RESUMO
Although tyrosine supplementation is well recognized to improve cognitive function, its impact on endurance performance is debatable and needs to be clarified further. The purpose of this systematic review and meta-analysis was to evaluate the effects of tyrosine supplementation on whole-body endurance performance in physically active population. The search strategy follow the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA), using four databases (Cochrane Library, Web of Science, Scopus, PsycINFO, and PubMed) until 3 August 2023. The effect of tyrosine (experimental condition) was compared against placebo (control condition). The methodological quality of the included studies was evaluated using the Physiotherapy Evidence Database (PEDro) scale. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE Pro software) System was also used to assess the quality of evidence. A total of 10 interventions from 8 studies were included. The sub-group analysis revealed no significant differences between tyrosine and placebo conditions for time to exhaustion (SMD = 0.02; p = 0.94) and time trial performance (SMD = -0.04; p = 0.85). The level of evidence as qualified with GRADE was moderate. In conclusion, moderate-quality evidence suggests that tyrosine supplementation is ineffective on endurance performance in the physically active population, independently of the endurance task (TTE or ETT).
Assuntos
Suplementos Nutricionais , Resistência Física , Tirosina , Humanos , Resistência Física/fisiologia , Resistência Física/efeitos dos fármacos , Tirosina/administração & dosagem , Desempenho Atlético/fisiologiaRESUMO
PURPOSE: To determine the influence of two commonly occurring genetic polymorphisms on exercise, cognitive performance, and caffeine metabolism, after caffeine ingestion. METHODS: Eighteen adults received caffeine or placebo (3 mg kg-1) in a randomised crossover study, with measures of endurance exercise (15-min cycling time trial; 70-min post-supplementation) and cognitive performance (psychomotor vigilance test; PVT; pre, 50 and 95-min post-supplementation). Serum caffeine and paraxanthine were measured (pre, 30 and 120-min post-supplementation), and polymorphisms in ADORA2A (rs5751876) and CYP1A2 (rs762551) genes analysed. RESULTS: Caffeine enhanced exercise performance (P < 0.001), but effects were not different between participants with ADORA2A 'high' (n = 11) vs. 'low' (n = 7) sensitivity genotype (+ 6.4 ± 5.8 vs. + 8.2 ± 6.8%), or CYP1A2 'fast' (n = 10) vs. 'slow' (n = 8) metabolism genotype (+ 7.2 ± 5.9 vs. + 7.0 ± 6.7%, P > 0.05). Caffeine enhanced PVT performance (P < 0.01). The effect of caffeine was greater for CYP1A2 'fast' vs. 'slow' metabolisers for reaction time during exercise (- 18 ± 9 vs. - 1.0 ± 11 ms); fastest 10% reaction time at rest (- 18 ± 11 vs. - 3 ± 15 ms) and lapses at rest (- 3.8 ± 2.7 vs. + 0.4 ± 0.9) (P < 0.05). There were no PVT differences between ADORA2A genotypes (P > 0.05). Serum caffeine and paraxanthine responses were not different between genotypes (P > 0.05). CONCLUSION: Caffeine enhanced CYP1A2 'fast' metabolisers' cognitive performance more than 'slow' metabolisers. No other between-genotype differences emerged for the effect of caffeine on exercise or cognitive performance, or metabolism.
Assuntos
Cafeína/farmacologia , Citocromo P-450 CYP1A2/efeitos dos fármacos , Exercício Físico/fisiologia , Genótipo , Receptor A2A de Adenosina/efeitos dos fármacos , Adulto , Cafeína/administração & dosagem , Feminino , Humanos , Masculino , Substâncias para Melhoria do Desempenho/administração & dosagem , Substâncias para Melhoria do Desempenho/farmacologia , Adulto JovemRESUMO
INTRODUCTION: Cognitive-motor interference is the decrease in cognitive performance and/or physical performance occurring when a cognitive task and a physical task are performed concurrently (dual task) compared to when they are performed in isolation (single task). The aim of this study was to investigate the construct validity and test-retest reliability of two cognitive-motor interference tests in military contexts. MATERIALS AND METHODS: Twenty-two soldiers, officers, and cadets performed a 10-min loaded marching, a 10-min Psychomotor Vigilance Task, and the two tasks combined (visit 1). During visit 2, a 5-min running time trial, a 5-min Word Recall Task, and the two tasks combined. These tests were repeated by 20 participants after 2 weeks (visits 3 and 4). RESULTS: Significant impairments were shown on both running distance (P < .001) and number of words recalled (P = .004) in the dual-task condition compared to the single-task condition. Significantly shorter step length (P < .001) and higher step frequency (P < .001) were found during the loaded marching in the dual-task condition compared to the single-task condition. No significant differences were observed in mean reaction time (P = .402) and number of lapses (P = .479) during the Psychomotor Vigilance Task. Good-to-excellent reliability was found for all the cognitive and physical variables in both single- and dual-task conditions, except for the number of lapses. CONCLUSION: These findings suggest that the Running + Word Recall Task test is a valid and reliable dual-tasking test that could be used to assess cognitive-motor interference in military contexts.