Detalhe da pesquisa
1.
Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV.
Bioorg Med Chem Lett
; 27(9): 2038-2046, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28285916
2.
Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench-Stable Organozinc Reagents.
Angew Chem Int Ed Engl
; 55(44): 13714-13718, 2016 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-27690172
3.
A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells.
ACS Chem Biol
; 17(9): 2595-2604, 2022 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36044633
4.
Attenuation of scratch-induced reactive astrogliosis by novel EphA4 kinase inhibitors.
J Neurochem
; 118(6): 1016-31, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21736568
5.
First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates.
J Pharmacol Exp Ther
; 328(1): 131-40, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18854490
6.
Reducing Limitation in Probe Design: The Development of a Diazirine-Compatible Suzuki-Miyaura Cross Coupling Reaction.
ACS Med Chem Lett
; 10(1): 56-61, 2019 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30655947
7.
Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.
J Med Chem
; 58(20): 8154-65, 2015 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26397965
8.
Novel selectfluor and deoxo-fluor-mediated rearrangements. New 5(6)-methyl and phenyl methanopyrrolidine alcohols and fluorides.
Org Lett
; 6(10): 1669-72, 2004 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-15128263
9.
Correction to Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.
J Med Chem
; 59(1): 486, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26709958
10.
Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors.
Bioorg Med Chem Lett
; 17(21): 5831-5, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17827011
11.
Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.
Bioorg Med Chem Lett
; 17(14): 4057-61, 2007 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17482814
12.
Strategies towards improving the pharmacokinetic profile of ε-substituted lysinol-derived HIV protease inhibitors.
ChemMedChem
; 6(2): 253-7, 2011 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21275047
13.
Convenient preparations of 2,4-methanopyrrolidine and 5-carboxy-2,4-methanopyrrolidines.
J Org Chem
; 68(19): 7562-4, 2003 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-12968923
14.
Evolution of tertiary carbinamine BACE-1 inhibitors: Abeta reduction in rhesus CSF upon oral dosing.
ChemMedChem
; 4(1): 37-40, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19085994