Detalhe da pesquisa
1.
A conserved folding nucleus sculpts the free energy landscape of bacterial and archaeal orthologs from a divergent TIM barrel family.
Proc Natl Acad Sci U S A
; 118(17)2021 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33875592
2.
Networks of electrostatic and hydrophobic interactions modulate the complex folding free energy surface of a designed ßα protein.
Proc Natl Acad Sci U S A
; 116(14): 6806-6811, 2019 04 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30877249
3.
Frustration and folding of a TIM barrel protein.
Proc Natl Acad Sci U S A
; 116(33): 16378-16383, 2019 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31346089
4.
Trifluoroethanol Partially Unfolds G93A SOD1 Leading to Protein Aggregation: A Study by Native Mass Spectrometry and FPOP Protein Footprinting.
Biochemistry
; 59(39): 3650-3659, 2020 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32924445
5.
Nonnative structure in a peptide model of the unfolded state of superoxide dismutase 1 (SOD1): Implications for ALS-linked aggregation.
J Biol Chem
; 294(37): 13708-13717, 2019 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31341015
6.
Toward a sustainable biomedical research enterprise: Finding consensus and implementing recommendations.
Proc Natl Acad Sci U S A
; 112(35): 10832-6, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26195768
7.
Modulation of frustration in folding by sequence permutation.
Proc Natl Acad Sci U S A
; 111(29): 10562-7, 2014 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25002512
8.
Sequential Closure of Loop Structures Forms the Folding Nucleus during the Refolding Transition of the Escherichia coli Adenylate Kinase Molecule.
Biochemistry
; 55(1): 79-91, 2016 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26666584
9.
Folding of the RNA recognition motif (RRM) domains of the amyotrophic lateral sclerosis (ALS)-linked protein TDP-43 reveals an intermediate state.
J Biol Chem
; 289(12): 8264-76, 2014 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24497641
10.
Interplay between drying and stability of a TIM barrel protein: a combined simulation-experimental study.
J Am Chem Soc
; 135(5): 1882-90, 2013 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23293932
11.
Microsecond acquisition of heterogeneous structure in the folding of a TIM barrel protein.
Proc Natl Acad Sci U S A
; 105(36): 13367-72, 2008 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-18757725
12.
Metal deficiency increases aberrant hydrophobicity of mutant superoxide dismutases that cause amyotrophic lateral sclerosis.
J Biol Chem
; 284(40): 27746-58, 2009 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-19651777
13.
Molecular dimensions and their distributions in early folding intermediates.
Curr Opin Struct Biol
; 16(1): 86-93, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16442277
14.
Mapping the structure of folding cores in TIM barrel proteins by hydrogen exchange mass spectrometry: the roles of motif and sequence for the indole-3-glycerol phosphate synthase from Sulfolobus solfataricus.
J Mol Biol
; 368(2): 582-94, 2007 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-17359995
15.
Topology and sequence in the folding of a TIM barrel protein: global analysis highlights partitioning between transient off-pathway and stable on-pathway folding intermediates in the complex folding mechanism of a (betaalpha)8 barrel of unknown function from B. subtilis.
J Mol Biol
; 372(1): 236-53, 2007 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-17619021
16.
A tightly packed hydrophobic cluster directs the formation of an off-pathway sub-millisecond folding intermediate in the alpha subunit of tryptophan synthase, a TIM barrel protein.
J Mol Biol
; 366(5): 1624-38, 2007 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-17222865
17.
Microsecond hydrophobic collapse in the folding of Escherichia coli dihydrofolate reductase, an alpha/beta-type protein.
J Mol Biol
; 368(1): 219-29, 2007 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-17331539
18.
Long-range side-chain-main-chain interactions play crucial roles in stabilizing the (betaalpha)8 barrel motif of the alpha subunit of tryptophan synthase.
Protein Sci
; 16(7): 1398-409, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17586773
19.
The folding energy landscape of the dimerization domain of Escherichia coli Trp repressor: a joint experimental and theoretical investigation.
J Mol Biol
; 363(1): 262-78, 2006 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-16956620
20.
Mapping the folding free energy surface for metal-free human Cu,Zn superoxide dismutase.
J Mol Biol
; 364(5): 1084-102, 2006 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17046019