Detalhe da pesquisa
1.
A Randomized Phase 2 KINETIC Trial Evaluating SAGE-324/BIIB124 in Individuals with Essential Tremor.
Mov Disord
; 39(4): 733-738, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38357797
2.
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.
Proc Natl Acad Sci U S A
; 115(31): E7438-E7447, 2018 07 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-30012612
3.
Protein kinase D and Gßγ mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2.
J Biol Chem
; 294(27): 10649-10662, 2019 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31142616
4.
Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission.
Proc Natl Acad Sci U S A
; 114(46): 12309-12314, 2017 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29087309
5.
G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease.
J Immunol
; 198(9): 3565-3575, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28320832
6.
Protein Kinase D and Gßγ Subunits Mediate Agonist-evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane.
J Biol Chem
; 291(21): 11285-99, 2016 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27030010
7.
Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum.
Hepatology
; 63(4): 1287-98, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26426865
8.
Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.
J Biol Chem
; 290(22): 13875-87, 2015 May 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-25878251
9.
Legumain is activated in macrophages during pancreatitis.
Am J Physiol Gastrointest Liver Physiol
; 311(3): G548-60, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27514475
10.
Endothelin-converting enzyme 1 and ß-arrestins exert spatiotemporal control of substance P-induced inflammatory signals.
J Biol Chem
; 289(29): 20283-94, 2014 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24898255
11.
Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.
J Biol Chem
; 289(39): 27215-27234, 2014 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25118282
12.
Inflammation-induced abnormalities in the subcellular localization and trafficking of the neurokinin 1 receptor in the enteric nervous system.
Am J Physiol Gastrointest Liver Physiol
; 309(4): G248-59, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26138465
13.
The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice.
Gastroenterology
; 147(6): 1417-28, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25194674
14.
Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling.
J Biol Chem
; 288(8): 5790-802, 2013 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23288842
15.
Feeding-dependent activation of enteric cells and sensory neurons by lymphatic fluid: evidence for a neurolymphocrine system.
Am J Physiol Gastrointest Liver Physiol
; 306(8): G686-98, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24578341
16.
Neurotrophin and GDNF family ligand receptor expression in vagal sensory nerve subtypes innervating the adult guinea pig respiratory tract.
Am J Physiol Lung Cell Mol Physiol
; 300(5): L790-8, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21335521
17.
Neuroplasticity in vagal afferent neurons involved in cough.
Pulm Pharmacol Ther
; 24(3): 276-9, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21376130
18.
Activation of pruritogenic TGR5, MrgprA3, and MrgprC11 on colon-innervating afferents induces visceral hypersensitivity.
JCI Insight
; 4(20)2019 10 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31536477
19.
A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain.
Nat Nanotechnol
; 14(12): 1150-1159, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31686009
20.
Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief.
Sci Transl Med
; 9(392)2017 05 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-28566424