Routine Venous Thromboembolism Prophylaxis May Be Inadequate in the Hypercoagulable State of Severe Coronavirus Disease 2019.

OBJECTIVES: The aim of this study was to determine the frequency of venous thromboembolism in critically ill coronavirus disease 2019 patients and associate a degree of inflammatory marker elevation to venous thromboembolism development. DESIGN: An observational study that identified patients with severe coronavirus disease 2019 between March 12, 2020, and March 31, 2020. Data reported are those available through May 6, 2020. SETTING: A multicenter study including three Indianapolis area academic hospitals. PATIENTS: Two-hundred forty consecutive patients with confirmed severe acute respiratory syndrome coronavirus 2 infection were admitted to one of three hospitals. One-hundred nine critically ill coronavirus disease 2019 patients admitted to the ICU were included in the analysis. INTERVENTIONS: All patients received routine subcutaneous chemical venous thromboembolism prophylaxis. MEASUREMENTS AND MAIN RESULTS: The primary outcome of this study was to determine the frequency of venous thromboembolism and the degree of inflammatory and coagulation marker elevation associated with venous thromboembolism development. Descriptive statistics outlined the frequency of venous thromboembolism at any time during severe coronavirus disease 2019. Clinical course and laboratory metrics were compared between patients that developed venous thromboembolism and patients that did not develop venous thromboembolism. Hypercoagulable thromboelastography was defined as two or more hypercoagulable parameters. MAIN RESULTS: One-hundred nine patients developed severe coronavirus disease 2019 requiring ICU care. The mean (± SD) age was 61 ± 16 years and 57% were male. Seventy-five patients (69%) were discharged home, 7 patients (6%) remain in the hospital, and 27 patients (25%) died. Venous thromboembolism was diagnosed in 31 patients (28%) 8 ± 7 days after hospital admission, including two patients diagnosed with venous thromboembolism at presentation to the hospital. Elevated admission D-dimer and peak D-dimer were associated with venous thromboembolism development (p < 0.05). D-dimer greater than 2,600 ng/mL predicted venous thromboembolism with an area under the receiver operating characteristic curve of 0.760 (95% CI, 0.661-0.858; p < 0.0001), sensitivity of 89.7%, and specificity of 59.5%. Twelve patients (11%) had thromboelastography performed and 58% of these patients had a hypercoagulable study. The calculated coagulation index was hypercoagulable in 50% of patients with thromboelastography. CONCLUSIONS: These data show that coronavirus disease 2019 results in a hypercoagulable state. Routine chemical venous thromboembolism prophylaxis may be inadequate in preventing venous thromboembolism in severe coronavirus disease 2019.

Fibrin Clot Strength in Patients with Diabetes Mellitus Measured by Thrombelastography.

BACKGROUND: Patients with diabetes mellitus (DM) exhibit increased risk of recurrent myocardial infarction. Maximal clot strength measured by thrombelastography (TEG) is a risk factor for recurrent ischemic events. We hypothesized that diabetic subjects exhibit increased fibrin clot strength in platelet-poor plasma and that glycemic control correlates with maximal fibrin clot strength. METHODS: We collected plasma samples from subjects with known or suspected coronary artery disease undergoing cardiac catheterization (n = 354). We measured kaolin-activated TEG in platelet-poor citrate plasma. Time to fibrin formation (R), clot formation time (K), and maximal fibrin clot strength (MA) were recorded. RESULTS: Plasma fibrin MA was increased among subjects with DM (n = 152) as compared to non-DM (n = 202) (37.0 ± 8 versus 34.1 ± 8 mm; p < 0.001). Hemoglobin A1c (HbA1c) (ρ = 0.22; p = 0.001) and fibrinogen (ρ = 0.29; p < 0.001) correlated with fibrin MA. In multivariable regression analysis, DM remained significantly associated with plasma MA after adjustment for fibrinogen level (p = 0.003). CONCLUSIONS: Subjects with diabetes mellitus exhibit increased maximal fibrin clot strength measured by TEG in platelet-poor plasma.

Determination of sagittal alignment measurements in distal femurs.

OBJECTIVE: Open reduction and internal fixation is presently the treatment of choice for distal femur fractures. Anatomic reconstruction of the articular surface and restoration of biomechanical relations to the diaphysis are desired. A method to determine sagittal alignment on plain radiographs is warranted. METHODS: Consecutive adult, normal, distal femur/knee, plain lateral radiographs and scanned and digitalized cadaveric distal femurs were analyzed. Measurement of 7 different angles was performed. RESULTS: Ninety-four adults [39 men (41.5%) and 55 women (58.5%)] with a mean age of 54 years (range, 18-92 years) and body mass index (BMI) of 29.7 kg/m(2) (range, 16.6-47.2 kg/m(2)), as well and 35 cadaveric femora [24 men (68.6%) and 11 women (31.4%)] with a mean age of 53 years (25-85 years) and BMI of 29.8 kg/m(2) (17.7-53.3 kg/m(2)) were studied. Twenty-two of the patients (23.4%) had radiographic findings of arthrosis. If arthrosis was diagnosed, measurements including the proximal rim of the articular surface were significantly greater (P = 0.001). Two angles were significantly smaller in women (P < 0.05). No significant differences in any measurement for age or BMI were recorded. CONCLUSIONS: The necessity for reliability and quality of intraoperative and postoperative radiographic controls of the obtained fracture reduction, implant insertion, and final healed fracture increases with popularity of less invasive indirect reduction and stabilization methods. The ability to obtain exact sagittal alignment measurements has been problematic with other studies. Two different and reliable methods of measuring sagittal plane anatomy and measurements independent of implants were confirmed using plain radiographic images.