Detalhe da pesquisa
1.
Use of selective substrates and inhibitors to rapidly characterise batches of cryopreserved primary human hepatocytes for assessment of active uptake liability in drug discovery and development.
Xenobiotica
; 52(8): 868-877, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-36121307
2.
A mechanistic modelling approach for the determination of the mechanisms of inhibition by cyclosporine on the uptake and metabolism of atorvastatin in rat hepatocytes using a high throughput uptake method.
Xenobiotica
; 50(4): 415-426, 2020 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-31389297
3.
Comprehensive Evaluation of the Utility of 20 Endogenous Molecules as Biomarkers of OATP1B Inhibition Compared with Rosuvastatin and Coproporphyrin I.
J Pharmacol Exp Ther
; 368(1): 125-135, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30314992
4.
TRYBE®: an Fc-free antibody format with three monovalent targeting arms engineered for long in vivo half-life.
MAbs
; 15(1): 2160229, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36788124
5.
Serum albumin binding knob domains engineered within a VH framework III bispecific antibody format and as chimeric peptides.
Front Immunol
; 14: 1170357, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37251411
6.
PK/PD and Bioanalytical Considerations of AAV-Based Gene Therapies: an IQ Consortium Industry Position Paper.
AAPS J
; 25(5): 78, 2023 07 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37523051
7.
Simultaneous assessment of uptake and metabolism in rat hepatocytes: a comprehensive mechanistic model.
J Pharmacol Exp Ther
; 341(1): 2-15, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22190645
8.
Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes.
Drug Metab Dispos
; 40(9): 1744-56, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22665271
9.
Non-human primates in the PKPD evaluation of biologics: Needs and options to reduce, refine, and replace. A BioSafe White Paper.
MAbs
; 14(1): 2145997, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36418217
10.
Prediction of human renal clearance from preclinical species for a diverse set of drugs that exhibit both active secretion and net reabsorption.
Drug Metab Dispos
; 39(6): 1008-13, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21357702
11.
Designing Out PXR Activity on Drug Discovery Projects: A Review of Structure-Based Methods, Empirical and Computational Approaches.
J Med Chem
; 64(10): 6413-6522, 2021 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34003642
12.
PBPK Model of Coproporphyrin I: Evaluation of the Impact of SLCO1B1 Genotype, Ethnicity, and Sex on its Inter-Individual Variability.
CPT Pharmacometrics Syst Pharmacol
; 10(2): 137-147, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33289952
13.
Gaining Mechanistic Insight Into Coproporphyrin I as Endogenous Biomarker for OATP1B-Mediated Drug-Drug Interactions Using Population Pharmacokinetic Modeling and Simulation.
Clin Pharmacol Ther
; 104(3): 564-574, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29243231
14.
A rapid computational filter for predicting the rate of human renal clearance.
J Mol Graph Model
; 29(4): 529-37, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21075652