Detalhe da pesquisa
1.
Half-life prolongation of therapeutic proteins by conjugation to ATIII-binding pentasaccharides: a first-in-human study of CarboCarrier® insulin.
Br J Clin Pharmacol
; 75(5): 1221-30, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22978318
2.
Intranasal administration of recombinant human cartilage glycoprotein-39 as a treatment for rheumatoid arthritis: a phase II, multicentre, double-blind, randomised, placebo-controlled, parallel-group, dose-finding trial.
Ann Rheum Dis
; 69(9): 1655-9, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19778914
3.
Fine-Needle Aspiration for the Evaluation of Hepatic Pharmacokinetics of Vaniprevir: A Randomized Trial in Patients With Hepatitis C Virus Infection.
Clin Pharmacol Ther
; 107(6): 1325-1333, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31868916
4.
Synthesis and Evaluation of a Series of Long-Acting Glucagon-Like Peptide-1 (GLP-1) Pentasaccharide Conjugates for the Treatment of Typeâ 2 Diabetes.
ChemMedChem
; 10(8): 1424-34, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26059252
5.
The Absence of a Clinically Significant Effect of Food on the Single Dose Pharmacokinetics of Vorapaxar, a PAR-1 Antagonist, in Healthy Adult Subjects.
Clin Pharmacol Drug Dev
; 2(4): 310-5, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27121935
6.
Complete inhibition of rhTSH-, Graves' disease IgG-, and M22-induced cAMP production in differentiated orbital fibroblasts by a low-molecular-weight TSHR antagonist.
J Clin Endocrinol Metab
; 97(5): E781-5, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22419705
7.
Mechanism of action of a nanomolar potent, allosteric antagonist of the thyroid-stimulating hormone receptor.
Br J Pharmacol
; 165(7): 2314-24, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22014107
8.
Thyrotropin receptor-stimulating Graves' disease immunoglobulins induce hyaluronan synthesis by differentiated orbital fibroblasts from patients with Graves' ophthalmopathy not only via cyclic adenosine monophosphate signaling pathways.
Thyroid
; 21(2): 169-76, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20954819
9.
Effects of thyrotropin and thyrotropin-receptor-stimulating Graves' disease immunoglobulin G on cyclic adenosine monophosphate and hyaluronan production in nondifferentiated orbital fibroblasts of Graves' ophthalmopathy patients.
Thyroid
; 20(5): 535-44, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20384487
10.
The selective estrogen receptor alpha agonist Org 37663 induces estrogenic effects but lacks antirheumatic activity: a phase IIa trial investigating efficacy and safety of Org 37663 in postmenopausal female rheumatoid arthritis patients receiving stable background methotrexate or sulfasalazine.
Arthritis Rheum
; 62(2): 351-8, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20112368
11.
Decrease of disease activity under ineffective therapy in DMARD-naive patients with early rheumatoid arthritis: role of antibody profiles and carriage of the HLA shared epitope in predicting decrease of disease activity.
J Rheumatol
; 34(10): 1992-6, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17924607
12.
Cytokines elicited by T cell epitopes from a synovial autoantigen: altered peptide ligands can reduce interferon-gamma and interleukin-10 production.
Arthritis Rheum
; 48(8): 2375-85, 2003 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12905493
13.
Functional regulatory immune responses against human cartilage glycoprotein-39 in health vs. proinflammatory responses in rheumatoid arthritis.
Proc Natl Acad Sci U S A
; 101(49): 17180-5, 2004 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-15569925