Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract.

The respiratory tract is heavily populated with innate immune cells, but the mechanisms that control such cells are poorly defined. Here we found that the E3 ubiquitin ligase TRIM29 was a selective regulator of the activation of alveolar macrophages, the expression of type I interferons and the production of proinflammatory cytokines in the lungs. We found that deletion of TRIM29 enhanced macrophage production of type I interferons and protected mice from infection with influenza virus, while challenge of Trim29-/- mice with Haemophilus influenzae resulted in lethal lung inflammation due to massive production of proinflammatory cytokines by macrophages. Mechanistically, we demonstrated that TRIM29 inhibited interferon-regulatory factors and signaling via the transcription factor NF-κB by degrading the adaptor NEMO and that TRIM29 directly bound NEMO and subsequently induced its ubiquitination and proteolytic degradation. These data identify TRIM29 as a key negative regulator of alveolar macrophages and might have important clinical implications for local immunity and immunopathology.

Dielectric Liquid Microlens Array with Tunable Focal Length Based on Microdroplet Array Created via Dip-Coating Method.

A dielectric liquid microlens array (LMA) with a tunable focal length was fabricated by using a microdroplet array generated through the dip-coating method. The process began with treating the octadecyltrichlorosilane (OTS) layer with selective UV/O3 irradiation for 20 min to establish a hydrophilic-hydrophobic patterning surface. The substrate was subsequently immersed in glycerol and then withdrawn at a constant rate to create a microdroplet array. Upon filling the cell with matching oil (SL5267) and placing it within a square array of a 200 µm diameter glycerol microdroplet array, the LMA was produced. The focal length ranged from approximately -0.96 to -0.3 mm within a voltage range of 0 to 60 Vrms. The glycerol microdroplets, characterized by their shapes, sizes, curvatures, and filling factors, can be precisely controlled by designing an OTS patterning or adjusting the dip-coating speed. This approach offers a rapid and high-throughput method for preparation. Our approach to fabricating tunable LMA offers several advantages, including simplicity of fabrication, uniform structural properties, cost-effectiveness, polarization independence, and excellent optical performance. These focus-tunable LMAs hold significant potential for applications in image processing, 3D displays, medical endoscopy, and military technologies.

Polymeric microlens array formed on a discontinuous wetting surface using a self-assembly technique.

In this paper, we demonstrate a facile way to prepare polymeric microlens arrays (MLAs) based on a discontinuous wetting surface using a self-assembly technique. A patterned hydrophobic-octadecyltrichlorosilane (OTS) surface was prepared by U V/O 3 irradiation through a shadow mask. The area exposed to U V/O 3 irradiation turned highly hydrophilic, whereas the area protected by the mask remained highly hydrophobic, generating the patterned OTS surface. The surface energy of the OTS/glass surface changed from 23 to 72.8 mN/m after 17 min of U V/O 3 treatment. The scribing of the optical glue-NOA 81 onto the microhole array enabled one to obtain the MLAs due to the generation of the NOA 81 droplet array via the surface tension. After UV light curing, the cured NOA 81 droplet array with uniform dimensions within a large area exhibited excellent MLA characteristics. Moreover, the method developed in this study is simple in operation, low-cost, and requires neither a clean room nor expensive equipment.

Manipulation of sub-terahertz waves using digital coding metasurfaces based on liquid crystals.

This paper presents a novel sub-terahertz liquid crystal (LC) phase shifter based on digital coding metasurfaces. The proposed structure consists of metal gratings and resonant structures. They are both immersed in LC. The metal gratings function as reflective surfaces for electromagnetic waves and electrodes for controlling the LC layer. The proposed structure changes the state of the phase shifter by switching the voltage on every grating. It allows the deflection of LC molecules within a subregion of the metasurface structure. Four switchable coding states of the phase shifter are obtained experimentally. The phase of the reflected wave varies by 0°, 102°, 166°, and 233° at 120 GHz. Due to the presence of the transverse control electric field, modulation speed is approximately doubled compared to the free relaxation state. This work provides a novel idea for wavefront modulation of phase.

Electrically controllable broadband reflective linear cross-polarization conversion based on liquid crystals.

This paper presents an electrically controllable reflective broadband linear polarization (LP) converter based on liquid crystals (LCs) for cross-polarization conversion (CPC) in the terahertz frequency range. The proposed structure achieves a high polarization conversion ratio (PCR) exceeding 0.9 within the frequency range of 236.8 - 269.6 GHz. A vital feature of this design is the dynamic control of polarization conversion by re-orienting the nematic liquid crystal molecules through voltage bias switching between 'on' and 'off' states, allowing for precise manipulation of cross-polarized and co-polarized reflected waves. Experimental results validate the simulation outcomes, demonstrating excellent agreement. In contrast to conventional reflective polarization converters with fixed frequency responses, the proposed electrically controllable polarization conversion offers significant potential in imaging and optical communications.

Multi-stable dye-doped dual-frequency twisted nematic liquid crystal smart window.

In this study, a novel, to the best of our knowledge, dye-doped dual-frequency liquid crystal multi-stable smart window is proposed. A chiral dopant with appropriate content was introduced into dye-doped dual-frequency liquid crystals to achieve an initial 180° twisted state. These liquid crystals can be switched to a nematic phase or a 360° twisted state by controlling the magnitude and frequency of the applied voltage. These nematic phase and 360° twisted states can exist stably for a long time because of the backflow effect and the anisotropic nature of the dual-frequency liquid crystal material. Due to the optical waveguide effect of dye-doped liquid crystals in the long-pitch state, the transmittance was different in nematic phase, 180°, and 360° twisted three zero-field stabilized absorption states. Finally, a multi-stable smart window is developed to switch between three zero-field stabilized absorption and scattering states.

Fabrication of a bionic compound eye on a curved surface by using a self-assembly technique.

Microlens arrays on curved surfaces are regarded as critical elements of bionic compound eyes (BCEs), which exhibit the comparative advantages of a wide field of view and tracking fast-moving objects. However, the fabrication of a curved microlens array is still challenging. Along these lines, in this work, a straightforward, rapid, and low-cost technique for the fabrication of curved microlens arrays is reported by using the self-assembly technique. A reactive ion etching process treated the surface of the curved polydimethylsiloxane (PDMS) substrate to generate a hydrophobic-hydrophilic pattern. Then, the curved microlens array can be realized by dewetting a liquid glue onto the substrate using the dip-coating method and followed by crosslinking. The proposed BCE structure consists of 2400 microlenses (400 - µm diameter and 440 - µm center distance) arranged in a hexagonal configuration on a curved PDMS surface (34 - mm diameter and 40.4 - mm curvature radius). A field-of-view of 50° was demonstrated, which has potential applications in various fields including imaging sensors, medical diagnostics, machine vision systems, and photodetectors.

Liquid crystal-based wide-angle metasurface absorber with large frequency tunability and low voltage.

A tunable metasurface absorber (MA) based on polymer network liquid crystal is introduced in this paper. Despite the well-designed unit cell patterns, the proposed MA can achieve both large frequency tunability and wide-angle stability. Compared with traditional liquid crystal-based metasurfaces, the measured results suggest that the recovery time of the proposed structure was reduced by half. By applying an external voltage on the top electrode of the liquid crystal layer from 0 to a saturation voltage of 10 V, the absorption peak of the MA can be tuned from 112.7 GHz to 102.2 GHz, with a maximum frequency tunability of 9.3%, which is significantly higher than other proposed liquid crystal-based metasurfaces. Moreover, the proposed tunable absorber can maintain absorption greater than 90% with incident angles reaching up to 60° for both transverse electric and transverse magnetic polarizations. This design provides an efficient way for developing low-power consumption terahertz devices with large frequency tunability and wide-angle stability.

Active continuous control of terahertz wave based on a reflectarray element-liquid crystal-grating electrode hybrid structure.

In this work, a new and efficient terahertz reflective phase shifter is proposed. The phase shifter is composed of a metal-dielectric-metal structure with a double dipole patch array, as well as copper grating electrodes immersed within the nematic liquid crystal. More specifically, the employed copper grating electrodes consist of two sets of cross-distributed comb grids, whereas at each set of comb grids can be applied an external bias voltage separately. On top of that, the electric field in the liquid crystal (LC) layer can be continuously changed by enforcing an innovative technique. Consequently, the orientation of the LC molecules was fully controlled by the applied electric field, since the dielectric constant of the LC is controlled by the biased voltage. The phase of the reflective electromagnetic wave can be continuously manipulated. Under this direction, the experimental results show that the phase shift exceeds the value of 180° in the range of 102.5 GHz-104.3 GHz, where the maximum phase shift is 249° at 103 GHz. The proposed work provides a new regulation concept for the implementation of LC-based terahertz devices and the respective applications in the terahertz reconfigurable antennas field.

Rapid terahertz wave manipulation in a liquid-crystal-integrated metasurface structure.

A terahertz phase shifter based on liquid-crystal-integrated metasurface is proposed, which contains a three-slotted array structure and comb grating. The orientation of the liquid crystal molecules can be completely controlled by the direction of the electric field. From the acquired experimental results, it was demonstrated that the phase shift exceeds 300° in the range of 378.6 - 390.8 GHz, whereas the maximum phase shift reaches 374.1° at 383.1 GHz. The molecular reorientation transient process induced by the external electric field in the liquid crystal was measured and analyzed. Based on the molecular reorientation mechanism, which can be divided into three processes, a rapid modulation mechanism was demonstrated. From the performance of the proposed device, an actively controllable phase delay and reflectance with a cycle switching time of approximately 0.3 s was achieved, which is remarkably faster than the usual cycle time that exceeds 8 s. Our work provides useful ideas for improving the response speed of LC-based terahertz devices, which is considered of great significance for several applications, in terms of terahertz reconfigurable devices.

Variable-focus liquid lens based on electrically responsive fluid.

In this work, an adaptive liquid lens using a novel transparent electrically responsive fluid, dibutyl adipate (DBA), is demonstrated. The DBA liquid lens with a hemispherical plano-convex shape can change its curvature according to the application of various input voltages. More specifically, when an external direct current (DC) electric field is applied to the DBA liquid, the charges that are injected from the cathode move along with the DBA molecules toward the anode and accumulate on the surface of the anode. When the DC electric field is removed, the shape of the DBA liquid is recovered to its original state. This electrostatic force induces the deformation of the DBA liquid lens within a concentric annular anode electrode. In addition, the focal length of our system is increased from a value of approximately 7.5 mm to 13.1 mm when the voltage is changed from 0 to 100 V. Interestingly, the resolution of our DBA liquid lens can reach a value of ∼28.5 lp/mm. The proposed DBA liquid lens exhibits high optical transmittance (∼95%), good thermal stability (20-100°C), simple structure, and an excellent imaging property, which implies that the DBA liquid is a promising candidate for fabricating novel adaptive liquid lenses.

Ligand-mediated CsPbBrxI3-x/SiO2quantum dots for red, stable and low-threshold amplify spontaneous emission.

The red-emitting perovskite material has received widespread attention as a long-wavelength optical gain media. But the easy phase change in the air limits its practical application. Herein, red CsPbBrxI3-x/SiO2quantum dots (QDs) are prepared by a ligand-mediated hot injection method in which 3-aminopropyl-triethoxysilane (APTES) is used instead of the usual oleylamine (OAm) ligand. Through the hydrolysis of amino groups, a thin silicon layer is formed on the QD surface, improving the stability and without causing the aggregation of QDs. We find that the ratio of I/Br and the size of QDs can be tuned by adjusting the APTES amount. Moreover, this ligand-mediated synthesis effectively passivates the surface defects, so the photoluminescence quantum yield is remarkably improved, and the carrier lifetime is prolonged. The amplified spontaneous emission is achieved under 532 nm nanosecond laser excitation. Compared with the original CsPbBrI2-OAm QD films, the threshold of CsPbBrxI3-x/SiO2QD films is reduced from 403.5 to 98.7µJ cm-2, and the radiation stability is significantly enhanced. Therefore, this material shows great potential in the random laser field.

Liquid crystal microlens array with positive and negative focal lengths based on a patterned electrode.

A liquid crystal microlens array (LCMLA) with positive and negative focal lengths based on a ring-array patterned electrodes is demonstrated. By carefully designing patterned electrodes with a circular electrode array area and outer ring electrode region area, the switching of the positive and negative lens effect can be easily achieved in a single cell. A positive lens effect appeared when the voltage was applied to the outer ring electrode region and the top substrate. The focal length changed from infinity to 1 mm as the voltage varied from 0 to 3Vrms. A negative lens effect occurred when the voltage was applied to the circular electrode array and the top substrate. The focal length varied from infinity to -1mm when the voltage changed from 0 to 2Vrms. The imaging properties of the LCMLA at different voltages are evaluated. Our LCMLA, with simple structure, low driving voltage, and good stability, has potential applications in optical communication, imaging processing, and displays.

Vari-focal liquid microlens array using an electrically responsive fluid actuated by a ring array patterned electrode.

A transparent fluid dibutyl adipate (DBA) is suitable for fabricating the adaptive lens due to its unique deformation under a direct current (DC) electric field. In this report, a DBA liquid microlens array (LMA) with a tunable focal length is demonstrated. A hydrophobic layer deposited in the ring array patterns on the electrode induced the formation of the DBA liquid microdroplets array self-assembly. The electronegative DBA liquid tends to move to the anode at a DC voltage. The proposed DBA LMA with a diameter of 100 µm can change its focal length from 0.92 to 1.42 mm when the voltage changes from 0 to 200 V. The response time is relatively fast (∼790m s). Due to the high optical transmittance (∼91%) and good thermal stability in the temperature range of -24.8-161.5∘C, our DBA LMA shows good focusing properties and has potential applications in the field of image processing, portable electronic devices, beam steering, ophthalmology, and 3D displays.

Highly efficient and tunable terahertz polarization converter based on double subwavelength metallic gratings infiltrated with liquid crystal.

In this work, a tunable cross-polarized transmission structure at the terahertz frequency was demonstrated, and the polarization state during modulation was investigated. The proposed structure can significantly enhance the polarization conversion performance of nematic liquid crystals by leveraging the formation of a Fabry-Perot-like resonant cavity that consists of two metal gratings. As a result, the incident waves are continuously reflected in the liquid crystal layer to complete the accumulation of polarization angle changes. From the experimental results acquired, it was concluded that the insertion loss of the cross-polarization transmission was less than 3 dB and the extinction ratio was larger than 28 dB in the frequency range of 388-426 GHz. Our work provides useful insights for improving the efficiency of cross-polarization conversion by enhancing the resonance process in a Fabry-Perot-like resonant cavity and, thus, significantly extending the equivalent optical path.

Stable and tunable single-mode lasers based on cholesteric liquid crystal microdroplets.

Although many studies on cholesteric liquid crystal (CLC) microdroplet single-mode lasers are available, it has been shown that the stability and tunability of such microdroplets are difficult to achieve simultaneously. In this paper, a new, to the best of our knowledge, method is proposed for the mass and rapid preparation of stable and tunable monodisperse CLC microdroplet single-mode lasers. This is based on the formation of polymer networks on the surface of the microdroplet via interfacial polymerization and a disruption of the orderliness of the polymer networks by increasing the temperature during polymerization, which results in a single pitch inside the microdroplets. This approach enables CLC microdroplet single-mode lasers to achieve improved environmental robustness, while maintaining the same temperature tunability as the unpolymerized sample. Our method has promising future applications in integrated optics, flexible devices, and sensors.

Electrically active control of terahertz waves in a hybrid metasurface-grating structure with a liquid crystal.

A reflective terahertz phase shifter for wide-range dynamic and continuous phase modulation is proposed. By injecting a tunable liquid crystal between the slotted metasurface and the grating microstructure, the phases of reflected waves can be modulated with different electrically driven methods. Numerical simulations show that the proposed terahertz phase shifter has a phase difference of more than 360° between unbiased and biased states. Furthermore, an array of 35×35 patch elements was designed and fabricated. The performance of the phase shifter provides more than 360° between 379.6 and 391.8 GHz, where the maximum phase shift reaches 422.4° at 385.9 GHz. Moreover, the fully electrically controlled phase modulation of more than 180° is achieved between 382.0 and 394.1 GHz, with a maximum phase modulation of 248.4° at 383.3 GHz. This work may provide a reflective terahertz phase modulator for beam steering.

Tunable multi-mode laser based on robust cholesteric liquid crystal microdroplet.

To date, various studies have been dedicated to the development of cholesteric liquid crystal (CLC) microdroplet omnidirectional lasers. In this work, a stable and tunable multi-mode laser emission is achieved by designing a dye-doping CLC microdroplet. In such a structure, the polymer network only exists on the surface, maintaining stability while providing tunability, and due to the uneven distribution of the pitch, it leads to multi-mode laser emission. A large number of microdroplets are produced quickly via a new method based on ultrasonic separation. During the reaction, we introduce interfacial polymerization where monomers and photoinitiator are respectively distributed inside and outside the microdroplets through mutual diffusion, which enables one to make the polymer network exist on the surface instead of the interior. The obtained microdroplet-based multi-mode laser is shown to possess stability and tunability, demonstrating a great potential for flexible devices and 3D displays.

Polyvinyl alcohol microlens array obtained by solvent evaporation from a confined droplet array.

In this study, polyvinyl alcohol (PVA) microlens arrays (MLAs) were prepared, and the dynamics of contact lines and contact angles during confined PVA solution droplet evaporation were investigated by in situ optical microscopy. First, hydrophobic layers patterned with hydrophilic microholes array modified substrates were prepared by photolithography and coating methods. The flowing of PVA solution on the substrates formed droplets in each microhole self-assembly. The substrate was then heated to allow evaporation of the solvent. The results showed the contact line of confined droplets pinned at the junction between the hydrophilic and hydrophobic areas during the whole evaporation process. The apparent contact angle decreased nonlinearly during evaporation. The evaporation of PVA solution droplet in each microhole followed a constant contact radius mode, meaning constant contact area and declined contact angle during evaporation. After complete solvent evaporation, PVA formed a convex shape with convergent lens character in each microhole. In sum, the obtained PVA convex arrays with uniform sizes and good focusing properties would have potential applications in wavefront sensing, infrared focal plane detection or CCD array light accumulation, laser array scanning, laser display, optical fiber coupling, and many other optical systems.