Detalhe da pesquisa
1.
Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer.
Cell
; 175(5): 1244-1258.e26, 2018 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30454645
2.
DNA polymerase θ protects leukemia cells from metabolically induced DNA damage.
Blood
; 141(19): 2372-2389, 2023 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36580665
3.
Design and synthesis of functionalized piperazin-1yl-(E)-stilbenes as inhibitors of 17α-hydroxylase-C17,20-lyase (Cyp17).
Bioorg Med Chem Lett
; 28(13): 2270-2274, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29803730
4.
Design, synthesis, and evaluation of (2S,4R)-Ketoconazole sulfonamide analogs as potential treatments for Metabolic Syndrome.
Bioorg Med Chem Lett
; 26(23): 5825-5829, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27789139
5.
Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists.
Bioorg Med Chem Lett
; 25(6): 1196-205, 2015 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25686852
6.
MC180295 is a highly potent and selective CDK9 inhibitor with preclinical in vitro and in vivo efficacy in cancer.
Clin Epigenetics
; 16(1): 3, 2024 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38172923
7.
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors.
Nat Commun
; 15(1): 2862, 2024 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38580648
8.
Haploinsufficiency of ZNF251 causes DNA-PKcs-dependent resistance to PARP inhibitors in BRCA1-mutated cancer cells.
Res Sq
; 2023 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37066268
9.
Novel brain penetrant benzofuropiperidine 5-HT6 receptor antagonists.
Bioorg Med Chem Lett
; 22(1): 120-3, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22153937
10.
Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: identification of a potent and selective 5-HT6 receptor antagonist showing activity in rat social recognition test.
Bioorg Med Chem Lett
; 22(3): 1421-6, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22226656
11.
2-Arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: optimization via array synthesis.
Bioorg Med Chem Lett
; 18(8): 2640-4, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18374566
12.
A selective small molecule agonist of the melanocortin-1 receptor inhibits lipopolysaccharide-induced cytokine accumulation and leukocyte infiltration in mice.
J Leukoc Biol
; 80(4): 897-904, 2006 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16888084
13.
Discovery of tyrosine-based potent and selective melanocortin-1 receptor small-molecule agonists with anti-inflammatory properties.
J Med Chem
; 46(7): 1123-6, 2003 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-12646021
14.
Directed sorting approach for the synthesis of large combinatorial libraries of discrete compounds.
Methods Enzymol
; 369: 75-99, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-14722948