Detalhe da pesquisa
1.
Genetic complexity alters drug susceptibility of asexual and gametocyte stages of Plasmodium falciparum to antimalarial candidates.
Antimicrob Agents Chemother
; 68(3): e0129123, 2024 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38259087
2.
Defining the next generation of severe malaria treatment: a target product profile.
Malar J
; 23(1): 174, 2024 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38835069
3.
Predicting Optimal Antimalarial Drug Combinations from a Standardized Plasmodium falciparum Humanized Mouse Model.
Antimicrob Agents Chemother
; 67(6): e0157422, 2023 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37133382
4.
Cross-resistance of the chloroquine-derivative AQ-13 with amodiaquine in Cambodian Plasmodium falciparum isolates.
J Antimicrob Chemother
; 76(10): 2565-2568, 2021 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34245274
5.
A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria.
Malar J
; 20(1): 222, 2021 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34011358
6.
A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 522(7556): 315-20, 2015 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26085270
7.
In vitro activity of ferroquine against artemisinin-based combination therapy (ACT)-resistant Plasmodium falciparum isolates from Cambodia.
J Antimicrob Chemother
; 74(11): 3240-3244, 2019 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31518407
8.
Anti-malarial ozonides OZ439 and OZ609 tested at clinically relevant compound exposure parameters in a novel ring-stage survival assay.
Malar J
; 18(1): 427, 2019 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31849323
9.
African isolates show a high proportion of multiple copies of the Plasmodium falciparum plasmepsin-2 gene, a piperaquine resistance marker.
Malar J
; 18(1): 126, 2019 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30967148
10.
Susceptibility Testing of Medically Important Parasites.
Clin Microbiol Rev
; 30(3): 647-669, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28446445
11.
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29941635
12.
Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials.
J Antimicrob Chemother
; 73(5): 1279-1290, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29420756
13.
A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria.
BMC Med
; 15(1): 181, 2017 10 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28988541
14.
Screening a protein kinase inhibitor library against Plasmodium falciparum.
Malar J
; 16(1): 446, 2017 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29115999
15.
Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 537(7618): 122, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27281209
16.
Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.
PLoS Med
; 13(10): e1002138, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27701420
17.
Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development.
Antimicrob Agents Chemother
; 60(6): 3669-75, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27044554
18.
A chemical susceptibility profile of the Plasmodium falciparum transmission stages by complementary cell-based gametocyte assays.
J Antimicrob Chemother
; 71(5): 1148-58, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26888912
19.
Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination.
Malar J
; 14: 213, 2015 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25994518
20.
KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro.
Antimicrob Agents Chemother
; 58(3): 1586-95, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24366744