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1.
J Integr Neurosci ; 21(1): 8, 2022 Jan 28.
Artigo em Inglês | MEDLINE | ID: mdl-35164444

RESUMO

We report on our remote speech therapy experience in post-stroke aphasia. The aim was to test the feasibility and utility of telerehabilitation to support future randomized controlled trials. Post-stroke aphasia is a common and disabling speech disorder, which significantly affects patients' and caregivers' health and quality of life. Due to COVID-19 pandemic, most of the conventional speech therapy approaches had to stop or "switch" into telerehabilitation procedures to ensure the safety of patients and operators but, concomitantly, the best rehabilitation level possible. Here, we planned a 5-month telespeech therapy programme, twice per week, of a patient with non-fluent aphasia following an intracerebral haemorrhage. Overall, treatment adherence based on the operator's assessments was high, and incomplete adherence for technical problems occurred very rarely. In line with the patient's feedback, acceptability was also positive, since he was constantly motivated during the sessions and the exercises performed autonomously, as confirmed by the speech therapist and caregiver, respectively. Moreover, despite the sequelae from the cerebrovascular event, evident in some writing tests due to the motor deficits in his right arm and the disadvantages typical of all telepractices, more relevant results were achieved during the telerehabilitation period compared to those of the "face-to-face" therapy before the COVID-19 outbreak. The telespeech therapy performed can be considered successful and the patient was able to return to work. Concluding, we support it as a feasible approach offering patients and their families the opportunity to continue the speech and language rehabilitation pathway, even at the time of pandemic.


Assuntos
Afasia/reabilitação , Reabilitação do Acidente Vascular Cerebral/métodos , Acidente Vascular Cerebral/complicações , Telerreabilitação , Afasia/etiologia , COVID-19 , Humanos , Terapia da Linguagem/métodos , Masculino , Pessoa de Meia-Idade , Pandemias , Fonoterapia/métodos , Resultado do Tratamento
2.
Surg Endosc ; 30(4): 1503-7, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-26139504

RESUMO

BACKGROUND: Several laparoscopic approaches to the adrenal gland have been described. We prefer the lateral transabdominal approach. The aim of this study is to evaluate prospectively the presence of any anatomical and dynamic changes in the spleen after laparoscopic transperitoneal left adrenalectomy (LTLA), which can cause an increased risk of early and late complications. METHODS: We have evaluated 21 patients before and 6 months after surgery in order to verify the possible presence of a wandering spleen. A clinical and instrumental follow-up [ultrasound (US), magnetic resonance (MR)] were performed. During US protocol, in supine, right lateral, and orthostatic position, the longitudinal and anteroposterior diameter of the spleen and the resistive index within 3 cm of the origin of the splenic artery in three different measurements averaged were measured. MR protocol evaluated, in supine and right lateral position, the splenic volume and its distances from the diaphragm dome and the lateral margin of the costal arch. RESULTS: p Values calculated for each parameter were not statistically significant. Our results confirm the absence of any anatomical and dynamic changes in the spleen after LTLA. CONCLUSIONS: The most common complications after laparoscopic adrenalectomy are well known and widely described. Our experience does not exclude the occurrence of a wandering spleen, but allows us to state that a rightful mobilization of the pancreaticosplenic block can avoid this event, and in agreement with other authors, the presence of a wandering spleen remains an isolated complication.


Assuntos
Adrenalectomia , Laparoscopia , Baço Flutuante/diagnóstico por imagem , Adolescente , Doenças das Glândulas Suprarrenais/cirurgia , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias , Estudos Prospectivos , Baço Flutuante/etiologia , Adulto Jovem
3.
World J Surg Oncol ; 14: 98, 2016 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-27036391

RESUMO

BACKGROUND: Splenic cysts are rare disease. Epidermoid cysts of the spleen belong to the primary nonparasitic splenic cysts group. They are an unusual event in surgical practice. Usually, epidermoid cysts occur in children and young female. Most often, they are asymptomatic, but they may present with abdominal discomfort. CASE PRESENTATION: We are reporting a rare case of a 23-year-old female came to our attention with history of intermittent pain and previously undergone two times to laparoscopic decapsulation of the cyst in others institutions. During hospitalization, serum and intracystic levels of tumor marker CA19-9 increased. Enhanced CT of the abdomen showed recurrent large cyst in the upper pole of the spleen with satellite nodules. Laparotomic total splenectomy was performed. Histopathological and immunoreactive examinations were executed, and they revealed stratified squamous epithelium on the inner surface of cystic wall, which was positive for EMA, CEA, and CA19-9. The diagnosis of epidermoid cyst was confirmed. CONCLUSIONS: Recently, the surgical approach is changing towards conservative treatments in order to save the spleen in young patients for immunological reasons. Sometimes, this target is not achievable. In such circumstances, like recurrent large cyst, anomalous anatomical relationship to the surrounding tissues, total splenectomy is safe and necessary.


Assuntos
Cisto Epidérmico/patologia , Esplenopatias/patologia , Adulto , Cisto Epidérmico/cirurgia , Feminino , Humanos , Laparoscopia , Prognóstico , Recidiva , Esplenectomia , Esplenopatias/cirurgia , Adulto Jovem
4.
Ann Ital Chir ; 94: 435-442, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38051507

RESUMO

Pancreatic surgery e pancreatic fistula (POPF) is a potentially fatal sequela with substantial morbidity and mortality. POPF incidence and risk factors vary. This study aimed to evaluate the incidence and risk factors of patients with pancreatic fistula (PF) from patients undergoing various pancreatic surgeries for different pancreatic diseases. MATERIAL AND METHODS: A retrospective observational study was conducted in the surgical unit of our university hospitals from July 2014 to July 2019. Three hundred forty-seven patients were admitted with a clinical diagnosis of pancreatic fistula following both open and laparoscopic approaches for pancreatic benign and malignant tumors. RESULTS: The most prevalent age was >60 years (67%), with a male predominance (83%). The most common diagnosis before surgery was pancreatic head adenocarcinoma (32%), followed by duodenal neoplasm (19%) and true epithelial pancreatic cystic neoplasms (18%), ampullary neoplasms (15%), bile duct neoplasms (12%), neuroendocrine neoplasms (2%), and chronic pancreatitis (2%). The most prevalent site of the pancreatic tumor was the head (87%), while accompanied Jaundice (47%) and epigastric discomfort (37%) were the commonest presentations before surgery. Pancreatic duct diameter greater than 3 mm was present in 208 patients (60%), tumor size greater than 3 cm in 63%, hard pancreatic texture in 67%, and preoperative ERCP with a stent in 37% of cases. Tumor in the tail of the pancreas was found in 5% (17 patients) of cases. The commonest operations performed were open pylorus-preserving pancreaticoduodenectomy, open pancreaticoduodenectomy without pylorus-preserving, and open distal pancreatectomy with splenic preservation. Postoperative pancreatic fistula occurred in 8% of cases (27), with ISPGF grade A (biochemical leak) occurring in 17 patients (17/27) and clinically significant POPF occurring in 10 patients (10/27). POPF occurred in 13 patients after distal pancreatectomy, 11 patients after pancreaticoduodenectomy, two cases followed central pancreatectomy, and one. Grade B after pancreaticoduodenectomy and two after distal pancreatectomy. Grade C POPF occurred in four patients after pancreaticoduodenectomy but not after distal pancreatectomy. Age >55 (p=0.00), male (p=0.03), presence of symptom (p=0.0008), location at Head of the pancreas (p=0.0004), elevated CA19-9 (p=0.0004), jaundice (p=0.0001) and pancreatic texture (p=0.00**). CONCLUSION: Pancreatic fistula occurred in 27 patients (8%), a comparatively low incidence. POPF was linked to age, Jaundice, gender, pancreatic head cancer, symptoms, high CA 19-9, jaundice, and a soft pancreas. POPF incidence was higher after distal pancreatectomy, whereas POPF severity was higher after pancreaticoduodenectomy KEY WORDS: Pancreaticoduodenectomy, Pancreatic Fistula, Pancreatic Resection, Postoperative Complications.


Assuntos
Icterícia , Neoplasias Pancreáticas , Humanos , Masculino , Pessoa de Meia-Idade , Feminino , Fístula Pancreática/epidemiologia , Fístula Pancreática/etiologia , Pâncreas/patologia , Pancreatectomia/efeitos adversos , Pancreaticoduodenectomia/efeitos adversos , Neoplasias Pancreáticas/patologia , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/cirurgia , Fatores de Risco , Icterícia/etiologia , Icterícia/complicações , Estudos Retrospectivos
5.
Ann Ital Chir ; 82(5): 405-8, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-21988050

RESUMO

Biliary papillomatosis is a disease characterized by multiple papillary tumours of variable distribution and extent in the intrahepatic and/or extrahepatic biliary tree. Papillary carcinoma can develop within these lesions. Because biliary papillomatosis is a rare biliary pathological entity, its clinical features and outcome are not well known. The course of this disease is very prolonged. This diagnostic difficulty is due above all to the problematic distinction between biliary papillomatosis and cholelithiasis. Therapeutic strategy should be decided pre-operatively among resection, transplantation or stent. In many cases surgical strategy is decided during surgery, considering the mass extension, the local infiltration and the patient's age, and, when possible, with the aid of extemporaneous histological examination. Recently we experienced a case of biliary papillomatosis of the common hepatic duct in a 82-year-old man, presented with obstructive jaundice and pain in the right upper quadrant and epigastrium radiated to the ipsilateral scapula. First we made cholecystectomy and we positioned the T-tube. The follow-ups performed with laboratory tests and T-tube cholangiogram showed no jaundice but the filling defect in the common bile duct was still present. So we performed a resection of the common bile duct and an hepatico-jejunostomy at the hepatic pedicle. The histological examination showed a villous adenoma of the common bile duct with high-grade dysplasia.


Assuntos
Neoplasias dos Ductos Biliares/diagnóstico , Neoplasias dos Ductos Biliares/cirurgia , Ducto Hepático Comum , Papiloma/diagnóstico , Papiloma/cirurgia , Dor Abdominal/etiologia , Idoso de 80 Anos ou mais , Neoplasias dos Ductos Biliares/complicações , Colecistectomia , Diagnóstico Diferencial , Hepatectomia , Ducto Hepático Comum/patologia , Ducto Hepático Comum/cirurgia , Humanos , Icterícia Obstrutiva/etiologia , Jejunostomia , Masculino , Papiloma/complicações , Resultado do Tratamento
6.
Artigo em Inglês | MEDLINE | ID: mdl-34501904

RESUMO

Reliability, accuracy, and timeliness of diagnostic testing for SARS-CoV-2 infection have allowed adequate public health management of the disease, thus notably helping the timely mapping of viral spread within the community. Furthermore, the most vulnerable populations, such as people with intellectual disability and dementia, represent a high-risk group across multiple dimensions, including a higher prevalence of pre-existing conditions, lower health maintenance, and a propensity for rapid community spread. This led to an urgent need for reliable in-house rapid testing to be performed prior to hospital admission. In the present study, we describe a pooling procedure in which oropharyngeal and nasopharyngeal swabs for SARS-CoV-2 detection (performed prior to hospital admission using rapid RT-PCR assay) are pooled together at the time of sample collection. Sample pooling (groups of 2-4 samples per tube) allowed us to significantly reduce response times, consumables, and personnel costs while maintaining the same test sensitivity.


Assuntos
COVID-19 , Deficiência Intelectual , Hospitais , Humanos , Deficiência Intelectual/diagnóstico , Deficiência Intelectual/epidemiologia , Reação em Cadeia da Polimerase em Tempo Real , Reprodutibilidade dos Testes , SARS-CoV-2 , Sensibilidade e Especificidade
7.
Ann Ital Chir ; 92: 521-530, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34548426

RESUMO

INTRODUCTION: The improvement of surgical procedures and oncological outcomes in the treatment of low-ultralow rectal cancer, made important the evaluation of functional results. The aim of this study is to evaluate the functional results after open and laparoscopic approach. PATIENTS AND METHODS: From our global experience, over the period 2000/2018, within the patients surgically treated for rectal cancer, we have gathered and studied 37 patients with low-ultralow site of lesion, submitted to sphincterpreserving surgery, subdivided based on the approach: 20 open, 17 laparoscopic, of which 8 robotic . For each type of procedure, as low and ultralow anterior resection, intersphinteric resection, abdominoperineal resection, were investigated functional outcomes, as bowel continence, urinary functions, male and female sexual functions, based on the following tests: Wexner Incontinence Score, International Prostatic Symptom Score, International Index of Erectile Function- 5, Female Sexual Function Index. The controls were performed before surgery and 3-6-12 months postoperatively. Statistical analisis: X2-test, impaired and paired t-test two tailed, Bonferroni post-hoctest. RESULTS: The immediate surgical results and pathological features of the tumor are reported and evaluated. The evaluation of fecal continence in all patients submitted to rectal resection and primary anastomosis showed function compromission without differences statistically significant between the laparo and open approach. In the comparison between specific surgical procedures, the damage of continence function were more severe after intersphinteric resection mached with low-ultralow rectal resection. The rehabilitation therapies continued for several months after surgery showed clear improvement. The urinary continence, in male and female patients, did not show statistically significant alterations in the pre and postoperative comparison in relation to the approach and the type of resective intervention. The sexual function in male patients has had impairment after all type of surgical resection but the damage was more severe after intersphinteric resection. The female sexual function had not significant changes between pre and postoperative evaluation. CONCLUSION: Bowel continence damage, urinary and sexual dysfunctions after surgical treatment for low-ultralow rectal cancer are frequent and form the low anterior resection syndrome. The severity of the syndrome is connected with the site of anastomosis. The rehabilitation therapies can play an important role in achieving the appreciable improvements of the functional alterations. KEY WORDS: Laparoscopic surgery, Rectal cancer.


Assuntos
Laparoscopia , Protectomia , Neoplasias Retais , Feminino , Humanos , Masculino , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Neoplasias Retais/cirurgia , Síndrome , Resultado do Tratamento
8.
Ann Ital Chir ; 81(3): 177-81, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-21090557

RESUMO

OBJECTIVES: Acute biliary pancreatitis (ABP) is caused by alteration of the papillary patency. The normal transpapillar flux and the cleaning of the common biliary duct (CBD) may prevent potentially avoidable recurrent pancreatitis. METHODS: In the period September 1997/December 2008 we have treated 224 ABP (34 severe, 190 mild/moderate): 162 (72,4%) with the first attack, 62 (27.6%) with recurrent ABP (second or further attack). The patients with recurrent pancreatitis had not undergone, in the previous hospital stay elsewhere, the evaluation and, if necessary, the treatment of the papillary obstacle and/or CBD stones, sludge, etc. In our hospital all patients had undergone the treatment of ABR The treatment was completed with cholecystectomy. All the patients, after the discharge, were introduced in a follow-up program (clinical and ultrasonographic (US) control after 180 days and 1 year). RESULTS: In the follow-up of recurrent pancreatitis we have controlled 35 patients (56%-27 lost). The results of the follow-up showed, beside the absence of recurrent acute episodes, the stable normalization of laboratory cholestasis tests and US control. The same controls in 78 patients (48.1%) with a first attack of acute pancreatitis resulted normal in absence of a new acute episode. CONCLUSIONS: Recurrent ABP have been caused by persistent papillary obstacle. Therefore we confirm therapeutic validity of the instrumental control (US/MRCP) and the possible treatment of papillary or biliary lithiasic obstacle for the prevention of recurrent ABP?


Assuntos
Colelitíase/terapia , Pancreatite/terapia , Doença Aguda , Adulto , Idoso , Idoso de 80 Anos ou mais , Colecistectomia , Colecistectomia Laparoscópica , Colelitíase/complicações , Colelitíase/diagnóstico , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Pancreatite/diagnóstico , Pancreatite/etiologia , Estudos Retrospectivos , Prevenção Secundária , Índice de Gravidade de Doença , Resultado do Tratamento
9.
JSLS ; 13(2): 269-72, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-19660231

RESUMO

BACKGROUND: Peripancreatic fluid collection suggests the anatomical-clinical scenario of necrotizing acute pancreatitis. However, intrahepatic fluid collection is a rare occurrence with fewer than 30 cases being reported in the medical literature. We describe 2 cases of intrahepatic fluid collection in 2 patients with acute biliary pancreatitis and discuss the therapeutic possibilities. CASE REPORTS: The first case report is that of a 68-year-old female with a diagnosis of acute biliary pancreatitis with several necrotizing fluid collections and a large infected intrahepatic collection in the left lobe. The patient was successfully treated by percutaneous US/CT guided drainage. The second case report is that of a 72-year-old female with a diagnosis of acute biliary pancreatitis with several peripancreatic fluid collections and a voluminous intrahepatic fluid collection in the left lobe that caused epigastric pain. This patient was also successfully treated with percutaneous US/CT guided drainage. CONCLUSION: Intrahepatic fluid collection in the course of acute biliary pancreatitis is a rare occurrence. The therapeutic approach is the same as that for pancreatic and peripancreatic fluid collections. In case of infection, the patient undergoes percutaneous US/CT guided drainage. This therapeutic procedure can be added to the therapeutic program for necrotizing acute biliary pancreatitis together with ERCP/ES and videolaparocholecystectomy (VLC).


Assuntos
Colangiopancreatografia Retrógrada Endoscópica , Drenagem/métodos , Cálculos Biliares/complicações , Hepatopatias/cirurgia , Pancreatite/cirurgia , Idoso , Feminino , Humanos , Hepatopatias/etiologia , Pancreatite/complicações , Pancreatite/etiologia , Cirurgia Assistida por Computador , Tomografia Computadorizada por Raios X
10.
Ann Ital Chir ; 80(5): 363-7, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-20131548

RESUMO

OBJECTIVES: The importance of papillary obstruction in the pathogenesis of acute biliary pancreatitis (ABP) is widely recognized. The aim of this study was to evaluate the usefulness of the MRCP before the VLC in the patients with mild acute biliary pancreatitis. METHODS: In the period 2003-2008, 47 patients were submitted to a MRCP (F/M: 28/19) with mild ABP without increase of the cholestasis tests and absence of choledocholithiasis at the abdominal US. During a follow up from 30 to 60 days after the VLC, the presence of jaundice or relapse of ABP were evaluated in all patients. RESULTS: Thirteen patients had diagnosis of choledocholithiasis at the MRCP and they were submitted to an ERCP endoscopic sphincterotomy and stones removal; 34 patients with a negative MRCP were submitted to the VLC. Among these, on 10th postoperative days, one patient has had recurrent ABP, and was submitted to ERCP/ES. All the 47 patients submitted to the MRCP before the VLC did not have jaundice or relapse of the ABP during the follow-up period. CONCLUSION: The MRCP was an accurate investigation for the preoperatory diagnosis of choledocholithiasis; even if it is not possible to recommend its utilization extensively, it is an important procedure for the patients with diagnosis of mild ABP to select all those to submit to the ERCP.


Assuntos
Colangiopancreatografia por Ressonância Magnética , Colecistectomia , Pancreatite/diagnóstico , Pancreatite/cirurgia , Cuidados Pré-Operatórios , Doença Aguda , Adulto , Idoso , Colestase/complicações , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Pancreatite/etiologia , Índice de Gravidade de Doença
11.
Ann Coloproctol ; 35(5): 238-241, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31725998

RESUMO

PURPOSE: Surgery is the only treatment for anal fistula. Many surgical techniques have been described. The aim of this study was to communicate the authors' preliminary experience in the use of a recently proposed, simplified technique. METHODS: This was a prospective study of 28 patients admitted from January 13, 2016 through July 20, 2017. Patients were managed with the ligation of intersphincteric fistula tract (LIFT) technique and results were observed and documented, including recurrence rate, incontinence rate, and other postoperative complications. RESULTS: A total of 28 patients were studied. The mean operation time was 31 minutes (range, 23-44 minutes), and there were no intra- and postoperative complications. The overall complete healing rate was 85.7%, and the recurrence rate was 14.2%. Follow-up was conducted at 1, 3, and 6 months. CONCLUSION: Many surgical techniques have been described for the treatment of anal fistula. The correct choice of surgical technique out of available procedures is the most important factor for proper treatment and reducing the risk of recurrence or incontinence. In the authors' experience, the LIFT technique is simple and easy to learn, and is a good choice for the treatment of simple anal fistula; however, a tailored surgery remains the gold standard for this condition.

12.
JSLS ; 12(2): 126-32, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18435883

RESUMO

BACKGROUND AND OBJECTIVES: Umbilical port-site infections after video-laparoscopic cholecystectomy (VLC) are frequent complications. The aim of this prospective randomized study was to verify the validity of topical rifamycin for prevention of post-VLC umbilical infections. METHODS: From September 2006 to April 2007, 48 patients with uncomplicated cholelithiasis who underwent VLC were enrolled in the study. Enrolled patients were randomized into 2 groups. The first group of 24 patients was treated with topical rifamycin to the umbilicus. The second group of 24 patients was not treated with rifamycin. RESULTS: Postoperative umbilical pain with a need for analgesics, presence of signs of inflammation of the umbilical wound, dehiscence of the umbilical skin sutures, and the presence of incisional umbilical hernia on the 60th postoperative day were statistically significantly better in the rifamycin group compared with the control group. CONCLUSIONS: Topical administration of rifamycin to the umbilicus in the pre-, intra- and postoperative periods was a rapid, safe, and economic way to reduce infective complications after VLC.


Assuntos
Antibacterianos/administração & dosagem , Colecistectomia Laparoscópica/efeitos adversos , Colelitíase/cirurgia , Rifamicinas/administração & dosagem , Infecção da Ferida Cirúrgica/prevenção & controle , Administração Tópica , Adulto , Colecistectomia Laparoscópica/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Instrumentos Cirúrgicos , Infecção da Ferida Cirúrgica/etiologia , Resultado do Tratamento , Umbigo , Cirurgia Vídeoassistida
14.
Am J Case Rep ; 19: 400-405, 2018 Apr 05.
Artigo em Inglês | MEDLINE | ID: mdl-29618719

RESUMO

BACKGROUND Voluntary and involuntary ingestion of foreign bodies is a common condition; in most cases they pass through the digestive tract, but sometimes they stop, creating emergency situations for the patient. We report a case of meat bolus with cartilaginous component impacted in the cervical esophagus, with a brief literature review. CASE REPORT A 64-year-old man came to our attention for retention in the cervical esophagus of a piece of meat accidentally swallowed during lunch. After a few attempts of endoscopic removal carried out previously in other hospitals, the patient has been treated by us with a cervical esophagotomy and removal of the foreign body, without any complications. We checked the database of PubMed, Scopus, and the Cochrane Library from January 2007 to January 2017 in order to verify the presence of randomized controlled trials, clinical trials, retrospective studies, and case series regarding the use of the cervical esophagotomy for the extraction of foreign bodies impacted in the esophagus. CONCLUSIONS The crucial point is to differentiate the cases that must be immediately treated from those requiring simple observation. Endoscopic treatment is definitely the first therapeutic option, but in case of failure of this approach, in our opinion, cervical esophagotomy could be a safe, easy, viable, durable approach for the extraction of foreign bodies impacted in the cervical esophagus. Our review does not have the purpose of providing definitive conclusions but is intended to represent a starting point for subsequent studies.


Assuntos
Esofagectomia/métodos , Esôfago , Corpos Estranhos/cirurgia , Deglutição , Endoscopia Gastrointestinal , Corpos Estranhos/diagnóstico , Corpos Estranhos/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Pescoço/cirurgia , Estudos Retrospectivos
15.
Diabetes ; 55(4): 952-61, 2006 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-16567516

RESUMO

In this study, we evaluated the activation of various insulin signaling molecules in human fat in vivo and compared signaling reactions in visceral and subcutaneous fat depots. Paired abdominal omental and subcutaneous fat biopsies were obtained from nonobese subjects with normal insulin sensitivity under basal conditions and 6 and 30 min following administration of intravenous insulin. Insulin receptor phosphorylation was more intense and rapid and insulin receptor protein content was greater in omental than in subcutaneous adipose tissue (P < 0.05). Insulin-induced phosphorylation of Akt also occurred to a greater extent and earlier in omental than in subcutaneous fat (P < 0.05) in the absence of significant changes in Akt protein content. Accordingly, phosphorylation of the Akt substrate glycogen synthase kinase-3 was more responsive to insulin stimulation in omental fat. Protein content of extracellular signal-regulated kinase (ERK)-1/2 was threefold higher in omental than in subcutaneous fat (P < 0.05), and ERK phosphorylation showed an early 6-min peak in omental fat, in contrast with a more gradual increase observed in subcutaneous fat. In conclusion, the adipocyte insulin signaling system of omental fat shows greater and earlier responses to insulin than that of subcutaneous fat. These findings may contribute to explain the biological diversity of the two fat depots.


Assuntos
Tecido Adiposo/fisiologia , Insulina/fisiologia , Células 3T3 , Adipócitos/citologia , Adipócitos/fisiologia , Tecido Adiposo/citologia , Animais , Biópsia , Glicemia/metabolismo , Células Cultivadas , Feminino , Humanos , Masculino , Camundongos , Pessoa de Meia-Idade , Omento , Receptor de Insulina/metabolismo , Valores de Referência , Transdução de Sinais , Pele , Vísceras
16.
JSLS ; 11(2): 225-8, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17761085

RESUMO

BACKGROUND AND OBJECTIVES: The aim of this study was to evaluate the usefulness of gallbladder antegrade dissection (GAD) cholecystectomy to reduce the risk of common biliary duct injuries and to demonstrate that it is an easier and more time-sparing technique than the traditional one. METHODS: The operative procedure performed since 2002 consists of the incision of the visceral peritoneum from the infundibulum away from Calot's triangle along the gallbladder bed up to the fundus. Then it continues from the fundus up to the infundibulum. This method was used to perform 127 laparoscopic cholecystectomies (LC) (first group). We compared the results of 119 LC (second group) performed from 1998 to 2001 by means of a completely retrograde method. RESULTS: In both groups, there were no major complications; 1 vs 4 conversions (0.8% vs 3.4%), mean operative time 70 minutes vs 90 minutes, residual choledocholithiasis in 2 patients in both groups (1.6% for the first group vs 1.7% for the second group). CONCLUSIONS: GAD for laparoscopic cholecystectomy can reduce the time of surgery and is an easier technique to perform. Therefore, it can be proposed as the standard procedure and not only be used for difficult cholecystectomies.


Assuntos
Colecistectomia Laparoscópica/métodos , Doenças da Vesícula Biliar/cirurgia , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias , Estudos Retrospectivos , Resultado do Tratamento
17.
Ann Ital Chir ; 88: 330-335, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29051402

RESUMO

AIM: The purpose of this study is to communicate our experience about the results and effectiveness in the use of the Ttube biliary drainage during pancreaticoduodenectomy. MATERIAL OF STUDY: In accordance whit Whipple we perform the gastric antrum resection during pancreaticoduodenectomy. We have treated 42 patients with pancreaticoduodenectomy, 25 males and 17 females with a mean age of 62 years (range: 53-79 years), and in each of them we have placed a biliary T-tube. RESULTS: Pancreatic fistula was the most common complication and occurred in 10 patients (23.81%), all of these were low-flow fistula (<200 ml) and required only medical treatment. DISCUSSION: Resection of the pancreas is considered a major operative procedure. Pancreatic fistula is the most common complication after pancreaticoduodenectomy, and it was also the most frequent complication observed by us. In pancreaticoduodenectomy T-tube allows lesser risks of complications due to pancreatic fistula and it makes its faster healing. In all cases the treatment was not invasive. CONCLUSIONS: T-tube biliary drainage can make a positive contribution concerning all the complications that can occur after pancreaticoduodenectomy, especially against the pancreatic fistula. KEY WORDS: Pancreaticoduodenectomy, Pancreatic fistula, Pancreas head cancer, Pancreatic Tumors, T-tube drainage.


Assuntos
Sucção/instrumentação , Idoso , Idoso de 80 Anos ou mais , Perda Sanguínea Cirúrgica , Feminino , Humanos , Jejunostomia , Masculino , Pessoa de Meia-Idade , Duração da Cirurgia , Fístula Pancreática/etiologia , Fístula Pancreática/prevenção & controle , Neoplasias Pancreáticas/cirurgia , Pancreaticoduodenectomia/métodos , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/prevenção & controle
18.
Ann Ital Chir ; 62017 Nov 20.
Artigo em Inglês | MEDLINE | ID: mdl-29176078

RESUMO

INTRODUCTION: Neuroendocrine tumors (NETs) are a heterogeneous group of tumors. NET of colon represent less than 1% of colonic tumors. Synchronous liver metastases, present in 75-80%, are considered significant adverse prognostic indicators. Liver is the second commonest site for metastasis in patients with colorectal neuroendocrine tumors. Available treatment options include surgical resection, chemotherapy, biotherapy. Surgery is the gold standard for curative therapy and it is strictly related to the localization, the grade of tumor, and the stage of disease. CASE REPORT: We present a 64-year-old man with clinical carcinoid syndrome. Colonoscopy revealed ileocecal valve vegetating mass with negative biopsy. CT scans of thorax and abdomen showed a voluminous lesion (10 cm of diameter) of right liver. CEA, CA 19.9 and aFP were all normal. Only urinary 5HIAASerum 5-hydroxyindoleactic acid and blood Chromogranin A were positive. Surgical strategy was to treat the primary tumor and the liver synchronous metastasis in one stage surgery. DISCUSSION: Management of NETs liver metastases is challenging and requires aggressive therapy. Currently, there are many therapeutic options for metastatic NETs. Although complete surgical resection remains the optimal therapy and aggressive surgical resection increases the 5-year survival of NETs with solitary liver metastasis to 100%. In this case, clinical status with doubt of carcinoid syndrome was essential for diagnosis and for subsequent surgical strategy with one stage surgery. CONCLUSION: Resection of the primary tumor, liver metastases, and local mesenteric lymph node metastases is thought to strictly promote long-term survival and quality of life. Typically, a multidisciplinary approach is a cornerstone for decision making while dealing with this aggressive disease. KEY WORDS: Carcinoid syndrome, Liver surgery, NETs, Neuroendocrine tumor, One stage surgery, Synchronous liver metastasis.


Assuntos
Colectomia , Hepatectomia/métodos , Neoplasias Hepáticas/secundário , Neoplasias Hepáticas/cirurgia , Tumores Neuroendócrinos/secundário , Ablação por Cateter , Erros de Diagnóstico , Hemangioma/diagnóstico por imagem , Humanos , Neoplasias Hepáticas/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Tumores Neuroendócrinos/diagnóstico por imagem , Tumores Neuroendócrinos/cirurgia , Indução de Remissão
19.
JSLS ; 10(1): 66-9, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-16709361

RESUMO

OBJECTIVES: The aim of this study was to evaluate the safety and effectiveness of laparoscopic-assisted sigmoid colectomy for diverticulitis and to assess its postoperative advantages. METHODS: From 1999 to 2001, 5 patients were selectively operated on with a laparoscopic-assisted procedure for uncomplicated sigmoid diverticulitis. In the preceding period (September 1997 through December 1998), 4 patients underwent open procedures for the same pathology. The surgical indication with the same criteria was restrictive: at least 2 acute episodes had occurred that were treated with hospital admission and that were separated by an adequate period (2 months) of medical therapy. RESULTS: No conversions of laparoscopy to an open procedure were necessary. Age, sex, weight, morbidity, and mortality were similar between the 2 groups. Operative time was 180 minutes for laparoscopy and 120 minutes for laparotomy. Postoperative resumption of peristalsis was 24 hours versus 4 days, resumption of alimentation was on the second postoperative day versus the fifth postoperative day, and hospital stay was 7 days versus 12 days for laparoscopy and laparotomy, respectively. CONCLUSION: This study shows the feasibility and the advantages of elective laparoscopic-assisted colonic resection for uncomplicated sigmoid diverticulitis. The advantages of the laparoscopic approach are the lower need for analgesics and the more precocious ambulation, canalization, resumption of alimentation, and the shorter hospital stay.


Assuntos
Colectomia/métodos , Doença Diverticular do Colo/cirurgia , Laparoscopia , Doenças do Colo Sigmoide/cirurgia , Adulto , Procedimentos Cirúrgicos Eletivos , Feminino , Humanos , Laparotomia , Masculino , Pessoa de Meia-Idade
20.
Chir Ital ; 58(5): 549-56, 2006.
Artigo em Italiano | MEDLINE | ID: mdl-17069183

RESUMO

Minimally invasive video-assisted thyroidectomy, a recently developed technique, has been shown to be feasible and safe. Nevertheless, to obtain the best results, the surgeon should be well trained in endoscopic surgery. We attempted to answer the question whether an endocrine surgery division with no previous experience in endoscopic neck surgery could easily import the new technique. The inclusion criteria were nodules < or = 3.5 cm diameter or thyroid lobe volume less than 15 ml, and no thyroiditis or previous neck surgery. Suspect malignant nodules were excluded. The procedure was carried out through a 20 to 30 mm central neck incision, with external retraction and no neck insufflation. The vessels were ligated or closed by means of clips. From March 2004 to March 2005, 127 thyroidectomies were performed, of which 36 were thyroid lobectomies. Of these, 12 lobectomies by minimally invasive video-assisted thyroidectomy were performed for monolateral goiter (4 left, 8 right). There were no intraoperative complications. No recurrent laryngeal nerve palsy or permanent hypoparathyroidism occurred. The mean operative time was 74.4 min (median: 70; range: 45-115). The results, in terms of patient comfort, reduced postoperative pain and cosmetic quality were excellent. The technique allowed careful assessment of the inferior and superior laryngeal nerve. Thorough haemostasis was aided by the magnification of the image and optimal illumination. The learning curve appeared short, owing probably to previous experience in conventional endocrine surgery and the closer similarities of minimally invasive video-assisted thyroidectomy to enhanced-view conventional surgery than to laparoscopic surgery. In our experience the clinical impact was limited as a result of the small percentage of patients fulfilling the strict inclusion criteria.


Assuntos
Tireoidectomia/métodos , Cirurgia Vídeoassistida , Adenoma/cirurgia , Adulto , Idoso , Estudos de Viabilidade , Feminino , Bócio Nodular/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Minimamente Invasivos , Estudos Retrospectivos , Neoplasias da Glândula Tireoide/cirurgia , Nódulo da Glândula Tireoide/cirurgia , Resultado do Tratamento
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