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1.
BMJ Open ; 13(7): e069297, 2023 07 10.
Artigo em Inglês | MEDLINE | ID: mdl-37429683

RESUMO

BACKGROUND: There is a growing recognition on the importance of equality, diversity and inclusion (EDI) within surgery and the need to diversify the surgical community and its various organisations, in a bidto reflect the diverse populations they serve. To create, sustain and encourage a diverse surgical workforce requires an in-depth understanding of the current makeup of key surgical institutions, relevant issues pertaining to EDI and appropriate solutions and strategies to ensure tangible change. OBJECTIVES: Following on from the recent Kennedy Review into Diversity and Inclusion commissioned by the Royal College of Surgeons of England, the aim of this qualitative study was to understand the EDI issues which affected the membership of the Association of Coloproctology of Great Britain and Ireland, while seeking appropriate solutions to address them. DESIGN: Dedicated, online and qualitative focus groups. PARTICIPANTS: Colorectal surgeons, trainees and nurse specialists were recruited using a volunteer sampling strategy. METHODS: A series of online, dedicated, qualitative focus groups across the 20 chapter regions were held. Each focus group was run informed by a structured topic guide. All participants who were given the opportunity to remain anonymous were offered a debriefing at the end. This study has been reported in keeping with the Standards for Reporting Qualitative Research. RESULTS: Between April and May 2021, a total number of 20 focus groups were conducted, with a total of 260 participants across 19 chapter regions. Seven themes and one standalone code pertaining to EDI were identified: support, unconscious behaviours, psychological consequences, bystander behaviour, preconceptions, inclusivity and meritocracy and the one standalone code was institutional accountability. Five themes were identified pertaining to potential strategies and solutions: education, affirmative action, transparency, professional support and mentorship. CONCLUSION: The evidence presented here is of a range of EDI issues which affect the working lives of those within colorectal surgery in the UK and Ireland, and of potential strategies and solutions which can help build a more inclusive, equitable and diverse colorectal community.


Assuntos
Neoplasias Colorretais , Cirurgia Colorretal , Procedimentos Cirúrgicos do Sistema Digestório , Humanos , Pesquisa Qualitativa , Grupos Focais
2.
Acta Neurol Scand ; 124(3): 211-4, 2011 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-20969559

RESUMO

OBJECTIVE: To compare the medication dose reduction between deep brain stimulation (DBS) of the globus pallidus interna (GPi) vs subthalamic nucleus (STN) in matched patients with Parkinson's disease (PD). MATERIALS AND METHODS: Records of 12 patients with PD who underwent GPi-DBS at our institution from 2002 to 2008 were matched by pre-operative PD medication doses and pre-operative motor Unified Parkinson's Disease Rating Scale (UPDRS) scores to 12 cases of STN-DBS. PD medication doses were converted to levodopa equivalent doses (LEDs). RESULTS: GPi and STN groups had similar mean pre-operative LEDs and motor UPDRS scores. At 6 months post-DBS, there was no significant difference in percent reduction in LEDs between the GPi (47.95%) and STN (37.47%) groups (P = 0.52). The mean post-operative 'medication off/stimulation on' motor UPDRS scores did not differ significantly between GPi (15.33) and STN (16.25) groups (P = 0.74). The mean percent reduction in motor UPDRS scores was also similar between GPi (58.44%) and STN (58.98%) patients (P = 0.94). CONCLUSIONS: We conclude that in disease-matched patients with PD undergoing DBS, both GPi and STN may result in similar reduction in PD medication doses.


Assuntos
Estimulação Encefálica Profunda/estatística & dados numéricos , Globo Pálido/fisiologia , Levodopa/administração & dosagem , Doença de Parkinson/tratamento farmacológico , Doença de Parkinson/cirurgia , Núcleo Subtalâmico/fisiologia , Idoso , Antiparkinsonianos/administração & dosagem , Estimulação Encefálica Profunda/métodos , Humanos , Estudos Longitudinais , Pessoa de Meia-Idade , Vias Neurais/efeitos dos fármacos , Vias Neurais/fisiopatologia , Vias Neurais/cirurgia , Doença de Parkinson/fisiopatologia , Estudos Retrospectivos , Tempo , Resultado do Tratamento
3.
Int J Radiat Oncol Biol Phys ; 42(5): 953-8, 1998 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-9869215

RESUMO

PURPOSE: This analysis was performed to examine the outcome of patients with histologically confirmed ependymomas of the brain or spinal cord who received postoperative radiotherapy. METHODS AND MATERIALS: Eighty patients with histologically confirmed ependymomas were evaluated retrospectively. All were treated with various combinations of surgery, radiotherapy (RT), and chemotherapy. Follow-up ranged from 5 to 30 years (median 10.4 years). RESULTS: The 5- and 10-year survival rates for the entire study group were 79% and 73%, respectively. Patients with low-grade (1 and 2 of 4) tumors had a 5-year survival rate of 87% as compared to 27% for those with high-grade (3 and 4 of 4) tumors (p < 0.0001). Patients with tumors of the spine had a 5-year survival rate of 97% as compared to 68% for those with infratentorial tumors, and 62% for those with supratentorial tumors (p = 0.03). Patients with myxopapillary ependymomas of the spine had a 5-year survival rate of 100% as compared with 76% for patients with other histological subtypes of ependymoma (p = 0.02). Multivariate analysis revealed that the survival rate was independently associated with tumor grade (p = 0.0007) and histological subtype (p = 0.02). Twenty-eight patients (35%) experienced local failure and 10 patients (13%) developed leptomeningeal seeding. The 5-year leptomeningeal failure rate was 10% in patients with low-grade tumors as compared to 41% for patients with high grade tumors (p = 0.01). CONCLUSION: Patients with low-grade tumors, especially those with myxopapillary subtypes, have high 5-year survival rates when treated with post-operative radiotherapy. High grade ependymomas are associated with a much poorer outcome. New forms of therapy are required to improve the outcome of patients with high-grade ependymomas.


Assuntos
Neoplasias Encefálicas/radioterapia , Ependimoma/radioterapia , Neoplasias da Medula Espinal/radioterapia , Adolescente , Adulto , Idoso , Análise de Variância , Neoplasias Encefálicas/mortalidade , Neoplasias Encefálicas/patologia , Criança , Pré-Escolar , Ependimoma/mortalidade , Ependimoma/secundário , Feminino , Humanos , Lactente , Masculino , Neoplasias Meníngeas/secundário , Pessoa de Meia-Idade , Estudos Retrospectivos , Neoplasias da Medula Espinal/mortalidade , Neoplasias da Medula Espinal/patologia , Taxa de Sobrevida
4.
Int J Radiat Oncol Biol Phys ; 36(3): 557-63, 1996 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-8948339

RESUMO

PURPOSE: This analysis was performed to determine the clinical outcome of patients with primary nongerminomatous germ cell tumors of the brain. The efficacy of various treatment options was evaluated. METHODS AND MATERIALS: A total of 57 patients with primary nongerminomatous germ cell tumors of the brain were identified. Patient-related data were collected and analyzed retrospectively. Follow-up in surviving patients ranged from 3 to 243 months (median follow-up 36). Survival and failure rates were determined using the Kaplan-Meier method, and differences between the survival curves were evaluated using either the log rank test or the Wilcoxon test. RESULTS: The 3-year survival rate was 86% for patients with mature teratomas, 67% for patients with immature teratomas, 44% for patients with mixed germ cell tumors, and 13% for patients with the other histologic types (p = 0.02). The 3-year survival rate was 0% for patients having biopsies alone, 32% for patients having subtotal resections, and 73% for patients having gross total resections (p = 0.0001). Patients with tumors other than mature or immature teratomas were evaluated for possible relationships between the administration of chemotherapy or radiotherapy and survival. Patients who received chemotherapy had a 3-year survival rate of 56% compared to 8% for those patients who did not receive chemotherapy (p = 0.0001) Patients who received radiotherapy had a 3-year survival rate of 46% compared to 11% for those patients who did not receive radiotherapy (p = 0.0015). CONCLUSION: The survival of patients with primary nongerminomatous germ cell tumors of the brain is dependent on tumor histology and the extent of surgical resection. Patients with tumors other than mature or immature teratomas appear to benefit from the administration of chemotherapy and radiotherapy.


Assuntos
Neoplasias Encefálicas/terapia , Neoplasias Embrionárias de Células Germinativas/terapia , Neoplasias Encefálicas/tratamento farmacológico , Neoplasias Encefálicas/patologia , Neoplasias Encefálicas/radioterapia , Seguimentos , Humanos , Metástase Neoplásica , Neoplasias Embrionárias de Células Germinativas/tratamento farmacológico , Neoplasias Embrionárias de Células Germinativas/patologia , Neoplasias Embrionárias de Células Germinativas/radioterapia , Dosagem Radioterapêutica , Estudos Retrospectivos , Taxa de Sobrevida , Resultado do Tratamento
5.
Mayo Clin Proc ; 65(5): 684-707, 1990 May.
Artigo em Inglês | MEDLINE | ID: mdl-2190050

RESUMO

Increased intracranial pressure can result in irreversible injury to the central nervous system. Among the many functions of the cerebrospinal fluid, it provides protection against acute changes in venous and arterial blood pressure or impact pressure. Nevertheless, trauma, tumors, infections, neurosurgical procedures, and other factors can cause increased intracranial pressure. Both surgical and nonsurgical therapeutic modalities can be used in the management of increased intracranial pressure attributable to traumatic and nontraumatic causes. In patients with cerebral injury and increased intracranial pressure, monitoring of the intracranial pressure can provide an objective measure of the response to therapy and the pressure dynamics. Intraventricular, intraparenchymal, subarachnoid, and epidural sites can be used for monitoring, and the advantages and disadvantages of the various devices available are discussed. With the proper understanding of the physiologic features of the cerebrospinal fluid, the physician can apply the management principles reviewed herein to minimize damage from intracranial hypertension.


Assuntos
Líquido Cefalorraquidiano/fisiologia , Pseudotumor Cerebral/terapia , Absorção , Barreira Hematoencefálica/fisiologia , Líquido Cefalorraquidiano/análise , Líquido Cefalorraquidiano/metabolismo , Terapia Combinada , Estudos de Avaliação como Assunto , Homeostase/fisiologia , Humanos , Monitorização Fisiológica , Postura , Pseudotumor Cerebral/complicações , Pseudotumor Cerebral/fisiopatologia , Pseudotumor Cerebral/prevenção & controle
6.
Mayo Clin Proc ; 71(5): 453-7, 1996 May.
Artigo em Inglês | MEDLINE | ID: mdl-8628024

RESUMO

OBJECTIVE: To describe the diagnosis, management, and outcome in 10 patients with histologically confirmed primary spinal epidural non-Hodgkin's lymphoma. MATERIAL AND METHODS: We review the findings in a cohort of seven men and three women in whom this tumor was diagnosed between January 1979 and January 1993 and discuss the prognostic differences between primary and secondary spinal lymphomas. RESULTS: All patients (median age at diagnosis, 70 years) underwent a decompressive laminectomy, subtotal tumor resection, and spinal irradiation (median dose, 3,800 cGy). Nine of 10 tumors were of B-cell origin. Six patients are alive and well. In four patients, recurrent disease developed from 15 to 62 months after the original diagnosis; of these, one has died. The median duration of survival of all patients was 42 months; of those living more than 24 months after diagnosis, the median duration of survival was 80 months. CONCLUSION: A rapidly progressive spinal cord or cauda equina syndrome with neuroimaging findings consistent with an extradural compressive lesion should alert caregivers to the possibility of spinal epidural lymphoma. Although the prognosis for patients with secondary spinal epidural non-Hodgkin's lymphoma is often poor, primary spinal epidural non-Hodgkin's lymphoma can be associated with a favorable outcome if diagnosed and treated early.


Assuntos
Linfoma não Hodgkin/diagnóstico , Linfoma não Hodgkin/terapia , Neoplasias da Coluna Vertebral/diagnóstico , Neoplasias da Coluna Vertebral/terapia , Adulto , Idoso , Idoso de 80 Anos ou mais , Terapia Combinada , Feminino , Seguimentos , Humanos , Laminectomia , Linfoma não Hodgkin/patologia , Masculino , Pessoa de Meia-Idade , Metástase Neoplásica , Prognóstico , Recidiva , Neoplasias da Coluna Vertebral/patologia , Resultado do Tratamento
7.
Mayo Clin Proc ; 70(1): 33-6, 1995 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-7808047

RESUMO

OBJECTIVE: To determine why some patients have no improvement after surgical treatment of lumbar spinal stenosis. DESIGN: We conducted a retrospective study of patients who were referred to our institution between 1990 and 1993 because their symptoms were unchanged or worsened after lumbar decompressive laminectomy. MATERIAL AND METHODS: For the 45 study patients (25 women and 20 men; mean age, 70.8 years), preoperative and postoperative clinical status, preoperative and postoperative imaging studies, and operative reports were analyzed. RESULTS: Preoperatively, only 23 patients (51%) had the clinical syndrome of neurogenic claudication, and 15 (33%) had midline low-back pain without a radicular component. Three other patients had peripheral neuropathy, and three had atypical leg pain. Only 10 patients had radiographic evidence of severe lumbar canal stenosis; the others had moderate, mild, or no stenosis. In 10 patients, surgical decompression was inadequate. Only three patients had the triad of neurogenic claudication, radiographically confirmed severe lumbar stenosis, and adequate decompression of the lumbar canal and lateral recesses. CONCLUSION: The most common pattern in patients with early failure after lumbar laminectomy was the absence of actual neurogenic claudication coupled with the absence of severe stenosis on preoperative imaging studies. The most common technical error was inadequate neural decompression. These data suggest that the outcome may be improved by more careful selection of patients and by performance of an adequate surgical decompression.


Assuntos
Laminectomia , Estenose Espinal/cirurgia , Idoso , Feminino , Humanos , Laminectomia/métodos , Masculino , Seleção de Pacientes , Complicações Pós-Operatórias , Estudos Retrospectivos , Falha de Tratamento
8.
Mayo Clin Proc ; 75(10): 1002-7, 2000 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-11040847

RESUMO

OBJECTIVE: To provide further validation of the treadmill test by assessing its "test-retest" reproducibility. PATIENTS AND METHODS: In this prospective study, 28 patients with severe lumbar spinal stenosis underwent exercise treadmill testing, first at a walking speed of 1.2 mph and then at the patient's preferred walking speed. All patients had a second treadmill examination or "retest." No treatment intervention was performed between the initial test and the retest. Time to first symptoms (TFS) and total ambulation time (TAT) were measured. Differences between the baseline examination and the retest examination were assessed by using the concordance correlation coefficient (CCC) as well as graphically. RESULTS: There was good reproducibility between baseline test and retest results for all 4 end points: 1.2 mph, TFS (CCC = 0.90); 1.2 mph, TAT (CCC = 0.89); preferred walking speed, TFS (CCC = 0.98); and preferred walking speed, TAT (CCC = 0.96). The median difference between trials was not significantly different from zero for any of the 4 outcomes. CONCLUSIONS: Exercise treadmill testing has good test-retest reproducibility. There was no learning phenomenon associated with the test procedure. The study further validates the clinical utility of exercise treadmill testing in patients with lumbar spinal stenosis and neurogenic claudication.


Assuntos
Teste de Esforço , Vértebras Lombares/fisiopatologia , Estenose Espinal/fisiopatologia , Idoso , Idoso de 80 Anos ou mais , Teste de Esforço/estatística & dados numéricos , Feminino , Humanos , Laminectomia , Aprendizagem , Perna (Membro)/inervação , Vértebras Lombares/cirurgia , Masculino , Pessoa de Meia-Idade , Dor/etiologia , Parestesia/etiologia , Doenças do Sistema Nervoso Periférico/complicações , Estudos Prospectivos , Estenose Espinal/cirurgia , Estatísticas não Paramétricas , Fatores de Tempo , Caminhada/fisiologia
9.
Am J Infect Control ; 30(4): 226-33, 2002 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-12032498

RESUMO

BACKGROUND: Nosocomial infections are a major problem in health care facilities, resulting in extended durations of care and substantial morbidity. Since alcohol gel hand sanitizers combine high immediate antimicrobial efficacy with ease of use, this study was carried out to determine the effect of the use of alcohol gel hand sanitizer by caregivers on infection types and rates in an extended care facility. METHOD: Infection rate and type data were collected in a 275-bed extended care facility for 34 months (July 1997 to May 2000), during which an alcohol gel hand sanitizer was used by the caregivers in 2 units of the facility. RESULTS: The primary infection types found were urinary tract with Foley catheter, respiratory tract, and wound infections. Comparison of the infection types and rates for the units where hand sanitizer was used with those for the control units where the hand sanitizer was not used showed a 30.4% decrease in infection rates for the 34-month period in the units where hand sanitizer was used. CONCLUSION: This study indicates that use of an alcohol gel hand sanitizer can decrease infection rates and provide an additional tool for an effective infection control program.


Assuntos
Anti-Infecciosos Locais/uso terapêutico , Infecção Hospitalar/prevenção & controle , Etanol/uso terapêutico , Desinfecção das Mãos/métodos , Infecção Hospitalar/epidemiologia , Feminino , Géis , Mãos/microbiologia , Humanos , Masculino , Casas de Saúde , Ohio/epidemiologia
10.
Brain Res ; 545(1-2): 339-42, 1991 Apr 05.
Artigo em Inglês | MEDLINE | ID: mdl-1860056

RESUMO

This experiment tested the hypothesis that corticotropin-releasing factor (CRF) contributes to hippocampal ischemic injury. The antagonist to CRF (alpha-CRF) was administered intraventricularly 15 min prior to 10 min of transient forebrain ischemia in the Wistar rat. alpha-CRF demonstrated a neuroprotective effect in a dose-dependent manner most notable in CA1. There was also an increase in postischemic EEG recovery. It is postulated that CRF contributes to hippocampal ischemic injury through increased neuronal activity.


Assuntos
Ventrículos Cerebrais/fisiologia , Hormônio Liberador da Corticotropina/antagonistas & inibidores , Hormônio Liberador da Corticotropina/farmacologia , Hipocampo/fisiopatologia , Ataque Isquêmico Transitório/fisiopatologia , Neurônios/fisiologia , Fragmentos de Peptídeos/farmacologia , Animais , Glicemia/metabolismo , Pressão Sanguínea/efeitos dos fármacos , Ventrículos Cerebrais/efeitos dos fármacos , Hormônio Liberador da Corticotropina/administração & dosagem , Hipocampo/efeitos dos fármacos , Hipocampo/patologia , Injeções Intraventriculares , Ataque Isquêmico Transitório/patologia , Masculino , Neurônios/efeitos dos fármacos , Neurônios/patologia , Fragmentos de Peptídeos/administração & dosagem , Tratos Piramidais/efeitos dos fármacos , Tratos Piramidais/patologia , Tratos Piramidais/fisiopatologia , Ratos , Ratos Endogâmicos
11.
Brain Res ; 558(2): 315-20, 1991 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-1723639

RESUMO

This experiment was designed to determine if intraventricular administration of basic fibroblast growth factor (bFGF) could promote cerebral angiogenesis in a model of mild chronic forebrain ischemia. Wistar rats underwent bilateral carotid artery ligation. Animals received intraventricular injections of bFGF every 4 days for 28 days. Basic fibroblast growth factor caused a significant dose-dependent increase in capillary density compared to ischemic controls in all regions examined. These results support the hypothesis that chronic intraventricular administration of bFGF induces in vivo cerebral angiogenesis.


Assuntos
Isquemia Encefálica/complicações , Fator 2 de Crescimento de Fibroblastos/farmacologia , Neovascularização Patológica/induzido quimicamente , Animais , Pressão Sanguínea/efeitos dos fármacos , Isquemia Encefálica/patologia , Capilares/efeitos dos fármacos , Dióxido de Carbono/sangue , Artérias Carótidas/fisiologia , Córtex Cerebral/patologia , Fator 2 de Crescimento de Fibroblastos/administração & dosagem , Concentração de Íons de Hidrogênio , Injeções Intraventriculares , Masculino , Neovascularização Patológica/complicações , Neovascularização Patológica/patologia , Oxigênio/sangue , Ratos , Ratos Endogâmicos
12.
J Neurol Sci ; 103(1): 16-21, 1991 May.
Artigo em Inglês | MEDLINE | ID: mdl-1865226

RESUMO

Cerebral angiotropic large cell lymphoma (neoplastic angioendotheliosis) is a rare disease with a particular propensity to affect the central nervous system by vascular occlusion. Because the disease is rare and there are no specific diagnostic procedures apart from cerebral biopsy, it is difficult to diagnose in life. Accordingly, chemotherapy or radiotherapy has only rarely been attempted and their effectiveness is uncertain. We established the diagnosis in a 62-year-old patient by cerebral biopsy and observed remission following institution of combination chemotherapy. Unfortunately, neurologic deterioration recurred during maintenance chemotherapy. We identified 30 patients in the literature who initially presented with definite central nervous system manifestations and whose clinical conditions were described sufficiently enough for comparison with our case. Eleven patients had the diagnosis made in life, but only 5 received chemotherapy other than corticosteroid hormones. Our patient's survival for 16 months exceeded that in the majority of the 30 reported cases. Intense anti-lymphoma chemotherapy, and possibly radiotherapy, may be beneficial and should be studied in this otherwise rapidly fatal disease. It seems certain that early diagnosis is essential if therapeutic intervention is to be successful.


Assuntos
Neoplasias Encefálicas/tratamento farmacológico , Hemangioendotelioma/tratamento farmacológico , Linfoma Difuso de Grandes Células B/tratamento farmacológico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Biópsia , Neoplasias Encefálicas/diagnóstico , Neoplasias Encefálicas/patologia , Hemangioendotelioma/diagnóstico , Hemangioendotelioma/patologia , Humanos , Imuno-Histoquímica , Linfoma Difuso de Grandes Células B/diagnóstico , Linfoma Difuso de Grandes Células B/patologia , Masculino , Pessoa de Meia-Idade
13.
Neurosurgery ; 28(5): 659-64; discussion 664-5, 1991 May.
Artigo em Inglês | MEDLINE | ID: mdl-1876243

RESUMO

Thirty patients with histologically confirmed posterior fossa ependymomas operated on between January 1976 and December 1988 were reviewed. The median age was 44 years (range, 1-69 yr). There were 7 children (aged 5 yr or younger) and 23 adults (aged 16 yr or older). There were 18 female patients and 12 male patients. Headache, nausea and vomiting, and disequilibrium were the most frequent symptoms. The most common findings were ataxia and nystagmus. Gross total resection was performed in 8 patients (27%), subtotal resection in 21 patients (70%), and biopsy in only 1 patient (3%). Tumors were low grade in 73% and high grade in 27%. Twenty-seven patients underwent posterior fossa radiotherapy (median dose, 5400 cGy). Fourteen patients also underwent spinal irradiation (median dose, 3520 cGy). Age was the only significant prognostic factor identified (P less than 0.01). The 5-year survival rates were 76% for adults and 14% for children. All 14 patients who died had recurrent or residual tumor at the primary site. This review suggests that in patients with primary posterior fossa ependymomas the following is true: 1) the young patient (5 yr old or younger) has a poor prognosis; 2) there was a trend toward a better 5-year survival rate with a gross total resection; 3) if recurrence occurs, it will be at the primary intracranial site; and 4) symptomatic spinal seeding does not occur frequently.


Assuntos
Fossa Craniana Posterior , Ependimoma/cirurgia , Neoplasias Cranianas/cirurgia , Adolescente , Adulto , Fatores Etários , Idoso , Neoplasias Encefálicas/tratamento farmacológico , Neoplasias Encefálicas/radioterapia , Neoplasias Encefálicas/cirurgia , Pré-Escolar , Terapia Combinada , Ependimoma/tratamento farmacológico , Ependimoma/radioterapia , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Prognóstico , Neoplasias Cranianas/tratamento farmacológico , Neoplasias Cranianas/radioterapia , Tomografia Computadorizada por Raios X
14.
Neurosurgery ; 30(5): 675-80, 1992 May.
Artigo em Inglês | MEDLINE | ID: mdl-1584377

RESUMO

Eight patients treated for histologically confirmed primary spinal epidural non-Hodgkin's lymphoma diagnosed between January 1979 and August 1989 (6.6% of all cases of intraspinal lymphoma) were studied. There were six men and two women. The median age was 70 years (range, 43-80 yr). Patients sought treatment for a prodrome of back pain (median duration, 3 mo) followed by an acute neurological deterioration (median duration, 6 d). The most common findings were a discrete sensory level in 5 patients, hyperreflexia in 5 patients, and paraparesis or paraplegia in 5 patients. Radiographically, there was an absence of bony destruction by these tumors. All patients underwent a decompressive laminectomy, subtotal tumor resection, and spinal irradiation (median dose, 3800 cGy). Two patients had low-grade lymphomas (one B cell and one T cell), and 6 patients had intermediate-grade lesions (six B cell). Two patients with B-cell lymphomas (one low-grade and one intermediate-grade) developed metastatic disease 15 and 17 months after the initial diagnosis; no evidence of lymphoma developed in the other 6 patients. The median survival was 22 months (range, 2-71 mo). Lymphoma was the cause of death in only 1 of the 4 patients who died, and the 4 younger patients are alive and well. Primary spinal epidural non-Hodgkin's lymphoma should be a diagnostic consideration in the older patient who seeks treatment for spinal cord compression manifested by a prodrome of back pain, followed by a rapid neurological deterioration, normal plain spine radiographs, and neuroimaging consistent with an extradural compressive lesion. Surgery for this diagnosis followed by spinal irradiation should result in significant neurological improvement.


Assuntos
Neoplasias Epidurais/mortalidade , Linfoma não Hodgkin/mortalidade , Neoplasias da Coluna Vertebral/mortalidade , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias Epidurais/cirurgia , Feminino , Seguimentos , Humanos , Linfoma não Hodgkin/cirurgia , Masculino , Pessoa de Meia-Idade , Compressão da Medula Espinal/etiologia , Neoplasias da Coluna Vertebral/cirurgia , Taxa de Sobrevida
15.
J Neurosurg ; 93(1 Suppl): 53-7, 2000 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-10879758

RESUMO

OBJECT: The authors report a retrospective analysis of 194 patients surgically treated at their institutions for symptomatic lumbar synovial cysts from January 1974 to January 1996. METHODS: Patient characteristics including age, sex, symptoms, signs, and preoperative neuroimaging studies were reviewed. Surgical procedures, complications, results, and pathological findings were correlated with preoperative assessment. One hundred ninety-four patients were surgically treated for symptomatic lumbar synovial cysts. Eighty percent were diagnosed and treated between 1987 and 1996. There were 100 men and 94 women with an average age of 66 years (range 28-94 years). The most common symptoms were painful radiculopathy (85%) and neurogenic single or multiroot claudication (44%). However, sensory loss (43%) and motor weakness (27%) were also presenting symptoms. Eleven percent of patients had undergone previous lumbar surgery prior to being referred to the Mayo Clinic. Preoperative neurological examination demonstrated motor weakness (40%), sensory loss (45%), reflex changes (57%), and variants of cauda equina syndrome (13%). In 19% of patients, normal neurological status was demonstrated. There was equal left/right-sided laterality, and eight patients presented with bilateral synovial cysts. The most commonly affected level was L4-5 (64%). All patients underwent laminectomy and resection of the cyst. Concomitant fusion was performed in 18 patients in whom clinical evidence of instability had been observed. However, subsequent fusion was required in only four patients who developed symptomatic spondylolisthesis. Surgery-related complications included cerebrospinal fluid leak (three patients), discitis (one patient), epidural hematoma (one patient), seroma (one patient), and deep vein thrombosis (one patient). One patient died 3 days after surgery of cardiac dysrhythmia. Follow-up data obtained for at least 6 months postoperatively were available in 147 patients. Of these, 134 (91%) reported good relief of their pain and 82% experienced improvement in their motor deficits. CONCLUSIONS: Lumbar synovial cysts are a more common cause of lumbar radicular pain than previously thought. Surgical removal of the cyst is a safe and effective treatment for symptomatic relief in patients with lumbar synovial cysts. A concomitant fusion procedure may be performed in select cases. In this study, only a few patients developed symptomatic spinal instability requiring a second operation.


Assuntos
Vértebras Lombares/cirurgia , Doenças da Coluna Vertebral/cirurgia , Cisto Sinovial/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Líquido Cefalorraquidiano , Feminino , Seguimentos , Humanos , Instabilidade Articular/cirurgia , Laminectomia/efeitos adversos , Masculino , Pessoa de Meia-Idade , Debilidade Muscular/etiologia , Síndromes de Compressão Nervosa/etiologia , Polirradiculopatia/etiologia , Complicações Pós-Operatórias/cirurgia , Radiculopatia/etiologia , Reflexo Anormal/fisiologia , Estudos Retrospectivos , Transtornos de Sensação/etiologia , Doenças da Coluna Vertebral/complicações , Fusão Vertebral , Raízes Nervosas Espinhais/patologia , Espondilolistese/etiologia , Espondilolistese/cirurgia , Taxa de Sobrevida , Cisto Sinovial/complicações , Resultado do Tratamento
16.
J Neurosurg ; 83(1): 27-30, 1995 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-7782845

RESUMO

A prospective study of patients with neurogenic claudication and lumbar spinal stenosis was undertaken to determine whether measurement of exercise tolerance on the treadmill would be useful in defining baseline functional status and response to surgical treatment. Twenty patients with an average age of 73 years, all of whom had intractable neurogenic claudication and radiographically confirmed severe lumbar spinal stenosis, were studied. Lumbar decompressive laminectomy was performed in all patients. Preoperatively and 2 months postoperatively, quantitative assessment of ambulation was conducted on a treadmill at 0 degree ramp incline at two different speeds: 1.2 mph and the patient's preferred walking speed. The following information was recorded: time to first symptoms, time to severe symptoms, and nature of symptoms (leg pain, back pain, or generalized fatigue). The examination was stopped after 15 minutes or at the onset of severe symptoms. In the preoperative 1.2-mph trial, the mean time to first symptoms was 2.68 minutes (median 1.31) and the mean time to severe symptoms was 5.47 minutes (median 3.42). In the postoperative trial at the same speed, 13 patients (65%) were able to walk symptom free for 15 minutes. The mean time to first symptoms was 11.12 minutes (median 15) and the mean time to severe symptoms was 11.81 minutes (median 15). Similar findings were recorded in the preferred walking-speed trials. There were no complications from the treadmill testing procedure. These findings indicate that exercise stress testing on a treadmill is a safe, easily administered, and quantifiable means of assessing baseline functional status and outcome following laminectomy in patients with symptomatic lumbar spinal stenosis.


Assuntos
Tolerância ao Exercício/fisiologia , Laminectomia/reabilitação , Estenose Espinal/fisiopatologia , Estenose Espinal/cirurgia , Idoso , Idoso de 80 Anos ou mais , Teste de Esforço , Feminino , Humanos , Vértebras Lombares/diagnóstico por imagem , Vértebras Lombares/cirurgia , Masculino , Pessoa de Meia-Idade , Período Pós-Operatório , Prognóstico , Estudos Prospectivos , Radiografia , Estenose Espinal/reabilitação , Resultado do Tratamento
17.
Spine (Phila Pa 1976) ; 23(2): 244-8, 1998 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-9474733

RESUMO

STUDY DESIGN: A prospective study of exercise tolerance on the treadmill before and after decompressive laminectomy in patients with severe lumbar spinal stenosis. OBJECTIVES: To determine whether treadmill testing provides useful information about baseline functional status and surgical outcome. SUMMARY OF BACKGROUND DATA: Historically, criteria for selecting patients for surgery and assessing postoperative outcome have been variable. Functional testing has not been used in a systematic fashion. METHODS: Fifty patients with severe lumbar spinal stenosis underwent decompressive laminectomy. Preoperatively and 3 months postoperatively, functional capacity was assessed on an exercise treadmill. Time to first symptoms and total ambulation time were recorded. The examination was stopped at the onset of severe symptoms or after 15 minutes. RESULTS: In the preoperative trial, mean time to first symptoms (+/- standard deviation) was 1.82 minutes (median, 0.58), and mean total ambulation time was 6.91 minutes (median, 5.22). In the postoperative trial, mean time to first symptoms increased to 11.93 minutes (median, 15) and mean total ambulation time increased to 13.26 minutes (median, 15). There was significant improvement after surgery in both time to first symptoms (P < 0.001) and total ambulation time (P < 0.001). CONCLUSION: Exercise stress testing on a treadmill is a safe, easily administered, and quantifiable means of assessing baseline functional status and surgical outcome in patients with neurogenic claudication due to lumbar spinal stenosis. Treadmill testing provides objective evidence that surgery is beneficial in most cases and is helpful in guiding subsequent management of patients with residual symptoms.


Assuntos
Teste de Esforço/métodos , Estenose Espinal/cirurgia , Idoso , Teste de Esforço/instrumentação , Feminino , Humanos , Região Lombossacral , Masculino , Período Pós-Operatório , Fatores de Tempo , Resultado do Tratamento , Caminhada
18.
Surg Neurol ; 43(6): 542-5, 1995 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-7482231

RESUMO

BACKGROUND Video-assisted thoracoscopy (VAT) is being increasingly utilized by thoracic surgeons as an alternative to thoracotomy for several thoracic disorders. Neuroendoscopy is an exciting addition to the neurosurgical armamentarium. These procedures are attractive alternatives in the era of minimally invasive surgery and cost containment, while providing the highest quality medical care to patients. METHODS We report the application of this technology in a patient presenting with intractable thoracic radicular pain secondary to an intercostal neurofibroma. Complete excision of the intercostal neurofibroma was performed utilizing VAT. RESULTS The patient reported good relief of her preoperative thoracic radicular pain. She was ready for discharge from the hospital within 72 hours of surgery. CONCLUSIONS With the advent of improved instrumentation, video-assisted thoracoscopy offers a safe alternative to thoracotomy and the potential benefits of less postoperative discomfort and shorter hospital stays. The potential neurosurgical applications of VAT should not be overlooked.


Assuntos
Nervos Intercostais/cirurgia , Neurofibroma/cirurgia , Neoplasias do Sistema Nervoso Periférico/cirurgia , Toracoscopia/métodos , Gravação em Vídeo , Adulto , Feminino , Humanos , Toracoscópios
19.
Surg Neurol ; 44(5): 476-8, 1995 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-8629233

RESUMO

BACKGROUND: In patients with unstable cervical spine injuries initially managed with in-line traction, there is some risk of loss of cervical alignment and of new neurologic deficit when the halo vest is applied. This report outlines a simple technique which facilitates halo application in these patients. METHODS: The back of the halo vest is "prepositioned" before traction is instituted. Once alignment is optimized, halo vest application is easily completed without lifting the patient or discontinuing cervical traction. RESULTS: The authors have used this technique in four patients without complication. CONCLUSIONS: In patients with unstable cervical spine injuries who require an initial period of in-line traction, halo vest application is made easier and safer by "prepositioning" the back of the vest.


Assuntos
Vértebras Cervicais , Traumatismos da Coluna Vertebral/terapia , Tração/instrumentação , Humanos , Tração/métodos
20.
Surg Neurol ; 42(1): 8-13, 1994 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-7524172

RESUMO

A 47-year-old woman with a convexity meningioma presenting as a chronic subdural hematoma is reported. This case is unique in that the symptoms were cyclical and stereotypic. The tumor contained an unusually high number of mast cells. A possible etiologic role of histamine-related vasodilation and tumoral hemorrhage is explored. The relationship between meningioma and subdural hematoma is discussed, and the literature is reviewed.


Assuntos
Neoplasias Encefálicas/diagnóstico , Hematoma Subdural/diagnóstico , Mastócitos/patologia , Meningioma/diagnóstico , Encéfalo/patologia , Neoplasias Encefálicas/patologia , Hemorragia Cerebral/complicações , Doença Crônica , Diagnóstico Diferencial , Potenciais Somatossensoriais Evocados , Feminino , Hematoma Subdural/etiologia , Hematoma Subdural/patologia , Liberação de Histamina , Humanos , Imageamento por Ressonância Magnética , Meningioma/complicações , Meningioma/patologia , Pessoa de Meia-Idade , Fotomicrografia , Vasodilatação
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