1.
J Org Chem
; 78(4): 1655-9, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23308360
RESUMO
Aldehyde-bisulfite adducts dervied from unstable parent aldehydes were reductively alkylated in a direct fashion with a variety of amines. This approach features the use of 2-picoline borane as the reducing agent and a protic solvent for the reaction media and has been successfully applied to the synthesis of a DPP-IV inhibitor and a variety of other amines.