Prevention and treatment of cisplatin-induced ototoxicity in adults: A systematic review.

OBJECTIVES: Ototoxicity is a common disabling side effect of platinum-based chemotherapy. This study aimed to assess the evidence on the management of platinum-induced ototoxicity in adult cancer patients. METHODS: Four databases were searched up to 1 November 2022. Original studies were included if they reported on a pharmacologic or non-pharmacologic intervention to prevent or treat platinum ototoxicity in adults. The articles' quality was assessed via two grading scales. RESULTS: Nineteen randomised controlled trials and five quasi-experimental studies with 1673 patients were analysed. Eleven interventions were identified, nine pharmacological and two non-pharmacological. Six of the interventions (sodium thiosulphate, corticoids, sertraline, statins, multivitamins and D-methionine) showed mild benefits in preventing cisplatin-induced ototoxicity. Only one trial assessed corticoids as a potential treatment. Overall, only six trials were deemed with a low risk of bias. The majority of studies inadequately documented intervention-related adverse effects, thereby limiting safety conclusions. CONCLUSIONS: Current interventions have mild benefits in preventing cisplatin-induced ototoxicity in adult cancer patients. Sodium thiosulphate is the most promising intervention as a preventive strategy. Rigorous, high-quality research is warranted, encompassing an evaluation of all potential symptoms and innovative treatment modalities.

Clonal Distribution and Antibiotic Susceptibility of Staphylococcus aureus from Pediatric Patients: 8-Year Trends in a Children's Hospital in Colombia.

Emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strains in healthcare settings has changed the hospital epidemiology of MRSA in the last few years. Despite a global increase in MRSA frequency, infections caused by methicillin-susceptible S. aureus (MSSA) have persisted in healthcare settings and the community. Staphylococcus aureus isolates were collected between 2009 and 2017 at the Children's Hospital of a Caribbean city in South America. Methicillin-resistant isolates were subjected to SCCmec typing. Representative isolates were analyzed by multilocus sequence typing (MLST) and spa typing. Antibiotic susceptibility was assessed by agar dilution method. D-zone test was performed in erythromycin-resistant isolates to determine macrolide/lincosamide/streptogramin resistance. Spa typing revealed 10 different spa types. The main epidemic clones circulating during the study period were: ST8-MRSA-IVc, ST923-MRSA-IVa and ST8-MRSA-IVa. The study found high frequencies of PVL genes and resistance to erythromycin and clindamycin in the isolates. This study provides the first description of the population structure of MRSA and MSSA causing infections attended in the participating Children's Hospital. ST8-MRSA-IVc, ST923-MRSA-IVa and ST8-MRSA-IVa were the most prevalent in the isolate population.

This study was aimed to determine the distribution of sequence types, SCCmec types and antibiotic resistance profiles of MRSA and MSSA isolates recovered from pediatric patients with clinical infections attended in the Children's Hospital of a Caribbean city in South America in a period spanning 8 years. We found high frequencies of PVL genes and resistance to erythromycin and clindamycin in the isolates. The fact that MRSA and MSSA isolates in this study were frequently resistant to erythromycin and clindamycin is an indication of the selective pressure imposed by the extensive use of these two antibiotics in the treatment of skin and soft tissue infections in the geographical area of this study. This is the first study reporting the clonal distribution of Staphylococcus aureus causing infections in the pediatric population of Cartagena, a tropical city in the Caribbean coast of Colombia.

Appendectomy Skin Closure Technique, Randomized Controlled Trial: Changing Paradigms (ASC).

BACKGROUND: Appendectomy is the most frequent and urgent gastrointestinal surgery. Overtime, the surgical techniques have been improved upon, in order to reduce complications, get better cosmetic results, and limit the discomfort associated with this procedure, by its high impact in the surgery departments. The traditional skin closure is associated with a poor cosmetic result and it requires stitches removal, alongside the pain associated with this procedure, and no benefits were demonstrated in the literature regarding separated stitches over intradermic stitch. This is a randomized controlled trial, and our objective is to compare two different skin closure techniques in open appendectomy. METHODS: A prospective randomized trial method was used, with a total number of 208 patients participating in the study, after acute appendicitis diagnosis in the emergency department. They were randomized into two groups: patients who would receive skin closure with a unique absorbable intradermic stitch (Group A) and another group that would receive the traditional closure technique, consistent in non-absorbable separated stitches (Group B). General characteristics like gender, age, Body Mass Index (BMI), comorbidities, and allergies were registered. Days of Evolution (DOE) until surgery, previous use of antibiotics, complicated or uncomplicated appendicitis, surgical time, and wound complications like skin infection, dehiscence, seroma or abscess were also registered in each case. RESULTS: 8 patients were excluded due to negative appendicitis during surgery and lack of follow-up. Two groups, each containing 100 patients, were formed. General characteristics and parity were compared, and no statistically significant differences were observed. Difference in the surgical time (Group A: 47.35 min vs Group B: 54.13 min, p < .001) and cases with complicated appendicitis (Group A: 58 and Group B:38, p = .005) were found to be statistically significant. Four wound complications were reported, and the incidence of seroma (Group A:0 and Group B:5, p = .02) and abscess (Group A:2 and Group B:8, p = .05) were found to have some statistical significant difference. In a multivariate analysis, a relationship was observed between BMI > 25 kg/m2 and seroma (p = .006), BMI > 25 kg/m2 and abscess (p = .02), surgical time >50 min and seroma (p < .001), >2 DOE and abscess (p = .001), and complicated appendicitis with seroma development (p = .03). CONCLUSION: Open appendectomy skin closure with a unique absorbable intradermic stitch is safe, with a reduced seroma and abscess incidence, compared to traditional closure, and an equivalent dehiscence and superficial infection incidence, allowing a lower hospital attention cost and length of hospital stay for treatment of complications. The relative risk of complications with traditional skin closure is 2.91 higher, compared to this new technique.

Venous thromboembolism and cannabis consumption, outcomes among hospitalized patients in the United States: A nationwide analysis.

Venous Thromboembolism (VTE) carries significant clinical implications, and with the rise in cannabis consumption, its potential influence on VTE outcomes warrants investigation. Using the National Inpatient Sample (NIS) database (2016-2019), we analyzed 2,217,184 hospitalized VTE patients. Among these, 1.8 % (38,810) reported cannabis use. We compared demographics, comorbidities, in-hospital outcomes, and quality metrics between cannabis users and non-users with VTE. Cannabis users were chiefly younger males (average age 45 in cannabis users vs. 62 in non-cannabis users) from lower-income brackets. Notably, 5.4 % discharged against medical advice. Although in-hospital mortality was initially lower for cannabis users (2.8 % vs. 5.1 %, OR 0.6, 95 % CI 0.69-0.94, p = 0.008), this difference became non-significant post-propensity-score matching (aOR 0.9, 95% CI 0.72-1.10, p = 0.3). Non-users faced higher in-hospital complications, a trend that persisted post-PSM. Among cannabis users, key mortality predictors were peripheral vascular disease, acute kidney injury, vasopressor use, cardiogenic shock, myocardial infarction, invasive ventilation, and surgical embolectomy. Cannabis users also had a shorter hospital stay (4.2 vs. 5.4 days) and slightly reduced costs ($27,472.95 vs. $31,660.75). The significantly younger age of VTE patients who use cannabis, coupled with the considerable proportion discharging against medical advice, underscores the urgency for tailored care interventions. Additional research is vital to comprehensively understand the interplay between cannabis consumption and VTE outcomes.

Leser-Trélat Syndrome, an Underdiagnosed Cutaneous Paraneoplastic Syndrome That Could Aid in Early Detection of Colon Cancer: A Case Report.

Leser-Trélat syndrome, a rare cutaneous paraneoplastic phenomenon, has gained attention for its potential role as an early indicator of underlying internal malignancies. This article presents a comprehensive case study of a 67-year-old male with a history of alcohol and tobacco use, emphasizing the importance of recognizing this syndrome in clinical practice. The sudden onset of seborrheic keratoses on the thorax and back, retrospectively identified as Leser-Trélat syndrome, prompted investigations that led to the early diagnosis of a colon adenocarcinoma. We discuss the pathophysiology, clinical relevance, and controversies surrounding this syndrome, highlighting the need for increased awareness among healthcare professionals. Timely recognition of Leser-Trélat syndrome can significantly impact patient care, leading to improved prognoses for associated neoplasms. This case underscores the importance of comprehensive evaluations and further research to enhance our understanding and management of cutaneous paraneoplastic syndromes.

Unraveling Bacillus Calmette-Guérin (BCG) Therapy Side Effects in Bladder Cancer: A Tale of Triumph Over Treatment Challenges.

This case report presents a 66-year-old male with a complex medical history, including testicular cancer, chronic obstructive pulmonary disease, obstructive sleep apnea, tobacco use disorder, erectile dysfunction, and obesity. The patient exhibited recurrent gross hematuria, leading to a comprehensive workup. Cystoscopy revealed a bladder tumor, prompting transurethral resection and mitomycin C instillation. Subsequent intravesical Bacillus Calmette-Guérin (BCG) therapy was initiated but resulted in severe sepsis during maintenance. Despite initial suspicion of BCG-induced sepsis, further evaluation suggested a reaction with chemical cystitis. Treatment involved brief antimicrobial therapy, and the patient's condition improved. This case highlights the challenges in managing BCG therapy complications, emphasizing the need for prompt intervention, careful monitoring, and consideration of risk factors. Patient education and vigilant follow-ups are crucial for addressing potential long-term effects.

COVID-19 and Clostridioides difficile Coinfection Outcomes among Hospitalized Patients in the United States: An Insight from National Inpatient Database.

The incidence of Clostridioides difficile infection (CDI) has been increasing compared to pre-COVID-19 pandemic levels. The COVID-19 infection and CDI relationship can be affected by gut dysbiosis and poor antibiotic stewardship. As the COVID-19 pandemic transitions into an endemic stage, it has become increasingly important to further characterize how concurrent infection with both conditions can impact patient outcomes. We performed a retrospective cohort study utilizing the 2020 NIS Healthcare Cost Utilization Project (HCUP) database with a total of 1,659,040 patients, with 10,710 (0.6%) of those patients with concurrent CDI. We found that patients with concurrent COVID-19 and CDI had worse outcomes compared to patients without CDI including higher in-hospital mortality (23% vs. 13.4%, aOR: 1.3, 95% CI: 1.12-1.5, p = 0.01), rates of in-hospital complications such as ileus (2.7% vs. 0.8%, p < 0.001), septic shock (21.0% vs. 7.2%, aOR: 2.3, 95% CI: 2.1-2.6, p < 0.001), length of stay (15.1 days vs. 8 days, p < 0.001) and overall cost of hospitalization (USD 196,012 vs. USD 91,162, p < 0.001). Patients with concurrent COVID-19 and CDI had increased morbidity and mortality, and added significant preventable burden on the healthcare system. Optimizing hand hygiene and antibiotic stewardship during in-hospital admissions can help to reduce worse outcomes in this population, and more efforts should be directly made to reduce CDI in hospitalized patients with COVID-19 infection.

Complete genome and plasmid sequences of Staphylococcus aureus strain COL52-A5 isolated from a persistent nasal carrier.

OBJECTIVES: Persistent colonization with Staphylococcus aureus is associated with a higher risk of invasive infections. With increasing rates of colonization, especially with antibiotic-resistant strains, it may be useful to identify specific characteristics of colonization that confer a greater infection risk. Therefore, whole-genome sequencing (WGS) of an S. aureus strain isolated from a medical student identified as a persistent carrier in Cartagena, Colombia, was performed to better characterize the strain and to identify genetic components associated with virulence and antimicrobial resistance. METHODS: Antimicrobial susceptibility testing was performed for several antibiotics. Total genomic DNA was extracted and WGS was performed on a PacBio RS II sequencing platform. Whole-genome assembly was generated using PacBio SMRT Analysis v.2.3.0 and HGAP v.1.2. In silico analysis of the chromosomal and plasmid components of this strain was performed using tools available online. RESULTS: Strain COL52-A5 was identified as a Panton-Valentine leukocidin (PVL)-positive methicillin-resistant S. aureus (MRSA) carrying staphylococcal cassette chromosome mec (SCCmec) type IVa and was resistant to cefoxitin, erythromycin, clindamycin and tetracycline. The completely closed genome of strain COL52-A5 was 2 820 086 bp with a GC content of 32.84% and it harboured one large plasmid, two active prophages, five antimicrobial resistance determinants and several virulence factors. The allelic profile was consistent with sequence type ST923 (CC8). CONCLUSION: Genome analysis of strain COL52-A5 found numerous virulence and resistance factors. Further comparison of genomic sequences from persistent and intermittent strains is required to gain insights into the genomic features that favour persistent carriage in healthy individuals.

Detection of Escherichia coli enteropathogens by multiplex polymerase chain reaction from children's diarrheal stools in two Caribbean-Colombian cities.

Acute diarrheal disease is a leading cause of childhood morbidity and mortality in the developing world and Escherichia coli intestinal pathogens are important causative agents. Information on the epidemiology of E. coli intestinal pathogens and their association with diarrheal disease is limited because no diagnostic testing is available in countries with limited resources. To evaluate the prevalence of E. coli intestinal pathogens in a Caribbean-Colombian region, E. coli clinical isolates from children with diarrhea were analyzed by a recently reported two-reaction multiplex polymerase chain reaction (Gomez-Duarte et al., Diagn Microbiol Infect Dis 2009;63:1-9). The phylogenetic group from all E. coli isolates was also typed by a single-reaction multiplex polymerase chain reaction. We found that among 139 E. coli strains analyzed, 20 (14.4%) corresponded to E. coli diarrheagenic pathotypes. Enterotoxigenic, shiga-toxin-producing, enteroaggregative, diffuse adherent, and enteropathogenic E. coli pathotypes were detected, and most of them belonged to the phylogenetic groups A and B1, known to be associated with intestinal pathogens. This is the first report on the molecular characterization of E. coli diarrheogenic isolates in Colombia and the first report on the potential role of E. coli in childhood diarrhea in this geographic area.

Staphylococcus aureus nasal carriage and microbiome composition among medical students from Colombia: a cross-sectional study.

Background: The anterior nares are the main ecological niche for Staphylococcus aureus, an important commensal and opportunistic pathogen. Medical students are frequently colonized by a variety of pathogens. Microbial interactions in the human nose can prevent or favor colonization by pathogens, and individuals colonized by pathogens have increased risk of infection and are the source of transmission to other community members or susceptible individuals. According to recent studies, the microbiome from several anatomic areas of healthy individuals varies across different ethnicities. Although previous studies analyzed the nasal microbiome in association with S. aureus carriage, those studies did not provide information regarding ethnicity of participants. Our aim was to assess S. aureus nasal carriage patterns and prevalence among medical students from Colombia, a country of Hispanic origin, and to investigate possible associations of colonization and nasal microbiome composition (bacterial and fungal) in a subgroup of students with known S. aureus carriage patterns. Methods: Nasal swabs from second-year medical students were used to determine prevalence and patterns of S. aureus nasal carriage. Based on microbiological results, we assigned participants into one of three patterns of S. aureus colonization: persistent, intermittent, and non-carrier. Then, we evaluated the composition of nasal microbial communities (bacterial and fungal) in 5 individuals from each carriage category using 16S rRNA and Internal-Transcribed-Spacer sequencing. Results: Prevalence of S. aureus nasal carriage among medical students was 28%. Carriage of methicillin-resistant strains was 8.4% and of methicillin-sensitive strains was 19.6%. We identified 19.6% persistent carriers, 17.5% intermittent carriers, and 62.9% non-carriers. Conclusions: Analysis of nasal microbiome found that bacterial and fungal diversity was higher in individuals colonized by S. aureus than in non-carriers; however, the difference among the three groups was non-significant. We confirmed that fungi were present within the healthy anterior nares at substantial biomass and richness.

Características clínicas de gestantes en trabajo de parto con infección SARSCoV-2 en la altura: serie de casos / Clinical characteristics of pregnant women in labor with SARS-CoV-2 infection at high altitude: A case series

Resumen Introducción. A gran altitud, se ha observado menos casos y menos letalidad de COVID-19 en comparación con cifras reportadas a nivel del mar. Actualmente no hay publicaciones que informen el comportamiento clínico de COVID-19 en mujeres embarazadas adaptadas a la altura e hipoxia crónica en el Perú. Métodos. Estudio retrospectivo mediante revisión de historias clínicas del 6 de marzo de 2020 al 15 de junio de 2020. Se describe los primeros trece casos de gestantes con COVID-19 atendidos en el Hospital COVID-19 Simón Bolívar, ubicado a 2 750 msnm. Los casos procedían de altitudes entre 2 035 msnm y 3 502 msnm. El análisis estadístico se realizó con SPSS, versión 19.0. Resultados. Trece casos de gestantes con COVID-19 confirmado por IGM para SARS-CoV-2, fueron tratadas a 2 750 msnm (9 022,31 pies), en los Andes peruanos. El parto fue por cesárea en ocho casos (61,5%) y por vía vaginal en cinco (38,5%). Hubo dos casos (15,4%) de preeclampsia, uno de ellos diagnosticado como síndrome HELLP, prematuridad y muerte fetal. Tres casos (23,1%) desarrollaron hipotonía uterina posparto y requirieron sutura de Hayman o B-Lynch. Dos casos (15,4%) se complicaron con oligohidramnios y otros dos casos con infección urinaria. Los niveles de hemoglobina variaron entre 11,1 y 16 g/dL. Solo un caso (7,7%) presentó sintomatología, con dolor faríngeo leve. No se observó transmisión vertical detectada por IgM/IgG para SARS-CoV-2. La evolución clínica fue favorable en los trece casos y el alta fue a los 2 a 4 días, para continuar la cuarentena en domicilio. Conclusiones. En el presente estudio preliminar, las gestantes en trabajo de parto con COVID-19 por prueba rápida IgM para SARS-CoV-2 en la altura fueron generalmente asintomáticas; no hubo transmisión vertical. Se presentó alto porcentaje de otras complicaciones obstétricas.

Abstract Introduction: Fewer COVID-19 cases and less lethality have been observed at high altitude compared to cases reported at sea level. There are currently no publications reporting clinical behavior of pregnant women with COVID-19 at high altitude. Methods: This is a retrospective study with review of medical records between March 6, 2020 and June 15, 2020. The first thirteen cases of pregnant women with COVID-19 who were attended at Simón Bolívar COVID-19 Hospital, located at 2 750 meters above sea level, are described. The cases came from altitudes between 2 035 and 3 502 meters above sea level (masl). Statistical analysis used SPSS, version 19.0. Results: Thirteen cases of pregnant women with COVID-19 confirmed by IgM for SARS-CoV-2 were attended at 2 750 masl (9 022.31 feet) in the Peruvian Andes. Delivery by cesarean section occurred in eight cases (61.5%) and five (38.5%) delivered vaginally. There were two cases (15.4%) of preeclampsia, one with diagnosis of HELLP syndrome, prematurity and fetal death. Three cases (23.1%) developed uterine hypotonia that required Hayman or B-Lynch suture. Two cases (15.38%) were complicated with oligohydramnios and two with urinary infection. Hemoglobin levels were between 11.1 and 16 g/dL. Only one case (7.7%) was symptomatic, with mild pharyngeal pain. No vertical transmission was detected by IgM/IgG for SARS-CoV-2. Clinical evolution was favorable in the thirteen cases and they were discharged after 2 to 4 days hospitalization to continue home quarantine. Conclusions: Results in this short study show pregnant women in labor with COVID-19 by rapid IgM test for SARS-CoV-2 at high altitude were mostly asymptomatic; there was no vertical transmission, but high presence of other obstetrical complications.

Simulación versus exposición convencional en la enseñanza de preeclampsia severa

Objective: To determine if simulation is more effective than conventional exposition in the improvement in nurses' knowledge of severe preeclampsia. Methods: Crosssectional quasi-experimental study in two private clinics in Cajamarca, Peru. We compared the improvement in nurses' knowledge of severe preeclampsia: 13 attended to a conventional exposition about severe preeclampsia (Exconv) and 16, the experimental group, had the same exposition and four simulation training sessions (Sim). We conducted a pretest in both groups and a posttest in 20 participants; these were composed of multiple choice questions previously validated by experts; Spearman-Brown reliability was 0.76. The simulation training sessions were recorded in video and evaluated by an expert with a checklist adapted from the American College of Obstetricians and Gynecologists. Data was processed with SPSS 20.0. We used Spearman-Brown correlation tests and Student's t test for paired samples to compare the scores obtained in pretest and posttest, p <0.05. Results: The control group's (Exconv) pretest and posttest scores were 11.69 ± 2.53 and 13.85 ± 2.27, p = 0.02, and pedagogical gain was 2.15 ± 2.88. The experimental group's (Sim) pretest and posttest scores were 10.25 ± 2.79 and 14.69 ± 1.89, with a pedagogical gain of 4.44 ± 2.22, p = 0.000. The pedagogical gain of the experimental group was greater than that of the control group, p = 0.002. Conclusions: Greater improvement in knowledge was obtained by teaching severe preeclampsia with simulation training sessions than with conventional exposition solely.

Objetivo. Determinar si la simulación es más efectiva que la exposición convencional en la mejora cognitiva de enfermeras en preeclampsia severa. Métodos. Investigación transversal cuasiexperimental realizada en dos clínicas de Cajamarca, Perú. Se comparó las mejoras cognitivas de enfermeras sobre la preeclampsia severa: 13 fueron sometidas a exposición convencional sobre preeclampsia severa (Exconv) y 16, asignadas al grupo experimental, tuvieron una exposición y 4 sesiones de simulación (Sim). Ambos grupos respondieron un pretest y, luego de las sesiones, un postest de 20 preguntas de opción múltiple, previamente validado por expertos y con confiabilidad de Spearman-Brown de 0,76. Todas las sesiones de simulación fueron guardadas en vídeo y evaluadas por un experto, con lista de verificación adaptada del American College of Obstetricians and Gynecologists. Los datos fueron procesados con el programa SPSS 20.0. Se usaron las pruebas Spearman-Brown de correlación, t de student para muestras relacionadas para comparar los puntajes obtenidos en pretest y postest, con p< 0,05. Resultados. Los puntajes del grupo control (Exconv) en el pretest y postest fueron: 11,69 ± 2,53 y 13,85 ± 2,27, p=0,02, con ganancia pedagógica de 2,15 ± 2,88. Los puntajes de pretest y postest del grupo experimental (Sim) fueron 10,25 ± 2,79 y 14,69 ± 1,89, con ganancia pedagógica de 4,44 ± 2,22 con p=0,000. Las ganancias pedagógicas del grupo experimental fueron mayores que las del grupo control, con p=0,002. Conclusión. La enseñanza de preeclampsia severa con simulación obtuvo mejoras cognitivas mayores que con la exposición convencional.

Enfermedad cerebrovascular hemorrágica en la eclampsia asociada al síndrome HELLP / Stroke in HELLP syndrome-associated eclampsia

Introduction: Eclampsia (E) and HELLP syndrome (H) are two complications of preeclampsia that increase maternal morbidity and mortality. The main complication and the main cause of death of this EH / HE association is the hemorrhagic cerebrovascular disease (HCD). Objectives: To determine differences between women with EH / HE who presented HCD and those who did not. To define the types of HCD in women with EH / HE. Design: Cross-sectional comparative study. Patients: Cases of EH / HE at the Hospital Regional Docente de Cajamarca, Peru, 2015. Interventions: Patients with EH / HE were divided into two groups: those without HCD and those with HCD. SPSS 20.0 was used. The comparison of groups was done with Mann Whitney U and chi square tests. Significant differences were when p <0.05. Results: There were 23 women with EH / HE: 18 (78.3%) without HCD and 5 (21.7%) with HCD. We compared women with EH / HE who had HCD and those who did not. HCD had OR = 4.44 (95% CI 1.19-16.55) p = 0.043 for risk of death, and platelets less than 30 000 had OR = 4.44 (95% CI 1.19-16,55) with p = 0.043 risk for HCD. In addition, the stay in ICU was longer in those with HCD than without HCD. Mortality was 60%; 80% of the HCD had ventricular compromise. There was 66.7% of the patients presented subarachnoid hemorrhage and 66.7%, intraventricular hemorrhage (IVH). In IVH, 100% had lobar compromise of which 66.7% had occipital compromise. Conclusions: Hemorrhagic cerebrovascular disease in women with HELLP syndrome associated with eclampsia is related to lower platelet levels; this increases the risk of death and prolongs stay in the intensive care unit.

Introducción. La eclampsia (E) y el síndrome HELLP (H) son dos complicaciones de la preeclampsia que, asociadas, pueden aumentar la morbimortalidad materna. La principal complicación y la causa principal de muerte de esta asociación EH/ HE es la enfermedad cerebrovascular hemorrágica (ECH). Objetivos. Determinar diferencias entre las mujeres con EH/HE que presentan ECH y las que no. Definir los tipos de ECH en mujeres con EH/HE. Diseño. Estudio transversal comparativo. Pacientes. Casos de EH/HE en el Hospital Regional Docente de Cajamarca, Perú, 2015. Intervenciones. Se dividió las pacientes con EH/HE en dos grupos: sin ECH y con ECH. Se utilizó el software SPSS 20.0. La comparación de los grupos se realizó con la U de Mann Whitney y chi cuadrado. Fueron diferencias significativas cuando p< 0,05. Resultados. Hubo 23 mujeres con EH/HE: 18 (78,3%) sin ECH y 5 (21,7%) con ECH. Comparamos las mujeres con EH/HE que tenían o no ECH. ECH tuvo OR 4,44 (IC95% 1,19 a 16,55) con p=0,043 de riesgo de muerte, y las plaquetas menores de 30 000 tuvieron OR 4,44 (IC95% 1,19 a 6,55) con p=0,043 de riesgo de ECH. Además, la permanencia en UCI fue mayor que en las que no tuvieron ECH. La mortalidad fue 60%. El 80% de las ECH mostró compromiso ventricular. Hubo 66,7% de hemorragia subaracnoidea y 66,7% de hemorragia intraventricular (HIC). En las HIC, el 100% tuvo compromiso lobar, de las cuales 66,7% mostró compromiso occipital. Conclusiones. La ECH en mujeres con síndrome HELLP asociado a eclampsia estuvo relacionado a valores más bajos de plaquetas y aumentó el riesgo de muerte y estancia en cuidados intensivos.

Características moleculares y susceptibilidada antibióticos de cepas de Staphylococcusaureus colonizantes de pacientes conpatologías nasales procedentes de Cartagena(Colombia), 2015: estudio observacional / Molecular characterization and antibiotic susceptibility of Staphylococcus aureus strains colonizing patients with nasal pathology from Cartagena (Colombia), 2015: observational study

Staphylococcus aureus es uno de los principales patógenos causantes deinfecciones tanto a nivel hospitalario como comunitario. El objetivo de este estudio fuedeterminar características moleculares y los perfiles de resistencia a antibióticos deaislamientos de Staphylococcus aureus colonizantes de pacientes con patología nasalatendidos en el servicio de Otorrinolaringología del Hospital Universitario del Caribede la ciudad de Cartagena, Colombia. Métodos: los aislamientos de Staphylococcusaureus obtenidos de pacientes colonizados fueron sometidos a extracción de ADNy ensayos de PCR para determinar la presencia de los genes mecA y lukS/F-PV.Se determinó la pertenencia de las cepas a los complejos clonales CC5 y CC8, y sedeterminaron las relaciones clonales de los aislamientos mediante análisis de PFGE.A las cepas SARM se les tipificó y sub-tipificó el casete cromosomal estafilocócicoSCCmec mediante PCR múltiple. Resultados: la prevalencia de colonización encontradapara Staphylococcus aureus fue 22.8% y 5.26% para SARM. Del total de aislamientosSARM, 33.3% estuvieron relacionados con el clon CC8-SARM-IVc y 22.28%con CC8-SARM-IVa. Los genes para la leucocidina PVL se identificaron en 66.7% deaislamientos SARM y 40% de aislamientos sensibles a meticilina (SASM)...

Comercializacion de sucedaneos de la leche materna en farmacias de la ciudad de La Paz y El Alto, 1996 / Commerce of succedaneous maternal milk in drug strores in the cities of La Paz and El Alto, 1996

El estudio muestra los resultados de una encuesta realizada en las ciudades de la Paz y El Alto, sobre comercializacion de sucedaneos de la leche materna (todo alimento comercializado o de otro modo presentado como substituto parcial o toal de la leche materna, sea o no adecuado para este fin) y alimentos complentarios (todo alimento manufacturado o preparado localmente, que convenga como complemento de la leche matrna o de las preparaciones para lactantes, cuando aquella o estas resulten insuficientes para satisfacer las necesidades nutricionales del lactante. Este tipo de alimento se suele llamar tambien "alimento de destete" o suplemento de la leche materna) en 78 farmacias de estas ciudades. Los encuestadores personificaron familiares con problemas para amamantar a su bebe, solicitando orientacion sobre acciones mas aconsejables. Preguntas tales como si es necesario visitar a un medico, suspender la lactancia materna, iniciar alimentacion con leche artificial o formula infantil, precio del sucedaneo, tiempo de administracion, producto aconsejado, edad de incio de alimentos complementarios al bebe, fueron planteadas. Se indago sobre el criterio de los responsables de farmacias sobre la utilidad o no de los estimulantes del apetito y/o vitaminas, las marcas de biberones (mamaderas) y chupones (tetinas), si ellos los recomiendan y si las leches maternizadas son saludables, sus desventajas y ventajas. Los resultados de estas interrogantes y otras se presentan y discusion en el presente articulo