Detalhe da pesquisa
1.
SAR340835, a Novel Selective Na+/Ca2+ Exchanger Inhibitor, Improves Cardiac Function and Restores Sympathovagal Balance in Heart Failure.
J Pharmacol Exp Ther
; 377(2): 293-304, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33602875
2.
The use of virtual screening and differential scanning fluorimetry for the rapid identification of fragments active against MEK1.
Bioorg Med Chem Lett
; 23(12): 3620-6, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23648182
3.
Structure-based design and optimization of potent renin inhibitors on 5- or 7-azaindole-scaffolds.
Bioorg Med Chem Lett
; 21(18): 5487-92, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21840215
4.
Structure-based optimization of potent 4- and 6-azaindole-3-carboxamides as renin inhibitors.
Bioorg Med Chem Lett
; 21(18): 5480-6, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21840218
5.
SAR439859, a Novel Selective Estrogen Receptor Degrader (SERD), Demonstrates Effective and Broad Antitumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models.
Mol Cancer Ther
; 20(2): 250-262, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33310762
6.
Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors.
Bioorg Med Chem Lett
; 20(21): 6268-72, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20850300
7.
Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer.
J Med Chem
; 63(2): 512-528, 2020 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31721572
8.
Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors.
J Med Chem
; 58(1): 376-400, 2015 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25402320
9.
Serotonin aggravates exercise-induced cardiac ischemia in the dog: effect of serotonin receptor antagonists.
Eur J Pharmacol
; 497(1): 55-63, 2004 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-15321735