1.
Nat Neurosci
; 25(10): 1273-1278, 2022 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36171430
RESUMO
Oligodendrocyte precursor cells (OPCs) give rise to myelinating oligodendrocytes throughout life, but the functions of OPCs are not limited to oligodendrogenesis. Here we show that OPCs contribute to thalamocortical presynapse elimination in the developing and adult mouse visual cortex. OPC-mediated synapse engulfment increases in response to sensory experience during neural circuit refinement. Our data suggest that OPCs may regulate synaptic connectivity in the brain independently of oligodendrogenesis.
Assuntos
Células Precursoras de Oligodendrócitos , Animais , Encéfalo , Diferenciação Celular/fisiologia , Camundongos , Camundongos Transgênicos , Células Precursoras de Oligodendrócitos/fisiologia , Oligodendroglia/fisiologia , Sinapses
2.