Pesquisa | BVS Violência e Saúde

1.

Cell death.

Newton, Kim; Strasser, Andreas; Kayagaki, Nobuhiko; Dixit, Vishva M.

Cell ; 187(2): 235-256, 2024 01 18.

Artigo em Inglês | MEDLINE | ID: mdl-38242081

2.

Targeted alveolar regeneration with Frizzled-specific agonists.

Nabhan, Ahmad N; Webster, Joshua D; Adams, Jarret J; Blazer, Levi; Everrett, Christine; Eidenschenk, Celine; Arlantico, Alexander; Fleming, Isabel; Brightbill, Hans D; Wolters, Paul J; Modrusan, Zora; Seshagiri, Somasekar; Angers, Stephane; Sidhu, Sachdev S; Newton, Kim; Arron, Joseph R; Dixit, Vishva M.

Cell ; 186(14): 2995-3012.e15, 2023 07 06.

Artigo em Inglês | MEDLINE | ID: mdl-37321220

3.

Selective activation of PFKL suppresses the phagocytic oxidative burst.

Amara, Neri; Cooper, Madison P; Voronkova, Maria A; Webb, Bradley A; Lynch, Eric M; Kollman, Justin M; Ma, Taylur; Yu, Kebing; Lai, Zijuan; Sangaraju, Dewakar; Kayagaki, Nobuhiko; Newton, Kim; Bogyo, Matthew; Staben, Steven T; Dixit, Vishva M.

Cell ; 184(17): 4480-4494.e15, 2021 08 19.

Artigo em Inglês | MEDLINE | ID: mdl-34320407

4.

Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPß in Microglia.

Ndoja, Ada; Reja, Rohit; Lee, Seung-Hye; Webster, Joshua D; Ngu, Hai; Rose, Christopher M; Kirkpatrick, Donald S; Modrusan, Zora; Chen, Ying-Jiun Jasmine; Dugger, Debra L; Gandham, Vineela; Xie, Luke; Newton, Kim; Dixit, Vishva M.

Cell ; 182(5): 1156-1169.e12, 2020 09 03.

Artigo em Inglês | MEDLINE | ID: mdl-32795415

5.

N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation.

Gitlin, Alexander D; Maltzman, Allie; Kanno, Yuzuka; Heger, Klaus; Reja, Rohit; Schubert, Alexander F; Wierciszewski, Linsey J; Pantua, Homer; Kapadia, Sharookh B; Harris, Seth F; Webster, Joshua D; Newton, Kim; Dixit, Vishva M.

Immunity ; 57(5): 973-986.e7, 2024 May 14.

Artigo em Inglês | MEDLINE | ID: mdl-38697117

6.

Necroptosis and Inflammation.

Newton, Kim; Manning, Gerard.

Annu Rev Biochem ; 85: 743-63, 2016 Jun 02.

Artigo em Inglês | MEDLINE | ID: mdl-26865533

7.

ß-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1.

Suriben, Rowena; Kaihara, Kelly A; Paolino, Magdalena; Reichelt, Mike; Kummerfeld, Sarah K; Modrusan, Zora; Dugger, Debra L; Newton, Kim; Sagolla, Meredith; Webster, Joshua D; Liu, Jinfeng; Hebrok, Matthias; Dixit, Vishva M.

Cell ; 163(6): 1457-67, 2015 Dec 03.

Artigo em Inglês | MEDLINE | ID: mdl-26627735

8.

Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury.

Kayagaki, Nobuhiko; Stowe, Irma B; Alegre, Kamela; Deshpande, Ishan; Wu, Shuang; Lin, Zhonghua; Kornfeld, Opher S; Lee, Bettina L; Zhang, Juan; Liu, John; Suto, Eric; Lee, Wyne P; Schneider, Kellen; Lin, WeiYu; Seshasayee, Dhaya; Bhangale, Tushar; Chalouni, Cecile; Johnson, Matthew C; Joshi, Prajakta; Mossemann, Jan; Zhao, Sarah; Ali, Danish; Goldenberg, Neil M; Sayed, Blayne A; Steinberg, Benjamin E; Newton, Kim; Webster, Joshua D; Kelly, Ryan L; Dixit, Vishva M.

Nature ; 618(7967): 1072-1077, 2023 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-37196676

9.

Integration of innate immune signalling by caspase-8 cleavage of N4BP1.

Gitlin, Alexander D; Heger, Klaus; Schubert, Alexander F; Reja, Rohit; Yan, Donghong; Pham, Victoria C; Suto, Eric; Zhang, Juan; Kwon, Youngsu C; Freund, Emily C; Kang, Jing; Pham, Anna; Caothien, Roger; Bacarro, Natasha; Hinkle, Trent; Xu, Min; McKenzie, Brent S; Haley, Benjamin; Lee, Wyne P; Lill, Jennie R; Roose-Girma, Merone; Dohse, Monika; Webster, Joshua D; Newton, Kim; Dixit, Vishva M.

Nature ; 587(7833): 275-280, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-32971525

10.

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis.

Newton, Kim; Wickliffe, Katherine E; Dugger, Debra L; Maltzman, Allie; Roose-Girma, Merone; Dohse, Monika; Komuves, László; Webster, Joshua D; Dixit, Vishva M.

Nature ; 574(7778): 428-431, 2019 10.

Artigo em Inglês | MEDLINE | ID: mdl-31511692

11.

Activity of caspase-8 determines plasticity between cell death pathways.

Newton, Kim; Wickliffe, Katherine E; Maltzman, Allie; Dugger, Debra L; Reja, Rohit; Zhang, Yue; Roose-Girma, Merone; Modrusan, Zora; Sagolla, Meredith S; Webster, Joshua D; Dixit, Vishva M.

Nature ; 575(7784): 679-682, 2019 11.

Artigo em Inglês | MEDLINE | ID: mdl-31723262

12.

The RIPK4-IRF6 signalling axis safeguards epidermal differentiation and barrier function.

Oberbeck, Nina; Pham, Victoria C; Webster, Joshua D; Reja, Rohit; Huang, Christine S; Zhang, Yue; Roose-Girma, Merone; Warming, Søren; Li, Qingling; Birnberg, Andrew; Wong, Weng; Sandoval, Wendy; Komuves, László G; Yu, Kebing; Dugger, Debra L; Maltzman, Allie; Newton, Kim; Dixit, Vishva M.

Nature ; 574(7777): 249-253, 2019 10.

Artigo em Inglês | MEDLINE | ID: mdl-31578523

13.

OTULIN limits cell death and inflammation by deubiquitinating LUBAC.

Heger, Klaus; Wickliffe, Katherine E; Ndoja, Ada; Zhang, Juan; Murthy, Aditya; Dugger, Debra L; Maltzman, Allie; de Sousa E Melo, Felipe; Hung, Jeffrey; Zeng, Yi; Verschueren, Erik; Kirkpatrick, Donald S; Vucic, Domagoj; Lee, Wyne P; Roose-Girma, Merone; Newman, Robert J; Warming, Søren; Hsiao, Yi-Chun; Komuves, László G; Webster, Joshua D; Newton, Kim; Dixit, Vishva M.

Nature ; 559(7712): 120-124, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-29950720

14.

Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies.

Newton, Kim; Matsumoto, Marissa L; Wertz, Ingrid E; Kirkpatrick, Donald S; Lill, Jennie R; Tan, Jenille; Dugger, Debra; Gordon, Nathaniel; Sidhu, Sachdev S; Fellouse, Frederic A; Komuves, Laszlo; French, Dorothy M; Ferrando, Ronald E; Lam, Cynthia; Compaan, Deanne; Yu, Christine; Bosanac, Ivan; Hymowitz, Sarah G; Kelley, Robert F; Dixit, Vishva M.

Cell ; 134(4): 668-78, 2008 Aug 22.

Artigo em Inglês | MEDLINE | ID: mdl-18724939

15.

Deubiquitinases in cell death and inflammation.

Newton, Kim; Gitlin, Alexander D.

Biochem J ; 479(10): 1103-1119, 2022 05 27.

Artigo em Inglês | MEDLINE | ID: mdl-35608338

16.

RIPK1 inhibits ZBP1-driven necroptosis during development.

Newton, Kim; Wickliffe, Katherine E; Maltzman, Allie; Dugger, Debra L; Strasser, Andreas; Pham, Victoria C; Lill, Jennie R; Roose-Girma, Merone; Warming, Søren; Solon, Margaret; Ngu, Hai; Webster, Joshua D; Dixit, Vishva M.

Nature ; 540(7631): 129-133, 2016 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-27819682

17.

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.

Rutz, Sascha; Kayagaki, Nobuhiko; Phung, Qui T; Eidenschenk, Celine; Noubade, Rajkumar; Wang, Xiaoting; Lesch, Justin; Lu, Rongze; Newton, Kim; Huang, Oscar W; Cochran, Andrea G; Vasser, Mark; Fauber, Benjamin P; DeVoss, Jason; Webster, Joshua; Diehl, Lauri; Modrusan, Zora; Kirkpatrick, Donald S; Lill, Jennie R; Ouyang, Wenjun; Dixit, Vishva M.

Nature ; 518(7539): 417-21, 2015 Feb 19.

Artigo em Inglês | MEDLINE | ID: mdl-25470037

18.

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.

Wertz, Ingrid E; Newton, Kim; Seshasayee, Dhaya; Kusam, Saritha; Lam, Cynthia; Zhang, Juan; Popovych, Nataliya; Helgason, Elizabeth; Schoeffler, Allyn; Jeet, Surinder; Ramamoorthi, Nandhini; Kategaya, Lorna; Newman, Robert J; Horikawa, Keisuke; Dugger, Debra; Sandoval, Wendy; Mukund, Susmith; Zindal, Anuradha; Martin, Flavius; Quan, Clifford; Tom, Jeffrey; Fairbrother, Wayne J; Townsend, Michael; Warming, Søren; DeVoss, Jason; Liu, Jinfeng; Dueber, Erin; Caplazi, Patrick; Lee, Wyne P; Goodnow, Christopher C; Balazs, Mercedesz; Yu, Kebing; Kolumam, Ganesh; Dixit, Vishva M.

Nature ; 528(7582): 370-5, 2015 Dec 17.

Artigo em Inglês | MEDLINE | ID: mdl-26649818

19.

Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain.

Newton, Kim; Dugger, Debra L; Sengupta-Ghosh, Arundhati; Ferrando, Ronald E; Chu, Felix; Tao, Janet; Lam, Wendy; Haller, Susan; Chan, Sara; Sa, Susan; Dunlap, Debra; Eastham-Anderson, Jeffrey; Ngu, Hai; Hung, Jeffrey; French, Dorothy M; Webster, Joshua D; Bolon, Brad; Liu, Jinfeng; Reja, Rohit; Kummerfeld, Sarah; Chen, Ying-Jiun; Modrusan, Zora; Lewcock, Joseph W; Dixit, Vishva M.

Proc Natl Acad Sci U S A ; 115(44): 11244-11249, 2018 10 30.

Artigo em Inglês | MEDLINE | ID: mdl-30322923

20.

Is SIRT2 required for necroptosis?

Newton, Kim; Hildebrand, Joanne M; Shen, Zhirong; Rodriguez, Diego; Alvarez-Diaz, Silvia; Petersen, Sean; Shah, Saumil; Dugger, Debra L; Huang, Chunzi; Auwerx, Johan; Vandenabeele, Peter; Green, Douglas R; Ashkenazi, Avi; Dixit, Vishva M; Kaiser, William J; Strasser, Andreas; Degterev, Alexei; Silke, John.

Nature ; 506(7489): E4-6, 2014 Feb 27.

Artigo em Inglês | MEDLINE | ID: mdl-24572428

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