Detalhe da pesquisa
1.
Pyruvate formate-lyase activating enzyme: The catalytically active 5'-deoxyadenosyl radical caught in the act of H-atom abstraction.
Proc Natl Acad Sci U S A
; 120(47): e2314696120, 2023 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37956301
2.
Computational engineering of previously crystallized pyruvate formate-lyase activating enzyme reveals insights into SAM binding and reductive cleavage.
J Biol Chem
; 299(6): 104791, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37156396
3.
ENDOR Spectroscopy Reveals the "Free" 5'-Deoxyadenosyl Radical in a Radical SAM Enzyme Active Site Actually is Chaperoned by Close Interaction with the Methionine-Bound [4Fe-4S]2+ Cluster.
J Am Chem Soc
; 146(6): 3710-3720, 2024 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38308759
4.
Mechanism of Radical S-Adenosyl-l-methionine Adenosylation: Radical Intermediates and the Catalytic Competence of the 5'-Deoxyadenosyl Radical.
J Am Chem Soc
; 144(11): 5087-5098, 2022 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35258967