Detalhe da pesquisa
1.
In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions.
Xenobiotica
; 49(8): 961-969, 2019 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-30124356
2.
Pharmacokinetics of the Multi-kinase Inhibitor Pexidartinib: Mass Balance and Dose Proportionality.
Clin Pharmacol Drug Dev
; 12(2): 159-167, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36369799
3.
Species differences between rats and primates (humans and monkeys) in complex cleavage pathways of DS-8500a characterized by 14C-ADME studies in humans and monkeys after administration of two radiolabeled compounds and in vitro studies.
Drug Metab Pharmacokinet
; 45: 100459, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-35716472
4.
Covalent binding and tissue distribution/retention assessment of drugs associated with idiosyncratic drug toxicity.
Drug Metab Dispos
; 36(9): 1770-9, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18508880
5.
In vitro evaluation of the potential for drug-induced toxicity based on (35)S-labeled glutathione adduct formation and daily dose.
Bioanalysis
; 4(3): 263-9, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22303830
6.
Quantitative assessment of reactive metabolite formation using 35S-labeled glutathione.
Drug Metab Pharmacokinet
; 24(1): 100-7, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19252339
7.
Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediate: correlation of in vitro and in vivo generation of reactive intermediates and in vitro glutathione conjugate formation in rats and humans.
Chem Res Toxicol
; 20(3): 455-64, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17309281