Pesquisa | BVS Violência e Saúde

1.

Small molecule modulation of TrkB and TrkC neurotrophin receptors prevents cholinergic neuron atrophy in an Alzheimer's disease mouse model at an advanced pathological stage.

Gonzalez, Selena; McHugh, Tyne L M; Yang, Tao; Syriani, Wassim; Massa, Stephen M; Longo, Frank M; Simmons, Danielle A.

Neurobiol Dis ; 162: 105563, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-34838668

2.

A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.

Simmons, Danielle A; Belichenko, Nadia P; Ford, Ellen C; Semaan, Sarah; Monbureau, Marie; Aiyaswamy, Sruti; Holman, Cameron M; Condon, Christina; Shamloo, Mehrdad; Massa, Stephen M; Longo, Frank M.

Hum Mol Genet ; 25(22): 4920-4938, 2016 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-28171570

3.

The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking.

Darcq, Emmanuel; Morisot, Nadege; Phamluong, Khanhky; Warnault, Vincent; Jeanblanc, Jerome; Longo, Frank M; Massa, Stephen M; Ron, Dorit.

J Neurosci ; 36(39): 10116-27, 2016 09 28.

Artigo em Inglês | MEDLINE | ID: mdl-27683907

4.

A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease.

Simmons, Danielle A; Belichenko, Nadia P; Yang, Tao; Condon, Christina; Monbureau, Marie; Shamloo, Mehrdad; Jing, Deqiang; Massa, Stephen M; Longo, Frank M.

J Neurosci ; 33(48): 18712-27, 2013 Nov 27.

Artigo em Inglês | MEDLINE | ID: mdl-24285878

5.

Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury.

Tep, Chhavy; Lim, Tae Hee; Ko, Pyung On; Getahun, Sami; Ryu, Jae Cheon; Goettl, Virginia M; Massa, Stephen M; Basso, Michele; Longo, Frank M; Yoon, Sung Ok.

J Neurosci ; 33(2): 397-410, 2013 Jan 09.

Artigo em Inglês | MEDLINE | ID: mdl-23303920

6.

A small molecule p75(NTR) ligand protects neurogenesis after traumatic brain injury.

Shi, Jian; Longo, Frank M; Massa, Stephen M.

Stem Cells ; 31(11): 2561-74, 2013 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-23940017

7.

p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: a randomized, placebo-controlled phase 2a trial.

Shanks, Hayley R C; Chen, Kewei; Reiman, Eric M; Blennow, Kaj; Cummings, Jeffrey L; Massa, Stephen M; Longo, Frank M; Börjesson-Hanson, Anne; Windisch, Manfred; Schmitz, Taylor W.

Nat Med ; 2024 May 17.

Artigo em Inglês | MEDLINE | ID: mdl-38760589

8.

A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome.

Schmid, Danielle A; Yang, Tao; Ogier, Michael; Adams, Ian; Mirakhur, Yatin; Wang, Qifang; Massa, Stephen M; Longo, Frank M; Katz, David M.

J Neurosci ; 32(5): 1803-10, 2012 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-22302819

9.

Use of Botulinum Toxin for Limb Immobilization for Rehabilitation in Rats with Experimental Stroke.

Zhang, Hongxia; Liu, Jialing; Bingham, Deborah; Orr, Adrienne; Kawabori, Masahito; Kim, Jong Youl; Zheng, Zhen; Lam, Tina I; Massa, Stephen M; Swanson, Raymond A; Yenari, Midori A.

Biomolecules ; 13(3)2023 03 10.

Artigo em Inglês | MEDLINE | ID: mdl-36979446

10.

Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxic-ischemic stroke.

Han, Jullet; Pollak, Julia; Yang, Tao; Siddiqui, Mohammad R; Doyle, Kristian P; Taravosh-Lahn, Kereshmeh; Cekanaviciute, Egle; Han, Alex; Goodman, Jeremy Z; Jones, Britta; Jing, Deqiang; Massa, Stephen M; Longo, Frank M; Buckwalter, Marion S.

Stroke ; 43(7): 1918-24, 2012 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-22535263

11.

The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo.

Knowles, Juliet K; Rajadas, Jayakumar; Nguyen, Thuy-Vi V; Yang, Tao; LeMieux, Melburne C; Vander Griend, Lilith; Ishikawa, Chihiro; Massa, Stephen M; Wyss-Coray, Tony; Longo, Frank M.

J Neurosci ; 29(34): 10627-37, 2009 Aug 26.

Artigo em Inglês | MEDLINE | ID: mdl-19710315

12.

Small molecule modulation of the p75 neurotrophin receptor inhibits multiple amyloid beta-induced tau pathologies.

Yang, Tao; Tran, Kevin C; Zeng, Anne Y; Massa, Stephen M; Longo, Frank M.

Sci Rep ; 10(1): 20322, 2020 11 23.

Artigo em Inglês | MEDLINE | ID: mdl-33230162

13.

Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice.

Yang, Tao; Liu, Harry; Tran, Kevin C; Leng, Albert; Massa, Stephen M; Longo, Frank M.

Acta Neuropathol Commun ; 8(1): 156, 2020 09 05.

Artigo em Inglês | MEDLINE | ID: mdl-32891185

14.

Signaling through Rho GTPase pathway as viable drug target.

Lu, Qun; Longo, Frank M; Zhou, Huchen; Massa, Stephen M; Chen, Yan-Hua.

Curr Med Chem ; 16(11): 1355-65, 2009.

Artigo em Inglês | MEDLINE | ID: mdl-19355891

15.

Modulation of the p75 neurotrophin receptor suppresses age-related basal forebrain cholinergic neuron degeneration.

Xie, Youmei; Meeker, Rick B; Massa, Stephen M; Longo, Frank M.

Sci Rep ; 9(1): 5273, 2019 03 27.

Artigo em Inglês | MEDLINE | ID: mdl-30918278

16.

Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease.

Mufson, Elliott J; Counts, Scott E; Ginsberg, Stephen D; Mahady, Laura; Perez, Sylvia E; Massa, Stephen M; Longo, Frank M; Ikonomovic, Milos D.

Front Neurosci ; 13: 533, 2019.

Artigo em Inglês | MEDLINE | ID: mdl-31312116

17.

Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants.

James, Sarah E; Burden, Hubert; Burgess, Russell; Xie, Youmei; Yang, Tao; Massa, Stephen M; Longo, Frank M; Lu, Qun.

Neurotoxicology ; 29(4): 605-12, 2008 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-18539332

18.

Senolytic therapy for Alzheimer's disease.

Longo, Frank M; Massa, Stephen M.

Nat Med ; 29(10): 2409-2411, 2023 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-37758897

19.

Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death.

Massa, Stephen M; Xie, Youmei; Yang, Tao; Harrington, Anthony W; Kim, Mi Lyang; Yoon, Sung Ok; Kraemer, Rosemary; Moore, Laura A; Hempstead, Barbara L; Longo, Frank M.

J Neurosci ; 26(20): 5288-300, 2006 May 17.

Artigo em Inglês | MEDLINE | ID: mdl-16707781

20.

Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms.

Longo, Frank M; Yang, Tao; Knowles, Juliet K; Xie, Youmei; Moore, Laura A; Massa, Stephen M.

Curr Alzheimer Res ; 4(5): 503-6, 2007 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-18220511

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