Enacting the 'neuro' in practice: translational research, adhesion and the promise of porosity.

This article attends to the processes through which neuroscience and the neuro are enacted in a specific context: a translational neuroscience research group that was the setting of an ethnographic study. The article therefore provides a close-up perspective on the intersection of neuroscience and translational research. In the scientific setting we studied, the neuro was multiple and irreducible to any particular entity or set of practices across a laboratory and clinical divide. Despite this multiplicity, the group's work was held together through the 'promise of porosity'--that one day there would be translation of lab findings into clinically effective intervention. This promise was embodied in the figure of the Group Leader whose expertise spanned clinical and basic neurosciences. This is theorized in terms of a contrast between cohesion and adhesion in interdisciplinary groupings. We end by speculating on the role of 'vivification'--in our case mediated by the Group Leader--in rendering 'alive' the expectations of interdisciplinary collaboration.

Lay metrology and metroscoping: Towards the study of lay units.

This exploratory article provides groundwork towards a tentative framework for exploring how lay measures and units - what is here called 'lay metrology' - intersect with formal metrology, and its various mediations. This article concerns itself with the role that everyday 'units' - grounded in part in the material culture of bodies and experience - play in relation to a metrological landscape, or 'metroscape' that is also inhabited by standardised units routinely popularised through various media. After a brief overview of the relevant literature on metrology, examples of lay metrology are provided that examine the relation of everyday units of, for example, length and area, to particular forms of bodily experience, social identity and sensorial capacities. This article draws on elements from science communication and affect theory to develop the notion of 'metroscoping' and to articulate a series of orienting questions for engaging with lay metrological processes.

London's fatbergs and affective infrastructuring.

This exploratory article considers the accumulations of fat and other materials in London's sewerage system - known as fatbergs in the UK - in terms of the processes of infrastructuring. In particular, drawing on a range of media, including a major museum exhibition, numerous newspaper and online articles, and a TV documentary, this article analyses how London's fatbergs have been affectively enacted. The affects identified include: disgust in the composition of the fatberg, pride in the London-ness of the fatbergs, admiration at the 'flushers' courage, generic horror at the sewers, shame in the flushing of wet wipes, and anxiety about microbial threats. Such enactments simultaneously perform the fatbergs, the sewerage infrastructure, and the public audiences, through what we can call 'affective infrastructuring'. This extends the analysis of infrastructuring to encompass the ways in which public audiences are affectively 'made'. The article also suggests that the various affective enactments of the fatberg cumulatively perform London as spatially uniform and the sewerage system as temporally naturalized. A critical implication of this is an effacement of, on the one hand, class and cultural difference and, on the other, historical specificity.

Shifting paradigms? Reflections on regenerative medicine, embryonic stem cells and pharmaceuticals.

Will human embryonic stem (hES) cells lead to a revolutionary new regenerative medicine? We begin to answer this question by drawing on interviews with scientists and clinicians from leading labs and clinics in the UK and the USA, exploring their views on the bench-bedside interface in the fields of hES cells, neuroscience and diabetes. We employ Bourdieu's concepts of field, habitus and capital in order to understand stem cell science and cell transplantation. We also build on research on the sociology of expectations, and explore expectations of pharmaceutical approaches in hES research through our concept of 'expectational capital'. In the process we discuss emerging expectations within stem cell research, most especially the 'disease in a dish' approach, where hES cells will be used as tools for unravelling the mechanisms of disease to enable the development of new drugs. We argue that experts' persuasive promises advance their interests in the uncertain stem cell field, and explore how this performative strategy might stabilise the emerging 'disease in a dish' model of translational research.

Destroying iPhones: Feral science and the antithetical citizen.

This exploratory article considers the implications of a particular genre - YouTube videos of iPhone destruction - for the Citizen Science and Public Understanding of Science/Public Engagement with Science and Technology. Situating this genre within a broader TV tradition of 'destructive testing' programmes, there is a description of the forms of destruction visited upon the iPhone, and an analysis of the features shared by the videos (e.g. mode of address, enactments of the experiment). Drawing on the notion of the 'idiotic', there is a discussion of the genre that aims to treat its evident lack of scientific and citizenly 'seriousness' productively. In the process of this discussion, the notions of 'feral science' and 'antithetical citizenship' are proposed, and some of their ramifications for Citizen Science and Public Understanding of Science/Public Engagement with Science and Technology presented.

Auckland regional emergency medicine trainee mentoring uptake survey.

OBJECTIVE: The primary objective of this study is to quantify how many Auckland region emergency medicine (EM) trainees would like a formal mentoring programme. The secondary objectives were to quantify how many Auckland region EM trainees would like to participate in a formal mentoring programme; to determine trainees' current understanding of mentoring; how trainees prefer mentors to be allocated; why trainees may want a mentor; what mentees perceive would be good qualities in a mentor; and trainees' prior experience with mentoring. METHODS: Online survey of EM trainees in the Auckland region in June 2015. RESULTS: Of 61 potential respondents, 40 (65.6%) respondents replied to the survey. Of the 40, 38 (95%; 95% confidence interval (CI) 82.6-99.5) respondents indicated they would like some form of mentoring system, and of the 38, 25 (65.8%; 95% CI 49.8-78.9) preferred this to be formal. Of the 38, 19 (50%; 95% CI 34.9-65.2) currently wanted assistance obtaining a mentor. Of the 40, 30 (75%; 95% CI 59.6-86.0) are not currently in any form of mentoring relationship. Respondents believed that mentors would be most beneficial in critical incidents, career development and with work/life balance. The attributes participants considered most important in a mentor were respecting confidentiality, being honest and the ability to provide constructive feedback. CONCLUSIONS: Many EM trainees in Auckland want a formal mentoring system and would like a mentor. Appropriate mentor-mentee matching through a formalised voluntary system, with adequate mentor training, may enable the Auckland region to develop a suitable mentoring programme for EM trainees.

From bench to bedside? Biomedical scientists' expectations of stem cell science as a future therapy for diabetes.

The movement of scientific research from the bench to the bedside is becoming an increasingly important aspect of modern 'biomedical societies'. There is, however, currently a dearth of social science research on the interaction between the laboratory and the clinic. The recent upsurge in global funding for stem cell research is largely premised on the promise of translating scientific understanding of stem cells into regenerative medicine. In this paper, we report on the views of biomedical scientists based in the United Kingdom who are involved in human embryonic stem cell research in the field of diabetes. We explore their views on the prospects and problems of translational research in the field of stem cell science. We discuss two main themes: institutional influences on interactions between scientists and clinicians, and stem cell science itself as the major barrier to therapies. We frame our discussion within the emerging literature of the sociology of expectations.

Toward a manifesto for the 'public understanding of big data'.

In this article, we sketch a 'manifesto' for the 'public understanding of big data'. On the one hand, this entails such public understanding of science and public engagement with science and technology-tinged questions as follows: How, when and where are people exposed to, or do they engage with, big data? Who are regarded as big data's trustworthy sources, or credible commentators and critics? What are the mechanisms by which big data systems are opened to public scrutiny? On the other hand, big data generate many challenges for public understanding of science and public engagement with science and technology: How do we address publics that are simultaneously the informant, the informed and the information of big data? What counts as understanding of, or engagement with, big data, when big data themselves are multiplying, fluid and recursive? As part of our manifesto, we propose a range of empirical, conceptual and methodological exhortations. We also provide Appendix 1 that outlines three novel methods for addressing some of the issues raised in the article.

The performative function of expectations in translating treatment to prevention: the case of HIV pre-exposure prophylaxis, or PrEP.

This paper is about expectations of oral PrEP, 'a pill a day' HIV pre-exposure prophylaxis that could be the first systemic form of HIV prevention for sexual or needle stick exposures. If found safe and effective--a difficult criteria to establish and, as such, is central to this paper--PrEP has the potential to significantly alter HIV prevention, well ahead of a vaccine or topical microbicide. Hence, despite uncertainty about PrEP's viability, the potential significance of its impact on the HIV field requires early planning. In order to address this potentiality, we use a methodological approach drawn from the sociology of expectations to examine interviews with United States-based scientific stakeholders in the trialing of PrEP. We identify how PrEP is anticipated as both stable object and process involving multiple contingencies. These divergent conceptions enable us to illuminate a range of social, cultural, ethical, pharmaceutical and medical possibilities understood to potentially arise with PrEP. Further, they lead us to propose that the multiple contingencies that enact PrEP as an emergent entity offer scope for rethinking PrEP and, more broadly, the challenges of HIV prevention.

Towards the applied: the construction of ethical positions in stem cell translational research.

This paper aims to make an empirically informed analytical contribution to the development of a more socially embedded bioethics. Drawing upon 10 interviews with cutting edge stem cell researchers (5 scientists and 5 clinicians) it explores and illustrates the ways in which the role positions of translational researchers are shaped by the [Symbol: see text]normative structures' of science and medicine respectively and in combination. The empirical data is used to illuminate three overlapping themes of ethical relevance: what matters in stem cell research, experimental treatment, and responsible claim making (as contrasted with [Symbol: see text]hype'). Finally, we suggest that this kind of [Symbol: see text]descriptive' ethical analysis has potential relevance for understanding other substantive areas of stem cell ethics in practice, and we briefly consider the questions our analysis raises about role positions and ethical agency, and the implications for bioethics as a field of scholarship.

Regulating Hybrids: 'Making a Mess' and 'Cleaning Up' in Tissue Engineering and Transpecies Transplantation.

This paper explores the institutional regulation of novel biosciences, hybrid technologies that often disturb and challenge existing regulatory frameworks. Developing a conceptual vocabulary for understanding the relationship between material and institutional hybrids, the paper compares human tissue engineering (TE) and xenotransplantation (XT), areas of innovation which regulators have sought to govern separately and in isolation from one another. Contrasting definitional boundaries and regulatory mechanisms partition them socio-institutionally. But despite these attempts at purification, TE and XT have proven increasingly difficult to tell apart in practical and material terms. Human and animal matters, cell cultures and tissue products have much greater corporeal connection than has been institutionally recognized, and are therefore a source of acute instability in the regulation of implants and transplants. This paper tells the story of how the messy worlds of TE and XT have leaked into one another, calling into question the abilities of regulation to adequately control hybrid innovations.

Ethical boundary-work in the embryonic stem cell laboratory.

Most accounts of the ethics of stem cell research are de- contextualised reviews of the ethical and legal literature. In this chapter we present a socially embedded account of some of the ethical implications of stem cell research, from the perspectives of scientists directly involved in this area. Based on an ethnography of two leading embryonic stem cell laboratories in the UK, our data form part of the findings from a larger project mapping the scientific, medical, social and ethical dimensions of innovative stem cell treatment, focusing on the areas of liver cell and pancreatic islet cell transplantation. We explore three key issues: what individual scientists themselves view as ethical sources of human embryos and stem cells; their perceptions of human embryos and stem cells; and how scientists perceive regulatory frameworks in stem cell research. We argue that these dimensions of laboratory practice are all examples of 'ethical boundary-work', which is becoming an integral part of the routine practice and performance of biomedical science. Our work adds to the relatively few sociological studies that explore ethics in clinical settings and to an even smaller body of work that explores scientists' views on the ethical issues relating to their research.

Signifying across time and space: a case study of biomedical educational texts.

This paper is an analysis of educational materials produced by the United Kingdom's Medical Research Council (MRC). While the MRC's Research Updates are designed to be used in the classroom, interviews with MRC contributors to the Updates and with teachers and students show that their function is complex. Drawing on these data, we point to three facets of biomedical texts that have been neglected. First, we note that these texts are meant to influence only a proportion of their target audience. Their impact is to set up a 'resonance' in this proportion of students, a resonance that will at some point in the future materialise as a choice to pursue a career in biomedical research. This is our second observation: that texts are designed to have a latent effect. These texts also address another audience - government bodies who demand that the MRC engage in educational and public understanding of science activities. As such, and this is our third observation, scientific texts can signify laterally, not to readers directly engaged with them, but to observers whose concern is with their trajectory.