Pesquisa | BVS Violência e Saúde

1.

Relatlimab and nivolumab in the treatment of melanoma.

Au, Lewis; Larkin, James; Turajlic, Samra.

Cell ; 185(26): 4866-4869, 2022 12 22.

Artigo em Inglês | MEDLINE | ID: mdl-36563660

2.

Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition.

Litchfield, Kevin; Reading, James L; Puttick, Clare; Thakkar, Krupa; Abbosh, Chris; Bentham, Robert; Watkins, Thomas B K; Rosenthal, Rachel; Biswas, Dhruva; Rowan, Andrew; Lim, Emilia; Al Bakir, Maise; Turati, Virginia; Guerra-Assunção, José Afonso; Conde, Lucia; Furness, Andrew J S; Saini, Sunil Kumar; Hadrup, Sine R; Herrero, Javier; Lee, Se-Hoon; Van Loo, Peter; Enver, Tariq; Larkin, James; Hellmann, Matthew D; Turajlic, Samra; Quezada, Sergio A; McGranahan, Nicholas; Swanton, Charles.

Cell ; 184(3): 596-614.e14, 2021 02 04.

Artigo em Inglês | MEDLINE | ID: mdl-33508232

3.

Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal.

Mitchell, Thomas J; Turajlic, Samra; Rowan, Andrew; Nicol, David; Farmery, James H R; O'Brien, Tim; Martincorena, Inigo; Tarpey, Patrick; Angelopoulos, Nicos; Yates, Lucy R; Butler, Adam P; Raine, Keiran; Stewart, Grant D; Challacombe, Ben; Fernando, Archana; Lopez, Jose I; Hazell, Steve; Chandra, Ashish; Chowdhury, Simon; Rudman, Sarah; Soultati, Aspasia; Stamp, Gordon; Fotiadis, Nicos; Pickering, Lisa; Au, Lewis; Spain, Lavinia; Lynch, Joanna; Stares, Mark; Teague, Jon; Maura, Francesco; Wedge, David C; Horswell, Stuart; Chambers, Tim; Litchfield, Kevin; Xu, Hang; Stewart, Aengus; Elaidi, Reza; Oudard, Stéphane; McGranahan, Nicholas; Csabai, Istvan; Gore, Martin; Futreal, P Andrew; Larkin, James; Lynch, Andy G; Szallasi, Zoltan; Swanton, Charles; Campbell, Peter J.

Cell ; 173(3): 611-623.e17, 2018 04 19.

Artigo em Inglês | MEDLINE | ID: mdl-29656891

4.

Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal.

Turajlic, Samra; Xu, Hang; Litchfield, Kevin; Rowan, Andrew; Chambers, Tim; Lopez, Jose I; Nicol, David; O'Brien, Tim; Larkin, James; Horswell, Stuart; Stares, Mark; Au, Lewis; Jamal-Hanjani, Mariam; Challacombe, Ben; Chandra, Ashish; Hazell, Steve; Eichler-Jonsson, Claudia; Soultati, Aspasia; Chowdhury, Simon; Rudman, Sarah; Lynch, Joanna; Fernando, Archana; Stamp, Gordon; Nye, Emma; Jabbar, Faiz; Spain, Lavinia; Lall, Sharanpreet; Guarch, Rosa; Falzon, Mary; Proctor, Ian; Pickering, Lisa; Gore, Martin; Watkins, Thomas B K; Ward, Sophia; Stewart, Aengus; DiNatale, Renzo; Becerra, Maria F; Reznik, Ed; Hsieh, James J; Richmond, Todd A; Mayhew, George F; Hill, Samantha M; McNally, Catherine D; Jones, Carol; Rosenbaum, Heidi; Stanislaw, Stacey; Burgess, Daniel L; Alexander, Nelson R; Swanton, Charles.

Cell ; 173(3): 581-594.e12, 2018 04 19.

Artigo em Inglês | MEDLINE | ID: mdl-29656895

5.

SnapShot: Renal Cell Carcinoma.

Turajlic, Samra; Larkin, James; Swanton, Charles.

Cell ; 163(6): 1556-1556.e1, 2015 Dec 03.

Artigo em Inglês | MEDLINE | ID: mdl-26638079

6.

Antibodies against endogenous retroviruses promote lung cancer immunotherapy.

Ng, Kevin W; Boumelha, Jesse; Enfield, Katey S S; Almagro, Jorge; Cha, Hongui; Pich, Oriol; Karasaki, Takahiro; Moore, David A; Salgado, Roberto; Sivakumar, Monica; Young, George; Molina-Arcas, Miriam; de Carné Trécesson, Sophie; Anastasiou, Panayiotis; Fendler, Annika; Au, Lewis; Shepherd, Scott T C; Martínez-Ruiz, Carlos; Puttick, Clare; Black, James R M; Watkins, Thomas B K; Kim, Hyemin; Shim, Seohee; Faulkner, Nikhil; Attig, Jan; Veeriah, Selvaraju; Magno, Neil; Ward, Sophia; Frankell, Alexander M; Al Bakir, Maise; Lim, Emilia L; Hill, Mark S; Wilson, Gareth A; Cook, Daniel E; Birkbak, Nicolai J; Behrens, Axel; Yousaf, Nadia; Popat, Sanjay; Hackshaw, Allan; Hiley, Crispin T; Litchfield, Kevin; McGranahan, Nicholas; Jamal-Hanjani, Mariam; Larkin, James; Lee, Se-Hoon; Turajlic, Samra; Swanton, Charles; Downward, Julian; Kassiotis, George.

Nature ; 616(7957): 563-573, 2023 04.

Artigo em Inglês | MEDLINE | ID: mdl-37046094

7.

Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors.

Arce Vargas, Frederick; Furness, Andrew J S; Solomon, Isabelle; Joshi, Kroopa; Mekkaoui, Leila; Lesko, Marta H; Miranda Rota, Enrique; Dahan, Rony; Georgiou, Andrew; Sledzinska, Anna; Ben Aissa, Assma; Franz, Dafne; Werner Sunderland, Mariana; Wong, Yien Ning Sophia; Henry, Jake Y; O'Brien, Tim; Nicol, David; Challacombe, Ben; Beers, Stephen A; Turajlic, Samra; Gore, Martin; Larkin, James; Swanton, Charles; Chester, Kerry A; Pule, Martin; Ravetch, Jeffrey V; Marafioti, Teresa; Peggs, Karl S; Quezada, Sergio A.

Immunity ; 46(4): 577-586, 2017 04 18.

Artigo em Inglês | MEDLINE | ID: mdl-28410988

8.

Personalized cancer care can't rely on molecular testing alone.

Larkin, James; Beland, Chloe; Ramalingam, Sivatharshini; Lyon, Alexander R.

Nature ; 627(8002): 38, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-38443637

9.

Frequency of pathogenic germline variants in cancer susceptibility genes in 1336 renal cell carcinoma cases.

Yngvadottir, Bryndis; Andreou, Avgi; Bassaganyas, Laia; Larionov, Alexey; Cornish, Alex J; Chubb, Daniel; Saunders, Charlie N; Smith, Philip S; Zhang, Huairen; Cole, Yasemin; Research Consortium, Genomics England; Larkin, James; Browning, Lisa; Turajlic, Samra; Litchfield, Kevin; Houlston, Richard S; Maher, Eamonn R.

Hum Mol Genet ; 31(17): 3001-3011, 2022 08 25.

Artigo em Inglês | MEDLINE | ID: mdl-35441217

10.

Templated Synthesis of Copper Nanoclusters with a Hybrid Lysozyme-Polymer Material for Enhanced Fluorescence.

Larkin, James O; Cheng, Zhihua; Arefeayne, Yafet; Segatori, Laura; Jones, Matthew R; Ball, Zachary T.

Bioconjug Chem ; 2024 May 13.

Artigo em Inglês | MEDLINE | ID: mdl-38739108

11.

Temporary treatment cessation versus continuation of first-line tyrosine kinase inhibitor in patients with advanced clear cell renal cell carcinoma (STAR): an open-label, non-inferiority, randomised, controlled, phase 2/3 trial.

Brown, Janet E; Royle, Kara-Louise; Gregory, Walter; Ralph, Christy; Maraveyas, Anthony; Din, Omar; Eisen, Timothy; Nathan, Paul; Powles, Tom; Griffiths, Richard; Jones, Robert; Vasudev, Naveen; Wheater, Matthew; Hamid, Abdel; Waddell, Tom; McMenemin, Rhona; Patel, Poulam; Larkin, James; Faust, Guy; Martin, Adam; Swain, Jayne; Bestall, Janine; McCabe, Christopher; Meads, David; Goh, Vicky; Min Wah, Tze; Brown, Julia; Hewison, Jenny; Selby, Peter; Collinson, Fiona.

Lancet Oncol ; 24(3): 213-227, 2023 03.

Artigo em Inglês | MEDLINE | ID: mdl-36796394

12.

Predictive biomarkers for response to immune checkpoint inhibition.

Shum, Benjamin; Larkin, James; Turajlic, Samra.

Semin Cancer Biol ; 79: 4-17, 2022 02.

Artigo em Inglês | MEDLINE | ID: mdl-33819567

13.

Avelumab Plus Axitinib as First-Line Therapy for Advanced Renal Cell Carcinoma: Long-Term Results from the JAVELIN Renal 100 Phase Ib Trial.

Larkin, James; Oya, Mototsugu; Martignoni, Marcella; Thistlethwaite, Fiona; Nathan, Paul; Ornstein, Moshe C; Powles, Thomas; Beckermann, Kathryn E; Balar, Arjun V; McDermott, David; Gupta, Sumati; Philips, George K; Gordon, Michael S; Uemura, Hirotsugu; Tomita, Yoshihiko; Wang, Jing; Michelon, Elisabete; di Pietro, Alessandra; Choueiri, Toni K.

Oncologist ; 28(4): 333-340, 2023 04 06.

Artigo em Inglês | MEDLINE | ID: mdl-36576173

14.

Five-Year Analysis of Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma.

Dummer, Reinhard; Hauschild, Axel; Santinami, Mario; Atkinson, Victoria; Mandalà, Mario; Kirkwood, John M; Chiarion Sileni, Vanna; Larkin, James; Nyakas, Marta; Dutriaux, Caroline; Haydon, Andrew; Robert, Caroline; Mortier, Laurent; Schachter, Jacob; Lesimple, Thierry; Plummer, Ruth; Dasgupta, Kohinoor; Gasal, Eduard; Tan, Monique; Long, Georgina V; Schadendorf, Dirk.

N Engl J Med ; 383(12): 1139-1148, 2020 09 17.

Artigo em Inglês | MEDLINE | ID: mdl-32877599

15.

Imaging angiogenesis in an intracerebrally induced model of brain macrometastasis using α_v ß₃ -targeted iron oxide microparticles.

Buck, Jessica; Perez-Balderas, Francisco; Zarghami, Niloufar; Johanssen, Vanessa; Khrapitchev, Alexandre A; Larkin, James R; Sibson, Nicola R.

NMR Biomed ; : e4948, 2023 Apr 10.

Artigo em Inglês | MEDLINE | ID: mdl-37038086

16.

Hyperglycaemia following immune checkpoint inhibitor therapy-Incidence, aetiology and assessment.

Mulla, Kaenat; Farag, Sheima; Moore, Benedict; Matharu, Sheila; Young, Kate; Larkin, James; Popat, Sanjay; Morganstein, Daniel Laurence.

Diabet Med ; 40(4): e15053, 2023 04.

Artigo em Inglês | MEDLINE | ID: mdl-36696014

17.

Boronic Acid Resin for Selective Immobilization of Canonically Encoded Proteins.

Larkin, James O; Jayanthi, Brianna; Segatori, Laura; Ball, Zachary T.

Biomacromolecules ; 24(5): 2196-2202, 2023 05 08.

Artigo em Inglês | MEDLINE | ID: mdl-37084390

18.

Optimisation of b-values for the accurate estimation of the apparent diffusion coefficient (ADC) in whole-body diffusion-weighted MRI in patients with metastatic melanoma.

Knill, Annemarie K; Blackledge, Matthew D; Curcean, Andra; Larkin, James; Turajlic, Samra; Riddell, Angela; Koh, Dow Mu; Messiou, Christina; Winfield, Jessica M.

Eur Radiol ; 33(2): 863-871, 2023 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-36169688

19.

"Tell me what is 'better'!" How medical students experience feedback, through the lens of self-regulatory learning.

Spooner, Muirne; Larkin, James; Liew, Siaw Cheok; Jaafar, Mohamed Hasif; McConkey, Samuel; Pawlikowska, Teresa.

BMC Med Educ ; 23(1): 895, 2023 Nov 22.

Artigo em Inglês | MEDLINE | ID: mdl-37993832

20.

Health status of Syrian refugees in Ireland - research and routine data informing service provision.

Collins, Claire; Pericin, Ivana; Larkin, James; Kiely, Bridget; Diaz, Esperanza.

Rural Remote Health ; 23(1): 8119, 2023 01.

Artigo em Inglês | MEDLINE | ID: mdl-36802661

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