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1.
J Clin Med ; 13(10)2024 May 09.
Artigo em Inglês | MEDLINE | ID: mdl-38792339

RESUMO

Background: Male fertility is known to have been negatively influenced by the progress of civilization. Another condition whose incidence has been on the increase for the same reason is insulin resistance (IR). In addition, men increasingly often resign from the pursuit of active forms of leisure, preferring more sedentary ones. Considering these trends, this aim of this study was to investigate the relationships between lifestyle factors, insulin resistance, and male fertility in men with and without the condition. A further aim was to select those lifestyle factors that would make it possible to predict the level of male fertility, especially when IR is concerned. Methods: This study was performed in a group of 73 participants, divided into groups based on their insulin resistance status. Their physical activity, diet, perceived stress, sleep quality, libido level, and duration of sexual abstinence were assessed on the basis of a number of parameters, including indices proposed by the authors. In addition, relevant anthropometric measurements were taken and tests related to glucose metabolism and semen quality were carried out. On the basis of these data, statistical tests were performed to establish or disprove relationships between lifestyle choices and semen quality, as measured my sperm motility. Results: The results of this study highlighted the associations between a number of parameters, i.e., micronutrient and vitamin intake, diet quality, body composition, insulin resistance, and the duration of sexual abstinence, and semen quality, as measured by sperm motility. Significantly, the presence or absence of IR was linked to male fertility. A multivariate model was developed, incorporating parameters such as the Matsuda index, vitamin intake, and sexual abstinence duration, to predict motility scores. Conclusions: This study underscores the negative impact of modern civilization's lifestyle choices on male fertility. Notably, vitamin and mineral consumption, especially from antioxidant-rich diets like the Mediterranean diet, emerged as key modifiable factors affecting fertility. Routine diagnostics for insulin resistance in fertility-related interventions is recommended. This study also highlights the importance of considering sexual abstinence duration during semen collection for accurate diagnostic results. Future research should focus on validating the proposed multivariate model and exploring the effects of lifestyle modifications, particularly vitamin supplementation, on fertility outcomes in men, especially in the context of IR.

2.
Pediatr Endocrinol Diabetes Metab ; 25(3): 144-149, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31769272

RESUMO

One of the most important elements associated with increase in oncological outcome in children is fertility preservation for future. It is obvious that chemo and radio therapy used in cancer treatment aim to destroy tumor cells, but they also impact healthy tissues. The nega-tive influence of these types of therapy can be observed in every patient's organ. One of the most serious complication of oncological treatment is reproductive impairment. This determinates directly mental and social state of the patient as well as quality of life after the treatment, particularly in adolescent. Commonly used methods of fertility preservation in female children are: freezing ovarian tissue or unfertilized oocytes. Among male children freezing of testicular tissue or ejaculated sperm are conducted. Described methods of fertility preservation among children and adolescents are on the experimental stage and none of them provide 100% effectiveness.


Assuntos
Preservação da Fertilidade/métodos , Neoplasias/tratamento farmacológico , Adolescente , Criança , Feminino , Humanos , Masculino , Oncologia , Neoplasias/terapia
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