Pesquisa | BVS Violência e Saúde

1.

Generating human artery and vein cells from pluripotent stem cells highlights the arterial tropism of Nipah and Hendra viruses.

Ang, Lay Teng; Nguyen, Alana T; Liu, Kevin J; Chen, Angela; Xiong, Xiaochen; Curtis, Matthew; Martin, Renata M; Raftry, Brian C; Ng, Chun Yi; Vogel, Uwe; Lander, Angelika; Lesch, Benjamin J; Fowler, Jonas L; Holman, Alyssa R; Chai, Timothy; Vijayakumar, Siva; Suchy, Fabian P; Nishimura, Toshinobu; Bhadury, Joydeep; Porteus, Matthew H; Nakauchi, Hiromitsu; Cheung, Christine; George, Steven C; Red-Horse, Kristy; Prescott, Joseph B; Loh, Kyle M.

Cell ; 185(14): 2523-2541.e30, 2022 07 07.

Artigo em Inglês | MEDLINE | ID: mdl-35738284

2.

Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types.

Loh, Kyle M; Chen, Angela; Koh, Pang Wei; Deng, Tianda Z; Sinha, Rahul; Tsai, Jonathan M; Barkal, Amira A; Shen, Kimberle Y; Jain, Rajan; Morganti, Rachel M; Shyh-Chang, Ng; Fernhoff, Nathaniel B; George, Benson M; Wernig, Gerlinde; Salomon, Rachel E A; Chen, Zhenghao; Vogel, Hannes; Epstein, Jonathan A; Kundaje, Anshul; Talbot, William S; Beachy, Philip A; Ang, Lay Teng; Weissman, Irving L.

Cell ; 166(2): 451-467, 2016 Jul 14.

Artigo em Inglês | MEDLINE | ID: mdl-27419872

3.

Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma.

Chang, Chiung-Ying; Shipony, Zohar; Lin, Sherry G; Kuo, Ann; Xiong, Xiaochen; Loh, Kyle M; Greenleaf, William J; Crabtree, Gerald R.

Mol Cell ; 81(24): 4964-4978.e8, 2021 12 16.

Artigo em Inglês | MEDLINE | ID: mdl-34687603

4.

Building human artery and vein endothelial cells from pluripotent stem cells, and enduring mysteries surrounding arteriovenous development.

Loh, Kyle M; Ang, Lay Teng.

Semin Cell Dev Biol ; 155(Pt C): 62-75, 2024 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-37393122

5.

Affinity-matured DLL4 ligands as broad-spectrum modulators of Notch signaling.

Gonzalez-Perez, David; Das, Satyajit; Antfolk, Daniel; Ahsan, Hadia S; Medina, Elliot; Dundes, Carolyn E; Jokhai, Rayyan T; Egan, Emily D; Blacklow, Stephen C; Loh, Kyle M; Rodriguez, Paulo C; Luca, Vincent C.

Nat Chem Biol ; 19(1): 9-17, 2023 01.

Artigo em Inglês | MEDLINE | ID: mdl-36050494

6.

Author Correction: Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.

Wilkinson, Adam C; Ishida, Reiko; Kikuchi, Misako; Sudo, Kazuhiro; Morita, Maiko; Crisostomo, Ralph Valentine; Yamamoto, Ryo; Loh, Kyle M; Nakamura, Yukio; Watanabe, Motoo; Nakauchi, Hiromitsu; Yamazaki, Satoshi.

Nature ; 571(7766): E12, 2019 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-31289376

7.

Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.

Wilkinson, Adam C; Ishida, Reiko; Kikuchi, Misako; Sudo, Kazuhiro; Morita, Maiko; Crisostomo, Ralph Valentine; Yamamoto, Ryo; Loh, Kyle M; Nakamura, Yukio; Watanabe, Motoo; Nakauchi, Hiromitsu; Yamazaki, Satoshi.

Nature ; 571(7763): 117-121, 2019 07.

Artigo em Inglês | MEDLINE | ID: mdl-31142833

8.

Dach1 Extends Artery Networks and Protects Against Cardiac Injury.

Raftrey, Brian; Williams, Ian; Rios Coronado, Pamela E; Fan, Xiaochen; Chang, Andrew H; Zhao, Mingming; Roth, Robert; Trimm, Emily; Racelis, Raquel; D'Amato, Gaetano; Phansalkar, Ragini; Nguyen, Alana; Chai, Timothy; Gonzalez, Karen M; Zhang, Yue; Ang, Lay Teng; Loh, Kyle M; Bernstein, Daniel; Red-Horse, Kristy.

Circ Res ; 129(7): 702-716, 2021 09 17.

Artigo em Inglês | MEDLINE | ID: mdl-34383559

9.

Ex uno plures: molecular designs for embryonic pluripotency.

Loh, Kyle M; Lim, Bing; Ang, Lay Teng.

Physiol Rev ; 95(1): 245-95, 2015 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-25540144

10.

Isolation and 3D expansion of multipotent Sox9⁺ mouse lung progenitors.

Nichane, Massimo; Javed, Asif; Sivakamasundari, V; Ganesan, Monisha; Ang, Lay Teng; Kraus, Petra; Lufkin, Thomas; Loh, Kyle M; Lim, Bing.

Nat Methods ; 14(12): 1205-1212, 2017 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-29106405

11.

Spatially controlled stem cell differentiation via morphogen gradients: A comparison of static and dynamic microfluidic platforms.

Cui, Kiara W; Engel, Leeya; Dundes, Carolyn E; Nguyen, Tina C; Loh, Kyle M; Dunn, Alexander R.

J Vac Sci Technol A ; 38(3): 033205, 2020 May.

Artigo em Inglês | MEDLINE | ID: mdl-32255900

12.

Evaluating the regenerative potential and functionality of human liver cells in mice.

Tan, Antson Kiat Yee; Loh, Kyle M; Ang, Lay Teng.

Differentiation ; 98: 25-34, 2017.

Artigo em Inglês | MEDLINE | ID: mdl-29078082

13.

Stem cells: Equilibrium established.

Loh, Kyle M; Lim, Bing.

Nature ; 521(7552): 299-300, 2015 May 21.

Artigo em Inglês | MEDLINE | ID: mdl-25993958

14.

Differentiation of trophoblast cells from human embryonic stem cells: to be or not to be?

Roberts, R Michael; Loh, Kyle M; Amita, Mitsuyoshi; Bernardo, Andreia S; Adachi, Katsuyuki; Alexenko, Andrei P; Schust, Danny J; Schulz, Laura C; Telugu, Bhanu Prakash V L; Ezashi, Toshihiko; Pedersen, Roger A.

Reproduction ; 147(5): D1-12, 2014 May.

Artigo em Inglês | MEDLINE | ID: mdl-24518070

15.

Stem cells: Close encounters with full potential.

Loh, Kyle M; Lim, Bing.

Nature ; 502(7469): 41-2, 2013 Oct 03.

Artigo em Inglês | MEDLINE | ID: mdl-24048472

16.

Inflammatory risk contributes to post-COVID endothelial dysfunction through anti-ACKR1 autoantibody.

Lee, Ee-Soo; Nguyen, Nhi; Young, Barnaby E; Wee, Hannah; Wazny, Vanessa; Lee, Khang Leng; Tay, Kai Yi; Goh, Liuh Ling; Chioh, Florence Wj; Law, Michelle Cy; Lee, I Russel; Ang, Lay Teng; Loh, Kyle M; Chan, Mark Y; Fan, Bingwen E; Dalan, Rinkoo; Lye, David C; Renia, Laurent; Cheung, Christine.

Life Sci Alliance ; 7(7)2024 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-38740432

17.

Lineage-tracing hematopoietic stem cell origins in vivo to efficiently make human HLF+ HOXA+ hematopoietic progenitors from pluripotent stem cells.

Fowler, Jonas L; Zheng, Sherry Li; Nguyen, Alana; Chen, Angela; Xiong, Xiaochen; Chai, Timothy; Chen, Julie Y; Karigane, Daiki; Banuelos, Allison M; Niizuma, Kouta; Kayamori, Kensuke; Nishimura, Toshinobu; Cromer, M Kyle; Gonzalez-Perez, David; Mason, Charlotte; Liu, Daniel Dan; Yilmaz, Leyla; Miquerol, Lucile; Porteus, Matthew H; Luca, Vincent C; Majeti, Ravindra; Nakauchi, Hiromitsu; Red-Horse, Kristy; Weissman, Irving L; Ang, Lay Teng; Loh, Kyle M.

Dev Cell ; 59(9): 1110-1131.e22, 2024 May 06.

Artigo em Inglês | MEDLINE | ID: mdl-38569552

18.

Spatially Segregated Macrophage Populations Predict Distinct Outcomes In Colon Cancer.

Matusiak, Magdalena; Hickey, John W; van IJzendoorn, David G P; Lu, Guolan; Kidzinski, Lukasz; Zhu, Shirley; Colburg, Deana R C; Luca, Bogdan; Phillips, Darci J; Brubaker, Sky W; Charville, Gregory W; Shen, Jeanne; Loh, Kyle M; Okwan-Duodu, Derick K; Nolan, Garry P; Newman, Aaron M; West, Robert B; van de Rijn, Matt.

Cancer Discov ; 2024 Mar 28.

Artigo em Inglês | MEDLINE | ID: mdl-38552005

19.

Epigenetics: Actors in the cell reprogramming drama.

Loh, Kyle M; Lim, Bing.

Nature ; 488(7413): 599-600, 2012 Aug 30.

Artigo em Inglês | MEDLINE | ID: mdl-22932382

20.

Monolayer platform to generate and purify primordial germ-like cells in vitro provides insights into human germline specification.

Vijayakumar, Sivakamasundari; Sala, Roberta; Kang, Gugene; Chen, Angela; Pablo, Michelle Ann; Adebayo, Abidemi Ismail; Cipriano, Andrea; Fowler, Jonas L; Gomes, Danielle L; Ang, Lay Teng; Loh, Kyle M; Sebastiano, Vittorio.

Nat Commun ; 14(1): 5690, 2023 09 14.

Artigo em Inglês | MEDLINE | ID: mdl-37709760

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Generating human artery and vein cells from pluripotent stem cells highlights the arterial tropism of Nipah and Hendra viruses.

Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types.

Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma.

Building human artery and vein endothelial cells from pluripotent stem cells, and enduring mysteries surrounding arteriovenous development.

Affinity-matured DLL4 ligands as broad-spectrum modulators of Notch signaling.

Author Correction: Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.

Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.

Dach1 Extends Artery Networks and Protects Against Cardiac Injury.

Ex uno plures: molecular designs for embryonic pluripotency.

Isolation and 3D expansion of multipotent Sox9⁺ mouse lung progenitors.

Spatially controlled stem cell differentiation via morphogen gradients: A comparison of static and dynamic microfluidic platforms.

Evaluating the regenerative potential and functionality of human liver cells in mice.

Stem cells: Equilibrium established.

Differentiation of trophoblast cells from human embryonic stem cells: to be or not to be?

Stem cells: Close encounters with full potential.

Inflammatory risk contributes to post-COVID endothelial dysfunction through anti-ACKR1 autoantibody.

Lineage-tracing hematopoietic stem cell origins in vivo to efficiently make human HLF+ HOXA+ hematopoietic progenitors from pluripotent stem cells.

Spatially Segregated Macrophage Populations Predict Distinct Outcomes In Colon Cancer.

Epigenetics: Actors in the cell reprogramming drama.

Monolayer platform to generate and purify primordial germ-like cells in vitro provides insights into human germline specification.