Pesquisa | BVS Violência e Saúde

1.

The tumor microenvironment drives NK cell metabolic dysfunction leading to impaired antitumor activity.

Tumino, Nicola; Nava Lauson, Carina B; Tiberti, Silvia; Besi, Francesca; Martini, Stefania; Fiore, Piera Filomena; Scodamaglia, Francesca; Mingari, Maria Cristina; Moretta, Lorenzo; Manzo, Teresa; Vacca, Paola.

Int J Cancer ; 152(8): 1698-1706, 2023 04 15.

Artigo em Inglês | MEDLINE | ID: mdl-36468179

2.

Multimodal single-cell profiling of intrahepatic cholangiocarcinoma defines hyperactivated Tregs as a potential therapeutic target.

Alvisi, Giorgia; Termanini, Alberto; Soldani, Cristiana; Portale, Federica; Carriero, Roberta; Pilipow, Karolina; Costa, Guido; Polidoro, Michela; Franceschini, Barbara; Malenica, Ines; Puccio, Simone; Lise, Veronica; Galletti, Giovanni; Zanon, Veronica; Colombo, Federico Simone; De Simone, Gabriele; Tufano, Michele; Aghemo, Alessio; Di Tommaso, Luca; Peano, Clelia; Cibella, Javier; Iannacone, Matteo; Roychoudhuri, Rahul; Manzo, Teresa; Donadon, Matteo; Torzilli, Guido; Kunderfranco, Paolo; Di Mitri, Diletta; Lugli, Enrico; Lleo, Ana.

J Hepatol ; 77(5): 1359-1372, 2022 11.

Artigo em Inglês | MEDLINE | ID: mdl-35738508

3.

The transcription factor NFAT exhibits signal memory during serial T cell interactions with antigen-presenting cells.

Marangoni, Francesco; Murooka, Thomas T; Manzo, Teresa; Kim, Edward Y; Carrizosa, Esteban; Elpek, Natalie M; Mempel, Thorsten R.

Immunity ; 38(2): 237-49, 2013 Feb 21.

Artigo em Inglês | MEDLINE | ID: mdl-23313588

4.

Antigen-specific T cell therapies for cancer.

Manzo, Teresa; Heslop, Helen E; Rooney, Cliona M.

Hum Mol Genet ; 24(R1): R67-73, 2015 Oct 15.

Artigo em Inglês | MEDLINE | ID: mdl-26160910

5.

Depletion of CD11câº cells in the CD11c.DTR model drives expansion of unique CD64âº Ly6Câº monocytes that are poised to release TNF-α.

Sivakumaran, Shivajanani; Henderson, Stephen; Ward, Sophie; Sousa, Pedro Santos E; Manzo, Teresa; Zhang, Lei; Conlan, Thomas; Means, Terry K; D'Aveni, Maud; Hermine, Olivier; Rubio, Marie-Thérèse; Chakraverty, Ronjon; Bennett, Clare L.

Eur J Immunol ; 46(1): 192-203, 2016 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-26464217

6.

OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence.

Buchan, Sarah; Manzo, Teresa; Flutter, Barry; Rogel, Anne; Edwards, Noha; Zhang, Lei; Sivakumaran, Shivajanani; Ghorashian, Sara; Carpenter, Ben; Bennett, Clare; Freeman, Gordon J; Sykes, Megan; Croft, Michael; Al-Shamkhani, Aymen; Chakraverty, Ronjon.

J Immunol ; 194(1): 125-133, 2015 Jan 01.

Artigo em Inglês | MEDLINE | ID: mdl-25404365

7.

PI3K/AKT signaling inhibits NOTCH1 lysosome-mediated degradation.

Platonova, Natalia; Manzo, Teresa; Mirandola, Leonardo; Colombo, Michela; Calzavara, Elisabetta; Vigolo, Emilia; Cermisoni, Greta Chiara; De Simone, Daria; Garavelli, Silvia; Cecchinato, Valentina; Lazzari, Elisa; Neri, Antonino; Chiaramonte, Raffaella.

Genes Chromosomes Cancer ; 54(8): 516-526, 2015 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-26052821

8.

Concurrent allorecognition has a limited impact on posttransplant vaccination.

Manzo, Teresa; Hess Michelini, Rodrigo; Basso, Veronica; Ricupito, Alessia; Chai, Jian-Guo; Simpson, Elizabeth; Bellone, Matteo; Mondino, Anna.

J Immunol ; 186(3): 1361-8, 2011 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-21209285

9.

Fumarate disarms CD8⁺ T cells against cancer.

Nezi, Luigi; Manzo, Teresa.

Cell Metab ; 35(6): 907-909, 2023 06 06.

Artigo em Inglês | MEDLINE | ID: mdl-37285805

10.

Location and condition based reconstruction of colon cancer microbiome from human RNA sequencing data.

Sambruni, Gaia; Macandog, Angeli D; Wirbel, Jakob; Cagnina, Danilo; Catozzi, Carlotta; Dallavilla, Tiziano; Borgo, Francesca; Fazio, Nicola; Fumagalli-Romario, Uberto; Petz, Wanda L; Manzo, Teresa; Ravenda, Simona P; Zeller, Georg; Nezi, Luigi; Schaefer, Martin H.

Genome Med ; 15(1): 32, 2023 05 02.

Artigo em Inglês | MEDLINE | ID: mdl-37131219

11.

Linoleic acid potentiates CD8⁺ T cell metabolic fitness and antitumor immunity.

Nava Lauson, Carina B; Tiberti, Silvia; Corsetto, Paola A; Conte, Federica; Tyagi, Punit; Machwirth, Markus; Ebert, Stefan; Loffreda, Alessia; Scheller, Lukas; Sheta, Dalia; Mokhtari, Zeinab; Peters, Timo; Raman, Ayush T; Greco, Francesco; Rizzo, Angela M; Beilhack, Andreas; Signore, Giovanni; Tumino, Nicola; Vacca, Paola; McDonnell, Liam A; Raimondi, Andrea; Greenberg, Philip D; Huppa, Johannes B; Cardaci, Simone; Caruana, Ignazio; Rodighiero, Simona; Nezi, Luigi; Manzo, Teresa.

Cell Metab ; 35(4): 633-650.e9, 2023 04 04.

Artigo em Inglês | MEDLINE | ID: mdl-36898381

12.

GZMK^high CD8⁺ T effector memory cells are associated with CD15^high neutrophil abundance in non-metastatic colorectal tumors and predict poor clinical outcome.

Tiberti, Silvia; Catozzi, Carlotta; Croci, Ottavio; Ballerini, Mattia; Cagnina, Danilo; Soriani, Chiara; Scirgolea, Caterina; Gong, Zheng; He, Jiatai; Macandog, Angeli D; Nabinejad, Amir; Nava Lauson, Carina B; Quinte', Arianna; Bertalot, Giovanni; Petz, Wanda L; Ravenda, Simona P; Licursi, Valerio; Paci, Paola; Rasponi, Marco; Rotta, Luca; Fazio, Nicola; Ren, Guangwen; Fumagalli-Romario, Uberto; Schaefer, Martin H; Campaner, Stefano; Lugli, Enrico; Nezi, Luigi; Manzo, Teresa.

Nat Commun ; 13(1): 6752, 2022 11 08.

Artigo em Inglês | MEDLINE | ID: mdl-36347862

13.

Short-term treatment with multi-drug regimens combining BRAF/MEK-targeted therapy and immunotherapy results in durable responses in Braf-mutated melanoma.

White, Michael G; Szczepaniak Sloane, Robert; Witt, Russell G; Reuben, Alexandre; Gaudreau, Pierre Olivier; Andrews, Miles C; Feng, Ningping; Johnson, Sarah; Class, Caleb A; Bristow, Christopher; Wani, Khalida; Hudgens, Courtney; Nezi, Luigi; Manzo, Teresa; De Macedo, Mariana Pettaccia; Hu, Jianhua; Davis, Richard; Jiang, Hong; Prieto, Peter; Burton, Elizabeth; Hwu, Patrick; Tawbi, Hussein; Gershenwald, Jeffrey; Lazar, Alexander J; Tetzlaff, Michael T; Overwijk, Willem; Woodman, Scott E; Cooper, Zachary A; Marszalek, Joseph R; Davies, Michael A; Heffernan, Timothy P; Wargo, Jennifer A.

Oncoimmunology ; 10(1): 1992880, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-34777916

14.

To Remember or to Forget: The Role of Good and Bad Memories in Adoptive T Cell Therapy for Tumors.

Mondino, Anna; Manzo, Teresa.

Front Immunol ; 11: 1915, 2020.

Artigo em Inglês | MEDLINE | ID: mdl-32973794

15.

Graft-versus-host disease reduces lymph node display of tissue-restricted self-antigens and promotes autoimmunity.

Dertschnig, Simone; Evans, Pamela; Santos E Sousa, Pedro; Manzo, Teresa; Ferrer, Ivana R; Stauss, Hans J; Bennett, Clare L; Chakraverty, Ronjon.

J Clin Invest ; 130(4): 1896-1911, 2020 04 01.

Artigo em Inglês | MEDLINE | ID: mdl-31917684

16.

A cell-of-origin epigenetic tracer reveals clinically distinct subtypes of high-grade serous ovarian cancer.

Lo Riso, Pietro; Villa, Carlo Emanuele; Gasparoni, Gilles; Vingiani, Andrea; Luongo, Raffaele; Manfredi, Anna; Jungmann, Annemarie; Bertolotti, Alessia; Borgo, Francesca; Garbi, Annalisa; Lupia, Michela; Laise, Pasquale; Das, Vivek; Pruneri, Giancarlo; Viale, Giuseppe; Colombo, Nicoletta; Manzo, Teresa; Nezi, Luigi; Cavallaro, Ugo; Cacchiarelli, Davide; Walter, Jörn; Testa, Giuseppe.

Genome Med ; 12(1): 94, 2020 10 30.

Artigo em Inglês | MEDLINE | ID: mdl-33121525

17.

Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells.

Manzo, Teresa; Prentice, Boone M; Anderson, Kristin G; Raman, Ayush; Schalck, Aislyn; Codreanu, Gabriela S; Nava Lauson, Carina B; Tiberti, Silvia; Raimondi, Andrea; Jones, Marissa A; Reyzer, Michelle; Bates, Breanna M; Spraggins, Jeffrey M; Patterson, Nathan H; McLean, John A; Rai, Kunal; Tacchetti, Carlo; Tucci, Sara; Wargo, Jennifer A; Rodighiero, Simona; Clise-Dwyer, Karen; Sherrod, Stacy D; Kim, Michael; Navin, Nicholas E; Caprioli, Richard M; Greenberg, Philip D; Draetta, Giulio; Nezi, Luigi.

J Exp Med ; 217(8)2020 08 03.

Artigo em Inglês | MEDLINE | ID: mdl-32491160

18.

T Cells Redirected to a Minor Histocompatibility Antigen Instruct Intratumoral TNFα Expression and Empower Adoptive Cell Therapy for Solid Tumors.

Manzo, Teresa; Sturmheit, Tabea; Basso, Veronica; Petrozziello, Elisabetta; Hess Michelini, Rodrigo; Riba, Michela; Freschi, Massimo; Elia, Angela R; Grioni, Matteo; Curnis, Flavio; Protti, Maria Pia; Schumacher, Ton N; Debets, Reno; Swartz, Melody A; Corti, Angelo; Bellone, Matteo; Mondino, Anna.

Cancer Res ; 77(3): 658-671, 2017 02 01.

Artigo em Inglês | MEDLINE | ID: mdl-27872095

19.

Author Correction: GZMK^high CD8⁺ T effector memory cells are associated with CD15^high neutrophil abundance in non-metastatic colorectal tumors and predict poor clinical outcome.

Tiberti, Silvia; Catozzi, Carlotta; Croci, Ottavio; Ballerini, Mattia; Cagnina, Danilo; Soriani, Chiara; Scirgolea, Caterina; Gong, Zheng; He, Jiatai; Macandog, Angeli D; Nabinejad, Amir; Nava Lauson, Carina B; Quinte', Arianna; Bertalot, Giovanni; Petz, Wanda L; Ravenda, Simona P; Licursi, Valerio; Paci, Paola; Rasponi, Marco; Rotta, Luca; Fazio, Nicola; Ren, Guangwen; Fumagalli-Romario, Uberto; Schaefer, Martin H; Campaner, Stefano; Lugli, Enrico; Nezi, Luigi; Manzo, Teresa.

Nat Commun ; 13(1): 7380, 2022 Nov 30.

Artigo em Inglês | MEDLINE | ID: mdl-36450724

20.

3D modeling of human cancer: A PEG-fibrin hydrogel system to study the role of tumor microenvironment and recapitulate the in vivo effect of oncolytic adenovirus.

Del Bufalo, Francesca; Manzo, Teresa; Hoyos, Valentina; Yagyu, Shigeki; Caruana, Ignazio; Jacot, Jeffrey; Benavides, Omar; Rosen, Daniel; Brenner, Malcolm K.

Biomaterials ; 84: 76-85, 2016 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-26826297

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