RESUMO
The chemotactic activities of neutrophil granulocytes of patients with pustular and vulgar psoriasis were evaluated before and after treatment with etretinate. Control values before treatment were significantly different from those of vulgar psoriasis group but not from the pustular psoriasis group. The difference between the 2 groups with psoriasis was significant. Etretinate causes a significant reduction in neutrophil chemotaxis in pustular psoriasis patients and a less pronounced reduction in those with vulgar psoriasis.
Assuntos
Quimiotaxia de Leucócito/efeitos dos fármacos , Etretinato/farmacologia , Neutrófilos/imunologia , Psoríase/imunologia , Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , SupuraçãoRESUMO
To assess the differences in the granulometry of milk fat globules between swine and bovine species, milk samples from 30 lactating sows were analyzed for fat globule dimensions and compared with cow milk samples. Results showed differences between the fat globules: sow milk presents reduced globule diameters compared with cow milk (volume-weighted diameter 2.62 vs. 3.27 microm, p < 0.001) and reduced interglobular distance. A positive relationship was observed between milk fat content and globule diameter, while a slight, insignificant inverse trend was detected between the day of lactation and fat globule diameter. These complex interactions between milk lipids, globule membrane proteins, and globule dimensions provide a better understanding of digestion/absorption phenomena in the design of milk replacers.
Assuntos
Glicolipídeos/análise , Glicoproteínas/análise , Leite/química , Suínos/fisiologia , Animais , Bovinos , Feminino , Regulação da Expressão Gênica , Gotículas Lipídicas , Proteínas de Membrana/genética , Proteínas de Membrana/metabolismo , Leite/fisiologia , Especificidade da EspécieRESUMO
The authors describe a case of recurrent dermal abscess infections resistant to usual antibiotic therapy and demonstrating a failing of the activity of the neutrophils and a remarkable increase of plasmatic IgA. The treatment with Levamisole regularized the laboratory data and, as a result, determined a consequent important improvement of the patient.
Assuntos
Abscesso/tratamento farmacológico , Quimiotaxia de Leucócito , Imunoglobulina A/análise , Levamisol/uso terapêutico , Dermatopatias Infecciosas/tratamento farmacológico , Adulto , Antibacterianos/uso terapêutico , Humanos , Masculino , Neutrófilos , Fagocitose , RecidivaRESUMO
The authors show that the use of Isotretinoin (Ro 4-3740) in cystic acne brings a reduction of chemotactic activity of the neutrophil granulocytes, like another retinoid, Etretinate, in pustular and vulgar psoriasis. This effect of retinoids, with a direct action on the polymorphonuclear leukocytes plays an important role in the recovery of the disease.