Pesquisa | BVS Violência e Saúde

1.

P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates.

Sansó, Miriam; Levin, Rebecca S; Lipp, Jesse J; Wang, Vivien Ya-Fan; Greifenberg, Ann Katrin; Quezada, Elizabeth M; Ali, Akbar; Ghosh, Animesh; Larochelle, Stéphane; Rana, Tariq M; Geyer, Matthias; Tong, Liang; Shokat, Kevan M; Fisher, Robert P.

Genes Dev ; 30(1): 117-31, 2016 Jan 01.

Artigo em Inglês | MEDLINE | ID: mdl-26728557

2.

A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression.

Schachter, Miriam Merzel; Merrick, Karl A; Larochelle, Stéphane; Hirschi, Alexander; Zhang, Chao; Shokat, Kevan M; Rubin, Seth M; Fisher, Robert P.

Mol Cell ; 50(2): 250-60, 2013 Apr 25.

Artigo em Inglês | MEDLINE | ID: mdl-23622515

3.

RNA-binding proteome redux.

Larochelle, Stéphane.

Nat Methods ; 16(3): 219, 2019 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-30814707

4.

Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells.

Merrick, Karl A; Larochelle, Stéphane; Zhang, Chao; Allen, Jasmina J; Shokat, Kevan M; Fisher, Robert P.

Mol Cell ; 32(5): 662-72, 2008 Dec 05.

Artigo em Inglês | MEDLINE | ID: mdl-19061641

5.

RNA Splicing: Making the cut.

Larochelle, Stéphane.

Nat Chem Biol ; 14(2): 107, 2018 01 16.

Artigo em Inglês | MEDLINE | ID: mdl-29337968

6.

Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells.

Wohlbold, Lara; Merrick, Karl A; De, Saurav; Amat, Ramon; Kim, Jun Hyun; Larochelle, Stéphane; Allen, Jasmina J; Zhang, Chao; Shokat, Kevan M; Petrini, John H J; Fisher, Robert P.

PLoS Genet ; 8(8): e1002935, 2012 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-22927831

7.

SYSTEMS BIOLOGY. Protein isoforms: more than meets the eye.

Larochelle, Stéphane.

Nat Methods ; 13(4): 291, 2016 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-27482571

8.

Nanotechnology. Lock-and-key PORE-igami.

Larochelle, Stéphane.

Nat Methods ; 13(3): 198, 2016 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-27347589

9.

Antimicrobials: Targeting fungal chromatin.

Larochelle, Stéphane.

Nat Chem Biol ; 13(7): 693, 2017 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-28632708

10.

Imaging. RNA catch and release.

Larochelle, Stéphane.

Nat Methods ; 12(9): 813, 2015 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-26554093

11.

STOMPing at the bits.

Larochelle, Stéphane.

Nat Methods ; 12(12): 1114, 2015 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-26962581

12.

Solving XFEL's image problem.

Larochelle, Stéphane.

Nat Methods ; 12(5): 392, 2015 May.

Artigo em Inglês | MEDLINE | ID: mdl-26120633

13.

Insulin signaling: At a snail's pace.

Larochelle, Stéphane.

Nat Chem Biol ; 12(11): 889, 2016 10 18.

Artigo em Inglês | MEDLINE | ID: mdl-27755529

14.

Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics.

Larochelle, Stéphane; Batliner, Jasmin; Gamble, Matthew J; Barboza, Nora M; Kraybill, Brian C; Blethrow, Justin D; Shokat, Kevan M; Fisher, Robert P.

Nat Struct Mol Biol ; 13(1): 55-62, 2006 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-16327805

15.

Xpd/Ercc2 regulates CAK activity and mitotic progression.

Chen, Jian; Larochelle, Stéphane; Li, Xiaoming; Suter, Beat.

Nature ; 424(6945): 228-32, 2003 Jul 10.

Artigo em Inglês | MEDLINE | ID: mdl-12853965

16.

Cdk7 is required for full activation of Drosophila heat shock genes and RNA polymerase II phosphorylation in vivo.

Schwartz, Brian E; Larochelle, Stephane; Suter, Beat; Lis, John T.

Mol Cell Biol ; 23(19): 6876-86, 2003 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-12972606

17.

Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors.

Kalan, Sampada; Amat, Ramon; Schachter, Miriam Merzel; Kwiatkowski, Nicholas; Abraham, Brian J; Liang, Yanke; Zhang, Tinghu; Olson, Calla M; Larochelle, Stéphane; Young, Richard A; Gray, Nathanael S; Fisher, Robert P.

Cell Rep ; 21(2): 467-481, 2017 Oct 10.

Artigo em Inglês | MEDLINE | ID: mdl-29020632

18.

The Drosophila chk2 gene loki is essential for embryonic DNA double-strand-break checkpoints induced in S phase or G2.

Masrouha, Nisrine; Yang, Long; Hijal, Sirine; Larochelle, Stéphane; Suter, Beat.

Genetics ; 163(3): 973-82, 2003 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-12663536

19.

CDK-activating kinases: detection and activity measurements.

Larochelle, Stéphane; Fisher, Robert P.

Methods Mol Biol ; 296: 279-90, 2005.

Artigo em Inglês | MEDLINE | ID: mdl-15576939

20.

Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.

St Amour, Courtney V; Sansó, Miriam; Bösken, Christian A; Lee, Karen M; Larochelle, Stéphane; Zhang, Chao; Shokat, Kevan M; Geyer, Matthias; Fisher, Robert P.

Mol Cell Biol ; 32(13): 2372-83, 2012 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-22508988

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P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates.

A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression.

RNA-binding proteome redux.

Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells.

RNA Splicing: Making the cut.

Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells.

SYSTEMS BIOLOGY. Protein isoforms: more than meets the eye.

Nanotechnology. Lock-and-key PORE-igami.

Antimicrobials: Targeting fungal chromatin.

Imaging. RNA catch and release.

STOMPing at the bits.

Solving XFEL's image problem.

Insulin signaling: At a snail's pace.

Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics.

Xpd/Ercc2 regulates CAK activity and mitotic progression.

Cdk7 is required for full activation of Drosophila heat shock genes and RNA polymerase II phosphorylation in vivo.

Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors.

The Drosophila chk2 gene loki is essential for embryonic DNA double-strand-break checkpoints induced in S phase or G2.

CDK-activating kinases: detection and activity measurements.

Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.