JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles.

JASPAR (http://jaspar.genereg.net/) is an open-access database containing manually curated, non-redundant transcription factor (TF) binding profiles for TFs across six taxonomic groups. In this 9th release, we expanded the CORE collection with 341 new profiles (148 for plants, 101 for vertebrates, 85 for urochordates, and 7 for insects), which corresponds to a 19% expansion over the previous release. We added 298 new profiles to the Unvalidated collection when no orthogonal evidence was found in the literature. All the profiles were clustered to provide familial binding profiles for each taxonomic group. Moreover, we revised the structural classification of DNA binding domains to consider plant-specific TFs. This release introduces word clouds to represent the scientific knowledge associated with each TF. We updated the genome tracks of TFBSs predicted with JASPAR profiles in eight organisms; the human and mouse TFBS predictions can be visualized as native tracks in the UCSC Genome Browser. Finally, we provide a new tool to perform JASPAR TFBS enrichment analysis in user-provided genomic regions. All the data is accessible through the JASPAR website, its associated RESTful API, the R/Bioconductor data package, and a new Python package, pyJASPAR, that facilitates serverless access to the data.

Real-time conscious postural control is not affected when balancing on compliant surface by young adults.

Previous research has illustrated that real-time conscious postural control (i.e., reinvestment - shifting from movement automaticity to a more consciously controlled and monitoring of movement) increased with standing task difficulties among healthy older adults. However, such association has not been investigated in the younger population. This study attempted to examine real-time conscious postural control among healthy young adults when performing different standing tasks on a compliant (foam) surface. T3-Fz EEG (electroencephalography) coherence, indicative of real-time conscious postural control, was recorded during the standing tasks (i.e., wide base on foam (WBF), narrow base on foam (NBF) and tandem stance on foam (TAF)). Body sway was also recorded by a motion capture system. Participants' perceived difficulty on the different standing tasks was evaluated by the Visual Analogue Scale (VAS). Results revealed that while body sway and perceived difficulty increased significantly with task difficulties, T3-Fz EEG coherence did not differ among standing tasks. In addition, no differences of any measures were found between young adults with high and low trait reinvestment propensity. Our findings indicate that young adults do not pose higher real-time conscious postural control when task difficulty increases. We also add support to the existing literature; the between-group effect of trait reinvestment appears to be minimal in real-time.