RESUMO
A highly efficient BF3·Et2O-catalyzed cascade reaction of enaminones with propargylic alcohols under mild reaction conditions has been developed. This methodology offers regioselective access to multisubstituted 1,2-dihydropyridines in good to excellent yields.
Assuntos
Alcinos/química , Aminas/química , Di-Hidropiridinas/síntese química , Ácidos de Lewis/química , Propanóis/química , Catálise , Ciclização , Di-Hidropiridinas/química , Estrutura Molecular , EstereoisomerismoRESUMO
A highly efficient palladium-catalyzed cascade reactions of aryloxy-enynes with aryl halides under mild reaction conditions has been developed. This methodology offers rapid access to 2,3,4-trisubstituted furans in good to excellent yields in a regioselective manner.
Assuntos
Alcinos/química , Éteres/química , Furanos/síntese química , Hidrocarbonetos Halogenados/química , Compostos Organometálicos/química , Paládio/química , Catálise , Ciclização , Furanos/química , Estrutura Molecular , EstereoisomerismoRESUMO
A series of (E)-1-aryloxy-1-en-3-ynes has been prepared by Sonogashira coupling of 2-bromo-3-aryloxypropenoates with terminal alkynes using Pd(PPh(3))(4) and CuI as the catalysts in Et(3)N. The resulting enynyl-aryl ethers are found to be highly applicable to the synthesis of 2,4-disubstituted furans with an ester group at C-4 position through an Au/Ag-catalyzed annulation reaction under extremely mild reaction conditions.
Assuntos
Alcinos/química , Furanos/síntese química , Ouro/química , Catálise , Cobre/química , Ciclização , Éteres/química , Paládio/química , Prata/químicaRESUMO
An efficient palladium/copper-catalyzed approach to the synthesis of highly substituted 3-formyl furans from the reactions of readily available α-bromoenaminones with terminal alkynes has been developed. This methodology was realized by the cascade reactions of Sonogashira coupling and the subsequent intramolecular cyclization.
RESUMO
The construction process and characteristics of a deformable mirror eigenmode are introduced. The eigenmode of a 37-element micromachined membrane deformable mirror (MMDM) from OKO, Ltd. is analyzed. The Gaussian-Seidel low-order aberrations are fitted with eigenmodes as basic functions. An experimental adaptive optics (AO) system is constructed with the MMDM as the wavefront corrector, a deformable mirror eigenmode as the wavefront control algorithm, and a Shack-Hartmann wavefront sensor as the wavefront detector. The experimental results demonstrate that the deformable mirror eigenmode can act as the wavefront control algorithm for the AO system based on the MMDM.