Sex differences in event-related potential (ERP) waveforms of primary psychotic disorders: A systematic review.

Research aimed at understanding primary psychotic disorders such as schizophrenia, schizophreniform disorder, and schizoaffective disorder, with electrophysiological methods has flourished over recent years. However, a significant component that is often overlooked or underreported in electrophysiological research of psychosis is the factor of biological sex. Thus, the goal of this systematic review was to summarize the current understanding of EEG sex differences in primary psychotic disorders. Our study found a consistent sex difference relating to the P300 component (male amplitude < females), and that research examining sex differences of ERP waveforms, other than the P300, is very limited with ambiguous findings. This review also addressed the lack of consideration of sex as an influencing factor in electrophysiological research.

Water-cooled, high-intensity ultrasound surgical applicators with frequency tracking.

High-intensity, focused ultrasound (HIFU) applicators have been developed for arresting bleeding with the ultimate intent of use in surgery. The design uses a tapered titanium component for transmission coupling of the ultrasound energy from a spherically curved transducer to biological tissues. The nominal operating frequency is 5.5 MHz, in a highly resonant mode (quality factor of 327 with water load). Liquid cooling is used to remove energy loss important at net applied power greater than 18 W/cm2 at the surface of the piezoelectric element. A downward resonance frequency shift (>20 kHz) occurs, even with cooling, as the applicator warms with normal operation. A feedback technique is used for maintaining the excitation near optimum resonance. Standing wave ratios of the applied power of 1.6 or less are thus sustained. The system and applicators have been found to be highly robust, effective in achieving hemostasis in the hemorrhaging liver, spleen, lung, or blood vessels in rabbit and pig experiments. One unit has been operated for over 1.7 hours in treating organ hemorrhage in blunt trauma experiments with nine swine with electrical net power of up to 158 W (31 W/cm2 across the transducer) and intensity of 2560 W/cm2 at focus.