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A captive marmoset developed metastatic endometrioid carcinoma (EnC), a rare uterine tumor in non-human primates (NHPs). The neoplasm showed marked microscopical malignant and tubulopapillary aspects, immunopositivity for pan-cytokeratin, CK7, estrogen receptor, and a high mitotic index (Ki-67). These features may contribute to the diagnosis and therapeutics of EnC in NHPs.
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Callithrix , Carcinoma Endometrioide , Doenças dos Macacos , Animais , Feminino , Carcinoma Endometrioide/veterinária , Carcinoma Endometrioide/patologia , Carcinoma Endometrioide/diagnóstico , Doenças dos Macacos/patologia , Doenças dos Macacos/diagnóstico , Neoplasias Uterinas/veterinária , Neoplasias Uterinas/patologia , Neoplasias Uterinas/diagnósticoRESUMO
BACKGROUND: Repetitive Transcranial Magnetic Stimulation (rTMS) and EEG-guided neurofeedback techniques can reduce motor symptoms in Parkinson's disease (PD). However, the effects of their combination are unknown. Our objective was to determine the immediate and short-term effects on motor and non-motor symptoms, and neurophysiological measures, of rTMS and EEG-guided neurofeedback, alone or combined, compared to no intervention, in people with PD. METHODS: A randomized, single-blinded controlled trial with 4 arms was conducted. Group A received eight bilateral, high-frequency (10 Hz) rTMS sessions over the Primary Motor Cortices; Group B received eight 30-minute EEG-guided neurofeedback sessions focused on reducing average bilateral alpha and beta bands; Group C received a combination of A and B; Group D did not receive any therapy. The primary outcome measure was the UPDRS-III at post-intervention and two weeks later. Secondary outcomes were functional mobility, limits of stability, depression, health-related quality-of-life and cortical silent periods. Treatment effects were obtained by longitudinal analysis of covariance mixed-effects models. RESULTS: Forty people with PD participated (27 males, age = 63 ± 8.26 years, baseline UPDRS-III = 15.63 ± 6.99 points, H&Y = 1-3). Group C showed the largest effect on motor symptoms, health-related quality-of-life and cortical silent periods, followed by Group A and Group B. Negligible differences between Groups A-C and Group D for functional mobility or limits of stability were found. CONCLUSIONS: The combination of rTMS and EEG-guided neurofeedback diminished overall motor symptoms and increased quality-of-life, but this was not reflected by changes in functional mobility, postural stability or depression levels. TRIAL REGISTRATION: NCT04017481.
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Eletroencefalografia , Neurorretroalimentação , Doença de Parkinson , Estimulação Magnética Transcraniana , Humanos , Doença de Parkinson/terapia , Doença de Parkinson/reabilitação , Doença de Parkinson/complicações , Masculino , Feminino , Pessoa de Meia-Idade , Estimulação Magnética Transcraniana/métodos , Neurorretroalimentação/métodos , Idoso , Eletroencefalografia/métodos , Método Simples-Cego , Resultado do Tratamento , Córtex Motor/fisiologia , Córtex Motor/fisiopatologia , Qualidade de VidaRESUMO
This study evaluates the performance of large intelligent surface (LIS) technology in the context of a multi-user MIMO mobile communication system (Mu-MIMO) proposed for the sixth generation (6G). LIS employs digitally controlled reflectors to enhance Signal-to-Interference plus Noise Ratio (SINR) and establish line of sight (LoS) connectivity in non-LoS environments, improving transmission security. Analytical expressions are derived to assess LIS performance metrics, including distribution parameters, bit error probability, and secrecy outage probability, considering the presence of eavesdroppers and environmental fading. The study highlights the potential of LIS technology to enhance the confidentiality and reliability of digital communication systems in next-generation networks.
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Efficient energy management in residential environments is a constant challenge, in which Home Energy Management Systems (HEMS) play an essential role in optimizing consumption. Load recognition allows the identification of active appliances, providing robustness to the HEMS. The precise identification of household appliances is an area not completely explored. Gaps like improving classification performance through techniques dedicated to separability between classes and models that achieve enhanced reliability remain open. This work improves several aspects of load recognition in HEMS applications. In this research, we adopt Neighborhood Component Analysis (NCA) to extract relevant characteristics from the data, seeking the separability between classes. We also employ the Regularized Extreme Learning Machine (RELM) to identify household appliances. This pioneering approach achieves performance improvements, presenting higher accuracy and weighted F1-Score values-97.24% and 97.14%, respectively-surpassing state-of-the-art methods and enhanced reliability according to the Kappa index, i.e., 0.9388, outperforming competing classifiers. Such evidence highlights the promising potential of Machine Learning (ML) techniques, specifically NCA and RELM, to contribute to load recognition and energy management in residential environments.
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Load recognition remains not comprehensively explored in Home Energy Management Systems (HEMSs). There are gaps in current approaches to load recognition, such as enhancing appliance identification and increasing the overall performance of the load-recognition system through more robust models. To address this issue, we propose a novel approach based on the Analysis of Variance (ANOVA) F-test combined with SelectKBest and gradient-boosting machines (GBMs) for load recognition. The proposed approach improves the feature selection and consequently aids inter-class separability. Further, we optimized GBM models, such as the histogram-based gradient-boosting machine (HistGBM), light gradient-boosting machine (LightGBM), and XGBoost (extreme gradient boosting), to create a more reliable load-recognition system. Our findings reveal that the ANOVA-GBM approach achieves greater efficiency in training time, even when compared to Principal Component Analysis (PCA) and a higher number of features. ANOVA-XGBoost is approximately 4.31 times faster than PCA-XGBoost, ANOVA-LightGBM is about 5.15 times faster than PCA-LightGBM, and ANOVA-HistGBM is 2.27 times faster than PCA-HistGBM. The general performance results expose the impact on the overall performance of the load-recognition system. Some of the key results show that the ANOVA-LightGBM pair reached 96.42% accuracy, 96.27% F1, and a Kappa index of 0.9404; the ANOVA-HistGBM combination achieved 96.64% accuracy, 96.48% F1, and a Kappa index of 0.9434; and the ANOVA-XGBoost pair attained 96.75% accuracy, 96.64% F1, and a Kappa index of 0.9452; such findings overcome rival methods from the literature. In addition, the accuracy gain of the proposed approach is prominent when compared straight to its competitors. The higher accuracy gains were 13.09, 13.31, and 13.42 percentage points (pp) for the pairs ANOVA-LightGBM, ANOVA-HistGBM, and ANOVA-XGBoost, respectively. These significant improvements highlight the effectiveness and refinement of the proposed approach.
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We hypothesized that cottonseed cake in confined Nellore young bulls' diet as fiber source, could maintain or improve the nutrient intake, and productive and metabolic parameters. It was evaluated the total replacement of whole plant corn silage (WPCS) by cottonseed cake (CSC) as a source of fiber in the diet. A completely randomized design with two treatments and 12 replications was used. The treatments were two experimental diets containing 300 g/kg of WPCS or CSC as roughage. All animals at 0, 15, 30, 60 and 112 days were weighed to monitor productive performance and nutrient intake. Dry matter intakes, organic matter, neutral detergent fiber, physically effective neutral detergent fiber, crude protein and non-fiber carbohydrates of the WPCS treatment cattle were higher (p < 0.05), and the ethereal extract intake of cattle fed CSC diet was higher. The BW of cattle fed WPCS was higher in the two initial periods of confinement (p < 0.05). Animals from both treatments showed linear growth during the confinement period. There was a fiber source × period interaction for total weight gain (TWG), average daily gain (ADG) and feed efficiency (FE) (p < 0.05), with the lowest in the first 15 days and the highest at 30 days, reflecting a compensatory gain in animals fed with CSC. Bulls fed with CSC showed negative TWG and ADG in the first period (p < 0.05), but recovered in the following periods, surpassing that of the SC treatment in the last two periods. There was negative EF of bulls fed with CSC in the first period (P < 0.05), but in the following periods the CSC diet did not differ from the WPCS diet. The animals fed CSC diet showed a higher concentration of cholesterol and glucose in the blood plasma (p < 0.05). The forage-free diet containing cottonseed cake as a source of fiber replacing corn silage promoted better animal performance.
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Óleo de Sementes de Algodão , Detergentes , Animais , Bovinos , Masculino , Dieta , Ingestão de Alimentos , Ingestão de EnergiaRESUMO
This study aimed to investigate seven outbreaks of A. marginale infection in two regions of Brazil, affecting taurine, zebu, and crossbred cattle. We assessed the possible causes, treatment measures, and genetic diversity of A. marginale. These outbreaks occurred in two states (Goiás: outbreaks 1-7; Mato Grosso do Sul: outbreak 3), breeds (Holstein, Nellore, and crossbreed), age groups (beef cattle: 18-25 days old and 7-8 months; dairy cattle: 18-25 days old, 13-14 months, and cow after the first birth) and rearing systems (feedlot, pasture, pen in a wood shaving bedding system and compost bedded-pack barns). Metaphylactic or prophylactic treatments varied according to outbreak (imidocarb dipropionate: outbreaks 1-4 and 6; enrofloxacin: outbreaks 5 and 7; diminazene diaceturate: outbreak 5). In outbreaks 6 and 7, the packed cell volume was monitored. In all outbreaks, the practice of needle/syringe sharing was discontinued. For outbreaks 1-3, clinical signs and mortality (range, 4.8-13.3%) occurred 36-45 days after entry into the feedlot. In outbreak 4, A. marginale was diagnosed in 66.2% of the calves (bacteremia, 0-4.5%), with a mortality of 8.6%. Among nursing calves aged 60 days during outbreak 5, 53.8% were infected with A. marginale, with average bacteremia of 2.7% (range, 0-21.3%), and a mortality of 13.8%. In dairy heifers aged 14 months, raised in paddocks lacking vegetation cover and infested with R. microplus, then transitioned to a rotational grazing system also infested with R. microplus, the A. marginale bacteremia ranged from 3.2 to 6.7%, with a mortality of 20%. Before monitoring during outbreak 7, the mortality was 17.9%, but no further deaths were observed after monitoring initiation. In conclusion, possible causes triggering the outbreaks included primary tick infestation, needle/syringe sharing, and stress factors which may have affected the immunological statues of animals in the feedlots. Control measures performed in all outbreaks were effective. The partial msp4 gene sequences of A. marginale generated herein belonged to two haplotypes, but further research would be needed to investigate if this finding has any clinical significance.
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Anaplasma marginale , Anaplasmose , Doenças dos Bovinos , Surtos de Doenças , Variação Genética , Animais , Brasil/epidemiologia , Bovinos , Surtos de Doenças/veterinária , Anaplasmose/epidemiologia , Anaplasmose/microbiologia , Anaplasma marginale/genética , Doenças dos Bovinos/epidemiologia , Doenças dos Bovinos/microbiologia , Feminino , Criação de Animais Domésticos/métodos , MasculinoRESUMO
BACKGROUND: After the results of the ISCHEMIA Trial, the role of myocardial ischemia in the prognosis of coronary artery disease (CAD) was under debate. We sought to comparatively evaluate the long-term prognosis of patients with multivessel CAD with or without documented myocardial ischemia. METHODS: This is a single-center, retrospective, observational cohort study that included patients with CAD obtained from the research protocols database of "The Medicine, Angioplasty or Surgery Study," the MASS Study Group. Patients were stratified according to the presence or absence of myocardial ischemia. Cardiovascular events (overall mortality and myocardial infarction) were tracked from the registry entry up to a median follow-up of 8.7 years. Myocardial ischemia was assessed at baseline by a functional test with or without imaging. RESULTS: From 1995 to 2018, 2015 patients with multivessel CAD were included. Of these, 1001 presented with conclusive tests at registry entry, 790 (79%) presenting with ischemia and 211 (21%) without ischemia. The median follow-up was 8.7 years (IQR 4.04 to 10.07). The primary outcome occurred in 228 (28.9%) patients with ischemia and in 64 (30.3%) patients without ischemia (plog-rank=0.60). No significant interaction was observed with the presence of myocardial ischemia and treatment strategies in the occurrence of the combined primary outcome (pinteration=0.14). CONCLUSIONS: In this sample, myocardial ischemia was not associated with a worse prognosis compared with no ischemia in patients with multivessel CAD. These results refer to debates about the role of myocardial ischemia in the occurrence of cardiovascular events.
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Doença da Artéria Coronariana , Infarto do Miocárdio , Isquemia Miocárdica , Humanos , Seguimentos , Estudos Retrospectivos , Isquemia Miocárdica/complicações , Isquemia Miocárdica/epidemiologia , Infarto do Miocárdio/complicações , Prognóstico , Fatores de RiscoRESUMO
This work reports the implementation of a fiber-optics and visible light communication (VLC)-based flexible optical distribution network for beyond the fifth generation of mobile networks (B5G) applications. The proposed hybrid architecture is composed of a 12.5-km single-mode fiber fronthaul based on the analog radio-over-fiber (A-RoF) technology, followed by a red, green, and blue (RGB)-based VLC link of 1.2 m. As a proof of concept, we experimentally demonstrate a successful deployment of a 5G hybrid A-RoF/VLC system without using pre-/post-equalization, digital pre-distortion, or individual filters for each color, by means of using a dichroic cube filter at the receiver side. The system performance is evaluated in terms of the root mean square error vector magnitude (E V M R M S ), in accordance with the 3rd Generation Partnership Project requirements, and as a function of the light-emitting diodes' injected electrical power and signal bandwidth.
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Chronic kidney disease is a worldwide public health problem, and end-stage renal disease requires dialysis. Most patients requiring renal replacement therapy have to undergo hemodialysis. Therefore, vascular access is extremely important for the dialysis population, directly affecting the quality of life and the morbidity and mortality of this patient population. Since making, managing and salvaging of vascular accesses falls within the purview of the vascular surgeon, developing guideline to help specialists better manage vascular accesses for hemodialysis if of great importance. Thus, the objective of this guideline is to present a set of recommendations to guide decisions involved in the referral, evaluation, choice, surveillance and management of complications of vascular accesses for hemodialysis.
A doença renal crônica é um problema de saúde pública global e em seu estágio terminal está associada à necessidade de terapia dialítica. A grande maioria dos pacientes que necessitam realizar a terapia renal substitutiva, a fazem através da hemodiálise. Portanto, o acesso vascular é de extrema importância para a população dialítica, implicando diretamente na qualidade de vida e na morbimortalidade deste grupo de pacientes. Sendo a confecção, gerenciamento e resgate dos acessos vasculares uma das áreas de atuação do cirurgião vascular, é de grande importância a elaboração de uma diretriz que oriente o especialista no manejo mais adequado do acesso vascular para hemodiálise. Assim, o objetivo desta diretriz é apresentar um conjunto de recomendações para guiar as decisões na referenciação, avaliação, escolha, vigilância e gestão das complicações do acesso vascular para hemodiálise.
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BACKGROUND: The ISCHEMIA-CKD (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches-Chronic Kidney Disease) trial found no advantage to an invasive strategy compared to conservative management in reducing all-cause death or myocardial infarction (D/MI). However, the prognostic influence of angiographic coronary artery disease (CAD) burden and ischemia severity remains unknown in this population. We compared the relative impact of CAD extent and severity of myocardial ischemia on D/MI in patients with advanced chronic kidney disease (CKD). METHODS: Participants randomized to invasive management with available data on coronary angiography and stress testing were included. Extent of CAD was defined by the number of major epicardial vessels with ≥50% diameter stenosis by quantitative coronary angiography. Ischemia severity was assessed by site investigators as moderate or severe using trial definitions. The primary endpoint was D/MI. RESULTS: Of the 388 participants, 307 (79.1%) had complete coronary angiography and stress testing data. D/MI occurred in 104/307 participants (33.9%). Extent of CAD was associated with an increased risk of D/MI (P < .001), while ischemia severity was not (P = .249). These relationships persisted following multivariable adjustment. Using 0-vessel disease (VD) as reference, the adjusted hazard ratio (HR) for 1VD was 1.86, 95% confidence interval (CI) 0.94 to 3.68, P = .073; 2VD: HR 2.13, 95% CI 1.10 to 4.12, P = .025; 3VD: HR 4.00, 95% CI 2.06 to 7.76, P < .001. Using moderate ischemia as the reference, the HR for severe ischemia was 0.84, 95% CI 0.54 to 1.30, P = .427. CONCLUSION: Among ISCHEMIA-CKD participants randomized to the invasive strategy, extent of CAD predicted D/MI whereas severity of ischemia did not.
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Doença da Artéria Coronariana , Isquemia Miocárdica , Insuficiência Renal Crônica , Angiografia Coronária , Doença da Artéria Coronariana/complicações , Doença da Artéria Coronariana/diagnóstico , Doença da Artéria Coronariana/epidemiologia , Humanos , Isquemia/complicações , Isquemia Miocárdica/complicações , Isquemia Miocárdica/epidemiologia , Insuficiência Renal Crônica/complicações , Insuficiência Renal Crônica/epidemiologia , Fatores de RiscoRESUMO
BACKGROUND: Cold urticaria (ColdU), that is, the occurrence of wheals or angioedema in response to cold exposure, is classified into typical and atypical forms. The diagnosis of typical ColdU relies on whealing in response to local cold stimulation testing (CST). It can also manifest with cold-induced anaphylaxis (ColdA). We aimed to determine risk factors for ColdA in typical ColdU. METHODS: An international, cross-sectional study COLD-CE was carried out at 32 urticaria centers of reference and excellence (UCAREs). Detailed history was taken and CST with an ice cube and/or TempTest® performed. ColdA was defined as an acute cold-induced involvement of the skin and/or visible mucosal tissue and at least one of: cardiovascular manifestations, difficulty breathing, or gastrointestinal symptoms. RESULTS: Of 551 ColdU patients, 75% (n = 412) had a positive CST and ColdA occurred in 37% (n = 151) of the latter. Cold-induced generalized wheals, angioedema, acral swelling, oropharyngeal/laryngeal symptoms, and itch of earlobes were identified as signs/symptoms of severe disease. ColdA was most commonly provoked by complete cold water immersion and ColdA caused by cold air was more common in countries with a warmer climate. Ten percent (n = 40) of typical ColdU patients had a concomitant chronic spontaneous urticaria (CSU). They had a lower frequency of ColdA than those without CSU (4% vs. 39%, p = .003). We identified the following risk factors for cardiovascular manifestations: previous systemic reaction to a Hymenoptera sting, angioedema, oropharyngeal/laryngeal symptoms, and itchy earlobes. CONCLUSION: ColdA is common in typical ColdU. High-risk patients require education about their condition and how to use an adrenaline autoinjector.
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Angioedema , Urticária Crônica , Himenópteros , Mordeduras e Picadas de Insetos , Urticária , Angioedema/diagnóstico , Angioedema/epidemiologia , Angioedema/etiologia , Animais , Temperatura Baixa , Estudos Transversais , Humanos , Mordeduras e Picadas de Insetos/complicações , Prurido/complicações , Fatores de Risco , Urticária/diagnóstico , Urticária/epidemiologia , Urticária/etiologiaRESUMO
Teak wood residues were subjected to thermochemical pretreatment, enzymatic saccharification, and detoxification to obtain syrups with a high concentration of fermentable sugars for ethanol production with the ethanologenic Escherichia coli strain MS04. Teak is a hardwood, and thus a robust deconstructive pretreatment was applied followed by enzymatic saccharification. The resulting syrup contained 60 g l-1 glucose, 18 g l-1 xylose, 6 g l-1 acetate, less than 0.1 g l-1 of total furans, and 12 g l-1 of soluble phenolic compounds (SPCs). This concentration of SPC is toxic to E. coli, and thus two detoxification strategies were assayed: (1) treatment with Coriolopsis gallica laccase followed by addition of activated carbon and (2) overliming with Ca(OH)2. These reduced the phenolic compounds by 40% and 76%, respectively. The detoxified syrups were centrifuged and fermented with E. coli MS04. Cultivation with the overlimed hydrolysate showed a 60% higher volumetric productivity (0.45 gETOH l-1 hr-1). The bioethanol/sugar yield was over 90% in both strategies.
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Etanol , Madeira , Escherichia coli , Fermentação , Hidrólise , LigninaRESUMO
Zircon crystals from the Jack Hills, Western Australia, are one of the few surviving mineralogical records of Earth's first 500 million years and have been proposed to contain a paleomagnetic record of the Hadean geodynamo. A prerequisite for the preservation of Hadean magnetization is the presence of primary magnetic inclusions within pristine igneous zircon. To date no images of the magnetic recorders within ancient zircon have been presented. Here we use high-resolution transmission electron microscopy to demonstrate that all observed inclusions are secondary features formed via two distinct mechanisms. Magnetite is produced via a pipe-diffusion mechanism whereby iron diffuses into radiation-damaged zircon along the cores of dislocations and is precipitated inside nanopores and also during low-temperature recrystallization of radiation-damaged zircon in the presence of an aqueous fluid. Although these magnetites can be recognized as secondary using transmission electron microscopy, they otherwise occur in regions that are indistinguishable from pristine igneous zircon and carry remanent magnetization that postdates the crystallization age by at least several hundred million years. Without microscopic evidence ruling out secondary magnetite, the paleomagnetic case for a Hadean-Eoarchean geodynamo cannot yet been made.
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Surface urban heat islands (SUHIs) are one of the most studied phenomena in urban climates because they generate problems for the well-being of the urban population. This study analyzed the thermal comfort conditions at microclimate scale and SUHI for João Pessoa city, Brazil. Micrometeorological data (temperature and air humidity data) collected at 10 stations in 2011 and 2018 were used to calculate Thom's discomfort index (TDI) for João Pessoa city. Satellite images from Landsat 5/TM for 1991, 2006, and 2010 and Landsat 8/OLI for 2018 were used for land use and land cover classification and to identify SUHI. The obtained results highlighted that the SUHI area in João Pessoa city was 26 km2 and that almost half of the heat island area was concentrated in the Geisel, Aeroclube, Valentina, Distrito Industrial, Cristo Redentor, and Mangabeira neighborhoods. Regarding the micrometeorological data, higher values were obtained for 2018 in the dry periods (summer) and during the day. Based on the results, a considerable increase in discomfort during the daytime was observed in urbanized areas of the city from 2010 - 2018 due to the increase in the average temperature in João Pessoa between 1991 and 2018.
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Temperatura Alta , Microclima , Brasil , Cidades , Monitoramento Ambiental/métodosRESUMO
The production of biofuels, such as bioethanol from lignocellulosic biomass, is an important task within the sustainable energy concept. Understanding the metabolism of ethanologenic microorganisms for the consumption of sugar mixtures contained in lignocellulosic hydrolysates could allow the improvement of the fermentation process. In this study, the ethanologenic strain Escherichia coli MS04 was used to ferment hydrolysates from five different lignocellulosic agroindustrial wastes, which contained different glucose and xylose concentrations. The volumetric rates of glucose and xylose consumption and ethanol production depend on the initial concentration of glucose and xylose, concentrations of inhibitors, and the positive effect of acetate in the fermentation to ethanol. Ethanol yields above 80% and productivities up to 1.85 gEtOH/Lh were obtained. Furthermore, in all evaluations, a simultaneous co-consumption of glucose and xylose was observed. The effect of deleting the xyIR regulator was studied, concluding that it plays an important role in the metabolism of monosaccharides and in xylose consumption. Moreover, the importance of acetate was confirmed for the ethanologenic strain, showing the positive effect of acetate on the co-consumption rates of glucose and xylose in cultivation media and hydrolysates containing sugar mixtures.
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Repressão Catabólica , Escherichia coli , Fermentação , Escherichia coli/metabolismo , Xilose/metabolismo , Glucose/metabolismo , Açúcares/metabolismo , Etanol/metabolismoRESUMO
INTRODUCTION: This cross-sectional study aimed to investigate the crown and root characteristics of impacted central incisors compared with spontaneously erupted contralateral incisors and the influence of etiologic and local factors on their dimensions. METHODS: Forty-five patients (22 boys, 23 girls) who underwent orthodontic treatment for unilateral impaction of maxillary central incisors were referred for cone-beam imaging. Dimensions of the impacted and contralateral incisors were assessed using Dolphin 3D software (Dolphin Imaging & Management Solutions, Chatsworth, Calif). Paired t test and linear regression were used to compare the characteristics of the impacted and contralateral teeth. RESULTS: Contralateral and impacted central incisors showed statistically significant differences for root length (95% confidence interval [CI], 2.32-3.46; P <0.001), mesiodistal crown-root angulation (95% CI, 4.09-15.95; P = 0.001), and labiolingual crown-root angulation (95% CI, -18.69 to -4.70; P = 0.002). Etiologic factors did not alter the dimensions of incisors (95% CI, -1.17 to 0.76; P = 0.672). According to the multiple linear regression the independent variables associated with root length of contralateral and impacted incisors were sex (ß = -0.904; 95% CI, -1.62 to - 0.19; P = 0.014) and the presence of impaction (ß = -2.87; 95% CI, -3.67 to -2.07; P <0.001). CONCLUSIONS: Regardless of their etiology, the impacted incisors showed roots that were 2.89 mm shorter than the contralateral incisors and had greater angulation in the mesiodistal and labiolingual directions. Girls showed a reduction of 0.904 mm (7.6%) on the lengths of roots of both impacted and contralateral central incisors. The presence of impaction led to a reduction of 25% in incisor root lengths. Approximately 30% of the impacted teeth showed crown-root angulations >20° resulting in an increased distal and labial angulation of the root apical portion.
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Incisivo , Dente Impactado , Tomografia Computadorizada de Feixe Cônico/métodos , Estudos Transversais , Dente Canino , Humanos , Incisivo/diagnóstico por imagem , Maxila/diagnóstico por imagem , Dente Impactado/diagnóstico por imagem , Dente Impactado/terapiaRESUMO
Cotton cake can be a sustainable and economically viable alternative to maize silage as an effective fibre source in the finishing diet of feedlot beef cattle. Thus, the objective was to evaluate the economic viability and the productive performance of Nellore steers finished in feedlots using cotton cake as a source of fibre, replacing maize silage in the diet. Twenty-four non-castrated Nellore steers, with an average weight of 377.8 kg and an age of approximately 24 months, kept in individual pens, were used. The diet was 30% roughage, in the form of maize silage, and a diet without forage containing 30% cotton cake as an effective fibre source, based on dry matter. The design used was completely randomised with two treatments and 12 replications. Effects (p < 0.05) of the dietary fibre source were observed for final body weight (BW), total weight gain, hot carcass weight (HCW) and carcass yield (CY). Revenue and net margin were higher for the treatment with cotton cake. The corn silage diet promoted higher total costs per animal (U$ 408.41 vs. U$ 336.06) and daily costs (U$ 3.65 vs. U$ 3.00). Greater differences were observed between fibre sources for the concentrate cost, and the maize silage diet had a cost U$ 98.29 higher than the treatment with cotton cake (U$ 314.04 vs. U$ 215.75). The cotton cake treatment had a higher cost of U$106.98/animal for the net margin. Cotton cake is a viable alternative and can be used as a source of fibre in forage-free diets without affecting production performance, promoting benefits in economic performance for finishing beef steers in feedlots.
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Dieta , Silagem , Ração Animal/análise , Animais , Bovinos , Dieta/veterinária , Fibras na Dieta , Silagem/análise , Aumento de Peso , Zea maysRESUMO
INTRODUCTION: The COVID-19 pandemic dramatically disrupts health care around the globe. The impact of the pandemic on chronic urticaria (CU) and its management are largely unknown. AIM: To understand how CU patients are affected by the COVID-19 pandemic; how specialists alter CU patient management; and the course of CU in patients with COVID-19. MATERIALS AND METHODS: Our cross-sectional, international, questionnaire-based, multicenter UCARE COVID-CU study assessed the impact of the pandemic on patient consultations, remote treatment, changes in medications, and clinical consequences. RESULTS: The COVID-19 pandemic severely impairs CU patient care, with less than 50% of the weekly numbers of patients treated as compared to before the pandemic. Reduced patient referrals and clinic hours were the major reasons. Almost half of responding UCARE physicians were involved in COVID-19 patient care, which negatively impacted on the care of urticaria patients. The rate of face-to-face consultations decreased by 62%, from 90% to less than half, whereas the rate of remote consultations increased by more than 600%, from one in 10 to more than two thirds. Cyclosporine and systemic corticosteroids, but not antihistamines or omalizumab, are used less during the pandemic. CU does not affect the course of COVID-19, but COVID-19 results in CU exacerbation in one of three patients, with higher rates in patients with severe COVID-19. CONCLUSIONS: The COVID-19 pandemic brings major changes and challenges for CU patients and their physicians. The long-term consequences of these changes, especially the increased use of remote consultations, require careful evaluation.
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COVID-19/epidemiologia , Urticária Crônica/terapia , SARS-CoV-2 , Adolescente , Adulto , Idoso , Estudos Transversais , Feminino , Humanos , Internet , Masculino , Pessoa de Meia-Idade , Medidas de Resultados Relatados pelo Paciente , Adulto JovemRESUMO
We report the experimental implementation of optically-powered wireless sensor nodes based on the power-over-fiber (PoF) technology, aiming at Industrial Internet of Things (IIoT) applications. This technique employs optical fibers to transmit power and is proposed as a solution to address the hazardous industrial environment challenges, e.g., electromagnetic interference and extreme temperatures. The proposed approach enables two different IIoT scenarios, in which wireless transmitter (TX) and receiver (RX) nodes are powered by a PoF system, enabling local and remote temperature data monitoring, with the purpose of achieving an intelligent and reliable process management in industrial production lines. In addition, the system performance is investigated as a function of the delivered electrical power and power transmission efficiency (PTE), which is the primary performance metric of a PoF system. We report 1.4 W electrical power deliver with PTE = 24%. Furthermore, we carry out a voltage stability analysis, demonstrating that the PoF system is capable of delivering stable voltage to a wide range of applications. Finally, we present a comparison of temperature measurements between the proposed approach and a conventional industrial programmable logic controller (PLC). The obtained results demonstrate that PoF might be considered as a potential technology to power and enhance the energy efficiency of IIoT sensing systems.