Detalhe da pesquisa
1.
JNJ-26070109 [(R)4-bromo-N-[1-(2,4-difluoro-phenyl)-ethyl]-2-(quinoxaline-5-sulfonylamino)-benzamide]: a novel, potent, and selective cholecystokinin 2 receptor antagonist with good oral bioavailability.
J Pharmacol Exp Ther
; 338(1): 328-36, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21493750
2.
Characterization of a robust enzymatic assay for inhibitors of 2-oxoglutarate-dependent hydroxylases.
J Biomol Screen
; 14(6): 627-35, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19498081
3.
Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists I: discovery of CCKR1 selectivity in a previously CCKR2-selective lead series.
Bioorg Med Chem Lett
; 19(22): 6373-5, 2009 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19811913
4.
Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists II: tuning of receptor selectivity and in vivo efficacy.
Bioorg Med Chem Lett
; 19(22): 6376-8, 2009 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19815410
5.
Discovery of potent cholecystokinin-2 receptor antagonists: elucidation of key pharmacophore elements by X-ray crystallographic and NMR conformational analysis.
Bioorg Med Chem
; 16(7): 3917-25, 2008 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18289861
6.
Synthesis and solid-phase purification of anthranilic sulfonamides as CCK-2 ligands.
Bioorg Med Chem Lett
; 17(24): 6905-9, 2007 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18029172
7.
Species-dependent smooth muscle contraction to Neuromedin U and determination of the receptor subtypes mediating contraction using NMU1 receptor knockout mice.
Br J Pharmacol
; 147(8): 886-96, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16474416
8.
Neuromedin U stimulates contraction of human long saphenous vein and gastrointestinal smooth muscle in vitro.
Regul Pept
; 136(1-3): 109-16, 2006 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-16782214
9.
Pharmacological analysis of CCK2 receptors up-regulated using engineered transcription factors.
Regul Pept
; 129(1-3): 227-32, 2005 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15927720
10.
Cell lines for drug discovery: elevating target-protein levels using engineered transcription factors.
J Biomol Screen
; 9(1): 44-51, 2004 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-15006148
11.
Obestatin reduces food intake and suppresses body weight gain in rodents.
Biochem Biophys Res Commun
; 357(1): 264-9, 2007 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-17418097
12.
3-[5-(3,4-Dichloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-2-m-tolyl-propionate (JNJ-17156516), a novel, potent, and selective cholecystokinin 1 receptor antagonist: in vitro and in vivo pharmacological comparison with dexloxiglumide.
J Pharmacol Exp Ther
; 323(2): 562-9, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17684117