Pesquisa | BVS Violência e Saúde

1.

Using What We Already Have: Uncovering New Drug Repurposing Strategies in Existing Omics Data.

Pulley, Jill M; Rhoads, Jillian P; Jerome, Rebecca N; Challa, Anup P; Erreger, Kevin B; Joly, Meghan M; Lavieri, Robert R; Perry, Kelly E; Zaleski, Nicole M; Shirey-Rice, Jana K; Aronoff, David M.

Annu Rev Pharmacol Toxicol ; 60: 333-352, 2020 01 06.

Artigo em Inglês | MEDLINE | ID: mdl-31337270

2.

Walk before you run: Feasibility challenges and lessons learned from the PROCLAIM study, a multicenter randomized controlled trial of misoprostol for prevention of recurrent Clostridioides difficile during COVID-19.

Lavieri, Robert R; Dubberke, Erik R; McGill, Sarah K; Bartelt, Luther; Smith, Stephanie A; Pandur, Balint K; Phillips, Sharon E; Vermillion, Krista; Shirey-Rice, Jana; Pulley, Jill; Xu, Yaomin; Lindsell, Christopher J; Zaleski, Nicole; Jerome, Rebecca; Doster, Ryan S; Aronoff, David M.

Anaerobe ; 80: 102699, 2023 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-36702174

3.

Renin-Angiotensin System Modulation With Synthetic Angiotensin (1-7) and Angiotensin II Type 1 Receptor-Biased Ligand in Adults With COVID-19: Two Randomized Clinical Trials.

Self, Wesley H; Shotwell, Matthew S; Gibbs, Kevin W; de Wit, Marjolein; Files, D Clark; Harkins, Michelle; Hudock, Kristin M; Merck, Lisa H; Moskowitz, Ari; Apodaca, Krystle D; Barksdale, Aaron; Safdar, Basmah; Javaheri, Ali; Sturek, Jeffrey M; Schrager, Harry; Iovine, Nicole; Tiffany, Brian; Douglas, Ivor S; Levitt, Joseph; Busse, Laurence W; Ginde, Adit A; Brown, Samuel M; Hager, David N; Boyle, Katherine; Duggal, Abhijit; Khan, Akram; Lanspa, Michael; Chen, Peter; Puskarich, Michael; Vonderhaar, Derek; Venkateshaiah, Lokesh; Gentile, Nina; Rosenberg, Yves; Troendle, James; Bistran-Hall, Amanda J; DeClercq, Josh; Lavieri, Robert; Joly, Meghan Morrison; Orr, Michael; Pulley, Jill; Rice, Todd W; Schildcrout, Jonathan S; Semler, Matthew W; Wang, Li; Bernard, Gordon R; Collins, Sean P.

JAMA ; 329(14): 1170-1182, 2023 04 11.

Artigo em Inglês | MEDLINE | ID: mdl-37039791

4.

Medication history-wide association studies for pharmacovigilance of pregnant patients.

Challa, Anup P; Niu, Xinnan; Garrison, Etoi A; Van Driest, Sara L; Bastarache, Lisa M; Lippmann, Ethan S; Lavieri, Robert R; Goldstein, Jeffery A; Aronoff, David M.

Commun Med (Lond) ; 2: 115, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-36124058

5.

Human and Machine Intelligence Together Drive Drug Repurposing in Rare Diseases.

Challa, Anup P; Zaleski, Nicole M; Jerome, Rebecca N; Lavieri, Robert R; Shirey-Rice, Jana K; Barnado, April; Lindsell, Christopher J; Aronoff, David M; Crofford, Leslie J; Harris, Raymond C; Alp Ikizler, T; Mayer, Ingrid A; Holroyd, Kenneth J; Pulley, Jill M.

Front Genet ; 12: 707836, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-34394194

6.

Machine learning on drug-specific data to predict small molecule teratogenicity.

Challa, Anup P; Beam, Andrew L; Shen, Min; Peryea, Tyler; Lavieri, Robert R; Lippmann, Ethan S; Aronoff, David M.

Reprod Toxicol ; 95: 148-158, 2020 08.

Artigo em Inglês | MEDLINE | ID: mdl-32428651

7.

Repurposing of a Thromboxane Receptor Inhibitor Based on a Novel Role in Metastasis Identified by Phenome-Wide Association Study.

Werfel, Thomas A; Hicks, Donna J; Rahman, Bushra; Bendeman, Wendy E; Duvernay, Matthew T; Maeng, Jae G; Hamm, Heidi; Lavieri, Robert R; Joly, Meghan M; Pulley, Jill M; Elion, David L; Brantley-Sieders, Dana M; Cook, Rebecca S.

Mol Cancer Ther ; 19(12): 2454-2464, 2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-33033174

8.

Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity.

Lavieri, Robert; Scott, Sarah A; Lewis, Jana A; Selvy, Paige E; Armstrong, Michelle D; Alex Brown, H; Lindsley, Craig W.

Bioorg Med Chem Lett ; 19(8): 2240-3, 2009 Apr 15.

Artigo em Inglês | MEDLINE | ID: mdl-19299128

9.

Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity.

Lewis, Jana A; Scott, Sarah A; Lavieri, Robert; Buck, Jason R; Selvy, Paige E; Stoops, Sydney L; Armstrong, Michelle D; Brown, H Alex; Lindsley, Craig W.

Bioorg Med Chem Lett ; 19(7): 1916-20, 2009 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-19268584

10.

Systematically Prioritizing Candidates in Genome-Based Drug Repurposing.

Challa, Anup P; Lavieri, Robert R; Lewis, Judith T; Zaleski, Nicole M; Shirey-Rice, Jana K; Harris, Paul A; Aronoff, David M; Pulley, Jill M.

Assay Drug Dev Technol ; 17(8): 352-363, 2019.

Artigo em Inglês | MEDLINE | ID: mdl-31769998

11.

Phospholipase D: enzymology, functionality, and chemical modulation.

Selvy, Paige E; Lavieri, Robert R; Lindsley, Craig W; Brown, H Alex.

Chem Rev ; 111(10): 6064-119, 2011 Oct 12.

Artigo em Inglês | MEDLINE | ID: mdl-21936578

12.

Motivation for Launching a Cancer Metastasis Inhibition (CMI) Program.

Pulley, Jill M; Jerome, Rebecca N; Ogletree, Martin L; Bernard, Gordon R; Lavieri, Robert R; Zaleski, Nicole M; Hong, Charles C; Shirey-Rice, Jana K; Arteaga, Carlos L; Mayer, Ingrid A; Holroyd, Kenneth J; Cook, Rebecca S.

Target Oncol ; 13(1): 61-68, 2018 02.

Artigo em Inglês | MEDLINE | ID: mdl-29218624

13.

When Enough Is Enough: Decision Criteria for Moving a Known Drug into Clinical Testing for a New Indication in the Absence of Preclinical Efficacy Data.

Pulley, Jill M; Jerome, Rebecca N; Zaleski, Nicole M; Shirey-Rice, Jana K; Pruijssers, Andrea J; Lavieri, Robert R; Chettiar, Somsundaram N; Naylor, Helen M; Aronoff, David M; Edwards, David A; Niswender, Colleen M; Dugan, Laura L; Crofford, Leslie J; Bernard, Gordon R; Holroyd, Kenneth J.

Assay Drug Dev Technol ; 15(8): 354-361, 2017 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-29193979

14.

Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics.

Pulley, Jill M; Shirey-Rice, Jana K; Lavieri, Robert R; Jerome, Rebecca N; Zaleski, Nicole M; Aronoff, David M; Bastarache, Lisa; Niu, Xinnan; Holroyd, Kenneth J; Roden, Dan M; Skaar, Eric P; Niswender, Colleen M; Marnett, Lawrence J; Lindsley, Craig W; Ekstrom, Leeland B; Bentley, Alan R; Bernard, Gordon R; Hong, Charles C; Denny, Joshua C.

Assay Drug Dev Technol ; 15(3): 113-119, 2017 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-28379727

15.

EHRs could clarify drug safety in pregnant people.

Challa, Anup P; Lavieri, Robert R; Lippmann, Ethan S; Goldstein, Jeffery A; Bastarache, Lisa; Pulley, Jill M; Aronoff, David M.

Nat Med ; 26(6): 820-821, 2020 06.

Artigo em Inglês | MEDLINE | ID: mdl-32457445

16.

Discovery of desketoraloxifene analogues as inhibitors of mammalian, Pseudomonas aeruginosa, and NAPE phospholipase D enzymes.

Scott, Sarah A; Spencer, Cierra T; O'Reilly, Matthew C; Brown, Kyle A; Lavieri, Robert R; Cho, Chul-Hee; Jung, Dai-Il; Larock, Richard C; Brown, H Alex; Lindsley, Craig W.

ACS Chem Biol ; 10(2): 421-32, 2015 Feb 20.

Artigo em Inglês | MEDLINE | ID: mdl-25384256

17.

The ethical mouse: be not like Icarus.

Lavieri, Robert R.

Am J Bioeth ; 7(5): 57-8, 2007 May.

Artigo em Inglês | MEDLINE | ID: mdl-17497509

18.

Ethical considerations in the communication of unexpected information with clinical implications.

Lavieri, Robert R; Garner, Samual A.

Am J Bioeth ; 6(6): 46-8; author reply W10-2, 2006.

Artigo em Inglês | MEDLINE | ID: mdl-17085410

19.

Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor.

Lavieri, Robert R; Scott, Sarah A; Selvy, Paige E; Kim, Kwangho; Jadhav, Satyawan; Morrison, Ryan D; Daniels, J Scott; Brown, H Alex; Lindsley, Craig W.

J Med Chem ; 53(18): 6706-19, 2010 Sep 23.

Artigo em Inglês | MEDLINE | ID: mdl-20735042

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