Detalhe da pesquisa
1.
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2.
Proc Natl Acad Sci U S A
; 120(2): e2212931120, 2023 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36598939
2.
Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein-Protein Interaction from Nonselective Fragments.
J Am Chem Soc
; 145(37): 20328-20343, 2023 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37676236
3.
From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew Chem Int Ed Engl
; 62(37): e202308004, 2023 09 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37455289
4.
Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease.
PLoS Pathog
; 11(7): e1005058, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-26186534
5.
Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease.
Bioorg Med Chem Lett
; 25(21): 4834-4837, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26144347
6.
Identifying ligands for the PHD1 finger of KDM5A through high-throughput screening.
RSC Chem Biol
; 5(3): 209-215, 2024 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38456036
7.
Novel cinnoline-based inhibitors of LRRK2 kinase activity.
Bioorg Med Chem Lett
; 23(1): 71-4, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23219325
8.
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors.
Bioorg Med Chem Lett
; 23(16): 4674-9, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23856050
9.
Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors.
Bioorg Med Chem Lett
; 23(9): 2743-9, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23522834
10.
A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers.
ACS Cent Sci
; 9(5): 937-946, 2023 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37252362
11.
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 Macrodomain of SARS-CoV-2.
bioRxiv
; 2022 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35794891
12.
Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement.
Bioorg Med Chem Lett
; 21(12): 3726-9, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21570836
13.
Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor.
Bioorg Med Chem Lett
; 21(6): 1838-43, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21316234
14.
Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK.
Bioorg Med Chem Lett
; 20(24): 7303-7, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21071223
15.
TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling.
Int J Parasitol Drugs Drug Resist
; 8(3): 571-586, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30503203
16.
Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97.
ACS Med Chem Lett
; 9(11): 1075-1081, 2018 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30429948
17.
Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni.
PLoS Negl Trop Dis
; 10(1): e0004356, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26751972
18.
Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway.
ACS Med Chem Lett
; 7(2): 182-7, 2016 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26985295
19.
2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition.
Science
; 351(6275): 871-5, 2016 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26822609
20.
A Fragment-Based Ligand Screen Against Part of a Large Protein Machine: The ND1 Domains of the AAA+ ATPase p97/VCP.
J Biomol Screen
; 20(6): 788-800, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25690569