Detalhe da pesquisa
1.
Bosutinib prevents vascular leakage by reducing focal adhesion turnover and reinforcing junctional integrity.
J Cell Sci
; 133(9)2020 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32198280
2.
Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1.
Proc Natl Acad Sci U S A
; 116(52): 26709-26716, 2019 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31843903
3.
The development of highly potent and selective small molecule correctors of Z α1-antitrypsin misfolding.
Bioorg Med Chem Lett
; 41: 127973, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33753261
4.
Structure guided drug design to develop kallikrein 5 inhibitors to treat Netherton syndrome.
Bioorg Med Chem Lett
; 29(12): 1454-1458, 2019 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31005442
5.
Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome.
Bioorg Med Chem Lett
; 29(6): 821-825, 2019 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30691925
6.
Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors.
Bioorg Med Chem Lett
; 29(20): 126675, 2019 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31521475
7.
Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease.
Bioorg Med Chem Lett
; 28(21): 3458-3462, 2018 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30249354
8.
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.
Nature
; 488(7411): 404-8, 2012 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22842901
9.
Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
Nat Chem Biol
; 11(3): 189-91, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25622091
10.
The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.
Bioorg Med Chem Lett
; 27(9): 2023-2028, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28336141
11.
Chiral Brønsted Acid-Catalyzed Asymmetric Synthesis of N-Aryl-cis-aziridine Carboxylate Esters.
Angew Chem Int Ed Engl
; 56(19): 5322-5326, 2017 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28378388
12.
Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors.
Bioorg Med Chem Lett
; 26(19): 4606-4612, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27578246
13.
Corrigendum to 'Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors' [Bioorg. Med. Chem. Lett. 29 (2019) 126675].
Bioorg Med Chem Lett
; 30(2): 126771, 2020 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31859161
14.
Kruidenier et al. reply.
Nature
; 514(7520): E2, 2014 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25279927
15.
Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis.
Cell Rep
; 42(8): 112763, 2023 08 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37478012
16.
4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy.
Bioorg Med Chem Lett
; 22(16): 5222-6, 2012 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22801646
17.
The design of orally bioavailable 2, 5-diketopiperazine oxytocin antagonists: from concept to clinical candidate for premature labor.
Med Res Rev
; 31(4): 576-604, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20027670
18.
Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.
Bioorg Med Chem Lett
; 21(20): 6188-94, 2011 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21903390
19.
A Potent and Selective Kallikrein-5 Inhibitor Delivers High Pharmacological Activity in Skin from Patients with Netherton Syndrome.
J Invest Dermatol
; 141(9): 2272-2279, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33744298
20.
Development of a small molecule that corrects misfolding and increases secretion of Z α1 -antitrypsin.
EMBO Mol Med
; 13(3): e13167, 2021 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33512066