Association of area deprivation index (ADI) with demographics and postoperative outcomes in pediatric brain tumor patients.

PURPOSE: Although social determinants of health (SDOH) have been associated with adverse surgical outcomes, cumulative effects of multiple SDOH have never been studied. The area deprivation index (ADI) assesses cumulative impact of SDOH factors on outcomes. We analyzed the relationship between ADI percentile and postoperative outcomes in pediatric patients diagnosed with brain tumors. METHODS: A retrospective, observational study was conducted on our consecutive series of pediatric brain tumor patients presenting between January 1, 1999, and May 31, 2022. Demographics and outcomes were collected, identifying SDOH factors influencing outcomes found in the literature. ADI percentiles were identified based on patient addresses, and patients were stratified into more (ADI 0-72%) and less (ADI 73-100%) disadvantaged cohorts. Univariate and multivariate logistic regression analyses were completed for demographics and outcomes. RESULTS: A total of 272 patients were included. Demographics occurring frequently in the more disadvantaged group were Black race (13.1% vs. 2.8%; P = .003), public insurance (51.5% vs. 27.5%; P < .001), lower median household income ($64,689 ± $19,254 vs. $46,976 ± $13,751; P < .001), and higher WHO grade lesions (15[11.5%] grade III and 8[6.2%] grade IV vs. 8[5.6%] grade III and 5[3.5%] grade IV; P = .11). The more disadvantaged group required adjunctive chemotherapy (25.4% vs. 12.05%; P = .007) or radiation therapy (23.9% vs. 12.7%; P = .03) more frequently and had significantly greater odds of needing adjunctive chemotherapy (odds ratio [OR], 1.11; confidence interval [CI], 1.01-1.22; P = .03) in a multivariate model, which also identified higher WHO tumor grades at presentation (OR, 1.20; CI, 1.14-1.27; P < .001). CONCLUSION: These findings are promising for use of ADI to represent potential SDOH disadvantages that pediatric patients may face throughout treatment. Future studies should pursue large multicenter collaborations to validate these findings.

Dexmedetomidine for acute baclofen withdrawal.

BACKGROUND: Intrathecal baclofen is widely accepted as a treatment option for severe spasticity through its γ-Aminobutyric acid-B (GABAB ) agonist properties. Abrupt cessation can lead to severe and life-threatening withdrawal characterized by altered mental status, autonomic dysreflexia, rigidity, and seizures. This symptomatic presentation is similar to alcohol withdrawal, which is mediated by modification of GABAA expression. Use of the α2-adrenergic agonist dexmedetomidine for the treatment of ethanol withdrawal has been widely reported, raising the question of its potential role in baclofen withdrawal. We present a case of the successful treatment of acute severe baclofen withdrawal with a dexmedetomidine infusion. METHODS: A 15-year-old patient with spastic quadriparesis and cerebral palsy underwent unexpected removal of his baclofen pump due to an infection that was encountered during a planned pump revision. Following removal, he was placed on high dose enteral baclofen every 6 h. Despite further benzodiazepine supplementation, he had progressive hemodynamic instability, severe rebound spasticity, and intermittent spontaneous clonus consistent with baclofen withdrawal. A dexmedetomidine infusion was titrated to a peak dose of 16 mcg per hour with successful treatment of withdrawal symptoms. RESULTS: The patient became normotensive without tachycardia. Tone and agitation improved. CONCLUSION: Dexmedetomidine is to our knowledge a previously unreported option for treatment of acute severe baclofen withdrawal. We report a case of safe and efficacious use in a patient with spastic quadriparesis on chronic intrathecal baclofen. Scientifically rigorous comparison with other options remains to be performed.

An online calculator using machine learning for predicting survival in pediatric patients with medulloblastoma.

OBJECTIVE: Medulloblastoma is the most common malignant intracranial tumor affecting the pediatric population. Despite advancements in multimodal treatment over the past 2 decades yielding a 5-year survival rate > 75%, children who survive often have substantial neurological and cognitive sequelae. The authors aimed to identify risk factors and develop a clinically friendly online calculator for prognostic estimation in pediatric patients with medulloblastoma. METHODS: Pediatric patients with a histopathologically confirmed medulloblastoma were extracted from the Surveillance, Epidemiology, and End Results database (2000-2018) and split into training and validation cohorts in an 80:20 ratio. The Cox proportional hazards model was used to identify the univariate and multivariate survival predictors. Subsequently, a calculator with those factors was developed to predict 2-, 5-, and 10-year overall survival as well as median survival months for pediatric patients with medulloblastoma. The performance of the calculator was determined by discrimination and calibration. RESULTS: One thousand seven hundred fifty-nine pediatric patients with medulloblastoma met the prespecified inclusion criteria. Age, sex, race, ethnicity, median household income, county attribute, laterality, anatomical location, tumor grade, tumor size, surgery status, radiotherapy, and chemotherapy were variables included in the calculator (https://spine.shinyapps.io/Peds_medullo/). The concordance index was 0.769 in the training cohort and 0.755 in the validation cohort, denoting clinically useful predictive accuracy. Good agreement between the predicted and observed outcomes was demonstrated by the calibration plots. CONCLUSIONS: An easy-to-use prognostic calculator for a large cohort of pediatric patients with medulloblastoma was established. Future efforts should focus on improving granularity of population-based registries and externally validating the proposed calculator.

Social Determinants of Health and Associations With Outcomes in Pediatric Patients With Brain Tumors.

BACKGROUND AND OBJECTIVES: Social determinants of health (SDOH) are nonmedical factors that affect health outcomes. Limited investigation has been completed on the potential association of these factors to adverse outcomes in pediatric populations. In this study, the authors aimed to analyze the effects of SDOH disparities and their relationship with outcomes after brain tumor resection or biopsy in children. METHODS: The authors retrospectively reviewed the records of their center's pediatric patients with brain tumor. Black race, public insurance, median household income, and distance to hospital were the investigated SDOH factors. Univariate analysis was completed between number of SDOH factors and patient demographics. Multivariate linear regression models were created to identify coassociated determinants and outcomes. RESULTS: A total of 272 patients were identified and included in the final analysis. Among these patients, 81 (29.8%) had no SDOH disparities, 103 (37.9%) had 1, 71 (26.1%) had 2, and 17 (6.2%) had 3. An increased number of SDOH disparities was associated with increased percentage of missed appointments ( P = .002) and emergency room visits ( P = .004). Univariate analysis demonstrated increased missed appointments ( P = .01), number of postoperative imaging ( P = .005), and number of emergency room visits ( P = .003). In multivariate analysis, decreased median household income was independently associated with increased length of hospital stay ( P = .02). CONCLUSION: The SDOH disparities are prevalent and impactful in this vulnerable population. This study demonstrates the need for a shift in research focus toward identifying the full extent of the impact of these factors on postoperative outcomes in pediatric patients with brain tumor.

Anaplastic lymphoma kinase inhibitor therapy in the treatment of inflammatory myofibroblastic tumors in pediatric patients: Case reports and literature review.

BACKGROUND: Inflammatory myofibroblastic tumors (IMTs) are a rare subtype of inflammatory pseudotumor frequently associated with rearrangement of the anaplastic lymphoma kinase (ALK) gene. Their treatment has historically relied on at-times challenging and morbid surgical excision. Recent studies have shown that neo/adjuvant therapy with ALK inhibitors can significantly enhance outcomes in select patients. METHODS: A systematic literature review was performed to characterize comprehensive treatment of ALK-positive IMTs in the pediatric population. This report also includes two patients from our home institutions not previously reported in the literature. RESULTS: We identified a total of 27 patients in 12 studies in addition to 2 patients from the senior authors' institution for a total of 29 patients (median age, 7 years; 52% male). The IMTs comprised a wide range of anatomic locations. Almost half (12, 41.3%) were treated with ALK-inhibitors alone and felt to be in remission. The remainder was treated with ALK-inhibitors either before or after surgery and had a curative response. CONCLUSIONS: ALK-positive IMTs can be successfully treated with ALK-inhibition alone or in combination with surgical resection. Further genetic characterization may be helpful in determining more precise treatment and defining needed durations thereof.

Management of Intracranial Hemorrhage and Skull Fracture After Blunt Intrauterine Trauma.

BACKGROUND: Fetal trauma during pregnancy can have a significant impact on the developing brain. Fetal trauma can lead to several intracranial pathologies including hypoxic-ischemic injury, skull fractures, and intracranial hemorrhages. Blunt trauma to a fetus resulting in the need for neurosurgical intervention is a rare occurrence and seldom described in the literature. CASE DESCRIPTION: Here we present the case of a 28-year-old, 36-week pregnant woman who was brought to the hospital by ambulance following a high-speed motor vehicle collision as the restrained driver. On computed tomography of the abdomen, the fetus was found to have a left-sided skull fracture with intracranial hemorrhage. The fetus was emergently delivered by way of caesarean section for lack of fetal movement and indeterminate heart tracings. Postnatally, the neonate had a Glasgow Coma Scale of 7. A postnatal head computed tomography better defined the skull fractures and multiple areas of intracranial hemorrhage. The baby was taken to the operating room for evacuation of the hematomas. At 16 months of age, the baby was well with only mild developmental delay, although a ventriculoperitoneal shunt was needed in a delayed fashion at 3 months of age. CONCLUSIONS: We present a rare situation where emergent caesarean section delivery followed by neonatal craniotomy was necessary. Our case illustrates that good outcomes can be achieved with rapid identification of fetal intracranial injury and intervention.

Preoperative predictors for improvement after surgical untethering in occult tight filum terminale syndrome.

BACKGROUND/AIMS: An occult tight filum terminale syndrome has been described wherein clinical symptoms result from tension on the spinal cord despite nondiagnostic spinal magnetic resonance imaging (MRI). Recent reports have suggested a role for surgical untethering in this patient population; however, controversy remains regarding the surgical treatment of this condition. Owing to the various clinical presentations, the relationship of presenting signs and symptoms to postoperative outcomes might be useful in surgical selection. METHODS: A retrospective review was conducted of 22 pediatric cases of surgical untethering for suspected occult tight filum terminale syndrome. All patients had nondiagnostic MRI findings, defined as a conus medullaris above the L(3) vertebral body and a filum terminale diameter of less than 2 mm. Preoperative symptoms, signs and urodynamic test results were collected and compared with surgical outcomes determined by clinical notes and postoperative urodynamics reports. Abnormal findings on presentation were categorized as dermatologic, urologic, orthopedic and neurologic. RESULTS: Patient age ranged from 7 months to 17 years, and 12 were female. Sixteen (73%) patients experienced subjective and/or objective improvement following surgical untethering. Fourteen patients had abnormal preoperative urodynamic testing, of which 12 underwent postoperative urodynamic testing. Five of these 12 (42%) demonstrated objective improvement postoperatively. Patients presenting with abnormal findings in at least 2 categories were more likely to improve following untethering (88%) than those with abnormalities in only 1 category (20%; p = 0.009). CONCLUSION: Spinal cord untethering is a treatment option for occult tight filum terminale syndrome. Further evaluation of the relationship between preoperative findings and surgical outcomes may facilitate the selection of surgical candidates.

Risk of ventriculoperitoneal shunt infections after laparoscopic placement of Chait Trapdoor cecostomy catheters in children.

INTRODUCTION: Laparoscopic placement of Chait Trapdoor (Cook, Bloomington, IN) cecosotomy catheters has been practiced in our institution since 1999. Chait cecostomy catheters allow antegrade irrigation of the colon without the complications associated with appendicostomies. Although the use of laparoscopy allows precise placement of these catheters into the cecum under direct vision, the presence of a concomitant ventriculoperitoneal (VP) shunt raises concerns for the potential for a shunt infection. MATERIALS AND METHODS: This is a retrospective review of all patients with VP shunts who underwent laparoscopic placement of a Chait cecostomy catheter from 1999 to 2008. We recorded patient demographics, indication for VP shunt placement, the date of the most recent shunt operation, the method of cecal fixation, follow-up duration, and episodes of shunt infection. RESULTS: Sixteen patients with spina bifida and VP shunts who underwent laparoscopic placement of a Chait cecostomy catheter were identified. There were 12 males. Mean follow-up was 46 +/- 27 months (range, 3-87). Two patients (12.5%) developed a VP shunt infection related to the placement of their cecostomy catheter. One shunt infection occurred 5 days postoperatively and the other occurred several years later, when the shunt and cecostomy catheter tracts merged in the subcutaneous tissue. Both patients underwent shunt externalization. CONCLUSIONS: Cecostomy catheter placement in patients with preexisting VP shunts may increase the risk of shunt infections. Our series illustrates two different mechanisms by which a VP shunt can become infected after this procedure. In the first case, leakage of enteric content from a poorly sealed tract probably resulted in the shunt infection. More secure fixation of the cecum to the abdominal wall, using intracorporeal sutures rather than T-fasteners, may avoid this complication. The second complication could have been avoided if the cecostomy catheter had been placed further away from the VP shunt.

Differential and kinetic effects of cell cycle inhibitors on neoplastic and primary astrocytes.

Alterations in cell cycle regulation underlie the unrestricted growth of neoplastic astrocytes. Chemotherapeutic interventions of gliomas have poor prognostic outcomes due to drug resistance and drug toxicity. Here, we examined the in vitro growth kinetics of C6 glioma (C6G) cells and primary astrocytes and their responses to 2 phase-specific inhibitors, lovastatin and hydroxyurea. C6G cells demonstrated a shorter G1 phase and an earlier peak of DNA synthesis in S phase than primary astrocytes. As C6G cells and primary astrocytes re-entered the cell cycle in the presence of lovastatin or hydroxyurea, they exhibited different sensitivities to the inhibitory effects of these agents, as measured by [3H]-thymidine incorporation. Compared to primary astrocytes, C6G cells were more sensitive to lovastatin, but less sensitive to hydroxyurea. Studies using 2 different paradigms of exposure uncovered dramatic differences in the kinetics of DNA synthesis inhibition by these 2 agents in C6G cells and primary astrocytes. One notable difference was the ability of C6G cells to more easily recover from the inhibitory effects of hydroxyurea following short exposure. Our results provide insight into C6 glioma drug resistance as well as the inhibitory effects of these 2 phase-specific inhibitors and their chemotherapeutic potential.

Association between trauma and acute hemorrhage of cavernous malformations in children: report of 3 cases.

OBJECTIVE Cavernous hemangiomas are benign congenital vascular abnormalities. Intracerebral cavernous hemangiomas have an appreciable risk of spontaneous hemorrhage. Little is known as to whether head trauma increases the risk of bleeding for these lesions. In this study, the authors present a case series of 3 patients with posttraumatic nonspontaneous hemorrhage of intracerebral cavernous malformations (CMs). For the first time, to the authors' knowledge, they propose that trauma might constitute a risk factor for acute hemorrhage in intracerebral cavernomas. METHODS The authors reviewed the charts of all patients with a new diagnosis of intracerebral cavernoma at their pediatric hospital between 2010 and 2014. Patients with a history of head trauma prior to presentation were subsequently studied to identify features common to these posttraumatic, hemorrhage-prone lesions. RESULTS A history of head trauma was identified in 3 of 19 cases. These 3 patients presented with seizures and/or headaches and were found to have acute hemorrhage within a cavernous hemangioma. None of these patients had any history of abnormal neurological symptoms. All 3 abnormal vascular lesions had associated developmental venous anomalies (DVAs). The 3 patients underwent resection of their respective vascular abnormalities, and the diagnosis of cavernous hemangioma was confirmed with postsurgical tissue pathology. All 3 patients had complete resolution of symptoms following complete excision of their lesions. CONCLUSIONS Trauma may represent a risk factor for acute hemorrhage in patients with CMs. The presence of associated DVAs may represent a risk factor for posttraumatic hemorrhage of cavernomas. Excision should be considered in such cases, if feasible.

Transitional care in pediatric neurosurgical patients.

The relatively young specialty field of pediatric neurosurgery addresses a number of surgical diseases that, while first encountered in children, may involve long-term post-operative sequelae that persist into adulthood. These diagnoses present a challenge for care providers as patients transition from pediatric to adult age groups. Brain tumors, shunted hydrocephalus, and myelomeningocele are three of the most common examples of this interesting category. The provision of coordinated transitional care to affected pediatric neurosurgical patients is made all the more difficult by the common comorbidity of developmental delay, affecting not only personal and social growth but also the character and composition of the care team. This article seeks to provide a background for some of the common pediatric neurosurgical diseases requiring a transitional care framework for survivors entering young adulthood, a summary of the adult surgical care challenges faced by these patients, and a rationale for different approaches to optimize care.

Atlantoaxial rotatory fixation: Part 1--Biomechanics of normal rotation at the atlantoaxial joint in children.

OBJECTIVE: Atlantoaxial rotatory fixation (AARF) remains a recondite entity loosely included under the panoply of cervical trauma. The difficulty in finding a precise definition and reliable diagnostic criteria for AARF has been chiefly because of a lack of normative biomechanical data for C1-C2 rotation. As Part 1 and foundation of a comprehensive undertaking to define the biomechanics, mechanism, diagnosis, classification, and management of AARF, the present study focuses on the dynamic behavior of C1 and C2 during normal voluntary head rotation in children. METHODS: Twenty-one normal children 3 to 11.5 years old underwent computed tomographic examinations from the lower clivus to the base of C3 in various head positions during axial rotation. The angles made by C1, C2, and the occiput with the vertical 0 degrees were recorded, and from these, the separation angles between C1 and C2 (C1-C2 degrees) were calculated for each head position (represented by the C1 angle) studied. In 18 children, the range of rotation was between 90 and -90 degrees, i.e., with the head making a full 180-degree turn from one side to the other. In 3 children, the head was first turned from 0 to 90 degrees and then back from 90 to 0 degrees, making only a half turn. All separation angles (C1-C2 degrees) were then plotted against the corresponding C1 angle to create a motion curve, which, in essence, describes the interaction between C1 and C2 through the full range of head positions. In the 18 children with full turns, both individual motion curves and a composite motion curve comprising all data were constructed. RESULTS: There is a high degree of concordance for rotational behavior of C1 and C2 in the 18 subjects undergoing full turn. C1 always crosses C2 at or near 0 degrees, the null point of full rotation. The predictable relationship between C1 and C2 is depicted by three distinct regions on the composite motion curve: when C1 rotates from 0 to 23 degrees, it moves alone, with C2 remaining stationary at approximately 0 degrees (the single-motion phase). When C1 rotates from 24 to 65 degrees, C1 and C2 move together, but C1 always moves at a faster rate (the double-motion phase), C2 being pulled by yoking ligaments. From 65 degrees onward, C1 and C2 move in exact unison (the unison-motion phase) with a fixed, maximum separation angle of approximately 43 degrees, head rotation being carried exclusively by the subaxial segments. In the 3 children with half turn, the forward rotation curve and the reverse rotation curve are almost superimposable, suggesting that the "yoking" between C1 and C2 is a result of more than just tensing and relaxing of ligaments but probably also to a mutual dragging by irregular bony surfaces between the two bones. CONCLUSION: C1 and C2 in children move in a predictable manner during axial head rotation, with a high degree of concordance among subjects and a relatively narrow variance from the mean. The composite motion curve can thus be used as a touchstone against which may be judged all manners of pathological interlock or "stickiness" between C1 and C2 in rotation that could be defined as AARF.

Magnetic resonance imaging correlation in pediatric spinal cord injury without radiographic abnormality.

OBJECT: The authors conducted a study to determine correlations between clinical syndromes and early magnetic resonance (MR) imaging-documented findings in children with spinal cord injury without radiographic abnormality (SCIWORA). METHODS: The authors retrospectively reviewed the records obtained in 20 patients who presented with SCIWORA to the Children's Hospital of Buffalo between 1992 and 1999. Initial neurological syndromes, subsequent hospital course and outcome, and early MR imaging findings obtained using conventional sequences on a 1.5-tesla unit were recorded. Neurological syndromes on presentation were complete (Frankel Grade A) in two patients (10%), severe partial (Frankel Grade C) in one patient (5%), and mild partial (Frankel Grade D) in 17 patients (85%). Partial neurological deficits resolved in 14 (78%) of 18 patients within 72 hours and lasted more than 72 hours in four patients (22%). Magnetic resonance imaging was performed in both patients presenting with complete injuries and in 17 of 18 patients presenting with partial neurological deficits. The studies were obtained within 24 hours in 17 patients (85%). Neuroimaging revealed spinal cord swelling at the cervical level in one of the children with complete injury and cord edema with associated hemorrhage at cervical and thoracic levels in the other. Neural and extraneural elements were shown to be normal in all 17 patients with partial injuries who underwent MR imaging, including in the four patients with partial motor deficits lasting more than 72 hours. CONCLUSIONS: In this series, the predominant neurological presentation of SCIWORA was a mild, partial syndrome that resolved within 72 hours. Magnetic resonance imaging revealed abnormal features only in those patients with complete neurological deficits. These findings suggest that in the acute setting conventional MR imaging sequences may lack the sensitivity to demonstrate neural and extraneural abnormalities associated with partial or temporary neurological deficits of SCIWORA, even when those deficits persist beyond 72 hours.

Management of accidental minor head injuries in children: a prospective outcomes study.

OBJECT: The authors conducted a study to determine clinical, patient/family satisfaction, and financial outcomes following application of a management scheme that involves evaluation of computerized tomography (CT) scans and emergency department observation, rather than overnight admission, for children who have sustained accidental minor closed head injuries (Glasgow Coma Scale Scores 13-15) and who have met predefined clinical and radiographic criteria. METHODS: During 18 consecutive months, all children age 24 months and older who sustained accidental minor head injuries were managed prospectively according to a standard protocol. All children meeting prospectively established clinical criteria underwent immediate CT scanning and were observed in the emergency department. Those in whom there were no intracranial radiographically demonstrated abnormalities and who met established clinical criteria were discharged to home observation. Two hundred fifteen children met the criteria for the study. Falls (53%) and motor vehicle accidents (13%) constituted the most common mechanisms of injury. Of the patients for whom information was recorded, 40% experienced a loss of consciousness and 49% had amnesia. Repeated vomiting occurred in 45%. Skull fractures were rare. No child suffered a clinical complication or neurological deterioration. Two patients (0.9%) underwent reevaluation within 48 hours for persistent symptoms; no intracranial abnormality was demonstrated in either on repeated CT scanning and both recovered uneventfully. Follow-up phone surveys in a subgroup of patients indicated universal parent satisfaction. Compared with a control group that underwent both CT scanning and were admitted to the hospital, statistically significant cost savings were realized in the cohort. CONCLUSIONS: A management scheme that involves routine initial CT studies and a brief period of observation in the emergency department is safe and readily accepted by patients and families and can achieve significant cost savings.

Analysis of the growth pattern of a dermoid cyst.

Dermoid cysts are rare lesions of the CNS with a slow rate of growth. For this reason, they are rarely discovered during infancy. Although benign, these cysts may be associated with devastating complications due to mass effect or meningitis. The discovery of completely asymptomatic dermoid cysts in the pediatric population is exceedingly rare; however, correct and prompt diagnosis is crucial for early surgical treatment to minimize morbidity and mortality. The authors report the unique case of a posterior fossa dermoid cyst discovered in a 5-month-old girl and monitored for 2.5 years with serial imaging studies before performing a resection. The imaging characteristics of dermoid cysts are reviewed, and the challenges associated with the radiographic diagnosis of such lesions are discussed. Analyzing the growth of this particular cyst on MRI allowed comment, for the first time to the authors' knowledge, regarding the growth rate of dermoid cysts. Unlike true tumors, which grow in an exponential pattern, the dermoid cyst in the reported case exhibited a linear growth pattern. The increase in volume followed the classic appearance of a cuboid sequence, which is also consistent with linear growth in all 3 dimensions.

Antimicrobial suture wound closure for cerebrospinal fluid shunt surgery: a prospective, double-blinded, randomized controlled trial.

OBJECT: Implantation of cerebrospinal fluid (CSF) shunting devices is associated with a 5-15% risk of infection as cited in contemporary pediatric neurosurgical literature. Shunt infections typically require complete removal of the device and prolonged antibiotic treatment followed by shunt replacement. Moreover, shunt infections are commonly associated with prolonged hospital stays, potential comorbidity, and the increased risk of neurological compromise due to ventriculitis or surgical complications. The authors prospectively evaluated the incidence of CSF shunt infection following shunt procedures performed using either antimicrobial suture (AMS) or conventional suture. METHODS: In a single-center, prospective, double-blinded, randomized controlled trial, the authors enrolled 61 patients, among whom 84 CSF shunt procedures were performed over 21 months. Randomization to the study (AMS) or control (placebo) group was stratified to minimize the effect of known shunt infection risk factors on the findings. Antibacterial shunt components were not used. The primary outcome measure was the incidence of shunt infection within 6 months of surgery. RESULTS: The shunt infection rate in the study group was 2 (4.3%) of 46 procedures and 8 (21%) of 38 procedures in the control group (p = 0.038). There were no statistically significant differences in shunt infection risk factors between the groups (procedure type and time, age < 6 months, weight < 4 kg, recent history of shunt infection). No suture-related adverse events were reported in either group. CONCLUSIONS: These results support the suggestion that the use of AMS for CSF shunt surgery wound closure is safe, effective, and may be associated with a reduced risk of postoperative shunt infection. A larger randomized controlled trial is needed to confirm this association.

Atlantoaxial rotatory fixation: part 3-a prospective study of the clinical manifestation, diagnosis, management, and outcome of children with alantoaxial rotatory fixation.

OBJECTIVE: This is a prospective study of the clinical manifestations, diagnostic motion analysis, management, and outcome of children with atlantoaxial rotatory fixation (AARF). METHODS: Fifty children presenting with painful torticollis were subjected to the three-head positions diagnostic computed tomographic scanning protocol described in Part II of our AARF study. Twenty-nine children qualified as having AARF (8 Type I, 11 Type II, and 10 Type III), and six children were classified in the diagnostic gray zone (DGZ). The AARF patients were given either halter or calipers traction depending on the type and chronicity of pretreatment delay. Upon reduction, patients were immobilized with either a cervicothoracic brace or a halo. Recurrence of AARF on halo and patients whose deformity was not reducible were given posterior C1C2 fusion at the best achievable alignment. The difficulty and results of treatment were measured according to the following: duration of traction, number of reduction slippage, percent not reducible by traction, percent needing halo, percent needing fusion, total duration of treatment, total number of treatment procedures, and percent who lost normal C1C2 dynamics. Results were compared between groups stratified by AARF types, by chronicity of pretreatment delay (acute << 1 mo, subacute = 1-3 mo, chronic > or = 3 mo) and by the presence or absence of recurrence (recurrent AARF defined as having two or more slippages). DGZ patients were treated with only comfort measures for 2 weeks and then restudied. Only those children with persistent symptoms and DGZ or worse motion dynamics were given traction and bracing. RESULTS: Neither age nor etiology significantly influenced the severity of AARF. There was only a slight tendency for children younger than 5 years, and for trauma, to associate with severe C1C2 interlock. Delay of treatment up to 11 months did not result in improvement of the neck restriction or in abatement of pain. In fact, there are strong suggestions that prolonged delay could lead to worsening of the rotatory dynamics: Type I AARF are highly correlated with delays longer than 3 months and Type III with delays less than 1 month. Also, four patients who had serial motion studies during the delay period showed clear worsening in the pathological stickiness in C1C2 rotation. In addition, chronic rotatory deformity led to progressive occiput -C1 separation or laxity teleologically to compensate for a skewed visual axis. The mean occiput -C1 separation angle for chronic patients was 31.2 degrees versus 5 degrees for acute patients and less than 3 degrees for normal children. The difficulty and duration of treatment, the number of reslippage after reduction, the rate of irreducibility, the need for halo and fusion, and the percentile of patients ultimately loosing normal C1C2 rotation were significantly greater with Type I patients than Type III patients, with Type II patients being intermediate. Likewise, chronic patients of all AARF types were much worse in all parameters than acute patients; subacute patients were closer to chronic patients in complexity and outcome. Severity and chronicity exerted independent effects on outcome, and the worse identifiable subgroup were the chronic Type I patients versus the best subgroup of acute Type III patients.Thirteen patients developed recurrent AARF; they had much worse prognosis in all aspects measured than nonrecurrent patients. Recurrence was adversely influenced by both the severity (type) and chronicity of AARF. Half of the DGZ patients resolved with analgesics, but two of six remained symptomatic and in DGZ dynamics, and one deteriorated to Type III AARF. Two of those three patients responded easily to traction and bracing, and one was lost to follow-up. CONCLUSION: Children with painful torticollis should be subjected to the three-position computed tomographic diagnostic protocol, not only to secure the diagnosis of AARF but also to grade the severity of the condition by virtue of the dynamic motion curve. Closed reduction with traction should be instituted immediately to avoid the serious consequences of chronic AARF. Proper typing and reckoning of the pretreatment delay are requisites for selecting treatment modalities. Recurrent dislocation and incomplete reduction should be treated with posterior C1C2 fusion in the best achievable alignment. Open reduction and halo immobilization to avoid permanent fixation can be tried with select cases.

Atlantoaxial rotatory fixation: part 2--new diagnostic paradigm and a new classification based on motion analysis using computed tomographic imaging.

OBJECTIVE: This is Part II of a study on atlantoaxial rotatory fixation (AARF) that aims to introduce a new diagnostic paradigm and a new classification of this condition based on motion analysis of C1C2 rotation using computed tomographic (CT) imaging. This phase of the study is possible because Part I succeeded in defining physiological C1C2 axial rotation with CT data from 21 normal children, displayed in a highly concordant composite motion curve, which is used as the normal template for the present study. AARF is defined as flagrant departure from normal motion dynamics as delineated by abnormal motion curves. The new classification is predicated on the graded amount of pathological stickiness in the restricted rotation. METHODS: Forty children age 1.5 to 14 years with painful "cock-robin" necks resulting from minor trauma or otolaryngological procedures were subjected to 3 CT examinations: 1) in the presenting (P) position; 2) with the nose pointing up (P0 position); and 3) with the head forcefully turned to the opposite side as much as the patient could tolerate (P_ position). The angles made by C1 and C2 and the separation angle C1C2 degrees (C1 minus C2 degrees) were obtained as described in Part I. The test motion curve was generated by plotting C1 against C1C2 angles, and all motion curves were analyzed in the context of the normal template. RESULTS: Five distinct groups with highly characteristic motion curves could be identified. Group 1 (n = 5) patients showed essentially unaltered ("locked") C1C2 coupled configurations regardless of corrective counterrotation, with curves that are horizontal lines in the upper two quadrants of the template. Group 2 (n = 7) patients had reduction of the C1C2 separation angle with forced correction, but C1 could not be made to cross C2. Their curves slope downward from right to left in the upper quadrants but never traverse the x axis. Group 3 (n = 9) patients showed C1C2 crossover, but only when the head was cranked far to the opposite side. Their motion curves traverse the x axis left of C1 = -20 degrees. Groups 1, 2, and 3 motion dynamics are respectively classified as Types I, II, and III AARF in descending degree of pathological stickiness, which is in essence a resistance against closure of the C1C2 angle to counterrotation. Group 4 (n = 14) patients had normal dynamics, and Group 5 (n = 5) patients showed motion curve features between normal and Type III AARF, designated as belonging to the diagnostic gray zone, an uncertain group that may or may not revert to normal dynamics with only comfort measures. CONCLUSION: AARF can be reliably diagnosed with a simple and practical CT protocol and construction of a three-point motion curve superimposed on a reusable normal template. The type of AARF, reflective of the severity of pathological stickiness of rotation, can be identified readily by the shape of the motion curve. This system of classification is useful in selecting the best regimen of management.

Preventing abusive head trauma among infants and young children: a hospital-based, parent education program.

OBJECTIVE: Abusive head injuries among infants (shaken infant or shaken impact syndrome) represent a devastating form of child abuse; an effective prevention program that reduces the incidence of abusive head injuries could save both lives and the costs of caring for victims. We wished to determine whether a comprehensive, regional, hospital-based, parent education program, administered at the time of the child's birth, could be successfully implemented and to examine its impact on the incidence of abusive head injuries among infants <36 months of age. METHODS: All hospitals that provide maternity care in an 8-county region of western New York State participated in a comprehensive regional program of parent education about violent infant shaking. The program was administered to parents of all newborn infants before the infant's discharge from the hospital. The hospitals were asked to provide both parents (mothers and, whenever possible, fathers or father figures) with information describing the dangers of violent infant shaking and providing alternative responses to persistent infant crying and to have both parents sign voluntarily a commitment statement (CS) affirming their receipt and understanding of the materials. Program compliance was assessed by documenting the number of CSs signed by parents and returned by participating hospitals. Follow-up telephone interviews were conducted with a randomized 10% subset of parents, 7 months after the child's birth, to assess parents' recall of the information. Finally, the regional incidence of abusive head injuries among infants and children <36 months of age during the program (study group) was contrasted with the incidence during the 6 preceding years (historical control group) and with statewide incidence rates for the Commonwealth of Pennsylvania during the control and study periods, using Poisson regression analyses with a type I error rate of 0.05. RESULTS: During the first 5.5 years of the program, 65,205 CSs were documented, representing 69% of the 94,409 live births in the region during that time; 96% of CSs were signed by mothers and 76% by fathers/father figures. Follow-up telephone surveys 7 months later suggested that >95% of parents remembered having received the information. The incidence of abusive head injuries decreased by 47%, from 41.5 cases per 100,000 live births during the 6-year control period to 22.2 cases per 100000 live births during the 5.5-year study period. No comparable decrease was seen in the Commonwealth of Pennsylvania during the years 1996-2002, which bracketed the control and study periods in western New York State. CONCLUSIONS: A coordinated, hospital-based, parent education program, targeting parents of all newborn infants, can reduce significantly the incidence of abusive head injuries among infants and children <36 months of age.