Detalhe da pesquisa
1.
Structure, mechanism, and inhibition of Hedgehog acyltransferase.
Mol Cell
; 81(24): 5025-5038.e10, 2021 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34890564
2.
Dynamic Protein Acylation: New Substrates, Mechanisms, and Drug Targets.
Trends Biochem Sci
; 42(7): 566-581, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28602500
3.
Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)*.
Angew Chem Int Ed Engl
; 60(24): 13542-13547, 2021 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33768725
4.
Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity.
J Am Chem Soc
; 142(28): 12020-12026, 2020 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32579346
5.
Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus.
Bioorg Med Chem
; 27(20): 114962, 2019 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31307763
6.
Covalent Label Transfer between Peroxisomal Importomer Components Reveals Export-driven Import Interactions.
J Biol Chem
; 291(5): 2460-8, 2016 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-26567336
7.
Topological analysis of Hedgehog acyltransferase, a multipalmitoylated transmembrane protein.
J Biol Chem
; 290(6): 3293-307, 2015 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25505265
8.
Peroxisome protein import: a complex journey.
Biochem Soc Trans
; 44(3): 783-9, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27284042
9.
Correction to "Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity".
J Am Chem Soc
; 142(35): 15199, 2020 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32812749
10.
Membrane bound O-acyltransferases and their inhibitors.
Biochem Soc Trans
; 43(2): 246-52, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25849925
11.
Click chemistry armed enzyme-linked immunosorbent assay to measure palmitoylation by hedgehog acyltransferase.
Anal Biochem
; 490: 66-72, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26334609
12.
Modulation of Amide Bond Rotamers in 5-Acyl-6,7-dihydrothieno[3,2-c]pyridines.
J Org Chem
; 80(9): 4370-7, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25713927
13.
Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase.
J Med Chem
; 67(2): 1061-1078, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38198226
14.
Evaluating Hedgehog Acyltransferase Activity and Inhibition Using the Acylation-coupled Lipophilic Induction of Polarization (Acyl-cLIP) Assay.
Methods Mol Biol
; 2374: 13-26, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-34562239
15.
Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.
RSC Med Chem
; 13(2): 150-155, 2022 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35308027
16.
Correction: Peroxisome protein import: a complex journey.
Biochem Soc Trans
; 44(4): 1183, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27528768
17.
Getting a camel through the eye of a needle: the import of folded proteins by peroxisomes.
Biol Cell
; 102(4): 245-63, 2010 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-20146669
18.
Targeting the bacterial SOS response for new antimicrobial agents: drug targets, molecular mechanisms and inhibitors.
Future Med Chem
; 13(2): 143-155, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33410707
19.
Proteome-wide analysis of protein lipidation using chemical probes: in-gel fluorescence visualization, identification and quantification of N-myristoylation, N- and S-acylation, O-cholesterylation, S-farnesylation and S-geranylgeranylation.
Nat Protoc
; 16(11): 5083-5122, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34707257
20.
Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT).
Angew Chem Weinheim Bergstr Ger
; 133(24): 13654-13659, 2021 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38504937