Clinicopathological characteristics of incidental prostate cancer discovered from radical cystoprostatectomy specimen: a multicenter French study.

PURPOSE: The present study assessed the incidence and histopathological features of incidentally diagnosed prostate cancer (PCa) in specimens from radical cystoprostatectomy (RCP) for bladder cancer. The patient outcomes also were evaluated. METHODS: We retrospectively reviewed the histopathological features and survival data of 4,299 male patients who underwent a RCP for bladder cancer at 25 French centers between January 1996 and June 2012. No patients had preoperative clinical or biological suspicion of PCa. RESULTS: Among the 4,299 RCP specimens, PCa was diagnosed in 931 patients (21.7%). Most tumors (90.1%) were organ-confined (pT2), whereas 9.9% of them were diagnosed at a locally advanced stage (≥pT3). Gleason score was <6 in 129 cases (13.9%), 6 in 575 cases (61.7%), 7 (3 + 4) in 149 cases (16.0%), 7 (4 + 3) in 38 cases (4.1%), and >7 in 40 cases (4.3%). After a median follow-up of 25.5 months (interquartile range 14.2-47.4), 35.4% of patients had bladder cancer recurrence and 23.8% died of bladder cancer. Only 16 patients (1.9%) experienced PCa biochemical recurrence during follow-up, and no preoperative predictive factor was identified. No patients died from PCa. CONCLUSIONS: The rate of incidentally diagnosed PCa in RCP specimens was 21.7%. The majority of these PCas were organ-confined. PCa recurrence occurred in only 1.9% of cases during follow-up.

[Management of testicular torsion by a general surgeon isolated in Africa]. / Prise en charge de la torsion du testicule par un chirurgien généraliste isolé en Afrique.

The onset of sudden and intense scrotal pain exposes to several problems when it occurs in a young man in Africa. Among the possible etiologies, testicular torsion is the surgical emergency to rule out, because beyond 6 hours of evolution the functional prognosis of the testicle is concerned. The septic evolution towards a purulent melting, in case of exceeded torsion, is also possible. Of slightly lower incidence than in Western countries, lack of awareness of this pathology by local health actors, the precariousness or health isolation of certain populations in certain under-medicalized regions, contribute to diagnostic and therapeutic delays. This often leads to a pejorative development, loss of the testicle being directly correlated with the delay in treatment. Testicular torsion has thus been identified as one of the main causes of male infertility in Africa. However, clinical diagnosis and surgical treatment require few resources and remain accessible in an environment with low resources or in precarious conditions. Indeed, despite the contribution of ultrasound in certain situations, the clinical picture is at the center of the diagnosis and therapeutic decision making. At the slightest doubt, surgical exploration is necessary. The multi-tunic anatomy of the testicle facilitates its surgical fixation in the event of conservation, ideally by triangulation of single-strand non-absorbable thread. Simultaneous fixation of the contralateral testicle is currently the subject of debate in the literature. In Africa, the benefit/risk balance, taking into account in particular the difficulty of subsequent access to care, justifies, from our point of view, performing contralateral orchidopexy at the same time. Depending on the appearance of the testicle and, to a lesser extent, the duration of the evolution of the symptoms, orchidectomy may be necessary. This article describes the clinical picture of spermatic cord torsion and the orchidopexy technique.

Treatment of a ballistic wound of the common carotid artery revealed by a spontaneous carotid-jugular fistula.

The case reported is of a 30-year-old patient with a left internal carotid-jugular fistula secondary to the explosion of an improvised explosive device during the Afghan war. Carotid resection with arterial bypass using a venous allograft and internal jugular ligation were performed by left cervicotomy associated with sternotomy at a specialized center. The management of cervical arteriovenous fistulas that occur as a result of penetrating trauma faced during the war must be considered and it should be noted that, on battlefields, treatment is not always performed in specialized units.

Unusual presentation of testicular cancer with tumor thrombus extending to the inferior vena cava.

A 45-year-old man with a left testis tumor with a 25 mm para-aortic lymph node swelling, multiple bilateral pulmonary metastases, bilateral pulmonary embolism, and inferior vena cava (IVC) thrombus underwent a radical orchidectomy in our institution. The thrombus extended from the left gonadal vein to the left renal vein to the IVC. The fluorine-18 fluorodeoxyglucose (f-FDG) positron emission tomography (PET) computerized tomography (CT) demonstrated a hypermetabolic focus in the retroperitoneum and in the IVC thrombus. Before orchidectomy only lactate dehydrogenase (LDH) was high but all the serum tumor markers increased postoperatively. The tumor was staged pT1N2M1aS1, which was an intermediate prognosis, based on the International Germ Cell Cancer Collaborative Group consensus (IGCCCG). After 4 courses of bleomycin, etoposide, and cisplatin (BEP) chemotherapy the patient's tumor markers normalized and the thrombus disappeared. There was only one residual retroperitoneal lymph node M1. Retroperitoneal lymph node dissection was performed. The pathological examination revealed only necrotic tissues. The patient has been disease-free since surgery.

A 20-Year Epidemiological Review of Testis Cancer at a French Military Hospital.

OBJECTIVES: To determine if the epidemiology of testis cancer in military service has followed worldwide trends and if the end of conscription in 2000 in France marked an epidemiologic turn. METHODS: All of the patients who had an orchiectomy for a testis germ tumor from January 1990 to January 2011 were studied. The patients were divided into two groups: orchiectomy before 2000 and after 2000. RESULTS: 289 patients were included, with a mean age of 30.8. The mean age at diagnosis increased significantly as well as the proportion of stage 1 seminomas, whereas stage 1 nonseminomatous germ cell tumors (NSGCT) slightly decreased. For stage 1 seminomas, there was an increase in the surveillance (10% vs. 31%) and in the number of chemotherapies (19% vs. 22%); for stage 1 NSGCT, surveillance also increased (53% vs. 64%). The specific 5-year survival was 98.3%. CONCLUSIONS: We noted an increase in the number of stage 1 seminomas, the surveillance of located germ tumors, and an excellent survival rate. However, the population was younger with regard to national data, and the number of stage 1 NSGCT decreased in favor of advanced metastatic tumors.

Efficacy of flexible ureterorenoscopy with holmium laser in the management of stone-bearing caliceal diverticula.

PURPOSE: We aim to evaluate the outcome of flexible ureterorenoscopy (F-URS) with a holmium laser in managing stone-bearing caliceal diverticula as a minimally invasive option. PATIENTS AND METHODS: We retrospectively reviewed the records of 38 patients who underwent F-URS using a holmium laser from 2003 to 2009 for symptomatic stone-bearing caliceal diverticula. The presenting symptoms were renal colic, urinary tract infection, or hematuria. F-URS was used in 30 (78.9%) patients as an alternative after the failure of shockwave lithotropsy (SWL). F-URS was repeated twice for two patients. In the first patient, the indication was uncompleted fragmentation of the stone. In the second patient, it was because of failure to identify the diverticulum. The follow-up visit ranged from 4 to 6 weeks with plain radiography of the kidneys, ureters, and bladder and either renal ultrasonography or noncontrast CT. RESULTS: Patients who were included in the study were 38: 22 women and 16 men (mean age 45.7 years; range 18-72 years). Post-F-URS, 21 (55.3%) patients were rendered stone free (SF), 10 (26.3%) patients had clinically insignificant residual fragments (less than 4 mm) (CIRF), and a residual fragment (RF) was found in seven (18.4%) patients. The success rate was considered as SF or CIRF, which was obtained in 31 (81.6%) patients. In total, 34 (90%) patients were symptom free after the procedure. CONCLUSION: F-URS using a holmium laser is a very effective, minimally invasive technique. It could be the best option in managing stone-bearing caliceal diverticula, especially for those patients in whom there was SWL failure. The development of the actively deflectable ureteroscope with miniaturization allowed us to obtain a high success rate, low morbidity, and a brief hospital stay.

Flexible ureterorenoscopy with holmium laser in horseshoe kidneys.

OBJECTIVES: To assess the outcome of flexible ureterorenoscopy (F-URS) with the holmium laser in treating stones in the horseshoe kidney (HSK). METHODS: We retrospectively reviewed the records of 17 patients with a HSK stone (17 renal units) who had undergone F-URS with the holmium laser from December 2004 to May 2009. The presenting symptoms were renal colic, urinary tract infection, or hematuria. F-URS was used in as an alternative after the failure of shock wave lithotripsy in 8 patients (47%) and percutaneous nephrolithotomy failure in 4 patients (23.5%). Follow-up examination was performed after 4-6 weeks with plain radiography and either renal ultrasonography or noncontrast computed tomography. Success was defined as stone-free status or residual fragments <3 mm. The use of auxiliary procedures was considered to indicate treatment failure. RESULTS: A total of 17 patients were included in the present study (3 females and 14 males). Their age was 16-52 years (mean age ± SD 34.7 ± 6.3). The HSK stone location was 7 mixed caliceal, 3 mixed pelvic and caliceal, and 7 pelvic. The average stone burden was 16 mm (range 7-35). The overall number of procedures was 25 (mean 1.5 procedures/patient). Of the 17 patients, 15 (88.2%) were rendered stone free. CONCLUSIONS: The results of our study have shown that F-URS with the holmium laser is an efficient minimal invasive procedure for treating HSK stones.