Detalhe da pesquisa
1.
Macromolecular Complex Including MLL3, Carabin and Calcineurin Regulates Cardiac Remodeling.
Circ Res
; 134(1): 100-113, 2024 01 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38084599
2.
Large Extracellular Vesicle-Associated Rap1 Accumulates in Atherosclerotic Plaques, Correlates With Vascular Risks and Is Involved in Atherosclerosis.
Circ Res
; 127(6): 747-760, 2020 08 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32539601
3.
Elevated cAMP Protects against Diclofenac-Induced Toxicity in Primary Rat Hepatocytes: A Protective Effect Mediated by the Exchange Protein Directly Activated by cAMP/cAMP-Regulated Guanine Nucleotide Exchange Factors.
Mol Pharmacol
; 99(4): 294-307, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33574047
4.
Receptor-Specific Inside-Out cAMP Signaling Regulates Cardiomyocyte Fate.
Circ Res
; 133(11): 924-926, 2023 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37943945
5.
Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics.
J Comput Aided Mol Des
; 34(11): 1171-1179, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32700175
6.
Multifunctional Mitochondrial Epac1 Controls Myocardial Cell Death.
Circ Res
; 120(4): 645-657, 2017 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28096195
7.
Mechanism of Selective Enzyme Inhibition through Uncompetitive Regulation of an Allosteric Agonist.
J Am Chem Soc
; 140(30): 9624-9637, 2018 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30016089
8.
Cyclic AMP Sensor EPAC Proteins and Their Role in Cardiovascular Function and Disease.
Circ Res
; 118(5): 881-97, 2016 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26941424
9.
Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B.
J Neurosci
; 35(32): 11315-29, 2015 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26269639
10.
Carabin protects against cardiac hypertrophy by blocking calcineurin, Ras, and Ca2+/calmodulin-dependent protein kinase II signaling.
Circulation
; 131(4): 390-400; discussion 400, 2015 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-25369805
11.
Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke.
FASEB J
; 28(11): 4617-28, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25103224
12.
Epac proteins: specific ligands and role in cardiac remodelling.
Biochem Soc Trans
; 42(2): 257-64, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24646227
13.
EPAC1 enhances brown fat growth and beige adipogenesis.
Nat Cell Biol
; 26(1): 113-123, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38195707
14.
Ryanodine receptor dysfunction causes senescence and fibrosis in Duchenne dilated cardiomyopathy.
J Cachexia Sarcopenia Muscle
; 15(2): 536-551, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38221511
15.
Epac in cardiac calcium signaling.
J Mol Cell Cardiol
; 58: 162-71, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23220153
16.
Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac.
J Biol Chem
; 287(53): 44192-202, 2012 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23139415
17.
The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1).
Biochem Biophys Res Commun
; 440(3): 443-8, 2013 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24099776
18.
EPAC1 Pharmacological Inhibition with AM-001 Prevents SARS-CoV-2 and Influenza A Virus Replication in Cells.
Viruses
; 15(2)2023 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36851533
19.
Inhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation.
Front Physiol
; 14: 1120336, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36909224
20.
Diabetic cardiomyopathy: the need for adjusting experimental models to meet clinical reality.
Cardiovasc Res
; 119(5): 1130-1145, 2023 05 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36082907