RESUMO
During the mass measles/rubella vaccination campaign in 2003 in Iran, many pregnant women were vaccinated mistakenly or became pregnant within 1 month of vaccination. To distinguish pregnant women who were affected by rubella vaccine as primary infection from those who had rubella reinfection from the vaccine, serum samples were collected 1-3 months after the campaign from 812 pregnant women. IgG avidity assay showed that 0.3% of the women had no rubella-specific IgG response; 14.4% had low-avidity anti-rubella IgG and were therefore not immune to rubella before vaccination; 85.3% had high-avidity anti-rubella IgG and were regarded as cases of reinfection.
Assuntos
Anticorpos Antivirais/imunologia , Técnicas Imunoenzimáticas/métodos , Imunoglobulina G/imunologia , Complicações Infecciosas na Gravidez/epidemiologia , Vacina contra Rubéola/efeitos adversos , Vírus da Rubéola/imunologia , Rubéola (Sarampo Alemão)/epidemiologia , Adolescente , Adulto , Anticorpos Antivirais/sangue , Afinidade de Anticorpos/imunologia , Distribuição de Qui-Quadrado , Feminino , Humanos , Técnicas Imunoenzimáticas/normas , Imunoglobulina G/sangue , Irã (Geográfico)/epidemiologia , Vacinação em Massa/efeitos adversos , Vacinação em Massa/métodos , Erros Médicos/estatística & dados numéricos , Valor Preditivo dos Testes , Gravidez , Complicações Infecciosas na Gravidez/sangue , Complicações Infecciosas na Gravidez/imunologia , Complicações Infecciosas na Gravidez/virologia , Rubéola (Sarampo Alemão)/sangue , Rubéola (Sarampo Alemão)/imunologia , Rubéola (Sarampo Alemão)/virologia , Vacina contra Rubéola/imunologia , Estudos Soroepidemiológicos , Estatísticas não ParamétricasRESUMO
In this study in the Islamic Republic of Iran 365 measles cases were evaluated to distinguish between primary infection with measles and reinfection due to secondary vaccine failure. All cases previously confirmed by detection of specific IgM were tested for IgG avidity. A secondary immune response was seen in 18.4% of patients. All unvaccinated patients (16.7%) showed a primary immune response. Of 244 patients with documented vaccination, 75.8% showed a primary immune response and 24.2% showed a secondary immune response, thereby indicating a secondary vaccine failure. Almost all measles reinfections (99%) were seen in patients >10 years old, indicating that vaccination for 10-year-old children is recommended.
Assuntos
Anticorpos Antivirais/sangue , Imunoglobulina G/sangue , Vacina contra Sarampo/efeitos adversos , Vírus do Sarampo/imunologia , Sarampo/diagnóstico , Sarampo/etiologia , Adolescente , Adulto , Distribuição por Idade , Afinidade de Anticorpos , Criança , Pré-Escolar , Diagnóstico Diferencial , Necessidades e Demandas de Serviços de Saúde , Humanos , Imunização Secundária , Técnicas Imunoenzimáticas , Imunoglobulina M/sangue , Irã (Geográfico)/epidemiologia , Vacinação em Massa/efeitos adversos , Sarampo/sangue , Sarampo/epidemiologia , Sarampo/imunologia , Sarampo/prevenção & controle , Vacina contra Sarampo/imunologia , Recidiva , Inquéritos e Questionários , Falha de Tratamento , Saúde da População Urbana/estatística & dados numéricosRESUMO
During the mass measles/rubella vaccination campaign in 2003 in Iran, many pregnant women were vaccinated mistakenly or became pregnant within 1 month of vaccination. To distinguish pregnant women who were affected by rubella vaccine as primary infection from those who had rubella reinfection from the vaccine, serum samples were collected 1-3 months after the campaign from 812 pregnant women. IgG avidity assay showed that 0.3% of the women had no rubella-specific IgG response; 14.4% had low-avidity anti-rubella IgG and were therefore not immune to rubella before vaccination; 85.3% had high-avidity antirubella IgG and were regarded as cases of reinfection
Assuntos
Imunoglobulina G , Gravidez , Rubéola (Sarampo Alemão) , Afinidade de Anticorpos , Vacina contra RubéolaRESUMO
In this study in the Islamic Republic of Iran 365 measles cases were evaluated to distinguish between primary infection with measles and reinfection due to secondary vaccine failure. All cases previously confirmed by detection of specific IgM were tested for IgG avidity. A secondary immune response was seen in 18.4% of patients. All unvaccinated patients [16.7%] showed a primary immune response. Of 244 patients with documented vaccination, 75.8% showed a primary immune response and 24.2% showed a secondary immune response, thereby indicating a secondary vaccine failure. Almost all measles reinfections [99%] were seen in patients >10 years old, indicating that vaccination for 10- year- old children is recommended