RESUMO
30 patients comprised of 3 equal groups which were given 3 types of treatment. Group I given metformin HCl (1+1), maintained a sugar level of 129-340 mg/100 ml. Group II given glibenclamide(1+1), maintained a sugar level of 120-325 mg/100 ml. Group III given a combination of both drugs, maintained a sugar level 112 mg - 46 mg/100 ml. The most suitable of the 3 was the last treatment. Serum electrolytes were measured in all the three groups. Patients taking metformin HCl and glibenclamide showed non significant low sodium with high potassium values respectively. When used in combination, they maintained normal values. On the other hand, serum calcium levels were significantly high in patients taking metformin HCl only; when compared with glibenclamide. However, when both drugs were given to patients, serum calcium remained at normal levels.
Assuntos
Diabetes Mellitus Tipo 2/tratamento farmacológico , Eletrólitos/sangue , Hipoglicemiantes/uso terapêutico , Administração Oral , Glicemia/efeitos dos fármacos , Cálcio/sangue , Diabetes Mellitus Tipo 2/sangue , Quimioterapia Combinada , Glibureto/uso terapêutico , Humanos , Hipoglicemiantes/administração & dosagem , Metformina/uso terapêutico , Potássio/sangue , Sódio/sangue , Resultado do TratamentoRESUMO
This study deals with the effect of 7.1 mg/day, 10.5 mg/day and 14 mg/day doses of mefenamic acid administered for 12 days to three groups of Uromastix hardwickii respectively. Individual blood samples were obtained from the anterior abdominal vein and hemoglobin content was determined. The hemoglobin in test was 5.1 g/100 ml compared to 8.0 g/100 ml of controls in experiment I and its amount remained almost similar in the case of experiment II, whereas, 4.5 g/100 ml was observed of test compared to 8.0 g/100 ml of their counterparts.