Detalhe da pesquisa
1.
Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs.
Nat Chem Biol
; 16(3): 240-249, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32080630
2.
Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes.
Mol Pharmacol
; 93(6): 645-656, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29695609
3.
In Vitro Pharmacological Characterization and In Vivo Validation of LSN3172176 a Novel M1 Selective Muscarinic Receptor Agonist Tracer Molecule for Positron Emission Tomography.
J Pharmacol Exp Ther
; 365(3): 602-613, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29643252
4.
An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory.
J Biol Chem
; 291(17): 8862-75, 2016 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26826123
5.
Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus.
Cereb Cortex
; 26(1): 414-26, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26472558
6.
Gain and loss of function of P2X7 receptors: mechanisms, pharmacology and relevance to diabetic neuropathic pain.
Mol Pain
; 10: 37, 2014 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24934217
7.
Discovery of α-Amidobenzylboronates as Highly Potent Covalent Inhibitors of Plasma Kallikrein.
ACS Med Chem Lett
; 15(4): 501-509, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38628785
8.
PET ligands [18F]LSN3316612 and [11C]LSN3316612 quantify O-linked-ß-N-acetyl-glucosamine hydrolase in the brain.
Sci Transl Med
; 12(543)2020 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32404505
9.
Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M1 receptors.
Br J Pharmacol
; 176(1): 110-126, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30276808
10.
Sazetidine-A is a potent and selective agonist at native and recombinant alpha 4 beta 2 nicotinic acetylcholine receptors.
Mol Pharmacol
; 73(6): 1838-43, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18367540
11.
Current status of muscarinic M1 and M4 receptors as drug targets for neurodegenerative diseases.
Neuropharmacology
; 136(Pt C): 449-458, 2018 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29374561
12.
Ligands selective for alpha4beta2 but not alpha3beta4 or alpha7 nicotinic receptors generalise to the nicotine discriminative stimulus in the rat.
Psychopharmacology (Berl)
; 190(2): 157-70, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17115136
13.
M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss.
J Clin Invest
; 127(2): 487-499, 2017 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27991860
14.
TRPV3 in Drug Development.
Pharmaceuticals (Basel)
; 9(3)2016 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27618069
15.
Activation of transient receptor potential ankyrin 1 induces CGRP release from spinal cord synaptosomes.
Pharmacol Res Perspect
; 3(6): e00191, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27022465
16.
123I-iododexetimide preferentially binds to the muscarinic receptor subtype M1 in vivo.
J Nucl Med
; 56(2): 317-22, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25593117
17.
Functional responses and subunit composition of presynaptic nicotinic receptor subtypes explored using the novel agonist 5-iodo-A-85380.
Neuropharmacology
; 47(6): 848-59, 2004 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-15527819
18.
Pharmacological profiling of the TRPV3 channel in recombinant and native assays.
Br J Pharmacol
; 171(10): 2631-44, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23848361
19.
Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain.
J Clin Invest
; 124(5): 2023-36, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24743146
20.
Pharmacological characterisation of ligand- and voltage-gated ion channels expressed in human iPSC-derived forebrain neurons.
Psychopharmacology (Berl)
; 231(6): 1105-24, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24429870