Detalhe da pesquisa
1.
WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
Nature
; 568(7753): 551-556, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30971823
2.
Recurrent RhoGAP gene fusion CLDN18-ARHGAP26 promotes RHOA activation and focal adhesion kinase and YAP-TEAD signalling in diffuse gastric cancer.
Gut
; 2024 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38621923
3.
AMPK signaling mediates synphilin-1-induced hyperphagia and obesity in Drosophila.
J Cell Sci
; 134(3)2021 02 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33443093
4.
GTP-binding inhibitors increase LRRK2-linked ubiquitination and Lewy body-like inclusions.
J Cell Physiol
; 235(10): 7309-7320, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32180220
5.
Synphilin-1 Interacts with AMPK and Increases AMPK Phosphorylation.
Int J Mol Sci
; 21(12)2020 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32570982
6.
Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson's disease models.
Hum Mol Genet
; 25(4): 672-80, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26744328
7.
The Drosophila hep pathway mediates Lrrk2-induced neurodegeneration.
Biochem Cell Biol
; 96(4): 441-449, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29268033
8.
Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson's disease cell and mouse models.
Hum Mol Genet
; 23(23): 6212-22, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24993787
9.
P53-induced GAP-43 Upregulation in Primary Cortical Neurons of Rats.
Protein Pept Lett
; 2024 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38288820
10.
Development of Combination Strategies for Focal Adhesion Kinase Inhibition in Diffuse Gastric Cancer.
Clin Cancer Res
; 29(1): 197-208, 2023 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36278961
11.
Developing SHP2-based combination therapy for KRAS-amplified cancer.
JCI Insight
; 8(3)2023 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36752207
12.
LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: suppression by curcumin.
Neurobiol Dis
; 47(3): 385-92, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22668778
13.
Preproendothelin-1 expression is negatively regulated by IFNγ during hepatic stellate cell activation.
Am J Physiol Gastrointest Liver Physiol
; 302(9): G948-57, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22301113
14.
Effective Strategies to Promote the Cultivation of Public Legal Consciousness from the Perspective of Social Psychology.
J Environ Public Health
; 2022: 8275938, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36225754
15.
Hypogyrification in Generalized Anxiety Disorder and Associated with Insomnia Symptoms.
Nat Sci Sleep
; 14: 1009-1019, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35642211
16.
Case Report: A Case Report and Literature Review of 3p Deletion Syndrome.
Front Pediatr
; 9: 618059, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33643973
17.
A LRRK2 GTP Binding Inhibitor, 68, Reduces LPS-Induced Signaling Events and TNF-α Release in Human Lymphoblasts.
Cells
; 10(2)2021 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33672296
18.
A case of 15q11-q13 duplication syndrome and literature review.
Brain Behav
; 11(8): e2219, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34292674
19.
RAS-MAPK Reactivation Facilitates Acquired Resistance in FGFR1-Amplified Lung Cancer and Underlies a Rationale for Upfront FGFR-MEK Blockade.
Mol Cancer Ther
; 17(7): 1526-1539, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29654068
20.
Author Correction: Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.
Nat Med
; 24(10): 1627, 2018 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-30093730