Jovem
8.
Acta Obstet Gynecol Scand ; 97(6): 751-757, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29393505

RESUMO

INTRODUCTION: Levator trauma is a risk factor for the development of pelvic organ prolapse. We aimed to identify antenatal predictors for significant damage to the levator ani muscle during a first vaginal delivery. MATERIAL AND METHODS: A retrospective observational study utilizing data from two studies with identical inclusion criteria and assessment protocols between 2005 and 2014. A total of 1148 primiparae with an uncomplicated singleton pregnancy were recruited and assessed with translabial ultrasound at 36 weeks antepartum and 871 (76%) returned for reassessment 3-6 months postpartum. The ultrasound data of vaginally parous women were analyzed for levator avulsion and microtrauma. The former was diagnosed if the muscle insertion at the inferior pubic ramus in the plane of minimal hiatal dimensions and within 5 mm above were abnormal on tomographic ultrasound imaging. Microtrauma was diagnosed in women with an intact levator and if there was a postpartum increase in hiatal area on Valsalva by >20% with the resultant area ≥25 cm2 . RESULTS: The complete datasets of 844 women were analyzed. Among them, 609 delivered vaginally: by normal vaginal delivery in 452 (54%), a vacuum birth in 102 (12%) and a forceps delivery in 55 (6%). Levator avulsion was diagnosed in 98 and microtrauma in 97. On multivariate analysis, increasing maternal age, lower body mass index and lower bladder neck descent were associated with avulsion. Increased bladder neck descent and a family history of cesarean section (CS) were associcated with microtrauma. CONCLUSIONS: Maternal age, body mass index, bladder neck descent and family history of CS are antenatal predictors for levator trauma.


Assuntos
Complicações do Trabalho de Parto/diagnóstico por imagem , Diafragma da Pelve/diagnóstico por imagem , Diafragma da Pelve/lesões , Ultrassonografia/métodos , Adolescente , Adulto , Austrália , Índice de Massa Corporal , Parto Obstétrico , Feminino , Humanos , Idade Materna , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Gravidez , Estudos Retrospectivos , Fatores de Risco , Ultrassonografia Pré-Natal
9.
Acta Obstet Gynecol Scand ; 96(4): 426-431, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28117880

RESUMO

INTRODUCTION: Damage to the pelvic floor during vaginal childbirth is common, and may take the form of levator avulsion or irreversible overdistension of the levator hiatus (microtrauma). Such trauma is a major risk factor for pelvic organ prolapse later in life. In this study we aimed to identify intrapartum risk factors for levator trauma. MATERIAL AND METHODS: This is a retrospective analysis of data obtained in two perinatal studies on primiparous women. Between 2005 and 2014, 1148 women carrying an uncomplicated singleton pregnancy in the late third trimester were seen for 4D pelvic floor ultrasound and an interview. They were invited for a repeat assessment at three months postpartum. RESULTS: Of 1148 women, 871 (76%) returned for assessment at a mean of five months postpartum. The datasets of 844 women were analyzed due to missing data or concurrent pregnancy in 27. In all, 452 (54%) had a normal vaginal delivery, 102 (12%) a vacuum, 55 (6%) a forceps, and 235 (28%) a cesarean section. On multivariate analysis forceps, length of second stage and obstetric anal sphincter tears were significantly associated with levator avulsion. There were no significant predictors identified for irreversible overdistension. CONCLUSIONS: The use of forceps, a prolonged second stage, and obstetric anal sphincter tears were associated with levator avulsion. There were no associated intrapartum predictors for hiatal overdistension.


Assuntos
Canal Anal/lesões , Lacerações/epidemiologia , Complicações do Trabalho de Parto/epidemiologia , Diafragma da Pelve/lesões , Adulto , Canal Anal/diagnóstico por imagem , Parto Obstétrico/métodos , Feminino , Humanos , Lacerações/prevenção & controle , Serviços de Saúde Materna , New South Wales/epidemiologia , Complicações do Trabalho de Parto/prevenção & controle , Forceps Obstétrico/efeitos adversos , Diafragma da Pelve/diagnóstico por imagem , Gravidez , Estudos Retrospectivos , Fatores de Risco , Ultrassonografia
10.
J Neural Transm (Vienna) ; 123(10): 1133-8, 2016 10.
Artigo em Inglês | MEDLINE | ID: mdl-27565148

RESUMO

Synaptic plasticity in the form of long-term potentiation (LTP) and long-term depression (LTD) is considered to be the neurophysiological correlate of learning and memory. Impairments are discussed to be one of the underlying pathophysiological mechanisms of developmental disorders. In so-called RASopathies [e.g., neurofibromatosis 1 (NF1)], neurocognitive impairments are frequent and are affected by components of the RAS pathway which lead to impairments in synaptic plasticity. Transcranial magnetic stimulation (TMS) provides a non-invasive method to investigate synaptic plasticity in humans. Here, we review studies using TMS to evaluate synaptic plasticity in patients with RASopathies. Patients with NF1 and Noonan syndrome (NS) showed reduced cortical LTP-like synaptic plasticity. In contrast, increased LTP-like synaptic plasticity has been shown in Costello syndrome. Notably, lovastatin normalized impaired LTP-like plasticity and increased intracortical inhibition in patients with NF1. TMS has been shown to be a safe and efficient method to investigate synaptic plasticity and intracortical inhibition in patients with RASopathies. Deeper insights in impairments of synaptic plasticity in RASopathies could help to develop new options for the therapy of learning deficits in these patients.


Assuntos
Córtex Motor/fisiopatologia , Inibição Neural/fisiologia , Neurofibromatose 1/patologia , Plasticidade Neuronal/fisiologia , Síndrome de Noonan/patologia , Bases de Dados Bibliográficas/estatística & dados numéricos , Humanos , Estimulação Magnética Transcraniana
11.
Int Urogynecol J ; 27(12): 1899-1903, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27250832

RESUMO

INTRODUCTION AND HYPOTHESIS: Obstetric anal sphincter injuries (OASI) are a major form of maternal birth trauma. Ultrasound imaging is commonly used to evaluate the condition. We undertook a study to compare the sonographic appearance of the external anal sphincter (EAS) 3 to 6 months and 2 to 3 years after a first birth. METHODS: A retrospective analysis of data of primiparous women obtained in a prospective perinatal imaging study. Women were invited for postnatal assessment 3 - 6 months and 2 - 3 years after a first delivery. All had completed a standardized questionnaire, and had undergone clinical examination and translabial 4D ultrasound imaging. A "significant" EAS defect was diagnosed if four out of six slices on tomographic ultrasound imaging showed a defect of ≥30° circumference. RESULTS: Datasets of 76 women with complete data and no intervening birth were assessed. Their mean age was 30.0 years (range 19.5 - 45.3 years) at the time of antenatal assessment. They were delivered at a mean gestation of 40 weeks (range 37 - 42 weeks), by caesarean section in 19, normal vaginal delivery in 42, vacuum delivery in 14 and forceps delivery in 1. A significant EAS defect on transperineal ultrasound imaging was found in 13 of 57 women (23 %) at an average of 4.7 months and in 12 of 57 (21 %) at a mean 26.4 months after a first vaginal delivery. CONCLUSIONS: In this cohort of primiparous women after a term singleton delivery, we found only minor improvement in sonographic appearance of the EAS between 4.7 months and 26.4 months on transperineal ultrasound imaging, arguing against any significant degree of structural recovery during this time period.


Assuntos
Canal Anal/diagnóstico por imagem , Adulto , Canal Anal/lesões , Feminino , Humanos , Pessoa de Meia-Idade , Paridade , Parto , Estudos Retrospectivos , Fatores de Tempo , Ultrassonografia , Adulto Jovem
12.
Health Expect ; 18(6): 1995-2010, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25376672

RESUMO

BACKGROUND: Health outcomes for long-term conditions (LTCs) can be improved by lifestyle, dietary and condition management-related behaviour change. Primary care is an important setting for behaviour change work. Practitioners have identified barriers to this work, but there is little evidence examining practices of behaviour change in primary care consultations and how patients and practitioners perceive these practices. OBJECTIVE: To examine how behaviour change is engaged with in primary care consultations for LTCs and investigate how behaviour change is perceived by patients and practitioners. DESIGN: Multiperspective, longitudinal qualitative research involving six primary health-care practices in England. Consultations between patients with LTCs and health-care practitioners were audio-recorded. Semi-structured interviews were completed with patients and practitioners, using stimulated recall. Patients were re-interviewed 3 months later. Framework analysis was applied to all data. PARTICIPANTS: Thirty-two people with at least one LTC (chronic obstructive pulmonary disease, diabetes, asthma and coronary heart disease) and 10 practitioners. RESULTS: Behaviour change talk in consultations was rare and, when it occurred, was characterized by deflection and diffidence on the part of practitioners. Patient motivation tended to be unaddressed. While practitioners positioned behaviour change work as outside their remit, patients felt uncertain about, yet responsible for, this work. Practitioners raised concerns that this work could damage other aspects of care, particularly the patient-practitioner relationship. CONCLUSION: Behaviour change work is often deflected or deferred by practitioners in consultations, who nevertheless vocalize support for its importance in interviews. This discrepancy between practitioners' accounts and behaviours needs to be addressed within primary health-care organizations.


Assuntos
Doença Crônica , Gerenciamento Clínico , Comportamentos Relacionados com a Saúde , Relações Médico-Paciente , Atenção Primária à Saúde/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Inglaterra , Feminino , Humanos , Estilo de Vida , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Motivação , Pesquisa Qualitativa
13.
BMC Fam Pract ; 15: 164, 2014 Oct 06.
Artigo em Inglês | MEDLINE | ID: mdl-25284048

RESUMO

BACKGROUND: Long-term conditions such as chronic obstructive pulmonary disease (COPD) are growing challenges for health services. Psychosocial co-morbidity is associated with poorer quality of life and greater use of health care in these patients but is often un-diagnosed or inadequately treated in primary care, where most care for these patients is provided. We developed a brief intervention, delivered by 'liaison health workers' (LHWs), to address psychosocial needs in the context of an integrated approach to physical and mental health. We report a qualitative study in which we characterize the intervention through the experience of the patients receiving it and examine how it was incorporated into primary care. METHODS: Qualitative study using patient and practice staff informants. We audio-recorded interviews with 29 patients offered the intervention (three had declined it or withdrawn) and 13 practice staff (GPs, nurses and administrators). Analysis used a constant comparative approach. RESULTS: Most patients were enthusiastic about the LHWs, describing the intervention as mobilizing their motivation for self-management. By contrast with other practitioners, patients experienced the LHWs as addressing their needs holistically, being guided by patient needs rather than professional agendas, forming individual relationships with patients and investing in patients and their capacity to change. Practices accommodated and accepted the LHWs, but positioned them as peripheral to and separate from the priority of physical care. CONCLUSIONS: Despite being a short-term intervention, patients described it as having enduring motivational benefits. The elements of the intervention that patients described map onto the key features of motivating interventions described by Self-Determination Theory. We suggest that the LHWs motivated patients to self-management by: (i) respecting patients' competence to decide on needs and priorities; (ii) forming relationships with patients as individuals; and (iii) fostering patients' sense of autonomy. While truly integrated primary care for patients with long-term conditions such as COPD remains elusive, existing practice staff might adopt elements of the LHWs' approach to enhance motivational change in patients with long-term conditions such as COPD.


Assuntos
Atitude do Pessoal de Saúde , Atitude Frente a Saúde , Motivação , Papel do Profissional de Enfermagem , Atenção Primária à Saúde , Doença Pulmonar Obstrutiva Crônica/enfermagem , Autocuidado , Idoso , Idoso de 80 Anos ou mais , Feminino , Medicina Geral , Humanos , Masculino , Pessoa de Meia-Idade , Satisfação do Paciente , Doença Pulmonar Obstrutiva Crônica/psicologia , Pesquisa Qualitativa , Qualidade de Vida
14.
Anaerobe ; 29: 44-51, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-24342346

RESUMO

Biofilm-based reactors are effectively used for wastewater treatment but are not common in biogas production. This study investigated biofilm dynamics on biofilm carriers incubated in batch biogas reactors at high and low organic loading rates for sludge from meat industry dissolved air flotation units. Biofilm formation and dynamics were studied using various microscopic techniques. Resulting micrographs were analysed for total cell numbers, thickness of biofilms, biofilm-covered surface area, and the area covered by extracellular polymeric substances (EPS). Cell numbers within biofilms (10(11) cells ml(-1)) were up to one order of magnitude higher compared to the numbers of cells in the fluid reactor content. Further, biofilm formation and structure mainly correlated with the numbers of microorganisms present in the fluid reactor content and the organic loading. At high organic loading (45 kg VS m(-3)), the thickness of the continuous biofilm layer ranged from 5 to 160 µm with an average of 51 µm and a median of 26 µm. Conversely, at lower organic loading (15 kg VS m(-3)), only microcolonies were detectable. Those microcolonies increased in their frequency of occurrence during ongoing fermentation. Independently from the organic loading rate, biofilms were embedded completely in EPS within seven days. The maturation and maintenance of biofilms changed during the batch fermentation due to decreasing substrate availability. Concomitant, detachment of microorganisms within biofilms was observed simultaneously with the decrease of biogas formation. This study demonstrates that biofilms of high cell densities can enhance digestion of organic waste and have positive effects on biogas production.


Assuntos
Archaea/metabolismo , Bactérias/metabolismo , Biofilmes/crescimento & desenvolvimento , Metano/biossíntese , Consórcios Microbianos/fisiologia , Anaerobiose , Archaea/ultraestrutura , Bactérias/ultraestrutura , Carga Bacteriana , Técnicas de Cultura Celular por Lotes , Biocombustíveis , Reatores Biológicos , Fermentação , Produtos da Carne , Pressão , Temperatura , Resíduos
15.
BMC Neurol ; 13: 131, 2013 Oct 02.
Artigo em Inglês | MEDLINE | ID: mdl-24088225

RESUMO

BACKGROUND: Neurofibromatosis type 1 (NF1) is one of the most common genetic disorders causing learning disabilities by mutations in the neurofibromin gene, an important inhibitor of the RAS pathway. In a mouse model of NF1, a loss of function mutation of the neurofibromin gene resulted in increased gamma aminobutyric acid (GABA)-mediated inhibition which led to decreased synaptic plasticity and deficits in attentional performance. Most importantly, these defictis were normalized by lovastatin. This placebo-controlled, double blind, randomized study aimed to investigate synaptic plasticity and cognition in humans with NF1 and tried to answer the question whether potential deficits may be rescued by lovastatin. METHODS: In NF1 patients (n = 11; 19-44 years) and healthy controls (HC; n = 11; 19-31 years) paired pulse transcranial magnetic stimulation (TMS) was used to study intracortical inhibition (paired pulse) and synaptic plasticity (paired associative stimulation). On behavioural level the Test of Attentional Performance (TAP) was used. To study the effect of 200 mg lovastatin for 4 days on all these parameters, a placebo-controlled, double blind, randomized trial was performed. RESULTS: In patients with NF1, lovastatin revealed significant decrease of intracortical inhibition, significant increase of synaptic plasticity as well as significant increase of phasic alertness. Compared to HC, patients with NF1 exposed increased intracortical inhibition, impaired synaptic plasticity and deficits in phasic alertness. CONCLUSIONS: This study demonstrates, for the first time, a link between a pathological RAS pathway activity, intracortical inhibition and impaired synaptic plasticity and its rescue by lovastatin in humans. Our findings revealed mechanisms of attention disorders in humans with NF1 and support the idea of a potential clinical benefit of lovastatin as a therapeutic option.


Assuntos
Anticolesterolemiantes/farmacologia , Córtex Cerebral/efeitos dos fármacos , Potencial Evocado Motor/efeitos dos fármacos , Potenciação de Longa Duração/efeitos dos fármacos , Lovastatina/farmacologia , Neurofibromatose 1/patologia , Adulto , Anticolesterolemiantes/uso terapêutico , Atenção/efeitos dos fármacos , Atenção/fisiologia , Córtex Cerebral/fisiologia , Estudos de Coortes , Tomada de Decisões/efeitos dos fármacos , Método Duplo-Cego , Feminino , Humanos , Lovastatina/uso terapêutico , Masculino , Inibição Neural/efeitos dos fármacos , Neurofibromatose 1/tratamento farmacológico , Fatores de Tempo , Estimulação Magnética Transcraniana , Adulto Jovem
16.
BMC Fam Pract ; 14: 103, 2013 Jul 21.
Artigo em Inglês | MEDLINE | ID: mdl-23870537

RESUMO

BACKGROUND: Long-term conditions (LTCs) are increasingly important determinants of quality of life and healthcare costs in populations worldwide. The Chronic Care Model and the NHS and Social Care Long Term Conditions Model highlight the use of consultations where patients are invited to attend a consultation with a primary care clinician (practice nurse or GP) to complete a review of the management of the LTC. We report a qualitative study in which we focus on the ways in which QOF (Quality and Outcomes Framework) shapes routine review consultations, and highlight the tensions exposed between patient-centred consulting and QOF-informed LTC management. METHODS: A longitudinal qualitative study. We audio-recorded consultations of primary care practitioners with patients with LTCs. We then interviewed both patients and practitioners using tape-assisted recall. Patient participants were followed for three months during which the research team made weekly contact and invited them to complete weekly logs about their health service use. A second interview at three months was conducted with patients. Analysis of the data sets used an integrative framework approach. RESULTS: Practitioners view consultations as a means of 'surveillance' of patients. Patients present themselves, often passively, to the practitioner for scrutiny, but leave the consultation with unmet biomedical, informational and emotional needs. Patients perceived review consultations as insignificant and irrelevant to the daily management of their LTC and future healthcare needs. Two deviant cases, where the requirements of the 'review' were subsumed to meet the patient's needs, focused on cancer and bereavement. CONCLUSIONS: Routine review consultations in primary care focus on the biomedical agenda set by QOF where the practitioner is the expert, and the patient agenda unheard. Review consultations shape patients' expectations of future care and socialize patients into becoming passive subjects of 'surveillance'. Patient needs outside the narrow protocol of the review are made invisible by the process of review except in extreme cases such as anticipating death and bereavement. We suggest how these constraints might be overcome.


Assuntos
Atenção Primária à Saúde , Qualidade da Assistência à Saúde , Encaminhamento e Consulta/normas , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Avaliação de Resultados em Cuidados de Saúde
18.
Aust N Z J Obstet Gynaecol ; 52(3): 277-81, 2012 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-22497634

RESUMO

INTRODUCTION: In 10-30% of women, vaginal birth results in levator ani tears ('avulsion') that are associated with pelvic floor dysfunction in later life. We hypothesised that women notice reduced pelvic floor muscle strength after childbirth, especially those with avulsion. METHODS: This is a secondary analysis of two perinatal studies. At 3-6 months postpartum, women were asked to estimate pelvic floor muscle strength relative to antepartum strength. Translabial ultrasound was performed to determine pelvic floor structure and function. RESULTS: Five hundred and thirteen primiparous women were seen at a median of 129 days after delivery of a singleton at a mean gestation of 40 weeks. At follow-up, 481 were able to rate pelvic floor strength (mean 89%). This reduction was associated with delivery mode (P < 0.001), episiotomy (P = 0.01), perineal tears (P = 0.025) and avulsion (n = 45, P = 0.04). CONCLUSION: After the birth of a first child, women notice a significant reduction in pelvic floor muscle strength, which is associated with delivery mode as well as perineal and pelvic floor muscle trauma. SUMMARY: Many women notice reduced pelvic floor function after childbirth, especially those who have suffered an avulsion of the puborectalis muscle.


Assuntos
Doenças do Ânus/epidemiologia , Força Muscular , Parto/fisiologia , Distúrbios do Assoalho Pélvico/epidemiologia , Adolescente , Adulto , Doenças do Ânus/diagnóstico por imagem , Doenças do Ânus/fisiopatologia , Episiotomia , Feminino , Humanos , Pessoa de Meia-Idade , Distúrbios do Assoalho Pélvico/diagnóstico por imagem , Distúrbios do Assoalho Pélvico/fisiopatologia , Períneo/lesões , Períneo/fisiopatologia , Período Pós-Parto/fisiologia , Gravidez , Ultrassonografia , Adulto Jovem
20.
Int Urogynecol J ; 22(12): 1521-8, 2011 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-21809156

RESUMO

INTRODUCTION AND HYPOTHESIS: The purpose of this study is to evaluate whether antepartum use of a birth trainer may reduce levator trauma. METHODS: Two hundred nulliparous women were examined with four-dimensional translabial ultrasonography at 35-37 weeks of gestation and 3 months postpartum in a randomised controlled pilot study. Women in the intervention group were instructed to use the birth trainer from 37 weeks onwards. RESULTS: One hundred forty-six women returned for follow-up 5.6 months (range 2.3-22.1) after childbirth. Seventy-eight of them had had normal vaginal deliveries (53%), 32 vacuum/forceps (22%) and 36 a caesarean section (25%). The risk of avulsion was halved in the intervention group (6% vs 13%, P = 0.19) on modified intention to treat analysis. A treatment received analysis revealed a nonsignificant 42% and 30% reduction in levator avulsion and microtrauma, respectively (P ≥ 0.22). CONCLUSIONS: This pilot randomised controlled trial showed a nonsignificantly lower incidence of pelvic floor muscle injury in women who used the Epi-No device from 37 weeks onwards.


Assuntos
Cateterismo/instrumentação , Distúrbios do Assoalho Pélvico/epidemiologia , Prolapso de Órgão Pélvico/epidemiologia , Cuidado Pré-Natal/métodos , Adulto , Cateterismo/métodos , Cesárea , Parto Obstétrico , Feminino , Humanos , Incidência , Diafragma da Pelve/diagnóstico por imagem , Distúrbios do Assoalho Pélvico/prevenção & controle , Prolapso de Órgão Pélvico/prevenção & controle , Projetos Piloto , Estudos Prospectivos , Estudos Retrospectivos , Ultrassonografia
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