Availability of vision and tactile gating: vision enhances tactile sensitivity.

A multitude of events bombard our sensory systems at every moment of our lives. Thus, it is important for the sensory and motor cortices to gate unimportant events. Tactile suppression is a well-known phenomenon defined as a reduced ability to detect tactile events on the skin before and during movement. Previous experiments (Buckingham et al. in Exp Brain Res 201(3):411-419, 2010; Colino et al. in Physiol Rep 2(3):e00267, 2014) found detection rates decrease just prior to and during finger abduction and decrease according to the proximity of the moving effector. However, what effect does vision have on tactile gating? There is ample evidence (see Serino and Haggard in Neurosci Biobehav Rev 34:224-236, 2010) observing increased tactile acuity when participants see their limbs. The present study examined how tactile detection changes in response to visual condition (vision/no vision). Ten human participants used their right hand to reach and grasp a cylinder. Tactors were attached to the index finger and the forearm of both the right and left arm and vibrated at various epochs relative to a "go" tone. Results replicate previous findings from our laboratory (Colino et al. in Physiol Rep 2(3):e00267, 2014). Also, tactile acuity decreased when participants did not have vision. These results indicate that the vision affects the somatosensation via inputs from parietal areas (Konen and Haggard in Cereb Cortex 24(2):501-507, 2014) but does so in a reach-to-grasp context.

Benefits of using transcranial magnetic stimulation as a tool to facilitate the chronic knee injury rehabilitation.

[Purpose] While primary motor cortex activation has been implicated as a key factor in the arthrogenic muscle inhibition after knee joint injury, no viable rehabilitation protocol has been developed to accommodate this factor. In this study, transcranial magnetic stimulation was applied as a means of dissipating arthrogenic muscle inhibition by introducing temporary motor cortex excitation prior to the rehabilitation. [Subjects and Methods] Twenty-four subjects who have underwent the surgery due to knee injury were recruited, and randomly assigned to the control or the simulation groups. The levels of electromyography signals during the maximum voluntary contraction of the quadriceps muscle before, during, and after training designed for the quadriceps strength rehabilitation were measured. [Results] When compared to controls, subjects who received the transcranial magnetic stimulations showed significantly increased levels of voluntary muscle contraction after the training. Moreover, the beneficial effect of the stimulation increased as the rehabilitation progressed. [Conclusion] Transcranial magnetic stimulation itself does not directly improve the symptoms related to knee injuries. However, the use of this technique can provide a time window for effective intervention by dissipating the unwanted effect of the arthrogenic muscle inhibition during rehabilitation.

Effects of repetitive transcranial magnetic stimulation on the somatosensory cortex during prism adaptation.

Although the behavioral characteristics and the neural correlates of prism adaptation processes have been studied extensively, the underlying mechanism is yet to be investigated. Recently, somatosensory suppression was heralded as a mechanism for the sensory re-alignment process accompanying the adaptation. Somatosensory suppression should facilitate the re-alignment process in the proprioceptive system. The shift in the proprioceptive system takes place mostly during a concurrent visual feedback (CVF) condition; during a terminal visual feedback (TVF) condition, the visual system experiences significant adaptation (visual shift), so somatosensory suppression should have minimal functional consequences under TVF. To test this hypothesis, a repetitive transcranial magnetic stimulation (rTMS) was applied to the primary somatosensory cortex as an artificial somatosensory suppression right after the reaching initiation in CVF and TVF conditions, and changes in adaptation were observed. Because somatosensory suppression is already in effect during CVF, rTMS would cause no significant changes. During TVF with rTMS, however, significantly different patterns of adaptation could be expected when compared to a sham rTMS condition. Young adults (N = 12) participated in 4 sessions (CVF/ TVF, real/sham rTMS); visual proprioceptive, and total shifts were measured. Movement time and curvature of the reaching movement were measured during the adaptation phase. Results showed that while the total shift was unchanged, the proprioceptive shift increased and the visual shift decreased in the TVF condition when rTMS was delivered. However, the total, proprioceptive, and visual shifts were not influenced by rTMS in the CVF condition. Suppression of proprioception induced by the rTMS could be one of the requisites for successful proprioceptive shift during prism adaptation.

The human dorsal premotor cortex generates on-line error corrections during sensorimotor adaptation.

A number of different sites in the human brain have been shown to play a role in sensorimotor adaptation. However, the specific role played by each of these structures in the learning process is poorly understood. In the present study, the contribution of the dorsal aspect of the premotor cortex was examined by disrupting activity at this site using transcranial magnetic stimulation (TMS) while subjects wearing prism goggles pointed at visual targets. This manipulation slowed down the rate of adaptation when vision of the hand was available throughout the movement and reduced the presence of on-line trajectory corrections. This was accompanied by a reduced shift in the felt position of the arm. In contrast, TMS did not cause any alteration in the performance of this task when vision of the hand was available only at the end of the movement. Thus, we infer from this pattern of results that the human dorsal premotor cortex contributes to the generation of the visually based on-line error corrections that are responsible for the remapping of arm position sense underlying sensorimotor adaptation.

Motor Planning Influences the Perceived Timing of Vibrotactile Stimuli in an Amplitude-Dependent Manner.

The authors characterized how motor planning influences temporal order judgment (TOJ) tasks. They examined this by applying vibrotactile stimulation during the planning stages of a bimanual arm movement that would bring the arms into a crossed configuration. The authors have previously shown that planning to cross the arms induces a subjective reversal of spatially defined temporal order judgments that evolves over the course of the planning period. It was unclear, however, whether this effect is modulated by the extent to which the arms would be crossed after movement. The authors examined this issue by having participants plan to move to 4 different targets that would leave the arms in crossed configurations of varying extents. The results demonstrate that even though cutaneous stimuli were applied before the movements, if participants were planning to move into a more crossed configuration, performance on the TOJ task worsened depending on where they were in the planning process. This data suggest the brain uses planning signals to predict sensations from impending movements in a context-dependent manner.

Enhanced accuracy in novel mirror drawing after repetitive transcranial magnetic stimulation-induced proprioceptive deafferentation.

When performing visually guided actions under conditions of perturbed visual feedback, e.g., in a mirror or a video camera, there is a spatial conflict between visual and proprioceptive information. Recent studies have shown that subjects without proprioception avoid this conflict and show a performance benefit. In this study, we tested whether deafferentation induced by repetitive transcranial magnetic stimulation (rTMS) can improve mirror tracing skills in normal subjects. Hand trajectory error during novel mirror drawing was compared across two groups of subjects that received either 1 Hz rTMS over the somatosensory cortex contralateral to the hand or sham stimulation. Mirror tracing was more accurate after rTMS than after sham stimulation. Using a position-matching task, we confirmed that rTMS reduced proprioceptive acuity and that this reduction was largest when the coil was placed at an anterior parietal site. It is thus possible, with rTMS, to enhance motor performance in tasks involving a visuoproprioceptive conflict, presumably by reducing the excitability of somatosensory cortical areas that contribute to the sense of hand position.

Cortical frames of reference for eye-hand coordination.

To reach for an object the brain must transform visual input from the eye into motor output of the arm. Recent neurophysiological experiments have shown that this transformation maps onto a network of brain areas including the posterior parietal (PPC) and premotor (PMC) cortices. In this chapter, we review evidence from our own experiments which demonstrate that this network can only partially complete the transformation when the eye and limb movement amplitudes are dissociated. We also discuss the effects of disrupting either the PPC or PMC using transcranial magnetic stimulation (TMS) on the ability to carry out the transformation successfully.

Reactive balance adjustments to unexpected perturbations during human walking.

The purpose of this investigation was to determine the effect of unexpected forward perturbations (FP) during gait on lower extremity joint mechanics and muscle Electromyographic (EMG) patterns in healthy adults. The muscles surrounding the hip were found to be most important in maintaining control of the trunk and preventing collapse in response to the FP. Distinct lower extremity joint moment and power patterns were observed in response to the FP but an overall positive moment of support (M(s)) was maintained. Therefore, reactive balance control was a synchronized effort of the lower extremity joints to prevent collapse during the FP.

Eye-hand interactions differ in the human premotor and parietal cortices.

In order to successfully look at and reach for a visual target the central nervous system must perform a complex sensorimotor transformation. How this transformation is mapped onto relevant brain structures has become the subject of much recent investigation. In the present paper we examined the contribution of the human premotor cortex (PMC) to this transformation process during a task requiring coordinated eye and hand movements. For this purpose, we made use of single-pulse transcranial magnetic stimulation (TMS) to temporarily disrupt the processing occurring in the PMC during task performance. Subjects made open-loop pointing movements accompanied by saccades of the same size or two or three times larger. Under normal circumstances without TMS, the pointing movement amplitude increased with saccade amplitude. When TMS was applied over the PMC 100-200 ms after target presentation, the influence of saccade amplitude on the pointing movement amplitude was increased. This is the opposite effect to that observed in a previous study [Journal of Neurophysiology 84 (200) 1677-1680] when TMS was applied over the posterior parietal cortex (PPC) during the same task. We suggest that this pattern of results is consistent with the coding of the reach plan in eye-centered coordinates in the PPC and limb-centered coordinates in the PMC.

Gait mechanics in chronic ACL deficiency and subsequent repair.

OBJECTIVE: To determine how normal gait patterns may change as a result of chronic anterior cruciate ligament deficiency and subsequent reconstructive surgery. DESIGN: Gait testing of 10 chronic anterior cruciate ligament deficient subjects prior to and 3 months following reconstructive surgery, and 10 uninjured controls. BACKGROUND: There is controversy whether persons with chronic anterior cruciate ligament deficiency develop a "quadriceps avoidance" pattern and how anterior cruciate ligament reconstructive surgery influences gait mechanics in these same individuals. METHODS: Gait analysis was employed to determine kinematic, kinetic, and muscle Electromyographic data. RESULTS: Prior to surgery, no anterior cruciate ligament deficient subject exhibited a quadriceps avoidance pattern. Following surgery, the subjects exhibited a significantly greater knee extensor moment during early stance as compared to the control group. Prior to and following surgery, anterior cruciate ligament deficient subjects demonstrated a significantly greater hip extensor moment possibly to reduce anterior tibial translation. CONCLUSIONS; These data suggest that (1) development of a quadriceps avoidance pattern is less common than previously reported, (2) anterior cruciate ligament deficient subjects accommodate through alterations of hip joint mechanics, (3) surgical repair significantly alters lower extremity gait patterns, and (4) re-establishment of pre-injury gait patterns takes longer than 3 months to occur. RELEVANCE: The results suggest that chronic anterior cruciate ligament deficient subjects do not exhibit a quadriceps avoidance gait pattern. Surgical intervention significantly alters lower extremity gait mechanics in a population that has accommodated to anterior cruciate ligament deficiency.

Gait perturbation response in chronic anterior cruciate ligament deficiency and repair.

OBJECTIVE: To determine how chronic anterior cruciate ligament deficient and surgically repaired subjects react to unexpected forward perturbations during gait as compared to healthy controls. DESIGN: Gait testing of 10 chronic anterior cruciate ligament deficient subjects prior to and three months following reconstructive surgery, and 10 uninjured controls. BACKGROUND: The ability of an anterior cruciate ligament injured individual to react and maintain equilibrium during gait perturbations is critical for the prevention of reinjury. No studies have investigated how these individuals respond to unexpected perturbations during normal gait. METHODS: An unexpected forward perturbation was induced upon heel strike using a force plate capable of translational movement. RESULTS: Prior to surgery, the anterior cruciate ligament subjects exhibited a greater knee extensor moment in response to the perturbation compared to healthy controls. Following surgery, the anterior cruciate ligament injured subjects exhibited a static knee position and a sustained knee extensor moment throughout stance in response to the perturbation as compared to controls. CONCLUSIONS: These data suggest that chronic anterior cruciate ligament deficient subjects rely heavily on knee extensor musculature to prevent collapse in response to an unexpected perturbation. This same reactive response was more pronounced 3 months following surgery. RELEVANCE: The results suggest that, prior to and following surgery, chronic anterior cruciate ligament injured subjects respond differently than healthy controls to an unexpected perturbation during gait. Anterior cruciate ligament injured or repaired subjects do not reduce or avoid vigorous contraction of the quadriceps muscles when responding to gait perturbations.

Bilateral accommodations to anterior cruciate ligament deficiency and surgery.

UNLABELLED: OBJECTIVE To determine bilateral lower extremity joint accommodations during gait in anterior cruciate ligament deficient subjects and uninjured controls. DESIGN: Gait testing of 10 chronic anterior cruciate ligament deficient subjects prior to and 3 months following reconstructive surgery, and 10 uninjured controls. BACKGROUND: It is possible that bilateral joint accommodations could occur as a result of anterior cruciate ligament injury and in response to surgical repair. Few studies have investigated bilateral joint accommodations to anterior cruciate ligament injury and there is little consistency in the reported results. METHODS: Bilateral lower extremity kinematic and kinetic data were collected from 12 walking trials and inverse dynamics calculations were made to estimate bilateral knee and hip joint angle, moment, and power patterns during the stance phase of gait. RESULTS: Control subjects exhibited asymmetrical hip but symmetrical knee joint moment and power patterns. In contrast, the anterior cruciate ligament deficient subjects exhibited symmetrical hip and asymmetrical knee joint moment and power patterns prior to and following reconstructive surgery. CONCLUSIONS: Gait asymmetry in healthy subjects should not be considered pathological. In addition, chronic anterior cruciate ligament injury results in joint specific, bilateral lower extremity accommodations in gait mechanics. These accommodations persist 3 months following surgical repair.

Dorsal and ventral visual stream contributions to perception-action interactions during pointing.

The Ebbinghaus illusion, in which a central circle surrounded by large circles appears to be smaller than a central circle surrounded by small circles, affects the speed of pointing movements. When the central circle appears to be big, pointing movements directed towards it are faster than when the central circle appears to be small. This effect could be due to an interaction between ventral stream processing associated with determining relative object size and dorsal stream processing associated with sensorimotor output. Alternatively, the dorsal stream alone could mediate the effect via the transformation of object shape representations into motor output within the parietal lobe. Finally, ventral stream processing could be integrated into motor output through projections to the prefrontal cortex and subsequently to the motor areas of the cortex, thus bypassing the dorsal stream. These three alternatives were tested by disrupting either the ventral or dorsal stream processing using transcranial magnetic stimulation (TMS) while subjects made pointing movements as quickly and accurately as possible to the central target circles within the Ebbinghaus illusion display. The relative changes in reaction time, movement speed, and movement accuracy for small versus large appearing target circles were compared when TMS was delivered over each site as well as at a control site (SMA). The results showed that TMS over either the dorsal or ventral stream but not the SMA reduced the influence of the illusion on the pointing movement speed but did not affect reaction time or movement accuracy. A second control experiment was completed in which TMS was delivered during pointing movements to target circles of physically different sizes that were not surrounded by either large or small circles. This allowed us to determined whether the effect we observed in the main experiment was due specifically to the relative size information contained within the illusory display and the effect this has on the preparation of pointing responses or to an influence on basic perceptual and sensorimotor processes occurring within the ventral and dorsal streams, respectively. The results showed that the affect on pointing movement speed was still present with dorsal but not ventral stream stimulation. Taken together, this evidence suggests that the ventral stream contributes to pointing movements based on relative object size information via its projections to the prefrontal areas and not necessarily through interactions with the dorsal stream.