1.
Bioorg Med Chem Lett
; 28(5): 922-925, 2018 03 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29433927
RESUMO
Nicotinamide N-methyltransferase (NNMT) has been linked to obesity and diabetes. We have identified a novel nicotinamide (NA) analog, compound 12 that inhibited NNMT enzymatic activity and reduced the formation of 1-methyl-nicotinamide (MNA), the primary metabolite of NA by â¼80% at 2â¯h when dosed in mice orally at 50â¯mg/kg.