Sleep Differentially and Profoundly Impairs Recall Memory in a Patient with Fornix Damage.

In March 2020, C.T., a kind, bright, and friendly young woman underwent surgery for a midline tumor involving her septum pellucidum and extending down into her fornices bilaterally. Following tumor diagnosis and surgery, C.T. experienced significant memory deficits: C.T.'s family reported that she could remember things throughout the day, but when she woke up in the morning or following a nap, she would expect to be in the hospital, forgetting all the information that she had learned before sleep. The current study aimed to empirically validate C.T.'s pattern of memory loss and explore its neurological underpinnings. On two successive days, C.T. and age-matched controls watched an episode of a TV show and took a nap or stayed awake before completing a memory test. Although C.T. performed numerically worse than controls in both conditions, sleep profoundly exacerbated her memory impairment, such that she could not recall any details following a nap. This effect was replicated in a second testing session. High-resolution MRI scans showed evidence of the trans-callosal surgical approach's impact on the mid-anterior corpus callosum, indicated that C.T. had perturbed white matter particularly in the right fornix column, and demonstrated that C.T.'s hippocampal volumes did not differ from controls. These findings suggest that the fornix is important for processing episodic memories during sleep. As a key output pathway of the hippocampus, the fornix may ensure that specific memories are replayed during sleep, maintain the balance of sleep stages, or allow for the retrieval of memories following sleep.

Memory decay distinguishes subtypes of gist.

Memories are thought to become more gist-like over time. Multiple related memories might form generalized memory representations, losing specific details but enhancing or retaining gist. The time course within which gist memory emerges, however, is the subject of less consensus. To address this question, we focused our design on four kinds of gist: inferential gist (relations extracted across non-contiguous events), statistical learning (regularities extracted from a series), summary gist (a theme abstracted from a temporally contiguous series of items), and category gist (characterization of a stimulus at a higher level in the semantic hierarchy). Seventy participants completed memory encoding tasks addressing these types of gist and corresponding retrieval tasks the same evening, the morning after, and one week later, as well as an MRI at a later time point. We found little evidence that gist slowly emerges over time or that gist traces are more resistant to forgetting than detail traces. Instead, we found that initial gist memory shortly after encoding was either retained over time or decayed. Inferential gist and statistical learning were retained over a week, whereas memory for category and summary gist decayed. We discuss several interpretations for differences between these two subtypes of gist. Individual differences in REM or slow-wave sleep and hippocampal volumes did not predict changes in memory for these four kinds of gist in a healthy young adult population.