Detalhe da pesquisa
1.
Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P3-sparing S1P1 agonists.
Bioorg Med Chem Lett
; 22(9): 3083-8, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22487179
2.
The crucial protective role of glutathione against tienilic acid hepatotoxicity in rats.
Toxicol Appl Pharmacol
; 232(2): 280-91, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18708081
3.
Promising toxicological biomarkers for the diagnosis of liver injury types: Bile acid metabolic profiles and oxidative stress marker as screening tools in drug development.
Chem Biol Interact
; 255: 74-82, 2016 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26365562
4.
Oxidative stress markers, secondary bile acids and sulfated bile acids classify the clinical liver injury type: Promising diagnostic biomarkers for cholestasis.
Chem Biol Interact
; 255: 83-91, 2016 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26325587
5.
A predictive model of human myelotoxicity using five camptothecin derivatives and the in vitro colony-forming unit granulocyte/macrophage assay.
Clin Cancer Res
; 10(19): 6722-31, 2004 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15475463
6.
Analysis of the serum bile Acid composition for differential diagnosis in patients with liver disease.
Gastroenterol Res Pract
; 2015: 717431, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25821461
7.
Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor.
ACS Med Chem Lett
; 3(9): 754-8, 2012 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900544
8.
Prediction of human pharmacokinetics of therapeutic monoclonal antibodies from simple allometry of monkey data.
Drug Metab Pharmacokinet
; 26(4): 423-30, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21606605
9.
CM-dextran-polyalcohol-camptothecin conjugate: DE-310 with a novel carrier system and its preclinical data.
Adv Exp Med Biol
; 519: 145-53, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12675213
10.
Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediate: correlation of in vitro and in vivo generation of reactive intermediates and in vitro glutathione conjugate formation in rats and humans.
Chem Res Toxicol
; 20(3): 455-64, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17309281