Detalhe da pesquisa
1.
Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin.
Mol Cell
; 83(13): 2206-2221.e11, 2023 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37311463
2.
HIPK2 directs cell type-specific regulation of STAT3 transcriptional activity in Th17 cell differentiation.
Proc Natl Acad Sci U S A
; 119(14): e2117112119, 2022 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35344430
3.
Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth.
Proc Natl Acad Sci U S A
; 115(31): 7949-7954, 2018 07 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-30012592
4.
Correction to: BRADSHAW: a system for automated molecular design.
J Comput Aided Mol Des
; 34(7): 767, 2020 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-31691917
5.
BRADSHAW: a system for automated molecular design.
J Comput Aided Mol Des
; 34(7): 747-765, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31637565
6.
BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice.
Proc Natl Acad Sci U S A
; 114(11): 2952-2957, 2017 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28265070
7.
Structural features and inhibitors of bromodomains.
Drug Discov Today Technol
; 19: 3-15, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-27769355
8.
The bromodomain: from epigenome reader to druggable target.
Biochim Biophys Acta
; 1839(8): 676-85, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24686119
9.
ChEpiMod: a knowledgebase for chemical modulators of epigenome reader domains.
Bioinformatics
; 30(10): 1481-3, 2014 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24470572
10.
Computational profiling of bioactive compounds using a target-dependent composite workflow.
J Chem Inf Model
; 53(9): 2322-33, 2013 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-23941602
11.
sc-PDB: a database for identifying variations and multiplicity of 'druggable' binding sites in proteins.
Bioinformatics
; 27(9): 1324-6, 2011 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21398668
12.
Protein-ligand-based pharmacophores: generation and utility assessment in computational ligand profiling.
J Chem Inf Model
; 52(4): 943-55, 2012 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22480372
13.
Enhancing the accuracy of chemogenomic models with a three-dimensional binding site kernel.
J Chem Inf Model
; 51(7): 1593-603, 2011 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21644501
14.
Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
J Med Chem
; 62(10): 5096-5110, 2019 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31013427
15.
Structure-Activity Relationship Studies for Enhancer of Zeste Homologue 2 (EZH2) and Enhancer of Zeste Homologue 1 (EZH1) Inhibitors.
J Med Chem
; 59(16): 7617-33, 2016 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27468126
16.
Assessing the geometric diversity of cytochrome P450 ligand conformers by hierarchical clustering with a stop criterion.
J Chem Inf Model
; 49(2): 330-7, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19434834