Cardio-embolic stroke: Lessons from a single centre in Sub-Saharan Africa.

BACKGROUND: Limited information is available about cardio-embolic stroke (CES) in sub-Saharan Africa. The aim of this study was to describe the epidemiology, clinical features, etiology, the management and outcome of CES in our setting. METHODS: A retrospective cohort study was carried out in the Douala General Hospital (DGH), using files of ischemic stroke patients admitted in the Neurological Unit and the Intensive Care Unit. Socio-demographic, clinical and paraclinical data were collected. After hospitalization, follow-up was performed with focus on mortality, stroke recurrence and the functional outcome assessed with Barthel score. Multivariate analysis was performed to determine the factors associated with death. RESULTS: Of the 704 stroke cases included, 368 were ischemic with 86 (23.4%) of them being cardio-embolic. The mean age of patient with CES was 67±13.3 years. The main etiologies of CES were: atrial fibrillation (82.1%), dilated cardiomyopathy (12.8%), and rheumatic mitral stenosis (5.1%). Anti-platelet agents were the most prescribed anti-thrombotic drugs (50.7%). The in-hospital mortality rate was 23.3% with lesion in both internal carotid arteries [OR=110.3; 95% CI: 1.2-1040.7; P=0.043] and heart disease [OR=46.9; 95% CI: 1.2-1789.9; P=0.038] appeared to be predictive of this. Stroke recurrence was observed in 8 patients (12.1%) and the survival probability in 5 years was 10%. Functional outcome was progressively worse with the systolic blood pressure>140mmHg (P=0.025) been the associated factor. CONCLUSION: CES accounted for 1/4 of ischemic stroke with a high risk of early death and long-term recurrence. Atrial fibrillation was the leading cause of CES. The association of VKA and anti-platelet agent should be avoided to reduce early death during acute stroke.

HIV infection does not influence stroke outcomes in HIV-infected patients: A prospective study.

BACKGROUND: Human immunodeficiency virus (HIV) infection, opportunistic infections and antiretroviral therapy contribute to the pathogenesis of stroke, yet, little is known about the influence of HIV infection on outcome in stroke patients. The aim of this study was to compare the outcome of stroke in HIV-infected patients with that of HIV-negative patients at the Douala General Hospital (DGH). PATIENTS AND METHODS: A prospective cohort study was carried out at the Neurology unit and the Intensive Care Unit of the DGH from January 2010 to December 2015. All patients aged 15 years and above, admitted for stroke confirmed by brain imaging were included. HIV testing was systematically prescribed for all stroke patients. HIV-infected patients were then compared with HIV-uninfected patients. Quantitative variables were expressed as means while qualitative variables were expressed as frequencies, and were compared with the Chi2 test or the Fisher test and the Student test respectively. Stroke outcome was evaluated by the mortality, in-hospital stay and functional outcome at 6 months post-stroke. Kaplan-Meyer method was used to determine survival. RESULTS: Forty of the 608 patients with stroke were HIV-positive, giving an in-hospital HIV prevalence of 6.6%. Mean age of the HIV-infected stroke patients was 51.3±10.4 years as against 59.6±13.53 in the HIV-uninfected group (P=0.001). The proportion of dyslipidemia in HIV-infected stroke patients with was greater than that in HIV-uninfected stroke patients (57.5% vs 8.9%, P<0.001). The most common type of stroke was ischemic in two-thirds of the patients in both groups. HIV-infected stroke patients had a mean hospital stay longer than that of HIV-uninfected patients (10.3±8.1 days vs 8.1±6.3 days, P=0.042). Post-stroke infections were more frequent in HIV-infected patients (17.5% vs 6.9%, P=0.014). The cumulative mortality rates at 6 months were 37.5% and 34.5% for the HIV-infected and the HIV-uninfected groups respectively (P=0.471). The functional outcome was similar in both groups at the 6th month post-stroke (Rankin score>2: 38.5%vs 38.8%, P=0.973). There was no difference in survival between the two groups. CONCLUSION: HIV infection does not affect in-hospital mortality and functional outcome in stroke patients a part the length of hospital stay.

[Epilepsy in a cohort of Senegalese children]. / Epilepsie dans le contexte neuropédiatrique sénégalais.

Epilepsy is a significant health public problem in Senegal with an estimated prevalence of 8 to 14%. The aim of this study was to determine the clinical and electroencephalographic features of epilepsy in a cohort of Senegalese infants, search for etiological factors and determine the impact of disease on school life. This retrospective study concerned 459 children who attended the neurological outpatients clinic at the Fann hospital, Dakar, Senegal, between July 2003 and December 2006. All were aged under 19 years. Among the 135 children with idiopathic epilepsy, 23.7% had parental consanguinity and 37.77 % familial epilepsy. Rolandic epilepsy and epilepsy with absences were more frequent but several infants with idiopathic epilepsy were not classified. Non-idiopathic epilepsy was noted in 312 children. In this group, estimates of parental consanguinity and familial epilepsy were of 21.79 and 17.94%, respectively. Etiological factors were predominantly pregnancy and birth abnormalities (28.84%) and central nervous system infection (20.19%). Twelve children had febrile seizures. Of patients with idiopathic epilepsy, 65.18% were attending school versus only 9.29 with non-idiopathic epilepsy.

[Neuromeningeal cryptococcosis in patients apparently non-immunodeficient: report of 3 cases in Dakar, Senegal]. / Cryptococcose neuroméningée chez des patients apparemment non-immunodéprimes: à spropos de 3 cas à Dakar, Sénégal.

Cryptococcal infection is common in immunocompromised patients. Its occurrence in immuno-competent patients is rare. We report here 3 cases of neuromeningeal cryptococcosis in patients without any immunosuppressive documented factors. They were respectively 25, 36 and 50 years old presenting clinical signs of chronic meningo-encephalitis. The HIV test was negative for all of them and the CD4 counts were normal. One patient died on the seventh day of the treatment with amphotericin B; the second was discharged on parents' request, while the third patient improved with intravenous fluconazole. This study suggests that when facing a sub-acute or chronic meningitis, an investigation for cryptococcal infection is recommended as before AIDS epidemic.

[Vascular aphasias: clinical, epidemiologicaland evolutionary aspects]. / Aphasies vasculaires: aspects cliniques, epidemiologiques et evolutifs.

INTRODUCTION: Aphasias constitute an acquired disorder of the language. Aetiologies are dominated by stroke. The aim of this study was to describe the clinical, epidemiological and evolutionary aspects of the vascular aphasias. MATERIALS AND METHODS: We conducted from August 2003 to May 2005 a descriptive cross-sectional study at the Neurology department in Dakar. This study concerned all patients admitted at the Neurology department for stroke confirmed by the cerebral tom densitometry. All patients were subjected to an examination of the language allowing to confirm the diagnosis of aphasia and to determine the type. The follow-up was monthly during one year. RESULTS: 55 cases of aphasia were reported on 170 cases of stroke (frequency: 32.35%). Our patients were all right-handed. Mean age was 56.8 (28 to 86 years) with a sex-ratio of 0.61.76.36% of the patients could neither read nor to write. Only two made higher studies. The nature of stroke was ischemic in 73.7% and hemorrhagic in 26.3%. The aphasias with expressive language impairment were observed in 96.4% against 3.6% of the cases for aphasias with comprehensive language impairment. After one year of evolution, a regression of the disorders was observed only in 9 cases, and the regression was partial in 25 cases. The evolution of the aphasia was correlated with that of the motor deficit. Age, low educational level, ischemic stroke constitute factors of bad prognosis. CONCLUSION: Vascular aphasias are frequent and of reserved prognosis. It disturbs social professional and family reintegration.

[Factors associated with quality of life for patients with post-stroke aphasia in the Cotonou hospitals, Benin]. / Facteurs associes a la qualite de vie des aphasiques post accident vasculaire cerebral en milieu hospitalier a cotonou, Benin.

INTRODUCTION: The objective of this study was to determine the factors influencing quality of life for patients with post-stroke aphasia followed in Cotonou hospitals. METHOD: A prospective descriptive and analytical cross-sectional study was conducted in CNHU-HKM (Cotonou, Benin) from October to December 2012; focusing on patients with at least six months of post-stroke aphasia. For each patient, a SIP-65 questionnaire was administered. The Epi Info 3.5 software was used for data analysis. A multivariate analysis was performed to determine factors associated with quality of life for patients with aphasia. RESULTS: In total, 41 patients were included in this study with a sex ratio of 1.3. The average age was 55.3 ± 2.5 years. The average duration of the aphasia was 10 months. Broca's aphasia was predominant (68.3%). 60.8% of aphasia patients were able to preserve their quality of life. Multivariate analysis showed that age, family support, the type of stroke and aphasia and speech therapy were associated with quality of life. CONCLUSION: The treatment of post-stroke aphasia must incorporate these factors associated with quality of life for a better recovery of patients.

INTRODUCTION: L'objectif de ce travail était de déterminer les facteurs influençant la qualité de vie des patients aphasiques post-AVC suivis à Cotonou. MÉTHODE: Il s'agit d'une étude transversale, prospective descriptive et analytique qui s'est déroulée au CNHU-HKM de Cotonou d'Octobre à Décembre 2012; elle a inclus les patients aphasiques post-AVC d'au moins six mois. Pour chaque patient, un questionnaire SIP-65 a été administré. Le logiciel Epi info 3.5 a servi de base à l'analyse des données. Une analyse multivariée a été effectuée pour déterminer les facteurs associés à la qualité de vie des aphasiques. RÉSULTATS: Au total, 41 patients ont été inclus dans l'étude avec une sex-ratio de 1,3. L'âge moyen était de 55,3 ± 2,5 ans. La durée moyenne d'évolution de l'aphasie était 10 mois. L'aphasie de Broca était prédominante (68,3%). 60,8% des aphasiques avaient une qualité de vie préservée. L'analyse multivariée a montré que l'âge, le soutien de la famille, le type d'AVC et d'aphasie et le traitement orthophonique étaient associés à la qualité de vie. CONCLUSION: La prise en charge des aphasiques post-AVC doit intégrer ces facteurs associés à la qualité de vie pour une meilleure récupération des patients.

Correlates of cigarette smoking among university students in Cameroon.

OBJECTIVE: To determine factors associated with smoking among university students in Cameroon. DESIGN: A cross-sectional survey was carried out using an anonymous self-administered questionnaire among a convenience sample of 3000 students from three universities (the Université des Montagnes, and the Universities of Douala and Yaounde 1) in Cameroon; 190 students (5.9%) did not consent to the survey. Socio-demographic characteristics and smoking trends were recorded. Logistic regression was used to identify risk factors for smoking. RESULTS: Of the students selected, 1862 (62%) were male. The mean age was 23.3 years. We found that 30.1% of students had tried smoking and that 5.6% (n = 168) reported regular smoking. Smoking prevalence among male and female students was respectively 9.5% and 1%. The mean age of smokers was 24.1 years. Only 12.5% of regular smokers were nicotine-dependent. Factors motivating smoking were pleasure, imitation, snobbery and curiosity. In the multivariate analysis, smoking was statistically associated with age, male sex, exposure to friends who smoke and living with smokers. CONCLUSION: Although the prevalence of smoking found in our study was low, effective tobacco control programmes targeting factors such as age, male sex and peer influence should be implemented in universities. Future studies are needed to evaluate the impact of these interventions.